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1. 发明申请

US20070188704A1 Fundus Observation Device 有权
标题翻译：眼底观察装置
公开(公告)号：US20070188704A1
公开(公告)日：2007-08-16
申请号：US11675657
申请日：2007-02-16
申请人： Yasufumi Fukuma , Hisashi Tsukada , Tsutomu Kikawa
发明人： Yasufumi Fukuma , Hisashi Tsukada , Tsutomu Kikawa
IPC分类号： A61B3/10
CPC分类号： A61B3/102
摘要： Technology is provided, capable of easily acquiring high precision tomographic images of the desired observation site of the fundus oculi. A fundus observation device 1 is provided, comprising: an interferometer that generates interference light LC from a reference light LR via a reference mirror 174 and a signal light LS that reaches the fundus oculi Ef after low-coherence light L0 is split into that signal light LS and reference light LR; a CCD 184 that detects interference light LC; an image forming part 220 that forms image data G of a tomographic image based on detection results of the CCD 184; a display part 240A; an operation part 240B for specifying an observation mode (observation site); and a reference mirror drive mechanism 243. The image data G of a tomographic image includes image data of a normal image G (Re) and an inverse image G (Im). A controlling part 210 that displays the selected normal image G (Re) or inverse image G (Im) on the display part 240A along with moving the reference mirror 174 by controlling the reference mirror drive mechanism 243 based on the selected observation mode.
摘要翻译：提供技术，能够容易地获取眼底的所需观察部位的高精度断层图像。提供了一种眼底观察装置1，其包括：干涉仪，其经由参考镜174产生来自参考光LR的干涉光LC和在低相干光L 0被分割成该信号之后到达眼底Ef的信号光LS 光LS和参考光LR; 检测干涉光LC的CCD184; 基于CCD 184的检测结果形成断层图像的图像数据G的图像形成部220; 显示部分240A; 用于指定观察模式（观察部位）的操作部240B; 和参考镜驱动机构243。断层图像的图像数据G包括正常图像G（Re）和逆图像G（Im）的图像数据。控制部210，通过基于所选择的观察模式控制参考镜驱动机构243，在显示部240A上显示所选择的正常图像G（Re）或反转图像G（Im）。

2. 发明授权

US08348426B2 Optical image measurement device and image processing device 有权
标题翻译：光学图像测量装置和图像处理装置
公开(公告)号：US08348426B2
公开(公告)日：2013-01-08
申请号：US12052187
申请日：2008-03-20
申请人： Hisashi Tsukada , Hiroyuki Aoki , Yasufumi Fukuma , Tsutomu Kikawa
发明人： Hisashi Tsukada , Hiroyuki Aoki , Yasufumi Fukuma , Tsutomu Kikawa
IPC分类号： A61B3/14
CPC分类号： A61B3/102 , G01B9/0203 , G01B9/02044 , G01B9/02085 , G01B9/02087 , G01B9/02091 , G01B2290/65 , G06T3/4007
摘要： An optical image measurement device is configured to form a tomographic image at each of a plurality of cross sections of a measurement object, and the optical image measurement device comprises: an image processor configured to execute an arithmetic operation based on a tomographic image at one cross section of the plurality of cross sections and another tomographic image at each of one or more cross sections other than the one cross section, thereby forming a new tomographic image at the one cross section.
摘要翻译：光学图像测量装置被配置为在测量对象的多个横截面中的每一个处形成断层图像，并且所述光学图像测量装置包括：图像处理器，被配置为在一个十字交叉处执行基于断层图像的算术运算所述多个横截面的截面和在所述一个横截面以外的一个或多个横截面中的每一个处的另一断层图像，从而在所述一个横截面处形成新的断层图像。

