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    • 2. 发明授权
    • Adhesive material and adhesive preparation
    • 胶粘材料和粘合剂制备
    • US08394404B2
    • 2013-03-12
    • US11196936
    • 2005-08-04
    • Hitoshi AkemiKazuhisa NinomiyaHidetoshi KurodaKensuke MatsuokaYuji SaekiMasato Nishimura
    • Hitoshi AkemiKazuhisa NinomiyaHidetoshi KurodaKensuke MatsuokaYuji SaekiMasato Nishimura
    • A61L15/16C08F136/00
    • A61K9/7053
    • The present invention provides an adhesive material to be adhered to the skin etc., which maintains, for a certain time period after adhesion thereof to the skin surface, suitable adhesiveness that does not allow easy peeling or cause irritation to the skin, and which permits, when it is to be peeled off from the skin surface after the lapse of a desired certain time period, easy peeling without causing pain or physical irritation, and an adhesive preparation containing the adhesive material and a percutaneously absorbable drug in the adhesive layer. Specifically, the present invention provides an adhesive material containing a support and an adhesive layer laminated on one surface of the support, wherein the adhesive layer has an apparent viscosity at 30° C. of 0.2×104 to 10×104 Pa·s and comprises two kinds of synthetic rubbers having different flowability.
    • 本发明提供粘附到皮肤等上的粘合剂材料,其在粘附到皮肤表面上一段时间后保持适合的粘合性,其不容易剥离或对皮肤产生刺激,并且允许 当在期望的特定时间段之后要从皮肤表面剥离时,易于剥离而不引起疼痛或身体刺激,以及在粘合剂层中含有粘合剂材料和经皮吸收药物的粘合剂。 具体地说,本发明提供了一种粘合剂材料,其包含层叠在载体的一个表面上的载体和粘合剂层,其中所述粘合剂层在30℃下的表观粘度为0.2×10 4至1​​0×10 4 Pa·s,并且包含 两种具有不同流动性的合成橡胶。
    • 8. 发明授权
    • Patch preparation
    • 补丁准备
    • US08758312B2
    • 2014-06-24
    • US13542994
    • 2012-07-06
    • Masahiro MitsushimaHidetoshi KurodaYuji SaekiTomohito Takita
    • Masahiro MitsushimaHidetoshi KurodaYuji SaekiTomohito Takita
    • B32B15/04A61K6/00
    • A61K9/7061
    • The present invention provides a patch preparation that has an extremely low moisture permeability, has a sufficient ODT effect, is excellent in drug releasability and in anchoring property of its drug-containing pressure-sensitive adhesive layer, and has a preferred patch feeling. The patch preparation of the present invention includes a support; and a pressure-sensitive adhesive layer containing an adherent polymer and a drug on one surface of the support, wherein: the support has a polyester base layer, an inorganic oxide layer, and a polyester nonwoven fabric layer in the stated order; the polyester base layer has a thickness of 1.0 μm to 16 μm; and the pressure-sensitive adhesive layer is laminated on the polyester nonwoven fabric layer.
    • 本发明提供一种具有极低的透湿性,足够的ODT效果,药物释放性和药物含粘合剂层的锚定性优异的贴片制剂,并且具有优选的贴片感。 本发明的贴片制剂包括支持体; 以及在载体的一个表面上含有粘着性聚合物和药物的粘合剂层,其中:所述载体具有所述顺序的聚酯基层,无机氧化物层和聚酯无纺布层; 聚酯基层的厚度为1.0μm〜16μm; 并且将压敏粘合剂层层压在聚酯无纺布层上。