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1. 发明授权

US06194467B1 Diabetes remedies 失效
标题翻译：糖尿病治疗
公开(公告)号：US06194467B1
公开(公告)日：2001-02-27
申请号：US09367163
申请日：1999-08-09
申请人： Hua-Kang Wu , Nobuto Koyama , Eiji Nishiyama , Takanari Tominaga , Michio Hagiya , Ikunoshin Kato
发明人： Hua-Kang Wu , Nobuto Koyama , Eiji Nishiyama , Takanari Tominaga , Michio Hagiya , Ikunoshin Kato
IPC分类号： A61K3112
CPC分类号： C07C323/59 , A23L2/52 , A23L33/10 , A23V2002/00 , A61K31/122 , C07C45/60 , C07C45/78 , C07C49/707 , C07C323/58 , Y10S514/866 , A23V2200/224 , A23V2250/5026 , A23V2250/5024 , A23V2250/06 , A23V2250/21 , A23V2250/204 , A23V2250/70
摘要： A therapeutic or preventive agent for diabetes mellitus which is characterized in containing at least one compound selected from a group consisting of 4,5-dihydroxy-2-cyclopenten-1-one represented by the following formula [I] and an optically active substance and a salt thereof as an effective component.
摘要翻译：一种糖尿病治疗或预防剂，其特征在于含有至少一种选自由下式[I]表示的4,5-二羟基-2-环戊烯-1-酮和光学活性物质的化合物和其盐作为有效成分。

2. 发明授权

US06177592B1 Compounds 失效
标题翻译：化合物
公开(公告)号：US06177592B1
公开(公告)日：2001-01-23
申请号：US09341768
申请日：1999-07-16
申请人： Nobuto Koyama , Tatsuji Enoki , Katsushige Ikai , Hua-Kang Wu , Hiromu Ohnogi , Takanari Tominaga , Eiji Nishiyama , Michio Hagiya , Hiroaki Sagawa , Hideto Chono , Ikunoshin Kato
发明人： Nobuto Koyama , Tatsuji Enoki , Katsushige Ikai , Hua-Kang Wu , Hiromu Ohnogi , Takanari Tominaga , Eiji Nishiyama , Michio Hagiya , Hiroaki Sagawa , Hideto Chono , Ikunoshin Kato
IPC分类号： C07C6106
CPC分类号： C07C323/59 , A23K20/105 , A23L2/52 , A23L33/10 , A23V2002/00 , A61K31/122 , C07C45/60 , C07C45/78 , C07C49/707 , C07C323/58 , C07C2601/08 , Y02A50/478 , A23V2200/224 , A23V2250/5026 , A23V2250/5024 , A23V2250/70 , A23V2250/204 , A23V2250/06 , A23V2250/21
摘要： A compound represented by the following formula [I] or an optically active substance or a salt thereof. (In the formula, a bond shown by a dotted line in the five-membered ring means that said five-membered ring may be any of a cyclopentene ring having a double bond and a cyclopentane ring where said bond is saturated and, in the case of a cyclopentene ring, X is OH, Y is ═O and Z is H while, in the case of a cyclopentane ring, X is ═O, Y is OH and Z is OH. R is a residue after removal of an SH group from the SH-containing compound.)
摘要翻译：由下式[I]表示的化合物或光学活性物质或其盐（在该式中，五元环中虚线所示的键表示所述五元环可以是具有双键的环戊烯环和所述键饱和的环戊烷环，在环戊烯环的情况下，X为OH，Y为= O且Z为H，而在环戊烷环的情况下，X为= O，Y是OH，Z是OH，R是从含SH的化合物除去SH基团后的残基。

3. 发明授权

US06284801B1 Antirheumatic agents 失效
标题翻译：抗风湿剂
公开(公告)号：US06284801B1
公开(公告)日：2001-09-04
申请号：US09380239
申请日：1999-08-27
申请人： Nobuto Koyama , Hua-Kang Wu , Takanari Tominaga , Eiji Nishiyama , Michio Hagiya , Tatsuji Enoki , Hiromu Ohnogi , Ikunoshin Kato
发明人： Nobuto Koyama , Hua-Kang Wu , Takanari Tominaga , Eiji Nishiyama , Michio Hagiya , Tatsuji Enoki , Hiromu Ohnogi , Ikunoshin Kato
IPC分类号： A61K3112
CPC分类号： C07C323/59 , A23L2/52 , A23L33/10 , A23V2002/00 , A61K31/122 , C07C45/60 , C07C45/78 , C07C49/707 , C07C323/58 , A23V2200/224 , A23V2250/5026 , A23V2250/5024 , A23V2250/21 , A23V2250/70 , A23V2250/06 , A23V2250/204
摘要： An antirheumatic agent which is characterized in containing at least one compound selected from a group consisting of 4,5-dihydroxy-2-cyclopenten-l-one represented by the following formula [I] and an optically active substance and a salt thereof as an effective component.
摘要翻译：一种抗风湿剂，其特征在于含有至少一种选自由下式[I]表示的4,5-二羟基-2-环戊烯-1-酮的化合物和光学活性物质及其盐作为有效成分。