3. 发明授权

US07905596B2 Fundus observation device, an ophthalmologic image processing unit, an ophthalmologic image processing program, and an ophthalmologic image processing method 有权
标题翻译：眼底观察装置，眼科图像处理单元，眼科图像处理程序和眼科图像处理方法
公开(公告)号：US07905596B2
公开(公告)日：2011-03-15
申请号：US11760314
申请日：2007-06-08
申请人： Hiroyuki Aoki , Takashi Fujimura , Yasufumi Fukuma , Hisashi Tsukada , Tsutomu Kikawa
发明人： Hiroyuki Aoki , Takashi Fujimura , Yasufumi Fukuma , Hisashi Tsukada , Tsutomu Kikawa
IPC分类号： A61B3/14 , A61B3/10 , A61B3/00
CPC分类号： A61B3/102 , G06T7/12 , G06T7/174 , G06T7/181 , G06T2207/10101 , G06T2207/30041
摘要： First image forming part forms a two-dimensional surface image of a fundus oculi of an eye based on optically obtained data. Second image forming part forms tomographic images of fundus oculi based on data obtained by optically scanning a region of the surface of fundus oculi corresponding to at least part of two-dimensional image. Accumulated image generating part generates an accumulated image by accumulating the formed tomographic images in a depth-wise direction. Extracting part extracts first vascular territory corresponding to a fundus oculi vessel from two-dimensional image formed by first image forming part, and also extracts second vascular territory corresponding to a fundus oculi vessel from accumulated image generated by accumulated image generating part. Specification part specifies a position of a vascular cross sectional region corresponding to a cross section of a fundus oculi vessel in the tomographic image based on extracted first vascular territory and extracted second vascular territory.
摘要翻译：第一图像形成部件基于光学获得的数据形成眼睛的眼底的二维表面图像。第二图像形成部分基于通过光学扫描与至少部分二维图像相对应的眼底表面的区域获得的数据来形成眼底的断层图像。累积图像生成部通过在深度方向累积形成的断层图像来生成累积图像。提取部分从由第一图像形成部分形成的二维图像中提取与眼底容器相对应的第一血管区域，并且从由累积图像生成部分生成的累积图像中提取与眼底容器对应的第二血管区域。规格部分基于提取的第一血管区域和提取的第二血管区域来指定与断层图像中的眼底血管的横截面对应的血管横截面区域的位置。

4. 发明授权

US07756311B2 Optical image measuring device, optical image measuring program, fundus observation device, and fundus observation program 有权
标题翻译：光学图像测量装置，光学图像测量程序，眼底观察装置和眼底观察程序
公开(公告)号：US07756311B2
公开(公告)日：2010-07-13
申请号：US11545270
申请日：2006-10-10
申请人： Yoshiaki Yasuno , Toyohiko Yatagai , Yasufumi Fukuma , Hisashi Tsukada , Tsutomu Kikawa , Hiroyuki Aoki , Takashi Fujimura
发明人： Yoshiaki Yasuno , Toyohiko Yatagai , Yasufumi Fukuma , Hisashi Tsukada , Tsutomu Kikawa , Hiroyuki Aoki , Takashi Fujimura
IPC分类号： G06K9/00 , G01B9/02
CPC分类号： G01N21/4795 , A61B3/102 , A61B3/145 , G01N2021/1787
摘要： An optical image measuring device which can form a highly reliable image even if an object moves during scanning of a signal light is provided. An optical image forming device 1 comprises: an interferometer that splits a low coherence light L0 into a signal light LS and a reference light LR and generates an interference light LC by overlaying the signal light LS reflected by a fundus oculi with the reference light LR reflected by a reference mirror 14; a CCD 34 which receives the interference light LC and outputs a detection signal; Galvanometer mirrors 22 and 23 to scan the signal light LS in a main scanning direction and a sub-scanning direction; and a computer 40 forming tomographic images G1 to Gm along the main scanning direction at different positions of the sub-scanning direction. The Galvanometer mirrors 22 and 23 scan the signal light LS in a given direction crossing the main scanning direction, and the computer 40 forms a tomographic image for correction GR along the given direction to correct displacement of each topographic image Gi based on the tomographic image for correction GR.
摘要翻译：提供了即使在信号光的扫描期间物体移动时也可以形成高可靠性图像的光学图像测量装置。光学图像形成装置1包括：干涉仪，其将低相干光L0分解成信号光LS和参考光LR，并通过将由眼底反射的信号光LS与反射的参考光LR重叠而产生干涉光LC 通过参考反射镜14; CCD34，其接收干涉光LC并输出检测信号; 电流计镜22和23在主扫描方向和副扫描方向扫描信号光LS; 以及在副扫描方向的不同位置沿着主扫描方向形成断层图像G1〜Gm的计算机40。电流计反射镜22和23沿与主扫描方向相交的给定方向扫描信号光LS，并且计算机40沿着给定方向形成用于校正GR的断层图像，以校正基于断层图像的每个地形图像Gi的位移校正GR。

