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1. 发明授权

US6077527A Enhancer tolerant pressure sensitive adhesives for transdermal drug delivery 失效
标题翻译：用于透皮药物递送的增强剂耐受性压敏粘合剂
公开(公告)号：US6077527A
公开(公告)日：2000-06-20
申请号：US958862
申请日：1997-10-28
申请人： Hock S. Tan , Ingrid Zhang , Susan Lydzinski , Peter L. Merkel , Paul Foreman , Smita Shah , Rama S. Chandran
发明人： Hock S. Tan , Ingrid Zhang , Susan Lydzinski , Peter L. Merkel , Paul Foreman , Smita Shah , Rama S. Chandran
IPC分类号： A61K9/70 , C09J4/00 , C09J133/08 , C09J133/26 , A61F13/02
CPC分类号： A61K9/7061 , C09J133/26 , C09J4/00 , Y10T428/28 , Y10T428/2887
摘要： Pressure sensitive adhesive compositions for use in transdermal drug delivery systems comprising an adhesive composition which is tolerant to plasticization by cutaneous penetration enhancers contained in the transdermal drug formulation are disclosed. Specifically, the pressure sensitive adhesive composition of the present invention comprises an acrylic copolymer prepared from (i) at least 40% by weight of th total monomer composition of alkyl acrylate monomers with a Tg of -90 to 0.degree. C., (ii) 0-15% by weight of the total monomer composition of monomers with a Tg of 0 to 250.degree. C., and (iii) 10-60% by weight of the total monomer composition of substituted acrylamides or methacrylamides having the structural formula: ##STR1## wherein R.sub.1 is H or CH.sub.3,R.sub.2 is H or CH.sub.3, andR.sub.3 is (a) CH.sub.3,(b) C(CH.sub.3).sub.2 --(CH.sub.2).sub.n --CH.sub.3 where n is 0 through 17, or(c) substituents of the formula: ##STR2## where m is 0 through 10, and optionally(iv) at least 0.2% by weight of acrylic monomers containing at least one group having a reactive hydrogen, and (v) 0.01-2% by weight of a chelated metal alkoxide crosslinker to (i), (ii) and (iii).
摘要翻译：公开了用于透皮药物递送系统的压敏粘合剂组合物，其包含通过透皮药物制剂中包含的皮肤渗透增强剂耐受塑化的粘合剂组合物。具体地说，本发明的压敏粘合剂组合物包含丙烯酸共聚物，其由以下组分制备：（i）至少40重量％的总单体组成的Tg为-90至0℃的丙烯酸烷基酯单体，（ii） 0-15％（重量）Tg为0-250℃的单体的总单体组成，和（iii）具有以下结构式的取代的丙烯酰胺或甲基丙烯酰胺的总单体组成的10-60重量％：其中 R1为H或CH3，R2为H或CH3，R3为（a）CH3，（b）C（CH3）2-（CH2）n-CH3，其中n为0至17，或（c）：其中m为0至10，并且任选地（iv）至少0.2重量％的含有至少一个具有反应性氢的基团的丙烯酸单体，和（v）0.01-2重量％的螯合金属醇盐交联剂与（ i），（ii）和（iii）。

2. 发明授权

US09056060B2 Non-reactive adhesive useful in transdermal drug delivery system 有权
公开(公告)号：US09056060B2
公开(公告)日：2015-06-16
申请号：US09955644
申请日：2001-09-18
申请人： Eric Silverberg , Rama Chandran , Paul Foreman , Michael Philbin , Smita Shah
发明人： Eric Silverberg , Rama Chandran , Paul Foreman , Michael Philbin , Smita Shah
IPC分类号： A61F13/02 , A61L15/16 , A61F13/00 , A61K9/70 , C08F20/54 , C08F20/70 , C08F26/02 , C08F120/54 , C08F120/70 , C08F126/02 , C08F136/00 , C08F220/54 , C08F220/70 , C08F226/02 , C08F236/00 , C08F212/00 , C08F216/12 , C08F20/26 , C08F220/26 , C08F20/10 , C08F220/10 , A61L15/58 , C09J133/06
CPC分类号： A61K9/7053 , A61K9/7061 , A61L15/58 , C09J133/062 , C08L35/04 , C08L33/26 , C08L33/04
摘要： An adhesive composition which lacks functional groups containing reactive hydrogen moieties and contains no post-polymerization chemical crosslinker finds use in transdermal drug delivery systems. The invention enables the administration of drugs containing a reactive functional group, which drugs have heretofore not been able to be administered by the transdermal route using conventional acrylic adhesives.

