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1. 发明授权

US06410561B1 Amide derivatives and nociceptin antagonists 失效
标题翻译：酰胺衍生物和伤害感受肽拮抗剂
公开(公告)号：US06410561B1
公开(公告)日：2002-06-25
申请号：US09646781
申请日：2000-09-22
申请人： Hisashi Shinkai , Takao Ito , Hideki Yamada
发明人： Hisashi Shinkai , Takao Ito , Hideki Yamada
IPC分类号： A61K3147
CPC分类号： A61K31/4184 , A61K31/47 , A61K31/473 , A61K31/498 , C07C235/42 , C07D215/38 , C07D215/42 , C07D217/22 , C07D219/12 , C07D221/16 , C07D235/28 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to a compound of the formula [1′] wherein R2 is lower alkyl optionally substituted by hydroxy, amino and the like, ring B is phenyl, thienyl and the like, E is a single bond, —O—, —S— and the like, ring G is aryl, heterocyclic group and the like, R5 is halogen atom, hydroxy, lower alkyl optionally substituted by halogen atom etc., and the like, t is 0 or an integer of 1 to 5, when t is an integer of 2 to 5, each R5 may be the same or different, m is 0 or an integer of 1 to 8, and n is 0 or an integer of 1 to 4, and a nociceptin antagonist containing compound [1′] as an active ingredient. The compound [1′] shows, due to nociceptin antagonistic action, analgesic effect against sharp pain such as postoperative pain and the like. The present invention also relates to the use of certain amide derivative inclusive of compound [1′] as a nociceptin antagonist or analgesic.
摘要翻译：本发明涉及式[1']化合物，其中R 2为任选被羟基，氨基等取代的低级烷基，环B为苯基，噻吩基等，E为单键，-O-， - S-等，环G是芳基，杂环基等，R5是卤素原子，羟基，任选被卤素原子取代的低级烷基等，t是0或1〜5的整数，当 t为2〜5的整数，每个R 5可以相同或不同，m为0或1〜8的整数，n为0或1〜4的整数，含有化合物[1'的伤害杀伤肽拮抗剂 ]作为活性成分。化合物[1']表示，由于伤害感受器拮抗作用，对急性疼痛如手术后疼痛等的镇痛作用。本发明还涉及包含化合物[1']的某些酰胺衍生物作为伤害感受肽拮抗剂或止痛剂的用途。

2. 发明授权

US06903094B2 Amide derivatives and nociceptin antagonists 失效
标题翻译：酰胺衍生物和伤害感受肽拮抗剂
公开(公告)号：US06903094B2
公开(公告)日：2005-06-07
申请号：US10141866
申请日：2002-05-10
申请人： Hisashi Shinkai , Takao Ito , Hideki Yamada
发明人： Hisashi Shinkai , Takao Ito , Hideki Yamada
IPC分类号： A61K31/166 , A61K31/473 , A61P29/00 , C07C235/42 , C07D215/12 , C07D215/38 , C07D215/42 , C07D217/22 , C07D219/12 , C07D221/16 , C07D235/28 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , A61K31/535 , A61K31/4965 , A61K31/497 , A61K31/505 , A61K31/53
CPC分类号： A61K31/4184 , A61K31/47 , A61K31/473 , A61K31/498 , C07C235/42 , C07D215/38 , C07D215/42 , C07D217/22 , C07D219/12 , C07D221/16 , C07D235/28 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to a compound of the formula [1′] wherein R2 is lower alkyl optionally substituted by hydroxy, amino and the like, ring B is phenyl, thienyl and the like, E is a single bond, —O—, —S— and the like, ring G is aryl, heterocyclic group and the like, R5 is halogen atom, hydroxy, lower alkyl optionally substituted by halogen atom etc., and the like, t is 0 or an integer of 1 to 5, when t is an integer of 2 to 5, each R5 may be the same or different, m is 0 or an integer of 1 to 8, and n is 0 or an integer of 1 to 4, and a nociceptin antagonist containing compound [1′] as an active ingredient. The compound [1′] shows, due to nociceptin antagonistic action, analgesic effect against sharp pain such as postoperative pain and the like. The present invention also relates to the use of certain amide derivative inclusive of compound [1′] as a nociceptin antagonist or analgesic.
摘要翻译：本发明涉及式[1']化合物，其中R 2为任选被羟基，氨基等取代的低级烷基，环B为苯基，噻吩基等，E为单键，-O-，-S-等，环G为芳基，杂环基等，R 5为卤素原子，羟基，任选被卤素原子取代的低级烷基等， t为0或1〜5的整数，当t为2〜5的整数时，每个R 5可以相同或不同，m为0或整数1 至8，n为0或1〜4的整数，以及含有化合物[1']作为活性成分的伤害杀伤肽拮抗剂。化合物[1']表示，由于伤害感受器拮抗作用，对急性疼痛如手术后疼痛等的镇痛作用。本发明还涉及包含化合物[1']的某些酰胺衍生物作为伤害感受肽拮抗剂或止痛剂的用途。