5. 发明申请

US20080151256A1 OPTICAL IMAGE MEASUREMENT DEVICE 有权
标题翻译：光学图像测量装置
公开(公告)号：US20080151256A1
公开(公告)日：2008-06-26
申请号：US11961195
申请日：2007-12-20
申请人： Tsutomu KIKAWA , Hiroaki Okada , Takefumi Hayashi , Hisashi Tsukada , Yasufumi Fukuma
发明人： Tsutomu KIKAWA , Hiroaki Okada , Takefumi Hayashi , Hisashi Tsukada , Yasufumi Fukuma
IPC分类号： G01B11/02
CPC分类号： G01B9/02068 , A61B3/10 , A61B3/102 , A61B3/12 , G01B9/0203 , G01B9/02044 , G01B9/02064 , G01B9/02089 , G01B9/02091 , G01B2290/65
摘要： An optical image measurement device comprises: a light source configured to emit a low-coherence light; an interference-light generator configured to generate an interference light, by splitting the low-coherence light into a signal light and a reference light, and superimposing the signal light passed through a measurement object and the reference light passed through a reference object; a changer configured to change a difference in optical path length; a detector configured to detect the interference light; an image forming part configured to form an image of the measurement object within a predetermined frame based on the result of the detection; an analyzer configured to analyze the image, and specify a position of the image within the frame; and a controller configured to control the changer based on the specified position to change the difference so that an image newly formed is placed in a predetermined position within the frame.
摘要翻译：光学图像测量装置包括：被配置为发射低相干光的光源; 干涉光发生器，被配置为通过将低相干光分解为信号光和参考光来产生干涉光，并且叠加通过测量对象的信号光和通过参考对象的参考光; 更换器，被配置为改变光路长度的差异; 检测器，被配置为检测干涉光; 图像形成部，被配置为基于检测结果在预定帧内形成测量对象的图像; 分析器，其被配置为分析所述图像，并且指定所述图像在所述帧内的位置; 以及控制器，其被配置为基于所述指定位置来控制所述更换器以改变所述差异，使得新形成的图像被放置在所述帧内的预定位置。

6. 发明申请

US20070222946A1 Fundus Observation Device 有权
标题翻译：眼底观察装置
公开(公告)号：US20070222946A1
公开(公告)日：2007-09-27
申请号：US11689090
申请日：2007-03-21
申请人： Yasufumi Fukuma , Hiroyuki Aoki , Hisashi Tsukada , Tsutomu Kikawa
发明人： Yasufumi Fukuma , Hiroyuki Aoki , Hisashi Tsukada , Tsutomu Kikawa
IPC分类号： A61B3/14
CPC分类号： A61B3/102
摘要： Image forming part 220 forms a 2-dimensional image of the surface of the fundus oculi Ef (fundus oculi image) and a tomographic image of the fundus oculi Ef. The fundus oculi image 212a and the tomographic image Ga captured at the first examination time and the fundus oculi image 212b and the tomographic image Gb captured at the second examination time are stored in an image storage part 212. Position information generating part 214 generates the position information 213a indicating the position of the tomographic image Ga in the fundus oculi image 212a and the position information 213b indicating the position of the tomographic image Gb in the fundus oculi image 212b. The generated position information 213a and 213b are stored in information storage part 213. Image processing part 230 adjusts the position between the tomographic images Ga and Gb based on such position information 213a and 213b.
摘要翻译：图像形成部220形成眼底Ef（眼底图像）的表面的二维图像和眼底Ef的断层图像。在第一检查时间拍摄的眼底图像212a和眼底图像212b和在第二检查时间捕获的断层图像Gb被存储在图像存储部分212中。位置信息生成部214生成表示眼底图像212a中的断层图像Ga的位置的位置信息213a和表示眼底图像212b中的断层图像Gb的位置的位置信息213b。所生成的位置信息213a和213b被存储在信息存储部分213中。图像处理部分230基于这样的位置信息213a和213b来调整断层图像Ga和Gb之间的位置。

