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1. 发明申请

US20100255071A1 Patch and patch preparation 审中-公开
标题翻译：补丁和补丁准备
公开(公告)号：US20100255071A1
公开(公告)日：2010-10-07
申请号：US12662223
申请日：2010-04-06
申请人： Miki Makabe , Tsuyoshi Kasahara , Atsushi Hamada , Jun Ishikura
发明人： Miki Makabe , Tsuyoshi Kasahara , Atsushi Hamada , Jun Ishikura
IPC分类号： A61K9/70 , A61K31/405 , A61P17/02 , A61F13/02
CPC分类号： A61L15/58 , A61K9/7053 , C08L23/20
摘要： Provided are a patch and a patch preparation having an adhesive layer on at least one surface of a support, and particularly, a patch and a patch preparation superior in skin adhesive force, and causing less adhesive residue on the skin surface. A patch having a support and an adhesive layer formed on at least one surface of the support, wherein the adhesive layer contains an elastomer obtained by crosslinking a polymer having a butadiene skeleton in the presence of an organic peroxide, and the ratio of the weight of a toluene-insoluble component in the adhesive layer to the total weight of the adhesive layer is 5-32 wt %.
摘要翻译：本发明提供一种贴片和贴片制剂，其在支持体的至少一个表面上具有粘合剂层，特别是在皮肤粘合力方面优异的贴剂和贴剂，并且在皮肤表面上引起较少的粘合剂残留。一种具有支撑体的粘合剂层和形成在载体的至少一个表面上的粘合剂层，其中粘合剂层含有通过在有机过氧化物的存在下交联具有丁二烯骨架的聚合物而获得的弹性体，粘合剂层中的甲苯不溶性成分相对于粘合剂层的总重量为5-32重量％。

2. 发明申请

US20100247616A1 PATCH AND PATCH PREPARATION 审中-公开
标题翻译：配对和配对准备
公开(公告)号：US20100247616A1
公开(公告)日：2010-09-30
申请号：US12728829
申请日：2010-03-22
申请人： Yoshio FUNAKOSHI , Tsuyoshi KASAHARA , Atsushi HAMADA , Jun ISHIKURA
发明人： Yoshio FUNAKOSHI , Tsuyoshi KASAHARA , Atsushi HAMADA , Jun ISHIKURA
IPC分类号： A61K9/70 , A61F13/02
CPC分类号： A61L15/30 , A61L15/44 , A61L15/58 , A61L2300/606
摘要： The present invention provides a patch and a patch preparation having an adhesive layer with a sufficient thickness, as well as appropriate skin adhesiveness and flexibility, which resist falling off from the skin even when a load is applied to the side opposite to the surface of the patch or patch preparation to be adhered to the skin, i.e., an exposed surface of a support of the patch or patch preparation, and show low irritation to the skin; an adhesive layer, which is obtained by crosslinking a liquid rubber having a crosslinkable functional group in a molecule in the presence of a crosslinking agent having a functional group number of 3 or below and a catalyst, on at least one surface of a support; and a patch preparation having an adhesive layer containing a pharmaceutical agent.
摘要翻译：本发明提供了具有足够厚度的粘合剂层以及适当的皮肤粘附性和柔韧性的贴剂和贴剂，其即使当负荷施加到与该皮肤的表面相反的一侧时也能抵抗皮肤脱落斑块或贴剂制剂要粘附到皮肤上，即贴剂或贴剂制剂的支持物的暴露表面，并且对皮肤显示低刺激性; 在载体的至少一个表面上，在官能团数为3以下的交联剂和催化剂的存在下，将分子内具有交联性官能团的液态橡胶交联而获得的粘合剂层; 以及具有含有药剂的粘合剂层的贴片制剂。