3. 发明申请

US20070071800A1 Acrylic pressure sensitive adhesives 审中-公开
标题翻译：丙烯酸压敏粘合剂
公开(公告)号：US20070071800A1
公开(公告)日：2007-03-29
申请号：US11238277
申请日：2005-09-29
申请人： Paul Foreman , Allison Luciano
发明人： Paul Foreman , Allison Luciano
IPC分类号： A61F13/02
CPC分类号： A61K9/7061 , C08L33/06 , C09J7/22 , C09J7/38
摘要： Solution acrylic polymers suitable for dispersing drugs are particularly useful in transdermal drug delivery applications.
摘要翻译：适用于分散药物的溶液丙烯酸聚合物特别适用于透皮药物递送应用。

4. 发明申请

US20120207823A1 PHARMACEUTICAL PELLETS COMPRISING MODIFIED STARCH AND THERAPEUTIC APPLICATIONS THEREFOR 审中-公开
标题翻译：包含改性淀粉和治疗应用的药物颗粒
公开(公告)号：US20120207823A1
公开(公告)日：2012-08-16
申请号：US13454592
申请日：2012-04-24
申请人： Jean Paul Remon , Chris Vervaet , Paul Foreman
发明人： Jean Paul Remon , Chris Vervaet , Paul Foreman
IPC分类号： A61K9/48 , A61K31/4164 , A61K31/4174 , A61K9/14 , A61P31/10 , A61P31/00 , A61P29/00 , A61K31/57 , A61P15/02
CPC分类号： A61K9/0034 , A61K9/1652
摘要： Vaginal use compositions comprising pellets prepared from a debranched starch. Pellets may be conveniently prepared via extrusion/spheronization.
摘要翻译：阴道用组合物包含由脱支淀粉制备的颗粒。可以通过挤出/滚圆法方便地制备颗粒。

5. 发明申请

US20070104771A1 Transdermal galantamine delivery system 审中-公开
标题翻译：经皮加兰他敏递送系统
公开(公告)号：US20070104771A1
公开(公告)日：2007-05-10
申请号：US11525696
申请日：2006-09-22
申请人： Jay Audett , Eli Goldman , Delphine Imbert , Diane Nedberge , Jianye Wen , Allison Luciano , Eric Silverberg , Paul Foreman , Johan Geerke
发明人： Jay Audett , Eli Goldman , Delphine Imbert , Diane Nedberge , Jianye Wen , Allison Luciano , Eric Silverberg , Paul Foreman , Johan Geerke
IPC分类号： A61K9/70 , A61K31/55
CPC分类号： A61K9/7061 , A61K31/55
摘要： A transdermal galantamine delivery system to an individual. The system has a high galantamine loading with suitable permeation enhancers to effect therapeutic flux rate. Acrylate polymeric reservoir with the high galantamine and permeation enhancers dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties for multiple-day delivery.
摘要翻译：经皮加兰他敏给个体的输送系统。该系统具有高的加兰他敏负荷，并具有合适的渗透促进剂以实现治疗通量。溶解有高加兰他敏和渗透促进剂的丙烯酸酯聚合物储库提供了期望的粘合特性和有效的经皮治疗性能，用于多天的输送。

6. 发明申请

US20070072987A1 Acrylic polymer-based adhesives 审中-公开
标题翻译：丙烯酸聚合物基粘合剂
公开(公告)号：US20070072987A1
公开(公告)日：2007-03-29
申请号：US11526135
申请日：2006-09-22
申请人： Allison Luciano , Eric Silverberg , Paul Foreman , Jianye Wen , Eli Goldman , Jay Audette
发明人： Allison Luciano , Eric Silverberg , Paul Foreman , Jianye Wen , Eli Goldman , Jay Audette
IPC分类号： C09D5/02
CPC分类号： C09J133/066 , A61L15/585 , C08F220/06 , C08F220/18 , C08F220/20 , C08F220/26 , C08F220/28 , C08F220/56 , C09J133/26 , C08L33/08
摘要： Acrylic polymers comprising a non-primary hydroxyl functional monomer and low Tg alkyl acrylate monomers are useful in adhesive compositions that find use in skin contact applications.
摘要翻译：包含非伯羟基官能单体和低Tg丙烯酸烷基酯单体的丙烯酸聚合物可用于皮肤接触应用中使用的粘合剂组合物。

