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1. 发明授权

US08501008B2 Method for the elimination of leukocytes from blood 有权
标题翻译：从血液中消除白细胞的方法
公开(公告)号：US08501008B2
公开(公告)日：2013-08-06
申请号：US12065628
申请日：2006-09-02
申请人： Horst-Dieter Lemke , Frank Wiese , Bodo von Harten , Martin König , Wolfgang Ramlow
发明人： Horst-Dieter Lemke , Frank Wiese , Bodo von Harten , Martin König , Wolfgang Ramlow
IPC分类号： B01D11/00 , B01D61/00
CPC分类号： A61M1/3633 , A61M2202/0439 , A61M2202/0057
摘要： The invention relates to a method for reducing the number of leukocytes in blood through treating the blood in an arrangement of a plurality of fibers based on organic polymers, whereby the blood is channeled along the fibers and whereby the reduction in leukocytes from the blood occurs essentially through adsorption on the fibers, characterized in that the plurality of fibers based on organic polymers is fixed in a housing with an inlet arrangement and an outlet arrangement, and that the blood is channeled via the inlet arrangement into the housing, flows through the housing with the plurality of fibers made from organic polymers, and exits the housing via the outlet arrangement, that the arrangement of the fibers shows a high degree of order, that the blood flows along the external surface of the fibers, and that the fibers cause a generation of the complement activation product C5a in a concentration of at least 10 μg per m2 of fiber surface.
摘要翻译：本发明涉及一种通过基于有机聚合物在多根纤维的布置中处理血液来减少血液中白血球数量的方法，由此血液沿着纤维引导，从而血液中白血球的减少基本上发生通过在纤维上的吸附，其特征在于，基于有机聚合物的多根纤维被固定在具有入口布置和出口布置的壳体中，并且血液经由入口装置引导到壳体中，通过壳体流过壳体，多个由有机聚合物制成的纤维，并通过出口装置离开壳体，纤维的布置显示出高度的顺序，使得血液沿着纤维的外表面流动，并且纤维引起一代的补体活化产物C5a的浓度至少为10mug / m2纤维表面。

2. 发明申请

US20080203024A1 Method for the Elimination of Leukocytes from Blood 有权
标题翻译：从血液中消除白细胞的方法
公开(公告)号：US20080203024A1
公开(公告)日：2008-08-28
申请号：US12065628
申请日：2006-09-02
申请人： Horst-Dieter Lemke , Frank Wiese , Bodo von Harten , Martin Konig , Wolfgang Ramlow
发明人： Horst-Dieter Lemke , Frank Wiese , Bodo von Harten , Martin Konig , Wolfgang Ramlow
IPC分类号： B01D61/00
CPC分类号： A61M1/3633 , A61M2202/0439 , A61M2202/0057
摘要： The invention relates to a method for reducing the number of leukocytes in blood through treating the blood in an arrangement of a plurality of fibers based on organic polymers, whereby the blood is channeled along the fibers and whereby the reduction in leukocytes from the blood occurs essentially through adsorption on the fibers, characterized in that the plurality of fibers based on organic polymers is fixed in a housing with an inlet arrangement and an outlet arrangement, and that the blood is channeled via the inlet arrangement into the housing, flows through the housing with the plurality of fibers made from organic polymers, and exits the housing via the outlet arrangement, that the arrangement of the fibers shows a high degree of order, that the blood flows along the external surface of the fibers, and that the fibers cause a generation of the complement activation product C5a in a concentration of at least 10 μg per m2 of fiber surface.
摘要翻译：本发明涉及一种通过基于有机聚合物在多根纤维的布置中处理血液来减少血液中白血球数量的方法，由此血液沿着纤维引导，从而血液中白血球的减少基本上发生通过在纤维上的吸附，其特征在于，基于有机聚合物的多根纤维被固定在具有入口布置和出口布置的壳体中，并且血液经由入口装置引导到壳体中，通过壳体流过壳体，多个由有机聚合物制成的纤维，并通过出口装置离开壳体，纤维的布置显示出高度的顺序，使得血液沿着纤维的外表面流动，并且纤维引起一代的补体活化产物C5a的浓度至少为10mug / m 2的纤维表面。