4. 发明授权

US06228892B1 Antiallergic agents 失效
标题翻译：抗过敏剂
公开(公告)号：US06228892B1
公开(公告)日：2001-05-08
申请号：US09423883
申请日：1999-11-15
申请人： Takanari Tominaga , Eiji Nishiyama , Michio Hagiya , Nobuto Koyama , Ikunoshin Kato
发明人： Takanari Tominaga , Eiji Nishiyama , Michio Hagiya , Nobuto Koyama , Ikunoshin Kato
IPC分类号： A61K3112
CPC分类号： A61K31/122 , A23L33/10 , A23V2002/00 , Y10S514/826 , Y10S514/862 , Y10S514/885 , Y10S514/886 , A23V2250/156
摘要： An antiallergic agent which is characterized in containing at least one compound selected from a group consisting of 4,5-dihydroxy-2-cyclopenten-1-one represented by the following formula [I] and an optically active substance and a salt thereof as an effective component.
摘要翻译：一种抗过敏剂，其特征在于含有至少一种选自由下式[I]表示的4,5-二羟基-2-环戊烯-1-酮的化合物和光学活性物质及其盐作为有效成分。

5. 发明申请

US20050239100A1 Method for amplifying nucleic acid sequence 审中-公开
标题翻译：扩增核酸序列的方法
公开(公告)号：US20050239100A1
公开(公告)日：2005-10-27
申请号：US10973919
申请日：2004-10-27
申请人： Hiroyuki Mukai , Hiroaki Sagawa , Takashi Uemori , Junko Yamamoto , Jun Tomono , Eiji Kobayashi , Tatsuji Enoki , Osamu Takeda , Kazue Miyake , Yoshimi Sato , Mariko Moriyama , Haruhisa Sawaragi , Michio Hagiya , Kiyozo Asada , Ikunoshin Kato
发明人： Hiroyuki Mukai , Hiroaki Sagawa , Takashi Uemori , Junko Yamamoto , Jun Tomono , Eiji Kobayashi , Tatsuji Enoki , Osamu Takeda , Kazue Miyake , Yoshimi Sato , Mariko Moriyama , Haruhisa Sawaragi , Michio Hagiya , Kiyozo Asada , Ikunoshin Kato
IPC分类号： C07H21/04 , C12N9/22 , C12P19/34 , C12Q1/68
CPC分类号： C12N9/1252 , C12P19/34 , C12Q1/6853 , C12Q2531/119 , C12Q2525/121 , C12Q2521/301
摘要： A convenient and effective method for amplifying a nucleic acid sequence characterized by effecting a DNA synthesis reaction in the presence of chimeric oligonucleotide primers; a method for supplying a large amount of DNA amplification fragments; an effective method for amplifying a nucleic acid sequence by combining the above method with another nucleic acid sequence amplification method; a method for detecting a nucleic acid sequence for detecting or quantitating a microorganism such as a virus, a bacterium, a fungus or a yeast; and a method for detecting a DNA amplification fragment obtained by the above method in situ.
摘要翻译：一种用于扩增核酸序列的方法和方法，其特征在于在嵌合寡核苷酸引物存在下进行DNA合成反应; 提供大量DNA扩增片段的方法; 通过将上述方法与另一种核酸序列扩增方法结合来扩增核酸序列的有效方法; 用于检测用于检测或定量微生物如病毒，细菌，真菌或酵母的核酸序列的方法; 以及通过上述方法原位检测DNA扩增片段的方法。