7. 发明申请

US20070098772A1 Transdermal norelgestromin delivery system 审中-公开
标题翻译：透皮去甲肾上腺素输送系统
公开(公告)号：US20070098772A1
公开(公告)日：2007-05-03
申请号：US11525684
申请日：2006-09-22
申请人： Tyler Westcott , Jane Stepic , Delphine Imbert , Jay Audett , Jianye Wen , Allison Luciano , Eric Silverberg , Paul Foreman
发明人： Tyler Westcott , Jane Stepic , Delphine Imbert , Jay Audett , Jianye Wen , Allison Luciano , Eric Silverberg , Paul Foreman
IPC分类号： A61K9/70 , A61K31/56
CPC分类号： A61K9/7061 , A61K31/4439 , A61K31/56 , C09J7/255 , C09J7/385 , C09J133/06 , C09J2467/006
摘要： A system for transdermal delivery of norelgestromin (NGMN) to an individual. The system has a high NGMN loading with suitable permeation enhancers to effect therapeutic flux rate. Polyacrylate drug reservoir with the NGMN and high loading of one or more of permeation enhancers and NGMN dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties. Estrogen can be delivered with the NGMN.
摘要翻译：将norelgestromin（NGMN）透皮递送给个体的系统。该系统具有高的NGMN负载，具有合适的渗透增强剂以实现治疗通量。具有NGMN的聚丙烯酸酯药物储存器和溶解在其中的一种或多种渗透促进剂和NGMN的高负荷提供了所需的粘合特性和有效的经皮治疗性质。雌激素可与NGMN一起递送。

8. 发明申请

US20070098771A1 High enhancer-loading polyacrylate formulation for transdermal applications 有权
标题翻译：用于透皮应用的高增强剂负载聚丙烯酸酯制剂
公开(公告)号：US20070098771A1
公开(公告)日：2007-05-03
申请号：US11525683
申请日：2006-09-22
申请人： Jay Audett , Jianye Wen , Eli Goldman , Robert Gale , Allison Luciano , Paul Foreman , Eric Silverberg
发明人： Jay Audett , Jianye Wen , Eli Goldman , Robert Gale , Allison Luciano , Paul Foreman , Eric Silverberg
IPC分类号： A61K9/70
CPC分类号： A61K9/7061 , A61K9/7038 , A61K31/4439 , A61K31/465 , A61K31/55 , A61K31/567 , A61K31/57 , A61K47/32 , C07D401/04
摘要： A polyacrylate formulation suitable for delivery of drug to through a body surface of an individual. By loading the drug and permeation enhancers at a high concentration into a polyacrylate proadhesive that has inadequate adhesive properties for typical adhesive application on the skin, a formulation with desirable adhesive characteristics and effective therapeutic properties can be made. The proadhesive has higher glass transition temperature than typical pressure sensitive adhesives.
摘要翻译：适用于将药物递送至个体体表的聚丙烯酸酯制剂。通过将高浓度的药物和渗透促进剂加载到对皮肤上典型的粘合剂施加具有不良粘合性能的聚丙烯酸酯粘合剂中，可以制备具有所需粘合特性和有效治疗性质的制剂。粘合剂具有比典型的压敏粘合剂更高的玻璃化转变温度。

9. 发明申请

US20060246192A1 Use of debranched starch in extrusion-spheronization pharmaceutical pellets 有权
标题翻译：在挤出 - 滚圆化药丸中使用脱支淀粉
公开(公告)号：US20060246192A1
公开(公告)日：2006-11-02
申请号：US11410375
申请日：2006-04-25
申请人： Aleksandra Dukic , Chris Vervaet , Jean Remon , Paul Altieri , Paul Foreman
发明人： Aleksandra Dukic , Chris Vervaet , Jean Remon , Paul Altieri , Paul Foreman
IPC分类号： A23B4/03
CPC分类号： A61K47/36 , A61K9/1652 , A61K31/52
摘要： This patent pertains to the use of debranched starch in the preparation of pharmaceutical pellets by extrusion spheronization. Such excipients are useful in any dry dosage form, including tablets and capsules, for either immediate or sustained release.
摘要翻译：本专利涉及使用脱支淀粉通过挤出滚圆法制备药丸。这种赋形剂可用于任何干剂型，包括片剂和胶囊剂，用于立即或持续释放。

10. 发明申请

US20070190013A1 Film and film-forming compositions 审中-公开
标题翻译：薄膜和成膜组合物
公开(公告)号：US20070190013A1
公开(公告)日：2007-08-16
申请号：US11352959
申请日：2006-02-13
申请人： Yeli Zhang , Reema Puri , Patricia Siuta-Cruce , Paul Foreman , Todd Manegold
发明人： Yeli Zhang , Reema Puri , Patricia Siuta-Cruce , Paul Foreman , Todd Manegold
IPC分类号： A61K8/81 , A61K8/73
CPC分类号： C08L3/00 , A61K9/006 , A61K9/7007 , C08L3/02 , C08L5/00 , C08L5/14 , C08L33/02 , C08L33/08 , C08L2666/04 , C08L2666/02 , C08L2666/26 , C08L2666/18
摘要： The invention provides films and film forming compositions that can be applied onto a tissue surface. The film and the film forming composition comprise at least one polycarboxylated polymer and at least one polysaccharide.
摘要翻译：本发明提供了可以施加到组织表面上的膜和成膜组合物。薄膜和成膜组合物包含至少一种多羧基化聚合物和至少一种多糖。

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