专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080203024A1 Method for the Elimination of Leukocytes from Blood 有权
标题翻译：从血液中消除白细胞的方法
公开(公告)号：US20080203024A1
公开(公告)日：2008-08-28
申请号：US12065628
申请日：2006-09-02
申请人： Horst-Dieter Lemke , Frank Wiese , Bodo von Harten , Martin Konig , Wolfgang Ramlow
发明人： Horst-Dieter Lemke , Frank Wiese , Bodo von Harten , Martin Konig , Wolfgang Ramlow
IPC分类号： B01D61/00
CPC分类号： A61M1/3633 , A61M2202/0439 , A61M2202/0057
摘要： The invention relates to a method for reducing the number of leukocytes in blood through treating the blood in an arrangement of a plurality of fibers based on organic polymers, whereby the blood is channeled along the fibers and whereby the reduction in leukocytes from the blood occurs essentially through adsorption on the fibers, characterized in that the plurality of fibers based on organic polymers is fixed in a housing with an inlet arrangement and an outlet arrangement, and that the blood is channeled via the inlet arrangement into the housing, flows through the housing with the plurality of fibers made from organic polymers, and exits the housing via the outlet arrangement, that the arrangement of the fibers shows a high degree of order, that the blood flows along the external surface of the fibers, and that the fibers cause a generation of the complement activation product C5a in a concentration of at least 10 μg per m2 of fiber surface.
摘要翻译：本发明涉及一种通过基于有机聚合物在多根纤维的布置中处理血液来减少血液中白血球数量的方法，由此血液沿着纤维引导，从而血液中白血球的减少基本上发生通过在纤维上的吸附，其特征在于，基于有机聚合物的多根纤维被固定在具有入口布置和出口布置的壳体中，并且血液经由入口装置引导到壳体中，通过壳体流过壳体，多个由有机聚合物制成的纤维，并通过出口装置离开壳体，纤维的布置显示出高度的顺序，使得血液沿着纤维的外表面流动，并且纤维引起一代的补体活化产物C5a的浓度至少为10mug / m 2的纤维表面。

2. 发明授权

US08501008B2 Method for the elimination of leukocytes from blood 有权
标题翻译：从血液中消除白细胞的方法
公开(公告)号：US08501008B2
公开(公告)日：2013-08-06
申请号：US12065628
申请日：2006-09-02
申请人： Horst-Dieter Lemke , Frank Wiese , Bodo von Harten , Martin König , Wolfgang Ramlow
发明人： Horst-Dieter Lemke , Frank Wiese , Bodo von Harten , Martin König , Wolfgang Ramlow
IPC分类号： B01D11/00 , B01D61/00
CPC分类号： A61M1/3633 , A61M2202/0439 , A61M2202/0057
摘要： The invention relates to a method for reducing the number of leukocytes in blood through treating the blood in an arrangement of a plurality of fibers based on organic polymers, whereby the blood is channeled along the fibers and whereby the reduction in leukocytes from the blood occurs essentially through adsorption on the fibers, characterized in that the plurality of fibers based on organic polymers is fixed in a housing with an inlet arrangement and an outlet arrangement, and that the blood is channeled via the inlet arrangement into the housing, flows through the housing with the plurality of fibers made from organic polymers, and exits the housing via the outlet arrangement, that the arrangement of the fibers shows a high degree of order, that the blood flows along the external surface of the fibers, and that the fibers cause a generation of the complement activation product C5a in a concentration of at least 10 μg per m2 of fiber surface.
摘要翻译：本发明涉及一种通过基于有机聚合物在多根纤维的布置中处理血液来减少血液中白血球数量的方法，由此血液沿着纤维引导，从而血液中白血球的减少基本上发生通过在纤维上的吸附，其特征在于，基于有机聚合物的多根纤维被固定在具有入口布置和出口布置的壳体中，并且血液经由入口装置引导到壳体中，通过壳体流过壳体，多个由有机聚合物制成的纤维，并通过出口装置离开壳体，纤维的布置显示出高度的顺序，使得血液沿着纤维的外表面流动，并且纤维引起一代的补体活化产物C5a的浓度至少为10mug / m2纤维表面。

