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1. 发明申请

US20130069463A1 ELECTRIC MOTOR 有权
标题翻译：电动马达
公开(公告)号：US20130069463A1
公开(公告)日：2013-03-21
申请号：US13239130
申请日：2011-09-21
申请人： Weirong Zhang , Christof Frick , Zhendong Mi , Guoxian Wu
发明人： Weirong Zhang , Christof Frick , Zhendong Mi , Guoxian Wu
IPC分类号： H02K13/00 , H02K7/08
CPC分类号： H02K13/006 , H02K2205/06
摘要： An electric motor for moving a vehicle part, the electric motor having a stator with a stator housing, a drive shaft rotatable with respect to the stator, a rotor on the drive shaft and having a rotor winding, a commutator on the drive shaft for supplying an electric current to the rotor winding, at least two brushes mounted on the stator housing, the brushes in sliding contact with the commutator for supplying electric current to the rotor winding, a bushing mounted on the drive shaft adjacent to the commutator, and a cone element mounted on the drive shaft adjacent to the bushing on a side of the bushing facing away from the commutator, the cone element having an outer surface which conforms to the shape of a cone concentrical to the drive shaft and having a tip pointing away from the bushing.
摘要翻译：一种用于移动车辆部件的电动机，具有定子的电动机具有定子壳体，相对于定子可旋转的驱动轴，驱动轴上的转子，具有转子绕组，在驱动轴上的换向器，用于供给到转子绕组的电流，安装在定子壳体上的至少两个电刷，电刷与换向器滑动接触，用于向转子绕组提供电流，安装在驱动轴上的与换向器相邻的衬套，以及锥体所述元件安装在所述驱动轴上，所述驱动轴在所述衬套的相对于所述换向器的一侧的所述驱动轴上相邻，所述锥形元件具有与所述驱动轴同心的锥体形状的外表面，并且具有远离所述换向器的尖端衬套。

2. 发明申请

US20100004222A1 Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same 审中-公开
标题翻译：酰胺衍生物作为离子通道配体和药物组合物及其使用方法
公开(公告)号：US20100004222A1
公开(公告)日：2010-01-07
申请号：US12224357
申请日：2007-02-22
申请人： Michael G. Kelly , Carl J. Kaub , John Kincaid , Satyanarayana Janagani , Guoxian Wu , Zhi-Liang Wei , Kiran Sahasrabudhe , Matthew Duncton , Ravindra B. Upasani , Yunfeng Fang , Matthew Cox , Jianhua He
发明人： Michael G. Kelly , Carl J. Kaub , John Kincaid , Satyanarayana Janagani , Guoxian Wu , Zhi-Liang Wei , Kiran Sahasrabudhe , Matthew Duncton , Ravindra B. Upasani , Yunfeng Fang , Matthew Cox , Jianhua He
IPC分类号： A61K31/47 , C07D215/38 , C07D513/04 , C07D471/04 , C07D217/02 , C07D265/36 , C07D413/12 , C07D319/16 , C07D277/62 , C07D267/14 , C07D498/04 , A61K31/436 , A61K31/4375 , A61K31/498 , A61K31/404 , A61K31/428 , A61K31/437 , A61K31/553 , A61P25/00 , A61P11/00
CPC分类号： C07D209/08 , C07D209/48 , C07D215/06 , C07D217/02 , C07D217/22 , C07D231/56 , C07D235/08 , C07D237/28 , C07D241/42 , C07D263/58 , C07D265/36 , C07D267/14 , C07D277/64 , C07D295/088 , C07D295/13 , C07D317/52 , C07D317/58 , C07D319/18 , C07D333/54 , C07D401/12 , C07D405/12 , C07D413/12 , C07D471/04 , C07D491/04 , C07D498/04 , C07D513/04
摘要： Compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译：公开了具有由下式表示的式的化合物：式（I）。化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例，疼痛，炎症，创伤性损伤等。

