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1. 发明申请

US20100172803A1 METHOD AND APPARATUS FOR FLUID DISPERSION 有权
标题翻译：流体分散方法及装置
公开(公告)号：US20100172803A1
公开(公告)日：2010-07-08
申请号：US12726223
申请日：2010-03-17
申请人： Howard A. Stone , Shelley L. Anna , Nathalie Bontoux , Darren R. Link , David A. Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow Diluzio , George M. Whitesides
发明人： Howard A. Stone , Shelley L. Anna , Nathalie Bontoux , Darren R. Link , David A. Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow Diluzio , George M. Whitesides
IPC分类号： B01L3/00
CPC分类号： B01L3/5027 , B01F3/0807 , B01F5/0682 , B01F5/0688 , B01F13/0062 , B01F2215/0431 , B01F2215/045 , B05B7/0408 , B05B7/0416 , B05B7/0441 , Y10S516/924 , Y10S516/927 , Y10T29/49002 , Y10T137/0324 , Y10T137/0329 , Y10T137/206 , Y10T137/87346 , Y10T436/2575
摘要： A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.
摘要翻译：提供了用于在流体中聚焦和/或形成类似或不同尺寸的不连续部分的微流体方法和装置。该装置可以简单地使用简单的技术从容易获得的廉价材料制造。

2. 发明授权

US07708949B2 Method and apparatus for fluid dispersion 有权
标题翻译：流体分散方法和装置
公开(公告)号：US07708949B2
公开(公告)日：2010-05-04
申请号：US11024228
申请日：2004-12-28
申请人： Howard A. Stone , Shelley L. Anna , Nathalie Bontoux , Darren R. Link , David A. Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow Diluzio , George M. Whitesides
发明人： Howard A. Stone , Shelley L. Anna , Nathalie Bontoux , Darren R. Link , David A. Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow Diluzio , George M. Whitesides
IPC分类号： B01L3/02 , G01N11/04 , B01L99/00 , G05D7/00
CPC分类号： B01L3/5027 , B01F3/0807 , B01F5/0682 , B01F5/0688 , B01F13/0062 , B01F2215/0431 , B01F2215/045 , B05B7/0408 , B05B7/0416 , B05B7/0441 , Y10S516/924 , Y10S516/927 , Y10T29/49002 , Y10T137/0324 , Y10T137/0329 , Y10T137/206 , Y10T137/87346 , Y10T436/2575
摘要： A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.
摘要翻译：提供了用于在流体中聚焦和/或形成类似或不同尺寸的不连续部分的微流体方法和装置。该装置可以简单地使用简单的技术从容易获得的廉价材料制造。

3. 发明授权

US08337778B2 Method and apparatus for fluid dispersion 有权
标题翻译：流体分散方法和装置
公开(公告)号：US08337778B2
公开(公告)日：2012-12-25
申请号：US12726223
申请日：2010-03-17
申请人： Howard A. Stone , Shelley L. Anna , Nathalie Bontoux , Darren Roy Link , David A. Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow R. Diluzio , George M. Whitesides
发明人： Howard A. Stone , Shelley L. Anna , Nathalie Bontoux , Darren Roy Link , David A. Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow R. Diluzio , George M. Whitesides
IPC分类号： B01L3/00
CPC分类号： B01L3/5027 , B01F3/0807 , B01F5/0682 , B01F5/0688 , B01F13/0062 , B01F2215/0431 , B01F2215/045 , B05B7/0408 , B05B7/0416 , B05B7/0441 , Y10S516/924 , Y10S516/927 , Y10T29/49002 , Y10T137/0324 , Y10T137/0329 , Y10T137/206 , Y10T137/87346 , Y10T436/2575
摘要： A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.
摘要翻译：提供了用于在流体中聚焦和/或形成类似或不同尺寸的不连续部分的微流体方法和装置。该装置可以简单地使用简单的技术从容易获得的廉价材料制造。

4. 发明授权

US08986628B2 Method and apparatus for fluid dispersion 有权
标题翻译：流体分散方法和装置
公开(公告)号：US08986628B2
公开(公告)日：2015-03-24
申请号：US13679190
申请日：2012-11-16
申请人： Howard A. Stone , Shelley L. Anna , Nathalie Bontoux , Darren Roy Link , David A. Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow R. Diluzio , George M. Whitesides
发明人： Howard A. Stone , Shelley L. Anna , Nathalie Bontoux , Darren Roy Link , David A. Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow R. Diluzio , George M. Whitesides
IPC分类号： B01L3/00 , B01F3/08 , B01F5/06 , B01F13/00 , B05B7/04
CPC分类号： B01L3/5027 , B01F3/0807 , B01F5/0682 , B01F5/0688 , B01F13/0062 , B01F2215/0431 , B01F2215/045 , B05B7/0408 , B05B7/0416 , B05B7/0441 , Y10S516/924 , Y10S516/927 , Y10T29/49002 , Y10T137/0324 , Y10T137/0329 , Y10T137/206 , Y10T137/87346 , Y10T436/2575
摘要： A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.
摘要翻译：提供了用于在流体中聚焦和/或形成类似或不同尺寸的不连续部分的微流体方法和装置。该装置可以简单地使用简单的技术从容易获得的廉价材料制造。

