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1. 发明申请

US20050272798A1 Disulfide prodrugs and linkers and stabilizers useful therefor 有权
标题翻译：用于此的二硫化物前体药物和接头和稳定剂
公开(公告)号：US20050272798A1
公开(公告)日：2005-12-08
申请号：US11133970
申请日：2005-06-21
申请人： Howard Ng , Zhihong Li , Danny McGee , Oliver Saunders , Guoxian Wu , David King , Valeri Martichonok , Sharon Boyd , Thomas Lobl
发明人： Howard Ng , Zhihong Li , Danny McGee , Oliver Saunders , Guoxian Wu , David King , Valeri Martichonok , Sharon Boyd , Thomas Lobl
IPC分类号： A61K31/343 , A61K31/403 , A61K31/407 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K38/00 , A61K39/395 , A61K47/48 , A61P35/00 , A61P43/00 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07D487/10 , C07D521/00 , C07F7/18 , C07F9/6561 , C07K5/02 , C07K7/02 , C07K7/06 , C07D487/02
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14 , C07D487/04 , C07D487/10 , C07F7/1804 , C07F9/6561
摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
摘要翻译：本发明提供了作为有效的细胞毒素的杜卡霉素的类似物。还提供了在体内被切割的肽基和二硫键接头。连接体可用于形成本发明的细胞毒素的前药和缀合物以及其它诊断和治疗部分。本发明提供了杜卡霉素类似物与本发明的连接臂的前药和缀合物。

2. 发明授权

US10779515B1 Anchor device 有权
公开(公告)号：US10779515B1
公开(公告)日：2020-09-22
申请号：US16007159
申请日：2018-06-13
申请人： David King , Ray Stewart
发明人： David King , Ray Stewart
IPC分类号： A01K61/00 , A01K61/78 , F16B9/00 , A01K61/10
摘要： The present invention is an anchor for an artificial structure for attracting fish within a body of water. The structure is comprised of a base and has a central attachment post, a central column configured to secure to the attachment post, and a protective plate.

3. 发明授权

US10494671B2 Enzymatic ligation of nucleic acids 有权
公开(公告)号：US10494671B2
公开(公告)日：2019-12-03
申请号：US13980280
申请日：2012-01-17
申请人： Stephen Hendricks , David King
发明人： Stephen Hendricks , David King
IPC分类号： C12Q1/68 , C12Q1/6869 , C07H21/00 , C12Q1/6874 , A61J1/14 , B65D8/00 , B65B3/00 , B65B31/04 , A61J1/06 , C12N9/00 , C12Q1/6876 , A61M5/00 , B65B55/08 , B65B55/10 , A61M5/50
CPC分类号： C12Q1/6874 , A61J1/062 , A61J1/14 , B65B3/003 , B65B3/006 , B65B31/046 , B65D15/02 , C12N9/93 , C12Q1/6876 , A61J2200/76 , A61J2205/30 , A61M5/008 , A61M5/5086 , B65B55/08 , B65B55/10 , C12Q2600/16 , C12Y605/01001
摘要： Methods, assays, compositions and kits for the ligation of short polynucleotides are presented herein. The short polynucleotides are optionally no more than 7 nucleotides in length, and can be as short as 3 or 4 nucleotides in length. The ligation is optionally performed by CV ligase.

4. 发明申请

US20130202591A1 ANTIBODIES DIRECTED AGAINST IL-17 有权
标题翻译：针对IL-17的抗体
公开(公告)号：US20130202591A1
公开(公告)日：2013-08-08
申请号：US13814262
申请日：2011-08-02
申请人： Robert Horlick , David King , Peter Bowers , Jennifer Dalton , Betty Wu , Traci Roberts , Xue Zhang , Laurence Altobell, III
发明人： Robert Horlick , David King , Peter Bowers , Jennifer Dalton , Betty Wu , Traci Roberts , Xue Zhang , Laurence Altobell, III
IPC分类号： C07K16/24
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/76 , C07K2317/92
摘要： The disclosure relates to an isolated IL-17-binding agent which comprises an immunoglobulin heavy chain polypeptide comprising SEQ ID NO: 1 and optionally an immunoglobulin light chain polypeptide comprising SEQ ID NO: 23, except that one or more specific of residues of SEQ ID NO: 1 and SEQ ID NO: 23 are replaced with a different residue. The disclosure also provides vectors, compositions, and methods of using the IL-17-binding agent to treat an IL-17-mediated disease.
摘要翻译：本公开涉及分离的IL-17结合剂，其包含包含SEQ ID NO：1的免疫球蛋白重链多肽和任选的包含SEQ ID NO：23的免疫球蛋白轻链多肽，除了SEQ ID NO：23的一个或多个特异性残基 NO：1和SEQ ID NO：23被不同的残基取代。本公开还提供了使用IL-17结合剂治疗IL-17介导的疾病的载体，组合物和方法。

5. 发明授权

US08475797B2 Interferon alpha antibodies and their uses 有权
标题翻译：干扰素α抗体及其用途
公开(公告)号：US08475797B2
公开(公告)日：2013-07-02
申请号：US13211092
申请日：2011-08-16
申请人： Alison Witte , Denise Williams , Josphine M Cardelli , David King , David Passmore
发明人： Alison Witte , Denise Williams , Josphine M Cardelli , David King , David Passmore
IPC分类号： A61K39/395
CPC分类号： C07K16/249 , A61K51/1021 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/76
摘要： The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.
摘要翻译：本发明提供分离的抗干扰素α单克隆抗体，特别是人单克隆抗体，其抑制多种干扰素（IFN）α亚型的生物学活性，但基本上不抑制IFNα21的生物活性或IFNβ的生物学活性或IFNγ。还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。本发明还提供了使用本发明的抗体抑制IFNα的生物学活性的方法，以及通过施用本发明的抗体来治疗由IFNα介导的疾病或病症的方法，例如自身免疫疾病，移植排斥反应和移植物抗宿主病本发明的抗体。