3. 发明申请

US20080199401A1 Method for Dissolution of Gases with Short-Lived Physical Properties in a Liquid 审中-公开
标题翻译：液体中具有短寿命物理性质的气体溶解方法
公开(公告)号：US20080199401A1
公开(公告)日：2008-08-21
申请号：US11916662
申请日：2006-06-06
申请人： Peter Blumler , Horst-Dieter Lemke , Detlef Krieter , Hans-Wolfgang Spiess , Frank Wiese , Paul-Philipp Zanker
发明人： Peter Blumler , Horst-Dieter Lemke , Detlef Krieter , Hans-Wolfgang Spiess , Frank Wiese , Paul-Philipp Zanker
IPC分类号： A61K49/06
CPC分类号： A61K49/18 , B01F3/04269
摘要： The invention relates to a process for dissolving a gas with short-lived physical properties in a liquid, comprising the steps of providing the gas with short-lived physical properties, providing the liquid and bringing the gas with short-lived with short-lived physical properties is fed into the liquid via a semi-permeable membrane that is permeable to gas.
摘要翻译：本发明涉及一种将具有短暂物理性质的气体溶解在液体中的方法，包括以下步骤：提供具有短寿命物理性能的气体，提供液体并将短时间的气体带入短寿命物理性质通过可透气的半透膜进料到液体中。

4. 发明申请

US20050175830A1 Method for producing foamed polymer moulded bodies and foamed polymer moulded bodies 有权
标题翻译：发泡聚合物成型体和发泡聚合物成型体的制造方法
公开(公告)号：US20050175830A1
公开(公告)日：2005-08-11
申请号：US10513402
申请日：2003-04-30
申请人： Frank Wiese , Hartmut Stenzel , Quan Huang , Bernd Seibig , Dieter Paul
发明人： Frank Wiese , Hartmut Stenzel , Quan Huang , Bernd Seibig , Dieter Paul
IPC分类号： C08J9/12 , B29C44/34 , B29C47/64 , B29C47/92 , B29K101/12 , B29K105/04 , D01F1/08 , D01F6/46 , B32B3/26
CPC分类号： B29C44/3446 , B29C44/348 , B29C47/0011 , B29C47/364 , B29C47/40 , B29C47/889 , B29C47/92 , B29C2947/92514 , B29C2947/92704 , B29C2947/92895 , B29C2947/92904 , Y10T428/249953 , Y10T428/249958 , Y10T428/249978 , Y10T428/249979 , Y10T428/2982
摘要： Method for producing foamed microporous polymer molded bodies by melting a thermoplastic polymer in a first zone of an extrusion device, mixing in a highly volatile blowing agent, conveying the polymer melt containing the blowing agent into a second zone in which dissolution of the blowing agent occurs to saturation of the polymer melt at the foaming temperature, and molding and foaming of the loaded polymer melt to a foamed structure, whereby, in the second zone, a pressure above 90 bar, a blowing agent concentration above the critical minimum concentration for complete foaming, and the foaming temperature, lying above the solidification temperature of the polymer melt saturated with blowing agent, are set such that the polymer molded body obtained has a porosity in the range between 40 and 90 vol. % and an open-cell pore structure with uniform cross-sectional distribution. Foamed microporous polymer molded bodies in the form of particles comprising a thermoplastic polymer with uniform open-cell pore structure, a porosity of 40 to 90 vol. %, an accessible proportion of pore volume of at least 0.75 and an average cell size between 1 and 100 μm.
摘要翻译：通过在挤出装置的第一区域中熔化热塑性聚合物来制造发泡微孔聚合物成型体的方法，在高挥发性发泡剂中混合，将含有发泡剂的聚合物熔体输送到发生发泡剂溶解的第二区域在发泡温度下使聚合物熔体饱和，并将负载的聚合物熔体成型和发泡成泡沫结构，由此在第二区域中压力高于90巴，发泡剂浓度高于完全发泡的临界最小浓度并且在发泡剂饱和的聚合物熔体的凝固温度以上的发泡温度被设定为使得得到的聚合物成型体的孔隙率在40〜90体积％的范围内。％和具有均匀横截面分布的开孔细孔结构。发泡微孔聚合物成型体，其为包含具有均匀开孔形式的热塑性聚合物的颗粒形式，孔隙率为40至90体积％。％，孔体积的可接近比例为至少0.75，平均泡孔尺寸为1至100μm。