3. 发明申请

US20100084331A1 DEVICE FOR REMOVING LEUKOCYTES FROM BLOOD 有权
标题翻译：从血液中清除白细胞介素的装置
公开(公告)号：US20100084331A1
公开(公告)日：2010-04-08
申请号：US12522297
申请日：2008-01-10
申请人： Frank Heuser , Martin König , Horst-Dieter Lemke , Bodo Von Harten
发明人： Frank Heuser , Martin König , Horst-Dieter Lemke , Bodo Von Harten
IPC分类号： B01D63/02
CPC分类号： A61M1/3633
摘要： A device for reducing the number of leucocytes in blood comprising a plurality of hollow fibers based on organic polymers, whereby the hollow fibers have a lumen and a wall surrounding the lumen, said wall having an internal surface facing the lumen and an external surface, whereby the hollow fibers are arranged in a cylindrical housing with an inlet arrangement and an outlet arrangement and whereby an outer space is formed between the hollow fibers and the housing, which space is accessible for a fluid via the inlet arrangement and the outlet arrangement, characterized in that only the external surfaces of the hollow fibers are accessible for a fluid, that the lumina of the hollow fibers are not accessible for a fluid, that the arrangement of the hollow fibers shows a high degree of order and that the hollow fibers based on organic polymers cause a generation of the complement activation product C5a in a concentration of at least 10 μg per m2 of fiber surface.
摘要翻译：一种用于减少血液中白细胞数量的装置，包括基于有机聚合物的多个中空纤维，由此中空纤维具有内腔和围绕内腔的壁，所述壁具有面向内腔的内表面和外表面，由此中空纤维被布置在具有入口布置和出口布置的圆柱形壳体中，并且由此在中空纤维和壳体之间形成外部空间，该空间可经由入口装置和出口装置进入流体，其特征在于只有中空纤维的外表面可以接触流体，中空纤维的灯管不能用于流体，中空纤维的布置显示出高度的顺序，并且基于有机物的中空纤维聚合物引起补体活化产物C5a的产生，其浓度至少为每平方米纤维表面10微克。

4. 发明授权

US07985337B2 Device for removing leukocytes from blood 有权
标题翻译：用于从血液中除去白细胞的装置
公开(公告)号：US07985337B2
公开(公告)日：2011-07-26
申请号：US12522297
申请日：2008-01-10
申请人： Frank Heuser , Martin König , Horst-Dieter Lemke , Bodo Von Harten
发明人： Frank Heuser , Martin König , Horst-Dieter Lemke , Bodo Von Harten
IPC分类号： B01D63/02 , B01D61/00
CPC分类号： A61M1/3633
摘要： A device for reducing the number of leucocytes in blood comprising a plurality of hollow fibers based on organic polymers, whereby the hollow fibers have a lumen and a wall surrounding the lumen, said wall having an internal surface facing the lumen and an external surface, whereby the hollow fibers are arranged in a cylindrical housing with an inlet arrangement and an outlet arrangement and whereby an outer space is formed between the hollow fibers and the housing, which space is accessible for a fluid via the inlet arrangement and the outlet arrangement, characterized in that only the external surfaces of the hollow fibers are accessible for a fluid, that the lumina of the hollow fibers are not accessible for a fluid, that the arrangement of the hollow fibers shows a high degree of order and that the hollow fibers based on organic polymers cause a generation of the complement activation product C5a in a concentration of at least 10 μg per m2 of fiber surface.
摘要翻译：一种用于减少血液中白细胞数量的装置，包括基于有机聚合物的多个中空纤维，由此中空纤维具有内腔和围绕内腔的壁，所述壁具有面向内腔的内表面和外表面，由此中空纤维被布置在具有入口布置和出口布置的圆柱形壳体中，并且由此在中空纤维和壳体之间形成外部空间，该空间可经由入口装置和出口装置进入流体，其特征在于只有中空纤维的外表面可以接触流体，中空纤维的灯管不能用于流体，中空纤维的布置显示出高度的顺序，并且基于有机物的中空纤维聚合物引起补体活化产物C5a的产生，其浓度至少为每平方米纤维表面10微克。

5. 发明申请

US20080199401A1 Method for Dissolution of Gases with Short-Lived Physical Properties in a Liquid 审中-公开
标题翻译：液体中具有短寿命物理性质的气体溶解方法
公开(公告)号：US20080199401A1
公开(公告)日：2008-08-21
申请号：US11916662
申请日：2006-06-06
申请人： Peter Blumler , Horst-Dieter Lemke , Detlef Krieter , Hans-Wolfgang Spiess , Frank Wiese , Paul-Philipp Zanker
发明人： Peter Blumler , Horst-Dieter Lemke , Detlef Krieter , Hans-Wolfgang Spiess , Frank Wiese , Paul-Philipp Zanker
IPC分类号： A61K49/06
CPC分类号： A61K49/18 , B01F3/04269
摘要： The invention relates to a process for dissolving a gas with short-lived physical properties in a liquid, comprising the steps of providing the gas with short-lived physical properties, providing the liquid and bringing the gas with short-lived with short-lived physical properties is fed into the liquid via a semi-permeable membrane that is permeable to gas.
摘要翻译：本发明涉及一种将具有短暂物理性质的气体溶解在液体中的方法，包括以下步骤：提供具有短寿命物理性能的气体，提供液体并将短时间的气体带入短寿命物理性质通过可透气的半透膜进料到液体中。