3. 发明申请

US20100144901A1 Gel composition for medical material or hygiene material, molded article thereof and adhesive material or adhesive preparation using same 审中-公开
标题翻译：用于医疗材料或卫生材料的凝胶组合物，其模制品和粘合剂材料或使用其的粘合剂制剂
公开(公告)号：US20100144901A1
公开(公告)日：2010-06-10
申请号：US12453909
申请日：2009-05-27
申请人： Yoshio Funakoshi , Atsushi Hamada , Jun Ishikura , Tsuyoshi Kasahara
发明人： Yoshio Funakoshi , Atsushi Hamada , Jun Ishikura , Tsuyoshi Kasahara
IPC分类号： A61K47/32 , C09D4/00
CPC分类号： A61Q19/00 , A61K8/042 , A61K8/72 , A61K9/7038 , A61L15/30 , A61L15/60 , C08K5/0016 , C08K5/101 , C08K5/1515 , C08L13/00 , C08L19/006 , C08L9/10
摘要： The present invention can provide a composition for a medical material or a hygiene material, which can retain a considerable amount of a chemical substance such as a drug and the like or an organic liquid component, is associated with less limitation on molding, does not easily drop off when adhered to the skin, provides a better feeling during adhesion to the skin, produces decreased adhesive residue when detached from the skin, and shows good followability to the skin. The present invention provides a gel composition obtained by crosslinking a composition for gel preparation comprising a liquid rubber having a crosslinkable functional group in a molecule and 34.6-64.6 wt % of an organic liquid component relative to the total weight of the composition for gel preparation.
摘要翻译：本发明可以提供可以保持大量化学物质如药物等或有机液体成分的用于医疗材料或卫生材料的组合物与较少的模制限制相关联，不容易粘附于皮肤时脱落，在与皮肤粘合时提供更好的感觉，与皮肤分离时会产生较少的粘合剂残留，并且对皮肤表现出良好的追随性。本发明提供一种凝胶组合物，其通过将用于凝胶制剂的组合物交联，所述组合物包含分子中具有交联性官能团的液体橡胶和相对于凝胶制剂用组合物总重量为34.6-64.6重量％的有机液体组分。

4. 发明申请

US20100068248A1 Patch and patch preparation 审中-公开
标题翻译：补丁和补丁准备
公开(公告)号：US20100068248A1
公开(公告)日：2010-03-18
申请号：US12585315
申请日：2009-09-11
申请人： Yoshio Funakoshi , Tsuyoshi Kasahara , Atsushi Hamada , Jun Ishikura
发明人： Yoshio Funakoshi , Tsuyoshi Kasahara , Atsushi Hamada , Jun Ishikura
IPC分类号： A61K9/70
CPC分类号： A61L15/585 , C08L21/00
摘要： The present invention provides a patch containing a support and an adhesive layer formed on at least one surface of the support, wherein the adhesive layer has a gel fraction of 50 wt %-75 wt %, and is comprised of a composition containing 33 wt %-65 wt % of a liquid rubber having a crosslinkable functional group in a molecule, which has an adhesive layer with a thickness sufficient for protection of a skin lesion and a wounded surface, which is flexible, adheres well to the skin, provides good feeling during adhesion, leaves less adhesive residue when removed from the skin, and shows good followability to skin deformation, as well as a patch preparation capable of sufficiently retaining a medicament and the like.
摘要翻译：本发明提供了一种补片，其包含形成在支撑体的至少一个表面上的支撑体和粘合剂层，其中粘合剂层具有50重量％-75重量％的凝胶分数，并且由含有33重量％ -65重量％的分子中具有可交联官能团的液体橡胶，其具有足以保护皮肤损伤的厚度的粘合剂层和具有柔性的，适合于皮肤的受伤表面，具有良好的感觉在粘合时，从皮肤上除去粘合剂残留物，并且对皮肤变形显示良好的追随性，以及能够充分保持药物等的贴片制剂。

5. 发明申请

US20100015209A1 Patch and patch preparation 审中-公开
标题翻译：补丁和补丁准备
公开(公告)号：US20100015209A1
公开(公告)日：2010-01-21
申请号：US12458626
申请日：2009-07-17
申请人： Miki Funahashi , Atsushi Hamada , Tsuyoshi Kasahara , Jun Ishikura
发明人： Miki Funahashi , Atsushi Hamada , Tsuyoshi Kasahara , Jun Ishikura
IPC分类号： A61K9/70 , B32B7/12
CPC分类号： A61L15/58 , Y10T428/2852
摘要： Provided is a patch having good adhesion property, which stably maintains the quality for a long time.A patch containing a support and an adhesive layer formed on at least one surface of the support, wherein the adhesive layer contains an elastomer having a structure of the formula I: wherein P1 and P2 are each independently hydrogen, a hydroxy group or an organic group.
摘要翻译：提供具有良好粘附性的贴剂，其长期稳定地保持质量。一种在载体的至少一个表面上形成有载体和粘合层的贴剂，其中所述粘合剂层含有具有式I结构的弹性体：其中P1和P2各自独立地为氢，羟基或有机基团。