3. 发明申请

US20060030565A1 Amide derivatives and nociceptin antagonists 审中-公开
标题翻译：酰胺衍生物和伤害感受肽拮抗剂
公开(公告)号：US20060030565A1
公开(公告)日：2006-02-09
申请号：US11145169
申请日：2005-06-06
申请人： Hisashi Shinkai , Takao Ito , Hideki Yamada
发明人： Hisashi Shinkai , Takao Ito , Hideki Yamada
IPC分类号： A61K31/473 , A61K31/498 , A61K31/47 , A61K31/4184
CPC分类号： A61K31/4184 , A61K31/47 , A61K31/473 , A61K31/498 , C07C235/42 , C07D215/38 , C07D215/42 , C07D217/22 , C07D219/12 , C07D221/16 , C07D235/28 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to a compound of the formula [1′] wherein R2 is lower alkyl optionally substituted by hydroxy, amino and the like, ring B is phenyl, thienyl and the like, E is a single bond, —O—, —S— and the like, ring G is aryl, heterocyclic group and the like, R5 is halogen atom, hydroxy, lower alkyl optionally substituted by halogen atom etc., and the like, t is 0 or an integer of 1 to 5, when t is an integer of 2 to 5, each R5 may be the same or different, m is 0 or an integer of 1 to 8, and n is 0 or an integer of 1 to 4, and a nociceptin antagonist containing compound [1′] as an active ingredient. The compound [1′] shows, due to nociceptin antagonistic action, analgesic effect against sharp pain such as postoperative pain and the like. The present invention also relates to the use of certain amide derivative inclusive of compound [1′] as a nociceptin antagonist or analgesic.
摘要翻译：本发明涉及式[1']化合物，其中R 2为任选被羟基，氨基等取代的低级烷基，环B为苯基，噻吩基等，E为单键，-O-，-S-等，环G为芳基，杂环基等，R 5为卤素原子，羟基，任选被卤素原子取代的低级烷基等， t为0或1〜5的整数，当t为2〜5的整数时，每个R 5可以相同或不同，m为0或整数1 至8，n为0或1〜4的整数，以及含有化合物[1']作为活性成分的伤害杀伤肽拮抗剂。化合物[1']表示，由于伤害感受器拮抗作用，对急性疼痛如手术后疼痛等的镇痛作用。本发明还涉及包含化合物[1']的某些酰胺衍生物作为伤害感受肽拮抗剂或止痛剂的用途。