5. 发明授权

US07230541B2 High speed communication for measurement while drilling 有权
标题翻译：高速通信用于测量，同时钻孔
公开(公告)号：US07230541B2
公开(公告)日：2007-06-12
申请号：US10716807
申请日：2003-11-19
申请人： James G. Ripolone , Sascha Schwarze , Frank Wiese
发明人： James G. Ripolone , Sascha Schwarze , Frank Wiese
IPC分类号： G01V3/00
CPC分类号： G01V11/002
摘要： A communication system for communication with a downhole tool comprising: a first communication transceiver in a first tool for measurement while drilling and a second communication transceiver in at least one of the first tool, a second tool for measurement while drilling, and an external instrumentation interface. The communication system also includes a bus system comprising a first conductive connection and a second conductive connection in each of the first tool and at least one of the first tool, a second tool and an external instrumentation interface, said first conductive connection and the second conductive connection of the first tool in operable communication with the first communication transceiver and the first conductive connection and the second conductive connection of the at least one of the first tool, a second tool and an external instrumentation interface also in operable communication with the second communication transceiver.
摘要翻译：一种用于与井下工具进行通信的通信系统，包括：第一工具中的第一通信收发器，用于在钻孔期间进行测量;以及第二通信收发器，所述第一通信收发器在所述第一工具中的至少一个，用于在钻孔时测量的第二工具以及外部仪器接口。通信系统还包括总线系统，其包括第一工具和第一工具，第二工具和外部仪表接口中的至少一个中的第一导电连接和第二导电连接，所述第一导电连接和第二导电与第一通信收发器可操作地通信的第一工具的连接和第一工具，第二工具和外部仪表接口中的至少一个的第一导电连接和第二导电连接，也可与第二通信收发器。

6. 发明授权

US06497752B1 Integrally asymmetrical polyolefin membrane 有权
标题翻译：整体不对称聚烯烃膜
公开(公告)号：US06497752B1
公开(公告)日：2002-12-24
申请号：US09868593
申请日：2001-08-24
申请人： Erich Kessler , Thomas Batzilla , Friedbert Wechs , Frank Wiese
发明人： Erich Kessler , Thomas Batzilla , Friedbert Wechs , Frank Wiese
IPC分类号： B01D5322
CPC分类号： B01D67/0018 , B01D67/0027 , B01D67/003 , B01D69/02 , B01D69/08 , B01D71/26 , B01D2325/022
摘要： Process for producing integrally asymmetrical hydrophobic polyolefinic membranes with a separation layer, in particular for gas exchange, via thermally induced liquid-liquid phase separation. A solution of at least one polyolefin in a solvent system containing a compound A and a compound B is extruded to form a shaped object. Compound A is a strong solvent and compound B a weak non-solvent for the polymer. After leaving the die, the shaped object is cooled using a solid or liquid cooling medium, which does not dissolve the polymer and does not react chemically with it, until the phase separation and solidification of the high-polymer-content phase take place. The integrally asymmetrical membrane producible in this manner has a porosity of greater than 30% to 75% by volume, a sponge-like, open-pored, microporous support layer without macrovoids and on average isotropic pores, a separation layer on at least one of its surfaces with pores
摘要翻译：通过热诱导的液 - 液相分离制备具有分离层，特别是用于气体交换的整体不对称疏水性聚烯烃膜的方法。将至少一种聚烯烃在含有化合物A和化合物B的溶剂体系中的溶液挤出以形成成形物体。化合物A是强溶剂，化合物B是聚合物的弱非溶剂。离开模具后，使用固体或液体冷却介质冷却成形物体，其不溶解聚合物并且不与其发生化学反应，直到发生高分子量含量相的相分离和凝固。以这种方式生产的整体不对称膜具有大于30体积％至75体积％的孔隙率，不具有大孔和平均各向同性孔的海绵状，开孔，微孔支撑层，在至少一个其表面具有小于100nm的孔（如果有的话）和至少为1的气体分离因子α（CO 2 / N 2）。膜优选用于血氧。