6. 发明申请

US20090028928A1 Patch and patch preparation 审中-公开
标题翻译：补丁和补丁准备
公开(公告)号：US20090028928A1
公开(公告)日：2009-01-29
申请号：US12216366
申请日：2008-07-02
申请人： Atsushi Hamada , Tsuyoshi Kasahara , Jun Ishikura , Miki Funahashi
发明人： Atsushi Hamada , Tsuyoshi Kasahara , Jun Ishikura , Miki Funahashi
IPC分类号： A61K9/70 , B32B27/00
CPC分类号： A61K9/7053 , A61L31/041 , Y10T428/2883 , C08L21/00
摘要： The present invention aims to provide a patch and a patch preparation that do not require an acrylic polymer, and are capable of maintaining a large amount of an organic liquid component in an adhesive layer.The present invention provides a patch containing a support and an adhesive layer provided on at least one surface of the support, wherein the adhesive layer contains a synthetic rubber component other than polyisobutylene and solid at 25° C., a liquid rubber component having a crosslinkable functional group in a molecule, and an organic liquid component, the adhesive layer is crosslinked, and the liquid rubber component is contained in a proportion of less than 30 wt % relative to the total weight of the synthetic rubber component solid at 25° C. and the liquid rubber component.
摘要翻译：本发明的目的在于提供一种不需要丙烯酸类聚合物并且能够在粘合剂层中保持大量有机液体成分的贴剂和贴片制剂。本发明提供一种包含载体和粘合剂层的贴片，所述粘合剂层设置在所述载体的至少一个表面上，其中所述粘合层在25℃下包含除聚异丁烯和固体以外的合成橡胶组分，具有可交联的液体橡胶组分分子中的官能团和有机液体组分，粘合剂层交联，并且液体橡胶组分的含量相对于合成橡胶组分固体在25℃下的总重量小于30重量％。和液体橡胶组分。

7. 发明授权

US08361493B2 Transdermal patch having a pressure-sensitive adhesive comprising (meth)acrylic acid alkyl ester, N-hydroxyalkyl(meth)acrylamide, and vinyl monomers 有权
标题翻译：具有包含（甲基）丙烯酸烷基酯，N-羟烷基（甲基）丙烯酰胺和乙烯基单体的压敏粘合剂的透皮贴剂
公开(公告)号：US08361493B2
公开(公告)日：2013-01-29
申请号：US12945198
申请日：2010-11-12
申请人： Jun Ishikura , Raito Funayama , Yu Tachikawa , Junichi Sekiya , Tsuyoshi Kasahara , Ryo Hashino , Satoshi Ameyama , Hidetoshi Kuroda
发明人： Jun Ishikura , Raito Funayama , Yu Tachikawa , Junichi Sekiya , Tsuyoshi Kasahara , Ryo Hashino , Satoshi Ameyama , Hidetoshi Kuroda
IPC分类号： A61F13/02 , A61F13/00
CPC分类号： A61L15/585 , C09J133/26 , Y10T428/2887 , Y10T428/2891
摘要： The patch according to an embodiment of the present invention includes: a support; and a pressure-sensitive adhesive layer on at least one surface of the support, wherein: the pressure-sensitive adhesive layer contains an acrylic copolymer obtained by copolymerizing monomer components containing (a) at least one kind of a monomer of a (meth)acrylic acid alkyl ester and (b) at least one kind of a monomer of an N-hydroxyalkyl(meth)acrylamide; a content of the (meth)acrylic acid alkyl ester monomer (a) with respect to a total amount of the monomer components is 50 wt % to 90 wt % and a content of the N-hydroxyalkyl(meth)acrylamide monomer (b) with respect to the total amount is 1 wt % to 20 wt %; and the monomer components are substantially free of a monomer having a carboxyl group.
摘要翻译：根据本发明的实施例的贴片包括：支撑件; 和压敏粘合剂层，其中：所述压敏粘合剂层含有丙烯酸共聚物，所述丙烯酸共聚物通过共聚含有（a）至少一种（甲基）丙烯酸单体的单体成分而得到的丙烯酸共聚物酸性烷基酯和（b）至少一种N-羟烷基（甲基）丙烯酰胺的单体; 相对于单体成分的总量，（甲基）丙烯酸烷基酯单体（a）的含量为50重量％〜90重量％，N-羟烷基（甲基）丙烯酰胺单体（b）的含量与相对于总量为1重量％〜20重量％并且单体组分基本上不含具有羧基的单体。

