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1. 发明授权

US06410307B1 Membrane module for testing active substances at cells 失效
标题翻译：用于测试细胞活性物质的膜模块
公开(公告)号：US06410307B1
公开(公告)日：2002-06-25
申请号：US09936264
申请日：2001-11-21
申请人： Herma Glockner , Horst-Dieter Lemke , Friedrich Hauck , Christoph Zimmerer , Rudi Wollbeck
发明人： Herma Glockner , Horst-Dieter Lemke , Friedrich Hauck , Christoph Zimmerer , Rudi Wollbeck
IPC分类号： C12M134
CPC分类号： C12Q1/025 , B01J2219/00907 , C12M23/04 , C12M25/02 , C12M29/04
摘要： Membrane module for testing active substances in cells with an interior chamber (2) which is limited by a lid (3), a bottom (4), and a side wall (5) and a system of first capillary membranes (6) and a system of second capillary membranes (11) located therein and possibly additional systems of capillary membranes, whereby the capillary membranes in interior chamber (2) are arranged in at least one flat layer parallel to bottom (4) and in interior chamber (2) in the extracapillary space a cell culture chamber is formed around the capillary membranes, whereby the capillary membranes have a lumen that can be filled with a fluid, are passing with at least one of its ends through the side wall (5) of interior chamber (2) and are embedded at this end separated by systems in a casting material (9, 10) so that interior chamber (2) is sealed fluid-tight from the outside, and whereby the capillary membranes of each system are in a fluid connection with their lumens with an inlet device (7) and/or an outlet device (8), and whereby interior chamber (2) has a volume between 0.1 and 5 cm3.
摘要翻译：用于测试具有由盖（3），底部（4）和侧壁（5）以及第一毛细管（6）和第一毛细管（6）的系统限制的内部室（2）的细胞中的活性物质的膜模块第二毛细管膜（11）的系统，以及可能的另外的毛细管膜系统，其中内室（2）中的毛细管膜被布置在平行于底部（4）和内室（2）中的至少一个平坦层中毛细血管间隙形成在毛细血管膜周围的细胞培养室，由此毛细管膜具有可填充流体的内腔，其至少一端通过内腔（2）的侧壁（5）），并且在该端部嵌入在铸造材料（9,10）中的系统分开，使得内部室（2）从外部流体密封，并且由此每个系统的毛细管膜与它们的流体连接具有入口装置（7）和/或的流明出口装置（8），并且由此内部室（2）具有在0.1和5cm 3之间的体积。

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