7. 发明授权

US07604351B2 Optical image measurement device and optical image measurement method 有权
标题翻译：光学图像测量装置和光学图像测量方法
公开(公告)号：US07604351B2
公开(公告)日：2009-10-20
申请号：US12055954
申请日：2008-03-26
申请人： Yasufumi Fukuma , Hisashi Tsukada , Tsutomu Kikawa , Kazuhiko Yumikake
发明人： Yasufumi Fukuma , Hisashi Tsukada , Tsutomu Kikawa , Kazuhiko Yumikake
IPC分类号： A61B3/14
CPC分类号： G01B9/0203 , A61B3/102 , G01B9/02044 , G01B9/02067 , G01B9/02091 , G01B2290/65 , G01N21/4795
摘要： An optical image measurement device comprises: an interference-light generator configured to generate an interference light by splitting a low-coherence light into a signal light and a reference light and superimposing the signal light having passed through an eye and the reference light having passed through a reference object; a detector configured to detect the generated interference light; a calculator configured to obtain intensity distribution of the interference light in the eye, based on a result of the detection by the detector; a determining part configured to determine a projection position of the signal light to the eye, based on the obtained intensity distribution; and an image forming part configured to form an image of the eye, based on a result of detection of a new interference light based on a new signal light projected toward the determined projection position and a new reference light having passed through the reference object.
摘要翻译：光学图像测量装置包括：干涉光发生器，被配置为通过将低相干光分解成信号光和参考光来产生干涉光，并叠加已经通过眼睛的信号光和已经穿过的参考光参考对象; 检测器，被配置为检测所产生的干涉光; 配置为基于检测器的检测结果获得眼睛中的干涉光的强度分布的计算器; 确定部件，被配置为基于获得的强度分布来确定信号光对眼睛的投影位置; 以及基于对所确定的投影位置投射的新的信号光的新的干涉光的检测结果和通过所述参照对象的新的基准光，构成为形成所述眼睛的图像的图像形成部。

8. 发明申请

US20080151260A1 OPTICAL IMAGE MEASUREMENT DEVICE 有权
标题翻译：光学图像测量装置
公开(公告)号：US20080151260A1
公开(公告)日：2008-06-26
申请号：US11962196
申请日：2007-12-21
申请人： Tsutomu KIKAWA , Hiroaki Okada , Takefumi Hayashi , Hisashi Tsukada , Yasufumi Fukuma
发明人： Tsutomu KIKAWA , Hiroaki Okada , Takefumi Hayashi , Hisashi Tsukada , Yasufumi Fukuma
IPC分类号： G01B9/02
CPC分类号： G01B9/02067 , A61B3/102 , G01B9/0203 , G01B9/02044 , G01B9/02064 , G01B9/02089 , G01B9/02091 , G01N21/4795
摘要： A fundus oculi observation device acts as an optical image measurement device capable of measuring an OCT image such as a tomographic image of a fundus oculi, or the like, and is configured so as to calculate the signal level of the formed OCT image, determine whether the signal level exceeds a threshold value, and change the position of a reference mirror so that the signal level is determined to exceed the threshold value.
摘要翻译：眼底观察装置作为能够测量诸如眼底断层图像等OCT图像的光学图像测量装置，并且被配置为计算形成的OCT图像的信号电平，确定是否信号电平超过阈值，并且改变参考镜的位置，使得信号电平被确定为超过阈值。