5. 发明授权

US09757698B2 Fluid injection 有权
公开(公告)号：US09757698B2
公开(公告)日：2017-09-12
申请号：US13379782
申请日：2010-06-25
申请人： David A. Weitz , Adam R. Abate , Tony Hung , Pascaline Mary
发明人： David A. Weitz , Adam R. Abate , Tony Hung , Pascaline Mary
IPC分类号： F16K99/00 , B01F5/04 , B01F13/00 , B01J19/00 , B01L3/00 , G01N27/447 , G01N35/10
CPC分类号： B01F5/0471 , B01F13/0071 , B01F13/0076 , B01J19/0093 , B01J2219/00837 , B01J2219/00853 , B01J2219/00862 , B01J2219/00889 , B01L3/50273 , B01L3/502784 , B01L2300/0867 , B01L2400/0415 , F16K99/0042 , F16K99/0051 , G01N27/44791 , G01N2035/1034 , Y10T137/0391 , Y10T137/206
摘要： The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc. of a first fluid being urged into and/or out of a second fluid can be controlled by controlling various properties of the fluid and/or a fluidic droplet, for example curvature of the fluidic droplet, and/or controlling the applied electric field.

6. 发明授权

US09695390B2 Acoustic waves in microfluidics 有权
公开(公告)号：US09695390B2
公开(公告)日：2017-07-04
申请号：US13818146
申请日：2011-08-23
申请人： David A. Weitz , Thomas Franke , Achim Wixforth , Lothar Schmid , Jeremy Agresti , Adam R. Abate
发明人： David A. Weitz , Thomas Franke , Achim Wixforth , Lothar Schmid , Jeremy Agresti , Adam R. Abate
IPC分类号： B01L3/00 , C12M3/06 , C12M1/00 , F17D3/01 , G01N15/10
CPC分类号： C12M23/16 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0652 , B01L2300/0816 , B01L2400/0421 , B01L2400/0436 , B01L2400/0487 , B01L2400/0496 , C12M47/04 , F17D3/01 , G01N2015/1006 , G01N2015/1081 , Y10T137/0391
摘要： Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one set of embodiments, droplets may be sorted using surface acoustic waves. The droplets may contain cells or other species. In some cases, the surface acoustic waves may be created using a surface acoustic wave generator such as an interdigitated transducer, and/or a material such as a piezoelectric substrate. The piezoelectric substrate may be isolated from the microfluidic substrate except at or proximate the location where the droplets are sorted, e.g., into first or second microfluidic channels. At such locations, the microfluidic substrate may be coupled to the piezoelectric substrate (or other material) by one or more coupling regions. In some cases, relatively high sorting rates may be achieved, e.g., at rates of at least about 1,000 Hz, at least about 10,000 Hz, or at least about 100,000 Hz, and in some embodiments, with high cell viability after sorting.

7. 发明申请

US20150285282A1 METHOD AND APPARATUS FOR FORMING MULTIPLE EMULSIONS 审中-公开
标题翻译：用于形成多种乳液的方法和装置
公开(公告)号：US20150285282A1
公开(公告)日：2015-10-08
申请号：US14681560
申请日：2015-04-08
申请人： David A. Weitz , Darren Roy Link , Andrew S. Utada
发明人： David A. Weitz , Darren Roy Link , Andrew S. Utada
IPC分类号： F15D1/00
CPC分类号： F15D1/008 , A61K9/113 , A61K9/1273 , A61K9/5089 , B01F3/0807 , B01F5/045 , B01F5/046 , B01F13/0059 , B01F13/0062 , B01F2005/0022 , B82Y10/00 , B82Y30/00 , Y10S516/924 , Y10T137/0391
摘要： The present invention generally relates to multiple emulsions, and to methods and apparatuses for making multiple emulsions. A multiple emulsion generally describes larger droplets that contain one or more smaller droplets therein. The larger droplets may be suspended in a third fluid in some cases. These can be useful for encapsulating species such as pharmaceutical agents, cells, chemicals, or the like. In some cases, one or more of the droplets can change form, for instance, to become solidified to form a microcapsule, a liposome, a polymerosome, or a colloidosome. Multiple emulsions can be formed in one step in certain embodiments, with generally precise repeatability, and can be tailored to include one, two, three, or more inner droplets within a single outer droplet (which droplets may all be nested in some cases).
摘要翻译：本发明一般涉及多重乳液，以及制备多重乳液的方法和装置。多重乳液通常描述在其中含有一个或多个较小液滴的较大液滴。在一些情况下，较大的液滴可以悬浮在第三流体中。这些可用于包封物质如药剂，细胞，化学品等。在一些情况下，一个或多个液滴可以改变形式，例如变得固化以形成微胶囊，脂质体，聚合物体或胶体体。在某些实施方案中，多个乳液可以在一个实施方案中形成，具有大致精确的重复性，并且可以调整为在单个外部液滴内包含一个，两个，三个或更多个内部液滴（在一些情况下，这些液滴可以嵌套）。