6. 发明申请

US20050123950A1 Method for amplifying nucleic acid sequence 审中-公开
公开(公告)号：US20050123950A1
公开(公告)日：2005-06-09
申请号：US10929759
申请日：2004-08-31
申请人： Hiroyuki Mukai , Hiroaki Sagawa , Takashi Uemori , Junko Yamamoto , Jun Tomono , Eiji Kobayashi , Tatsuji Enoki , Osamu Takeda , Kazue Miyake , Yoshimi Sato , Mariko Moriyama , Haruhisa Sawaragi , Michio Hagiya , Kiyozo Asada , Ikunoshin Kato
发明人： Hiroyuki Mukai , Hiroaki Sagawa , Takashi Uemori , Junko Yamamoto , Jun Tomono , Eiji Kobayashi , Tatsuji Enoki , Osamu Takeda , Kazue Miyake , Yoshimi Sato , Mariko Moriyama , Haruhisa Sawaragi , Michio Hagiya , Kiyozo Asada , Ikunoshin Kato
IPC分类号： C07H21/04 , C12N9/22 , C12P19/34 , C12Q1/68
CPC分类号： C12N9/1252 , C12P19/34 , C12Q1/6853 , C12Q2531/119 , C12Q2525/121 , C12Q2521/301
摘要： A convenient and effective method for amplifying a nucleic acid sequence characterized by effecting a DNA synthesis reaction in the presence of chimeric oligonucleotide primers; a method for supplying a large amount of DNA amplification fragments; an effective method for amplifying a nucleic acid sequence by combining the above method with another nucleic acid sequence amplification method; a method for detecting a nucleic acid sequence for detecting or quantitating a microorganism such as a virus, a bacterium, a fungus or a yeast; and a method for detecting a DNA amplification fragment obtained by the above method in situ.

7. 发明授权

US06951722B2 Method for amplifying nucleic acid sequence 失效
公开(公告)号：US06951722B2
公开(公告)日：2005-10-04
申请号：US09935338
申请日：2001-08-23
申请人： Hiroyuki Mukai , Hiroaki Sagawa , Takashi Uemori , Junko Yamamoto , Jun Tomono , Eiji Kobayashi , Tatsuji Enoki , Osamu Takeda , Kazue Miyake , Yoshimi Sato , Mariko Moriyama , Haruhisa Sawaragi , Michio Hagiya , Kiyozo Asada , Ikunoshin Kato
发明人： Hiroyuki Mukai , Hiroaki Sagawa , Takashi Uemori , Junko Yamamoto , Jun Tomono , Eiji Kobayashi , Tatsuji Enoki , Osamu Takeda , Kazue Miyake , Yoshimi Sato , Mariko Moriyama , Haruhisa Sawaragi , Michio Hagiya , Kiyozo Asada , Ikunoshin Kato
IPC分类号： C07H21/04 , C12N9/22 , C12P19/34 , C12Q1/68
CPC分类号： C12N9/1252 , C12P19/34 , C12Q1/6853 , C12Q2531/119 , C12Q2525/121 , C12Q2521/301
摘要： A convenient and effective method for amplifying a nucleic acid sequence characterized by effecting a DNA synthesis reaction in the presence of chimeric oligonucleotide primers; a method for supplying a large amount of DNA amplification fragments; an effective method for amplifying a nucleic acid sequence by combining the above method with another nucleic acid sequence amplification method; a method for detecting a nucleic acid sequence for detecting or quantitating a microorganism such as a virus, a bacterium, a fungus or a yeast; and a method for detecting a DNA amplification fragment obtained by the above method in situ.

8. 发明授权

US06673578B1 Method for synthesizing DNA 失效
标题翻译： DNA合成方法
公开(公告)号：US06673578B1
公开(公告)日：2004-01-06
申请号：US09786684
申请日：2001-05-22
申请人： Takashi Uemori , Yoshimi Sato , Mariko Okawa , Tomoko Fujita , Kazue Miyake , Osamu Takeda , Hiroaki Sagawa , Michio Hagiya , Hiroyuki Mukai , Kiyozo Asada , Ikunoshin Kato
发明人： Takashi Uemori , Yoshimi Sato , Mariko Okawa , Tomoko Fujita , Kazue Miyake , Osamu Takeda , Hiroaki Sagawa , Michio Hagiya , Hiroyuki Mukai , Kiyozo Asada , Ikunoshin Kato
IPC分类号： C12P1934
CPC分类号： C12N15/1003 , C12Q1/686 , C12Q2527/125
摘要： A DNA synthesis method with a shortened time period required for DNA synthesis by polymerase chain reaction (PCR), characterized in that a DNA polymerase is used in an amount effective for providing more than 10 ng of amplified DNA fragments of about 2 kb per 50 &mgr;l of a reaction mixture, when PCR is carried out under the following conditions (A) and (B): (A) reaction mixture: 50 &mgr;l volume of a reaction mixture comprising DNA polymerase, 1 ng of genomic DNA from Escherichia coli, and 10 pmol each of primers Eco-1 and Eco-2 (nucleotide sequences of the primers Eco-1 and Eco-2 being shown in SEQ ID NOs: 10 and 11 of Sequence Listing, respectively); and having a composition suitable for the DNA polymerase; and (B) reaction conditions: 35 cycles of PCR, wherein one cycle consists of 99° C., 1 second-66° C., 7 seconds; a kit for DNA synthesis usable for the DNA synthesis method; and an article of manufacture of a PCR agent. According to the present invention, the procedures in the genetic engineering studies and industries involved with PCR can be speeded up.
摘要翻译：一种DNA合成方法，其通过聚合酶链式反应（PCR）进行DNA合成所需的时间缩短，其特征在于使用DNA聚合酶，其量有效提供超过10ng每50ul约2kb的扩增DNA片段的反应混合物，当在以下条件（A）和（B）下进行PCR时：（A）反应混合物：将50体积的包含DNA聚合酶的反应混合物，1ng来自大肠杆菌的基因组DNA和10ng 各引物Eco-1和Eco-2（引物Eco-1和Eco-2的核苷酸序列分别示于序列表的SEQ ID NO：10和11中）并具有适合于DNA聚合酶的组合物; 和（B）反应条件：35个循环的PCR，其中一个循环由99℃，1秒-66℃，7秒; 用于DNA合成方法的DNA合成试剂盒; 以及PCR试剂的制造。根据本发明，可以加快基因工程研究和涉及PCR的行业的程序。