6. 发明授权

US08290147B2 Systems and methods for efficiently creating digests of digital data 有权
标题翻译：有效地创建数字数据摘要的系统和方法
公开(公告)号：US08290147B2
公开(公告)日：2012-10-16
申请号：US12609888
申请日：2009-10-30
申请人： Gerardo Orlando , David King , Mark Krumpoch
发明人： Gerardo Orlando , David King , Mark Krumpoch
IPC分类号： H04L9/28
CPC分类号： H04L9/0637 , H03M13/09 , H04L9/3236 , H04L2209/12
摘要： Systems and methods efficiently process digests, hashes or other results by performing multiplicative functions in parallel with each other. In various embodiments, successive processing stages are provided, with each stage performing parallel multiplicative functions and also combining input terms to reduce the total number of terms that remain to be processed. By progressively combining the active terms into a smaller number of terms for subsequent processing, the time needed to process a result can be significantly reduced.
摘要翻译：系统和方法通过彼此并行执行乘法函数来有效地处理摘要，散列或其他结果。在各种实施例中，提供了连续的处理阶段，每个阶段执行并行乘法函数，并且还组合输入项以减少待处理的项的总数。通过将活动术语逐渐组合成较少数量的术语以用于后续处理，可以显着减少处理结果所需的时间。

7. 外观设计

USD655752S1 Clip for a photo album 有权
标题翻译：剪辑一张相册
公开(公告)号：USD655752S1
公开(公告)日：2012-03-13
申请号：US29384871
申请日：2011-02-04
申请人： David King , David Harbinson
设计人： David King , David Harbinson

8. 外观设计

USD625471S1 Fish retention structure 有权
标题翻译：养鱼结构
公开(公告)号：USD625471S1
公开(公告)日：2010-10-12
申请号：US29316174
申请日：2009-08-31
申请人： David King
设计人： David King

9. 发明申请

US20080034895A1 System and method for measuring interaction of loads 失效
公开(公告)号：US20080034895A1
公开(公告)日：2008-02-14
申请号：US11503766
申请日：2006-08-14
申请人： Shaun David McCarthy , Michael Andrew Daly , Alan Simpson , Ciaran Mythen , Martin Flood , Guillaume Reux , David King
发明人： Shaun David McCarthy , Michael Andrew Daly , Alan Simpson , Ciaran Mythen , Martin Flood , Guillaume Reux , David King
IPC分类号： G01L3/02
CPC分类号： G01L3/10 , G01M13/025
摘要： A test system for measuring a rotary load comprises a stepper motor drives a gear box that is mounted at one end of a frame. A torque sensor provides a measurement signal transmission. The gear box's output shaft is connected to one of the torque sensor's stubs by means of a universal joint coupling. On the other side of the torque sensor a second universal joint coupling connects the sensor to a stainless steel shaft. A low friction flange bearing is used to provide support for the shaft. An angle encoder is disposed on the end of the shaft distal to the gear box. The gear box's output shaft, the torque sensor's cylindrical shaft hubs and associated couplings are arranged such that they are directly aligned with the shaft. The test system has been designed to take automated torque and angle readings from a shaft capable of rotary motion. The measurement arm configuration with the stepper motor directly connects the torque and angle sensors to a PC based data acquisition card for acquisition and processing of data. The system operates according to a method used to make a true torque measurement of a rotary actuated shaft or wheel in a process where a first data set is acquired with the system unloaded as the shaft or wheel is actuated through the defined travel path. The actuation force applied by the stepper motor is accurately controlled through a computer interface. Torque data is measured at each angular step as the wheel is actuated in a first direction. Torque data is then measured at each angular step as the wheel is actuated in the opposite direction. A load is then placed on the test system. With the load on the system, torque data is acquired/measured at each angular step through the defined travel path. Torque data is then measured at each angular step as the wheel is actuated in the opposite direction through the defined travel path. Ultimately, the true torque, i.e. torque less the effects of friction and the system baseline mechanical profile, is determined by adjusting measurement data to virtually eliminate these two effects.

10. 发明申请

US20070091136A1 Printhead having a plurality of print modes 有权
标题翻译：打印头具有多种打印模式
公开(公告)号：US20070091136A1
公开(公告)日：2007-04-26
申请号：US11254456
申请日：2005-10-20
申请人： Lucas Barkley , David King , Randall Mayo , George Parish
发明人： Lucas Barkley , David King , Randall Mayo , George Parish
IPC分类号： B41J29/393
CPC分类号： B41J19/145 , B41J2/2132 , G06K15/107
摘要： Printheads configured to operate in accordance with a plurality of print modes. For example, one of the plurality of print modes can be selected in accordance with a bit of address data received by the printhead. In an exemplary embodiment, the selection of print mode can be accomplished by switching one or more actuator (e.g., heater) circuit addresses on the printhead.
摘要翻译：打印头被配置为根据多种打印模式进行操作。例如，可以根据由打印头接收到的地址数据的位来选择多个打印模式之一。在示例性实施例中，可以通过切换打印头上的一个或多个致动器（例如，加热器）电路地址来实现打印模式的选择。

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