4. 发明申请

US20110290125A1 SERVO PRESS APPARATUS DRIVEN BY MULTIPLE MOTORS 有权
标题翻译： SERVO压力机由多台电机驱动
公开(公告)号：US20110290125A1
公开(公告)日：2011-12-01
申请号：US13042752
申请日：2011-03-08
申请人： Takao Ito , Takashi Koshimizu , Hiroshi Nagase
发明人： Takao Ito , Takashi Koshimizu , Hiroshi Nagase
IPC分类号： B30B15/00
CPC分类号： B30B1/266
摘要： This invention is intended to provide a large-capacity servo press apparatus driven by multiple motors, the servo press apparatus enabling a drive at a high efficiency and with reduced torque pulsations in a simple structure. The disclosed servo press comprises a slide that is moved up and down by a plurality of crank structures (including eccentric rings and connecting rods), main gears that drive the crank structures, a plurality of drive gears interlinked with the main gears directly or indirectly, intermediate gears interlinked with the main gears directly or indirectly, and servo motor sets connected to drive shafts to drive the drive gears. In each of the servo motor sets, a plurality of servo motors are directly connected to each servo motor shaft.
摘要翻译：本发明旨在提供一种由多个电动机驱动的大容量伺服压力装置，该伺服压力装置能够以简单的结构实现高效率的驱动和减小的转矩脉动。所公开的伺服压力机包括由多个曲柄结构（包括偏心环和连杆）上升和下降的滑块，驱动曲柄结构的主齿轮，直接或间接地与主齿轮相互连接的多个驱动齿轮，直接或间接地与主齿轮相互连接的中间齿轮，以及连接到驱动轴以驱动驱动齿轮的伺服电动机组。在每个伺服电动机组中，多个伺服电动机直接连接到每个伺服电动机轴。

5. 发明授权

US07556297B2 Attachment structure of energy absorbing structure 失效
标题翻译：能量吸收结构的附件结构
公开(公告)号：US07556297B2
公开(公告)日：2009-07-07
申请号：US11878081
申请日：2007-07-20
申请人： Yoshikazu Ohno , Haruhiko Yamamoto , Takao Ito
发明人： Yoshikazu Ohno , Haruhiko Yamamoto , Takao Ito
IPC分类号： B60R19/18
CPC分类号： B60R19/18 , B60R2019/188
摘要： An attachment structure of an energy absorbing structure includes: a bumper reinforcement that includes an attachment surface, with insertion holes being formed in the attachment surface; an energy absorbing structure disposed in contact with the attachment surface; locking claws that are disposed on the energy absorbing structure and engage with the bumper reinforcement to lock the energy absorbing structure to the bumper reinforcement; and load receiving projections that are disposed on the energy absorbing structure and are inserted into the insertion holes, so that when a load in a direction along the attachment surface acts on the energy absorbing structure, the load receiving projections interfere with inner peripheral portions of the insertion holes and receive the load.
摘要翻译：能量吸收结构的安装结构包括：保险杠加强件，其包括附接表面，在所述附接表面中形成有插入孔; 设置成与所述附接表面接触的能量吸收结构; 锁定爪，其设置在能量吸收结构上并与保险杠加强件接合以将能量吸收结构锁定到保险杠加强件; 以及负载接收突起，其设置在能量吸收结构上并被插入到插入孔中，使得当沿着附着表面的方向上的负载作用在能量吸收结构上时，负载接收突起与内部的插入孔并接收负载。

6. 发明申请

US20080244490A1 Sequence-pair creating apparatus and sequence-pair creating method 失效
标题翻译：序列对创建设备和序列对创建方法
公开(公告)号：US20080244490A1
公开(公告)日：2008-10-02
申请号：US11730004
申请日：2007-03-29
申请人： Shigetoshi Nakatake , Masahiro Kawakita , Takao Ito
发明人： Shigetoshi Nakatake , Masahiro Kawakita , Takao Ito
IPC分类号： G06F17/50
CPC分类号： G06F17/5072 , G06F2217/08
摘要： A sequence-pair creating apparatus includes a block placement storing unit that stores information of size of a block bi in a block set B and information of block placement, creates a sequence-pair (P, M), serving as a pair of a sequence P and a sequence M of the block bi, and further includes a binary relation setting unit that sets, in accordance with the information of block placement and information of size, a binary relation serving as an order relation that indicates a relative configuration between the blocks of a block pair of two blocks and that is derived from a configuration constraint between the blocks extracted from the information of block placement and information of size or designated by an external input, and a total order relation setting unit that sets a series of ranks of the sequences P and M for all the blocks on the basis of the information of block placement and information of size so as to satisfy all binary relations set by the binary relation setting unit.
摘要翻译：序列对创建装置包括：块放置存储单元，其存储块组B中的块b i的大小的信息和块放置的信息，创建序列对（P，M），作为块b的序列P和序列M的一对，并且还包括二进制关系设置单元，其根据块放置的信息和大小的信息来设置，二元关系，用作指示两个块的块对的块之间的相对配置的相关配置，并且是从块放置的信息提取的块之间的配置约束导出的，以及由外部信息指定的大小的信息输入和总顺序关系设置单元，其基于块放置的信息和尺寸信息来设置所有块的序列P和M的一系列等级，以满足由二进制重新设置的所有二进制关系投影设定单位。