8. 发明授权

US08765485B2 Electronic control of fluidic species 有权
标题翻译：流体物种的电子控制
公开(公告)号：US08765485B2
公开(公告)日：2014-07-01
申请号：US11360845
申请日：2006-02-23
申请人： Darren Roy Link , David A. Weitz , Galder Cristobal-Azkarate , Zhengdong Cheng , Keunho Ahn
发明人： Darren Roy Link , David A. Weitz , Galder Cristobal-Azkarate , Zhengdong Cheng , Keunho Ahn
IPC分类号： G01N1/10 , G01N35/08 , B01F13/00 , B01L3/00
CPC分类号： B01L3/5027 , B01F5/0256 , B01F5/0646 , B01F5/0655 , B01F5/0682 , B01F5/0689 , B01F13/0069 , B01F13/0071 , B01F13/0074 , B01F13/0076 , B01J19/0093 , B01J2219/00783 , B01J2219/00862 , B01L3/0241 , B01L3/502761 , B01L3/502776 , B01L3/502784 , B01L3/502792 , B01L3/5088 , B01L2200/0636 , B01L2200/0652 , B01L2200/0673 , B01L2300/0864 , B01L2300/0867 , B01L2300/161 , B01L2400/0415 , B01L2400/0439 , B01L2400/0487 , C12Q2563/159 , C12Q2565/629 , G01N15/10 , G01N15/14 , G01N15/1459 , G01N15/1484 , G01N2015/1006 , G01N2015/1081 , G01N2015/149 , Y10S436/807 , Y10T436/118339 , Y10T436/2525 , Y10T436/2575
摘要： Various aspects of the present invention relates to the control and manipulation of fluidic species, for example, in microfluidic systems. In one aspect, the invention relates to systems and methods for making droplets of fluid surrounded by a liquid, using, for example, electric fields, mechanical alterations, the addition of an intervening fluid, etc. The invention also relates to systems and methods for fusing droplets according to another aspect of the invention, for example, through charge and/or dipole interactions. In some cases, the fusion of the droplets may initiate or determine a reaction. In still another aspect, the invention relates to systems and methods for sorting droplets, e.g., by causing droplets to move to certain regions within a fluidic system. Examples include using electrical interactions (e.g., charges, dipoles, etc.) or mechanical systems (e.g., fluid displacement) to sort the droplets.
摘要翻译：本发明的各个方面涉及流体物质的控制和操作，例如在微流体系统中。一方面，本发明涉及使用例如电场，机械改变，中间流体等的添加来制造由液体包围的流体液滴的系统和方法。本发明还涉及用于根据本发明的另一方面，例如通过电荷和/或偶极相互作用来熔融液滴。在一些情况下，液滴的融合可引发或确定反应。在另一方面，本发明涉及用于分选液滴的系统和方法，例如通过使液滴移动到流体系统内的某些区域。实例包括使用电相互作用（例如电荷，偶极子等）或机械系统（例如，流体位移）来对液滴进行分类。