8. 发明申请

US20100260826A1 Patch and patch preparation 审中-公开
标题翻译：补丁和补丁准备
公开(公告)号：US20100260826A1
公开(公告)日：2010-10-14
申请号：US12662253
申请日：2010-04-07
申请人： Miki Makabe , Tsuyoshi Kasahara , Atsushi Hamada , Jun Ishikura
发明人： Miki Makabe , Tsuyoshi Kasahara , Atsushi Hamada , Jun Ishikura
IPC分类号： A61K9/70 , A61P17/02 , A61F13/02
CPC分类号： A61L15/44 , A61K9/7053 , A61L15/585 , A61L2300/606
摘要： Provided are a patch and a patch preparation having an adhesive layer on at least one surface of a support, and particularly, a patch and a patch preparation superior in skin adhesive force, and causing less adhesive residue on the skin surface. A patch having a support and an adhesive layer formed on at least one surface of the support, wherein the adhesive layer is obtained by crosslinking a first polymer having a butadiene skeleton portion and a second polymer different from the first polymer in the presence of an organic peroxide.
摘要翻译：本发明提供一种贴片和贴片制剂，其在支持体的至少一个表面上具有粘合剂层，特别是在皮肤粘合力方面优异的贴剂和贴剂，并且在皮肤表面上引起较少的粘合剂残留。具有支撑体和形成在支撑体的至少一个表面上的粘合层的贴剂，其中所述粘合剂层通过在有机物存在下交联具有丁二烯骨架部分的第一聚合物和不同于第一聚合物的第二聚合物而获得过氧化物。

9. 发明授权

US6119078A Systems, methods and computer program products for automatically translating web pages 失效
标题翻译：用于自动翻译网页的系统，方法和计算机程序产品
公开(公告)号：US6119078A
公开(公告)日：2000-09-12
申请号：US949257
申请日：1997-10-13
申请人： Takashi Kobayakawa , Eiichi Tazoe , Jun Ishikura
发明人： Takashi Kobayakawa , Eiichi Tazoe , Jun Ishikura
IPC分类号： G06F13/00 , G06F17/21 , G06F17/27 , G06F17/28
CPC分类号： G06F17/289 , G06F17/272 , G06F17/2765
摘要： A Web page in a first language can be translated into a second language by interpreting the URL used to request the Web page. A character string is located that is similar to at least a portion of the URL. A translating environment is linked to the located character string and automatically translates the Web page transmitted from the server. The translated Web page may be displayed in both the first and second languages.
摘要翻译：可以通过解释用于请求网页的URL来将第一种语言的网页翻译成第二种语言。位于与URL的至少一部分相似的字符串。翻译环境与定位的字符串相关联，并自动翻译从服务器发送的网页。翻译的网页可以以第一语言和第二语言显示。

10. 发明申请

US20120225110A1 PATCH AND PATCH PREPARATION 审中-公开
标题翻译：配对和配对准备
公开(公告)号：US20120225110A1
公开(公告)日：2012-09-06
申请号：US13399384
申请日：2012-02-17
申请人： Ryo Hashino , Hidetoshi Kuroda , Satoshi Ameyama , Shiro Satoda , Jun Ishikura
发明人： Ryo Hashino , Hidetoshi Kuroda , Satoshi Ameyama , Shiro Satoda , Jun Ishikura
IPC分类号： A61K9/70 , B32B7/12
CPC分类号： A61L15/58 , A61K9/7061 , A61L15/44 , Y10T428/2887 , Y10T428/2891 , C08L33/10
摘要： A patch according to an embodiment of the present invention includes a support and a pressure-sensitive adhesive layer provided on at least one surface of the support. The pressure-sensitive adhesive layer contains an acrylic copolymer obtained by copolymerizing a monomer mixture containing (a) a (meth)acrylic acid alkyl ester, (b) a hydroxyl group-containing monomer, and (c) a diketone group-containing monomer.
摘要翻译：根据本发明的实施方式的贴片包括支撑体和设置在支撑体的至少一个表面上的压敏粘合剂层。压敏粘合剂层含有通过共聚含有（a）（甲基）丙烯酸烷基酯，（b）含羟基单体和（c）含二酮基团的单体）的单体混合物而获得的丙烯酸共聚物。

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