7. 发明申请

US20080036222A1 Automobile rear structure 有权
标题翻译：汽车后部结构
公开(公告)号：US20080036222A1
公开(公告)日：2008-02-14
申请号：US11882838
申请日：2007-08-06
申请人： Hiroaki Iwamoto , Takao Ito , Haruhiko Yamamoto , Ken Tsuruta
发明人： Hiroaki Iwamoto , Takao Ito , Haruhiko Yamamoto , Ken Tsuruta
IPC分类号： F01N7/20
CPC分类号： F01N13/082 , F01N13/20
摘要： The automobile rear structure includes a diffuser which is arranged on a vehicle-body rear side of a muffler and is configured to interfere with exhaust gas discharged from the muffler so as to make a portion of the exhaust gas flow downwardly, and a flow rectification plate which is arranged below the muffler and guides the downwardly flowing exhaust gas in the direction along an air flow flowing below the floor of the vehicle body to merge the exhaust gas into the air flow. The exhaust gas discharged downwardly from a space defined between a front end portion of the diffuser and a body portion of the muffler is guided in the direction inclined downwardly toward the rear side of the vehicle body and, thereafter, is guided in the direction along the air flow flowing below the floor of the vehicle body, and is merged into the air flow.
摘要翻译：汽车后部结构包括散气器，其设置在消声器的车身后侧，并且构成为干扰从消声器排出的排气，使排气的一部分向下流动，并且将整流板其布置在消声器下方并且沿着沿着车体底部下方的气流的方向引导向下流动的废气，以将排气合并到空气流中。从扩散器的前端部和消声器的主体部之间限定的空间向下方排出的废气沿着向车身后侧向下方倾斜的方向被引导，气流在车身底部流动，并被合并到空气流中。

8. 发明申请

US20060093134A1 Cellular phone and cellular phone manufacturing method 失效
标题翻译：蜂窝电话和手机制造方法
公开(公告)号：US20060093134A1
公开(公告)日：2006-05-04
申请号：US11260215
申请日：2005-10-28
申请人： Takao Ito
发明人： Takao Ito
IPC分类号： H04M1/00 , H04M9/00
CPC分类号： H04M1/0216 , H01R35/025
摘要： A cellular phone and a manufacturing method thereof capable of achieving attractive design as well as high operating efficiency in the assembly process. A cellular phone comprises a first housing, a second housing, a first circuit board, a second circuit board, a flexible cable to electrically connect the first and second circuit boards, and a hinge that rotates about a prescribed rotation axis. When the first and second housings are in their open positions resulting from the rotation of the hinge, one edge of the second housing is located vertically above one edge of the first housing. The hinge includes hinge semi-cylindrical portions that form a hollow part capable of accommodating the flexible cable. The first and second circuit boards are mounted on the first and second housings, respectively. The flexible cable is accommodated in the hollow part. One end of the flexible cable is threaded through an aperture formed at the one edge of the second housing. A protection cover is attached to the one edge of the second housing to cover over the aperture.
摘要翻译：一种蜂窝电话及其制造方法，其能够实现有吸引力的设计以及组装过程中的高操作效率。蜂窝电话包括第一壳体，第二壳体，第一电路板，第二电路板，用于电连接第一和第二电路板的柔性电缆以及围绕规定旋转轴线旋转的铰链。当第一和第二壳体处于由铰链旋转导致的打开位置时，第二壳体的一个边缘垂直地位于第一壳体的一个边缘上方。铰链包括铰链半圆柱形部分，其形成能够容纳柔性电缆的中空部分。第一和第二电路板分别安装在第一和第二壳体上。柔性电缆容纳在中空部分中。柔性电缆的一端穿过形成在第二壳体的一个边缘处的孔。保护盖附接到第二壳体的一个边缘以覆盖该孔。