9. 发明申请

US20130213488A1 ACOUSTIC WAVES IN MICROFLUIDICS 有权
标题翻译：微波中的声波
公开(公告)号：US20130213488A1
公开(公告)日：2013-08-22
申请号：US13818146
申请日：2011-08-23
申请人： David A. Weitz , Thomas Franke , Achim Wixforth , Lothar Schmid , Jeremy Agresti , Adam R. Abate
发明人： David A. Weitz , Thomas Franke , Achim Wixforth , Lothar Schmid , Jeremy Agresti , Adam R. Abate
IPC分类号： C12M3/06 , F17D3/01
CPC分类号： C12M23/16 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0652 , B01L2300/0816 , B01L2400/0421 , B01L2400/0436 , B01L2400/0487 , B01L2400/0496 , C12M47/04 , F17D3/01 , G01N2015/1006 , G01N2015/1081 , Y10T137/0391
摘要： Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one set of embodiments, droplets may be sorted using surface acoustic waves. The droplets may contain cells or other species. In some cases, the surface acoustic waves may be created using a surface acoustic wave generator such as an interdigitated transducer, and/or a material such as a piezoelectric substrate. The piezoelectric substrate may be isolated from the microfluidic substrate except at or proximate the location where the droplets are sorted, e.g., into first or second microfluidic channels. At such locations, the microfluidic substrate may be coupled to the piezoelectric substrate (or other material) by one or more coupling regions. In some cases, relatively high sorting rates may be achieved, e.g., at rates of at least about 1,000 Hz, at least about 10,000 Hz, or at least about 100,000 Hz, and in some embodiments, with high cell viability after sorting.
摘要翻译：本发明的各个方面涉及流体物质的控制和操作，例如在微流体系统中。在一组实施例中，可以使用表面声波对液滴进行分类。液滴可能含有细胞或其他物种。在一些情况下，表面声波可以使用表面声波发生器（例如交叉换能器）和/或诸如压电基板的材料来产生。压电衬底可以与微流体衬底隔离，除了在液滴被分类的位置处或附近，例如，进入第一或第二微流体通道。在这样的位置处，微流体衬底可以通过一个或多个耦合区域耦合到压电衬底（或其它材料）。在一些情况下，可以例如以至少约1000Hz，至少约10,000Hz或至少约100,000Hz的速率实现相对较高的分选率，并且在一些实施方案中，分选后具有高的细胞活力。

10. 发明申请

US20130209520A1 FOAMS, INCLUDING MICROCELLULAR FOAMS, CONTAINING COLLOIDAL PARTICULATES 审中-公开
标题翻译： FOAMS，包括微胶囊，含有胶体颗粒
公开(公告)号：US20130209520A1
公开(公告)日：2013-08-15
申请号：US13697706
申请日：2011-05-20
申请人： Kosta Ladavac , Rodrigo Guerra , David Kaz , Vinothan N. Manoharan , Jens B. Rieger , Roland S. Koltzenburg , David A. Weitz
发明人： Kosta Ladavac , Rodrigo Guerra , David Kaz , Vinothan N. Manoharan , Jens B. Rieger , Roland S. Koltzenburg , David A. Weitz
IPC分类号： A61K9/12
CPC分类号： A61K9/122 , A61K9/143 , A61K9/146 , A61K9/5115
摘要： The present invention generally relates to foams and particles made from such foams, for applications such as drug delivery. The foams or particles may comprise a pharmaceutically acceptable polymeric carrier. In some cases, the foams may include colloidal particulates. A first aspect of the present invention is generally related to polymer-based foams or particles containing pharmaceutically active agents. In some cases, the foam or particle may contain smaller colloidal particulates therein. Such colloidal particulates may be used, for example, to limit the amount of material within certain regions of the foam, or exclude pharmaceutically active agents from being located within certain portions of the foam, which may useful for enhancing release of pharmaceutically active agents from the foam. In some cases, the colloidal particulates may cause the foam or particle to have an unexpectedly high specific surface area. The foam, in certain embodiments, can exhibit a relatively high loading of the pharmaceutically active agent. The foam may be microcellular in certain instances. The foam may also be created using a supercritical fluid, for example, supercritical C02. For instance, a precursor to the foam, containing a pharmaceutically active agent, a pharmaceutically acceptable polymeric carrier, and colloidal particulates, can be mixed with a foaming agent. The pressure may then be decreased, thereby causing the foaming agent to expand and causing a foam to form. The foam may also be ground or milled, or otherwise processed, to form particles such as nanoparticles.
摘要翻译：本发明一般涉及由这种泡沫制成的泡沫和颗粒，用于诸如药物递送的应用。泡沫或颗粒可以包含药学上可接受的聚合物载体。在一些情况下，泡沫可以包括胶体颗粒。本发明的第一方面通常涉及基于聚合物的泡沫或含有药物活性剂的颗粒。在一些情况下，泡沫或颗粒中可含有较小的胶体颗粒。这种胶体颗粒可以用于例如限制泡沫的某些区域内的物质的量，或者不排除药物活性剂位于泡沫的某些部分内，其可用于增强药物活性剂从泡沫。在一些情况下，胶体颗粒可能导致泡沫或颗粒具有出乎意料的高比表面积。在某些实施方案中，泡沫体可以表现出相对高的药物活性剂的负载量。泡沫在某些情况下可能是微孔的。泡沫也可以使用超临界流体，例如超临界CO 2来产生。例如，含有药物活性剂，药学上可接受的聚合物载体和胶体颗粒的泡沫的前体可与发泡剂混合。然后可以降低压力，从而使发泡剂膨胀并引起泡沫形成。泡沫也可以研磨或研磨或以其它方式处理，以形成颗粒如纳米颗粒。

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