9. 发明授权

US07141389B1 Chromosome DNA coding for human hepatocyte growth factor 失效
标题翻译：编码人类肝细胞生长因子的染色体DNA
公开(公告)号：US07141389B1
公开(公告)日：2006-11-28
申请号：US08292160
申请日：1994-08-17
申请人： Toshikazu Nakamura , Tatsuya Seki , Michio Hagiya , Manabu Shimonishi , Shin Shimizu
发明人： Toshikazu Nakamura , Tatsuya Seki , Michio Hagiya , Manabu Shimonishi , Shin Shimizu
IPC分类号： C12N1/16 , C12N5/16 , C12N15/18 , C12N15/63 , C12N1/21
CPC分类号： C07K14/4753
摘要： A chromosome DNA which codes for human hepatocyte growth factor, a recombinant expression vector capable of expressing the DNA, a transformant transformed with the expression vector and a method of producing recombinant human hepatocyte growth factor. The DNA and polypeptide of the present invention are expected to serve well for hepatocyte cultivation reagents, liver regeneration promoters, various researches, clinical diagnostic reagents and therapeutic drugs for liver diseases.
摘要翻译：编码人肝细胞生长因子的染色体DNA，能够表达DNA的重组表达载体，用表达载体转化的转化体和产生重组人肝细胞生长因子的方法。本发明的DNA和多肽预期对于肝细胞培养试剂，肝脏再生促进剂，各种研究，临床诊断试剂和用于肝脏疾病的治疗药物起很好的作用。

10. 发明授权

US5480797A Augmenter of liver regeneration (ALR) 失效
标题翻译：肝脏再生增强剂（ALR）
公开(公告)号：US5480797A
公开(公告)日：1996-01-02
申请号：US197496
申请日：1994-02-16
申请人： Antonio T. Francavilla , Michio Hagiya , Thomas E. Starzl
发明人： Antonio T. Francavilla , Michio Hagiya , Thomas E. Starzl
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C12N1/21 , C12N5/10 , C12N15/63
CPC分类号： C07K14/47 , A61K38/00
摘要： A full-length cDNA clone has been isolated encoding a purified augmenter of liver regeneration (ALR) polypeptide prepared from the cytosol of livers from weanling rats. The 1.2 kb cDNA includes a 299 bp 5'-untranslated region, a 375 bp coding region and a 551 bp 3'-untranslated region. The cDNA encodes a protein consisting of 125 amino acids. The molecular weight of ALR calculated from the cDNA was 15,081 which is consistent with the size estimated by SDS-PAGE under reducing conditions. The molecular weight of the purified native ALR estimated by SDS-PAGE under non-reducing conditions is about 30,000, apparently with a homodimer structure. The recombinant ALR produced by expression of the cDNA in cultured cells was tested in vivo in the canine Eck's fistula model and found to have a potency equivalent to the purified native ALR. The most obvious immediate clinical use for the augmenter of liver regeneration is in the treatment of hepatic failure.
摘要翻译：已经分离了全长cDNA克隆，其编码从断奶大鼠的肝细胞质中制备的纯化的肝再生增强子（ALR）多肽。 1.2kb cDNA包括299bp的5'非翻译区，375bp的编码区和551bp的3'非翻译区。 cDNA编码由125个氨基酸组成的蛋白质。从cDNA计算的ALR的分子量为15,081，这与在还原条件下通过SDS-PAGE估计的大小一致。在非还原条件下通过SDS-PAGE估计的纯化天然ALR的分子量约为30,000，显然具有同二聚体结构。在犬Eck的瘘模型中体内测试了通过在培养细胞中表达cDNA产生的重组ALR，并发现其具有与纯化的天然ALR相当的效力。用于肝再生增强剂的最明显的临床应用是治疗肝衰竭。

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