3. 发明申请

US20090175888A1 METHODS OF TREATING CANCER WITH AN ANTIBODY-DRUG CONJUGATE 有权
标题翻译：用抗体药物治疗癌症的方法
公开(公告)号：US20090175888A1
公开(公告)日：2009-07-09
申请号：US12396266
申请日：2009-03-02
申请人： Howard P. Ng , Zhihong Li , Danny P.C. McGee , Oliver L. Saunders , Guoxian Wu , David J. King , Valeri Martichonok , Sharon Boyd , Thomas J. Lobl
发明人： Howard P. Ng , Zhihong Li , Danny P.C. McGee , Oliver L. Saunders , Guoxian Wu , David J. King , Valeri Martichonok , Sharon Boyd , Thomas J. Lobl
IPC分类号： A61K39/395 , C07D487/04 , A61P35/00
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14 , C07D487/04 , C07D487/10 , C07F7/1804 , C07F9/6561
摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
摘要翻译：本发明提供了作为有效的细胞毒素的杜卡霉素的类似物。还提供了在体内被切割的肽基和二硫键接头。连接体可用于形成本发明的细胞毒素的前药和缀合物以及其它诊断和治疗部分。本发明提供了杜卡霉素类似物与本发明的连接臂的前药和缀合物。

4. 发明授权

US07087600B2 Peptidyl prodrugs and linkers and stabilizers useful therefor 有权
公开(公告)号：US07087600B2
公开(公告)日：2006-08-08
申请号：US10161234
申请日：2002-05-31
申请人： Howard P. Ng , Danny P. C. McGee , Guoxian Wu , Jimmie Moore , Zhihong Li , Sanjeev Gangwar , Oliver L. Saunders , Irina Astafieva
发明人： Howard P. Ng , Danny P. C. McGee , Guoxian Wu , Jimmie Moore , Zhihong Li , Sanjeev Gangwar , Oliver L. Saunders , Irina Astafieva
IPC分类号： A61K31/535 , A61K31/407 , C07D487/02
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14 , C07D487/04 , C07D487/10 , C07F7/1804 , C07F9/6561
摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.

5. 发明授权

US06989452B2 Disulfide prodrugs and linkers and stabilizers useful therefor 有权
公开(公告)号：US06989452B2
公开(公告)日：2006-01-24
申请号：US10161233
申请日：2002-05-31
申请人： Howard P. Ng , Zhihong Li , Danny P. C. McGee , Oliver L. Saunders , Guoxian Wu , David J. King , Valeri Martichonok , Sharon Boyd , Thomas J. Lobl
发明人： Howard P. Ng , Zhihong Li , Danny P. C. McGee , Oliver L. Saunders , Guoxian Wu , David J. King , Valeri Martichonok , Sharon Boyd , Thomas J. Lobl
IPC分类号： C07D487/00 , C07D487/02
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14 , C07D487/04 , C07D487/10 , C07F7/1804 , C07F9/6561
摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.

6. 发明授权

US09325226B2 Electric motor having a commutator and brushes in sliding contact therewith 有权
标题翻译：具有换向器的电动机和与其滑动接触的电刷
公开(公告)号：US09325226B2
公开(公告)日：2016-04-26
申请号：US13239130
申请日：2011-09-21
申请人： Weirong Zhang , Christof Frick , Zhendong Mi , Guoxian Wu
发明人： Weirong Zhang , Christof Frick , Zhendong Mi , Guoxian Wu
IPC分类号： H02K5/14 , H02K13/00
CPC分类号： H02K13/006 , H02K2205/06
摘要： An electric motor for moving a vehicle part, the electric motor having a stator with a stator housing, a drive shaft rotatable with respect to the stator, a rotor on the drive shaft and having a rotor winding, a commutator on the drive shaft for supplying an electric current to the rotor winding, at least two brushes mounted on the stator housing, the brushes in sliding contact with the commutator for supplying electric current to the rotor winding, a bushing mounted on the drive shaft adjacent to the commutator, and a cone element mounted on the drive shaft adjacent to the bushing on a side of the bushing facing away from the commutator, the cone element having an outer surface which conforms to the shape of a cone concentrical to the drive shaft and having a tip pointing away from the bushing.
摘要翻译：一种用于移动车辆部件的电动机，具有定子的电动机具有定子壳体，相对于定子可旋转的驱动轴，驱动轴上的转子，具有转子绕组，在驱动轴上的换向器，用于供给到转子绕组的电流，安装在定子壳体上的至少两个电刷，电刷与换向器滑动接触，用于向转子绕组提供电流，安装在驱动轴上的与换向器相邻的衬套，以及锥体所述元件安装在所述驱动轴上，所述驱动轴在所述衬套的相对于所述换向器的一侧的所述驱动轴上相邻，所述锥形元件具有与所述驱动轴同心的锥体形状的外表面，并且具有远离所述换向器的尖端衬套。