7. 发明授权

US06409921B1 Integrally asymmetrical polyolefin membrane for gas exchange 有权
标题翻译：用于气体交换的整体不对称聚烯烃膜
公开(公告)号：US06409921B1
公开(公告)日：2002-06-25
申请号：US09463316
申请日：2000-02-28
申请人： Marcus O. Müller , Erich Kessler , Ralf R. Hornscheidt , Frank Wiese , Armin J. Lang
发明人： Marcus O. Müller , Erich Kessler , Ralf R. Hornscheidt , Frank Wiese , Armin J. Lang
IPC分类号： A61M118
CPC分类号： B01D67/0018 , B01D67/0027 , B01D67/003 , B01D69/02 , B01D69/08 , B01D71/26 , B01D2325/022 , G01N27/40 , G01N27/404
摘要： Process for producing hydrophobic polyolefinic membranes for gas exchange via thermally induced liquid-liquid phase separation is disclosed. A solution of at least one polyolefin in a solvent system, of a compound A and a compound B having a viscosity less than 60 mPa s, is extruded to form a shaped object. The compound A is a solvent and compound B preferably a non-solvent of the polymer, and the boiling point of compound A is at least 50° C. higher than that of compound B. After the shaped object leaves the die, at least one surface thereof is subjected to an atmosphere promoting evaporation of compound B, and the shaped object is subsequently cooled until the phase separation and solidification of the high-polymer-content phase take place. The integrally asymmetrical membrane producible in this manner has a porosity of greater than 50% to 75% by volume, a sponge-like, open-pored, microporous support layer without macrovoids and on average isotropic pores, and at least one separation layer with pores
摘要翻译：公开了通过热诱导的液 - 液相分离制备用于气体交换的疏水聚烯烃膜的方法。将至少一种聚烯烃在溶剂体系中的化合物A和粘度小于60mPa·s的化合物B的溶液挤出以形成成形物体。化合物A是溶剂，化合物B优选为聚合物的非溶剂，化合物A的沸点比化合物B的沸点高至少50℃。成形物离开模头后，至少一个其表面经受促进化合物B蒸发的气氛，随后冷却成形物体直到发生高分子含量相的相分离和固化。以这种方式可生产的整体不对称膜具有大于50体积％至75体积％的孔隙率，没有大孔和平均各向同性孔的海绵状，开孔，微孔支撑层，以及至少一个具有孔的分离层 <100nm，如果有的话。该膜优选用于血氧合。