9. 发明授权

US07905597B2 Fundus observation device and a program controlling the same 有权
标题翻译：眼底观察装置和程序控制相同
公开(公告)号：US07905597B2
公开(公告)日：2011-03-15
申请号：US11770124
申请日：2007-06-28
申请人： Hisashi Tsukada , Tsutomu Kikawa , Yasufumi Fukuma
发明人： Hisashi Tsukada , Tsutomu Kikawa , Yasufumi Fukuma
IPC分类号： A61B3/14 , A61B3/10
CPC分类号： A61B3/102
摘要： A fundus observation device comprises: an image forming part comprising a first image forming part and a second image forming part, the first image forming part forming a 2-dimensional surface image of fundus oculi of an eye through optical processing, the second image forming part optically scanning a surface region of the fundus oculi corresponding to at least a part of the 2-dimensional surface image to form a tomographic image of the fundus oculi; a controller configured to control the image forming part; and a storage configured to store control information including control instructions to be sent from the controller to the image forming part, when one of the 2-dimensional surface image and the tomographic image is formed. The controller, at the time of formation of new one of the 2-dimensional surface image and the tomographic image of the fundus oculi, instructs the image forming part to form the new one of the 2-dimensional surface image and the tomographic image based on the control information stored in the storage.
摘要翻译：眼底观察装置包括：图像形成部，包括第一图像形成部和第二图像形成部，所述第一图像形成部通过光学处理形成眼睛的眼底的2维表面图像，第二图像形成部光学扫描对应于所述二维表面图像的至少一部分的眼底的表面区域，以形成眼底的断层图像; 控制器，被配置为控制图像形成部; 以及存储器，被配置为当形成所述二维表面图像和断层图像中的一个时，存储包括要从所述控制器发送到所述图像形成部分的控制指令的控制信息。控制器在形成新的二维表面图像和眼底的断层图像时指示图像形成部分形成二维表面图像和断层图像中的新的基于存储在存储器中的控制信息。

10. 发明授权

US07837328B2 Optical image-measuring device 有权
标题翻译：光学图像测量装置
公开(公告)号：US07837328B2
公开(公告)日：2010-11-23
申请号：US11621779
申请日：2007-01-10
申请人： Yasufumi Fukuma , Hisashi Tsukada , Tsutomu Kikawa
发明人： Yasufumi Fukuma , Hisashi Tsukada , Tsutomu Kikawa
IPC分类号： A61B3/14
CPC分类号： G01B9/02091 , A61B3/102 , G01B9/0203 , G01B9/02044 , G01B9/02083 , G01B2290/65
摘要： Light is split into a signal light LS directed toward the fundus oculi Ef and a reference light LR directed toward a reference mirror 174, and interference light LC generated by superimposing the signal light LS passing through the fundus oculi Ef and the reference light LR passing through the reference mirror 174 using a spectrometer 180 is detected to form tomographic images. A reference mirror drive mechanism 243 shifts the reference mirror 174 toward the optical path direction of the reference light LR and an information storage part 225 storing the reference mirror 174 position information based on previous tomographic images. The controlling part 210 controls the reference mirror drive mechanism 243 so that the reference mirror 174 shifts into a position based on reference mirror position information stored in the information storage part 225.
摘要翻译：光被分成指向眼底Ef的信号光LS和指向参考反射镜174的参考光LR，以及通过叠加通过眼底Ef的信号光LS和通过的参考光LR产生的干涉光LC 检测使用光谱仪180的参考镜174以形成断层图像。基准反射镜驱动机构243使基准反射镜174向基准光LR的光程方向移动，存储基准镜174的位置信息的信息存储部225基于先前的断层图像。控制部件210控制参考反射镜驱动机构243，使得参考反射镜174基于存储在信息存储部分225中的参考镜位置信息移动到位置。

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