7. 发明申请

US20120309756A1 COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR 有权
标题翻译：化合物调节C-FMS和/或C-kit活性及其用途
公开(公告)号：US20120309756A1
公开(公告)日：2012-12-06
申请号：US13546923
申请日：2012-07-11
申请人： Jiazhong Zhang , Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Guoxian Wu , Hongyao Zhu , Marika Nespi , Chao Zhang
发明人： Jiazhong Zhang , Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Guoxian Wu , Hongyao Zhu , Marika Nespi , Chao Zhang
IPC分类号： C07D471/04 , A61K31/506 , A61K31/497 , A61K31/444 , A61K31/5377
CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06
摘要： Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.
摘要翻译：本文提供了对受体蛋白酪氨酸激酶c-kit和/或c-fms活性的化合物。本文还提供了可用于治疗c-kit介导的疾病或病症和/或c-fms介导的疾病或病症的组合物及其使用方法。

8. 发明授权

US08268858B2 Compounds and methods for kinase modulation, and indications therefor 有权
标题翻译：用于激酶调节的化合物和方法及其适应症
公开(公告)号：US08268858B2
公开(公告)日：2012-09-18
申请号：US11961901
申请日：2007-12-20
申请人： Guoxian Wu , Wayne Spevak , Songyuan Shi , Hanna Cho , Prabha N. Ibrahim , Chao Zhang , Shenghua Shi , Yong Zhou , Dean Artis , Jiazhong Zhang
发明人： Guoxian Wu , Wayne Spevak , Songyuan Shi , Hanna Cho , Prabha N. Ibrahim , Chao Zhang , Shenghua Shi , Yong Zhou , Dean Artis , Jiazhong Zhang
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D471/04 , C07D519/00
摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
摘要翻译：描述了对蛋白激酶有活性的化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。

9. 发明申请

US20120122860A1 SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS 审中-公开
标题翻译：磺酰胺和氨基酸的固体形式
公开(公告)号：US20120122860A1
公开(公告)日：2012-05-17
申请号：US13318760
申请日：2010-05-04
申请人： Gary Conard Visor , Prabha N. Ibrahim , Wayne Spevak , Hanna Cho , Songyuan Shi , Guoxian Wu
发明人： Gary Conard Visor , Prabha N. Ibrahim , Wayne Spevak , Hanna Cho , Songyuan Shi , Guoxian Wu
IPC分类号： A61K31/538 , A61K31/437 , A61K31/506 , A61P13/12 , A61K31/496 , C07D495/04 , A61P35/00 , A61P29/00 , C07D471/04 , A61K31/5377
CPC分类号： C07D471/04
摘要： Solid forms of phenyl sulfonamide compounds of formula (I) active on protein kinases, including Raf protein kinases, are described, as well as methods of using such solid forms to treat diseases and conditions associated with activity of protein kinases, e.g. Raf protein kinases, including pain, polycystic kidney disease, melanoma and colorectal cancer.
摘要翻译：描述了对蛋白激酶（包括Raf蛋白激酶）有活性的式（I）的苯基磺酰胺化合物的固体形式，以及使用这些固体形式治疗与蛋白激酶活性相关的疾病和病症的方法，例如， Raf蛋白激酶，包括疼痛，多囊肾病，黑素瘤和结肠直肠癌。

10. 发明申请

US20120053177A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 审中-公开
标题翻译：化合物及其调节方法及其适应症
公开(公告)号：US20120053177A1
公开(公告)日：2012-03-01
申请号：US13243748
申请日：2011-09-23
申请人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
发明人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
IPC分类号： A61K31/5377 , A61P35/00 , A61K31/496 , A61K31/506 , C12N9/99 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
摘要翻译：描述了对蛋白激酶有活性的化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。

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