9. 发明授权

US5582523A Connector inspecting apparatus 失效
标题翻译：连接器检查装置
公开(公告)号：US5582523A
公开(公告)日：1996-12-10
申请号：US398778
申请日：1995-03-06
申请人： Michimasa Noro , Takao Ito , Shigeo Sato
发明人： Michimasa Noro , Takao Ito , Shigeo Sato
IPC分类号： G01R31/04 , H01B13/012 , H01R13/64 , H01R43/26 , H01R13/62
CPC分类号： G01R31/04 , G01R31/045
摘要： A connector inspecting apparatus includes (i) a connector receiving portion for holding a connector which is to be inspected and which has a terminal and (ii) an inspecting portion which has a detecting piece corresponding to the terminal, and which is arranged for inspecting the connector by moving the connector receiving portion and the inspecting portion toward/away from each other. At least one of the connector receiving portion and the inspecting portion is rotatably attached to a base. The other of the receiving portion and the inspecting portion is so guided as to be moved toward/away from the first. When either of the receiving or inspecting portions is rotated, such a rotational movement is converted into a sliding movement of the other portion. Accordingly, by rotating one of the portions, the connector can be inspected. This not only reduces the space required for installing the connector inspecting apparatus, but also facilitates the inspecting operation.
摘要翻译：连接器检查装置包括：（i）用于保持待检查的连接器的连接器接收部分，并且具有端子;以及（ii）检测部，其具有与端子对应的检测片，并且被配置为检查通过将连接器接收部分和检查部分朝向/远离彼此移动来连接。连接器接收部分和检查部分中的至少一个可旋转地附接到基座。接收部分和检查部分中的另一个被引导为朝向/远离第一方向移动。当接收或检查部分中的任一个被旋转时，这种旋转运动被转换成另一部分的滑动运动。因此，通过旋转这些部分之一，可以检查连接器。这不仅减少了安装连接器检查装置所需的空间，而且也便于检查操作。

10. 发明授权

US4729352A Crankshaft supporting structure for multicylinder internal combustion engines 失效
标题翻译：多缸内燃机曲轴支撑结构
公开(公告)号：US4729352A
公开(公告)日：1988-03-08
申请号：US802696
申请日：1985-11-27
申请人： Koichi Fukuo , Takao Ito , Katsumi Ichida
发明人： Koichi Fukuo , Takao Ito , Katsumi Ichida
IPC分类号： F01B9/02 , F01M11/02 , F02B75/22 , F02F7/00 , F01M1/00
CPC分类号： F02F7/0053 , F01B9/02 , F01M11/02 , F02F7/0012 , F02B75/22 , F02F2200/06 , F05C2201/021 , F05C2201/0436
摘要： A crankshaft support structure for a multicylinder internal combustion engine employing a plurality of bearihng caps with pairs of vertical and horizontal surfaces fitting mating surfaces in the cylinder block for structurally mating the bearing caps to the cylinder block. A structural bridge extends across the bearing caps and is connected through the bearing caps to the block by one set of bolts and directly to the block by a second set of bolts. A second embodiment employs a third set of bolts connecting the bearing caps separately to the block. Arcuate baffle plates form the portion of the bridge between bearing caps to inhibit oil agitation and suppress noise.
摘要翻译：一种用于多缸内燃机的曲轴支撑结构，其采用具有垂直和水平表面对的多个比较帽来配合气缸体中的配合表面，用于将轴承盖结构地配合到气缸体。结构桥梁延伸穿过轴承盖，并通过一组螺栓通过轴承盖连接到块体，并通过第二组螺栓直接连接到块体。第二实施例采用将轴承盖分别连接到块的第三组螺栓。弧形挡板形成轴承盖之间桥梁的部分，以抑制油搅动并抑制噪音。

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