8. 发明授权

US06375876B1 Method for producing an integrally asymmetrical polyolefin membrane 有权
标题翻译：用于制造整体不对称的聚烯烃膜的方法
公开(公告)号：US06375876B1
公开(公告)日：2002-04-23
申请号：US09869153
申请日：2001-09-04
申请人： Erich Kessler , Thomas Batzilla , Friedbert Wechs , Frank Wiese
发明人： Erich Kessler , Thomas Batzilla , Friedbert Wechs , Frank Wiese
IPC分类号： B29C6500
CPC分类号： B01D67/0018 , B01D67/0027 , B01D67/003 , B01D69/02 , B01D69/08 , B01D71/26 , B01D2323/08 , B01D2323/12 , B01D2325/022 , B01D2325/026 , C08J9/28
摘要： Process for producing an integrally asymmetrical hydrophobic polyolefinic membrane with a sponge-like, open-pored, microporous support structure and a separation layer with a denser structure compared to the support structure, via a thermally induced liquid-liquid phase separation process. A solution of at least one polyolefin in a solvent system consisting of a compound A and a compound B is extruded to form a shaped object. Compound A is a weak solvent and compound B a non-solvent for the polymer. After leaving the die, the shaped object is cooled using a solid or liquid cooling medium that does not dissolve or react chemically with the polymer at temperatures up to the die temperature, until the phase separation and solidification of the high-polymer-content phase take place.
摘要翻译：通过热诱导的液 - 液相分离方法制备具有海绵状，开孔，微孔载体结构的整体不对称的疏水聚烯烃膜和具有比载体结构更致密结构的分离层的方法。将至少一种聚烯烃在由化合物A和化合物B组成的溶剂体系中的溶液挤出以形成成形物体。化合物A是弱溶剂，化合物B是聚合物的非溶剂。离开模具后，使用固体或液体冷却介质冷却成型物体，该固体或液体冷却介质在高达模具温度的温度下不与聚合物溶解或化学反应，直到高分子量含量相的相分离和凝固地点。

9. 发明授权

US10424916B2 Downhole component communication and power management 有权
公开(公告)号：US10424916B2
公开(公告)日：2019-09-24
申请号：US15152999
申请日：2016-05-12
申请人： Andre Koenecke , Matthias Gatzen , Wido Kunde , Ole-Hendrik Ohlendorf , Frank Wiese , Michael Szczepanski
发明人： Andre Koenecke , Matthias Gatzen , Wido Kunde , Ole-Hendrik Ohlendorf , Frank Wiese , Michael Szczepanski
IPC分类号： E21B41/00 , H02H7/20 , E21B47/00 , H02H3/08 , H02H3/10 , H02H3/20 , H02H7/26 , E21B47/06 , E21B47/12 , E21B49/02 , E21B49/08
摘要： A power control device includes a communication device configured to be disposed in a borehole and configured to couple electrical power from a power source to a downhole component from a conductor disposed along a borehole string, a circuit breaker system including a first circuit breaker disposed at a connection between the conductor and the downhole component and configured to be closed to connect the downhole component to the conductor, and a controller configured to monitor at least one of a current level and a voltage level at the connection and at the conductor. The controller is configured to control the circuit breaker system and autonomously perform opening the first circuit breaker in response to detecting a deviation in the at least one of the current levels and voltage levels at the connection, to isolate the downhole component from the conductor and the power source.

10. 发明申请

US20140019052A1 DEVICE AND METHOD FOR PREDICTIVE CALIBRATION 审中-公开
标题翻译：用于预测校准的装置和方法
公开(公告)号：US20140019052A1
公开(公告)日：2014-01-16
申请号：US13548666
申请日：2012-07-13
申请人： Ralf Zaeper , Frank Wiese , Matthias Moeller
发明人： Ralf Zaeper , Frank Wiese , Matthias Moeller
IPC分类号： G01V1/36 , G06F19/00 , G01D18/00
CPC分类号： G01V11/002 , G01V13/00
摘要： A method of calibrating a measurement device includes: compiling historical calibration data for the measurement device, the historical calibration data including values corresponding to outputs of the measurement device over a first operating duration in environmental conditions associated with an operating environment; projecting the historical calibration data over a subsequent operating duration to generate predictive calibration data; disposing the measurement device in the operating environment and generating measurement signals during the first operating duration and the subsequent operating duration; and generating measurement values from measurement signals generated during the subsequent operating duration based on the predictive calibration data.
摘要翻译：一种校准测量装置的方法包括：编译测量装置的历史校准数据，历史校准数据包括对应于在与操作环境相关联的环境条件下的第一操作持续时间内测量装置的输出的值; 在随后的操作持续时间内投影历史校准数据以产生预测校准数据; 将测量装置设置在操作环境中并在第一操作持续时间和随后的操作持续时间内产生测量信号; 以及基于所述预测校准数据，从随后的操作持续时间内产生的测量信号产生测量值。

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