6. 发明授权

US06410307B1 Membrane module for testing active substances at cells 失效
标题翻译：用于测试细胞活性物质的膜模块
公开(公告)号：US06410307B1
公开(公告)日：2002-06-25
申请号：US09936264
申请日：2001-11-21
申请人： Herma Glockner , Horst-Dieter Lemke , Friedrich Hauck , Christoph Zimmerer , Rudi Wollbeck
发明人： Herma Glockner , Horst-Dieter Lemke , Friedrich Hauck , Christoph Zimmerer , Rudi Wollbeck
IPC分类号： C12M134
CPC分类号： C12Q1/025 , B01J2219/00907 , C12M23/04 , C12M25/02 , C12M29/04
摘要： Membrane module for testing active substances in cells with an interior chamber (2) which is limited by a lid (3), a bottom (4), and a side wall (5) and a system of first capillary membranes (6) and a system of second capillary membranes (11) located therein and possibly additional systems of capillary membranes, whereby the capillary membranes in interior chamber (2) are arranged in at least one flat layer parallel to bottom (4) and in interior chamber (2) in the extracapillary space a cell culture chamber is formed around the capillary membranes, whereby the capillary membranes have a lumen that can be filled with a fluid, are passing with at least one of its ends through the side wall (5) of interior chamber (2) and are embedded at this end separated by systems in a casting material (9, 10) so that interior chamber (2) is sealed fluid-tight from the outside, and whereby the capillary membranes of each system are in a fluid connection with their lumens with an inlet device (7) and/or an outlet device (8), and whereby interior chamber (2) has a volume between 0.1 and 5 cm3.
摘要翻译：用于测试具有由盖（3），底部（4）和侧壁（5）以及第一毛细管（6）和第一毛细管（6）的系统限制的内部室（2）的细胞中的活性物质的膜模块第二毛细管膜（11）的系统，以及可能的另外的毛细管膜系统，其中内室（2）中的毛细管膜被布置在平行于底部（4）和内室（2）中的至少一个平坦层中毛细血管间隙形成在毛细血管膜周围的细胞培养室，由此毛细管膜具有可填充流体的内腔，其至少一端通过内腔（2）的侧壁（5）），并且在该端部嵌入在铸造材料（9,10）中的系统分开，使得内部室（2）从外部流体密封，并且由此每个系统的毛细管膜与它们的流体连接具有入口装置（7）和/或的流明出口装置（8），并且由此内部室（2）具有在0.1和5cm 3之间的体积。

7. 发明授权

US5171444A Dialysis membrane made of polysaccharide ether 失效
标题翻译：多糖醚的DIALYSIS膜
公开(公告)号：US5171444A
公开(公告)日：1992-12-15
申请号：US708788
申请日：1991-05-31
申请人： Michael Diamantoglou , Horst-Dieter Lemke
发明人： Michael Diamantoglou , Horst-Dieter Lemke
IPC分类号： A61M1/16 , B01D71/08 , B01D71/22 , C08B11/02 , C08B11/18
CPC分类号： B01D71/22 , B01D71/08 , C08B11/02 , C08B11/18
摘要： Dialysis membrane for hemodialysis in the form of membrane films, tubular films, or hollow filaments made of polysaccharide ethers, are characterized by the fact that the polysaccharide ether has a structure shown by the formula ##STR1## in which Cell is the skeleton of the unmodified cellulose molecule or of the chitin molecule, without hydroxyl groups in each case, s is 3 in the unmodified cellulose molecule and 2 in the chitin molecule, and x corresponds to the degree of etherification, which is in the range from 0.08 to (s-0.4).
摘要翻译：用于由多糖醚制成的膜膜，管状膜或中空细丝形式的血液透析用透析膜的特征在于，多糖醚具有由式（IMAGE）所示的结构，其中Cell是未修饰的骨架纤维素分子或几丁质分子，在每种情况下不含羟基，s在未修饰的纤维素分子中为3，在几丁质分子中为2，并且x对应于醚化度，其在0.08至（s- 0.4）。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式