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1. 发明申请

US20090060791A1 MICROCHANNEL CHIP AND METHOD FOR MANUFACTURING SUCH CHIP 审中-公开
标题翻译： MICROCHANNEL芯片和制造这种芯片的方法
公开(公告)号：US20090060791A1
公开(公告)日：2009-03-05
申请号：US12279241
申请日：2007-02-09
申请人： Hisashi Hagiwara , Yoshinori Mishina , Toshiharu Shiraishi
发明人： Hisashi Hagiwara , Yoshinori Mishina , Toshiharu Shiraishi
IPC分类号： B01J19/00 , C12M1/34 , B05D1/32
CPC分类号： B29C66/004 , B01L3/502707 , B01L2200/027 , B01L2200/12 , B01L2300/0816 , B01L2300/0887 , B29C66/1122 , B29C66/1222 , B29C66/1224 , B29C66/433 , B29C66/53461 , B29C66/71 , B29C66/723 , B29C66/72326 , B29C66/7234 , B29L2031/756 , G01N27/44791 , B29K2081/06 , B29K2079/08 , B29K2077/00 , B29K2071/00 , B29K2069/00 , B29K2067/046 , B29K2067/003 , B29K2067/00 , B29K2033/12 , B29K2033/08 , B29K2029/04 , B29K2027/12 , B29K2027/08 , B29K2025/06 , B29K2023/22 , B29K2023/18 , B29K2023/16 , B29K2023/12 , B29K2023/086 , B29K2023/06 , B29K2023/00 , B29K2021/003 , B29K2021/00 , B29K2011/00 , B29K2009/06 , B29K2007/00 , B29K2001/14 , B29K2001/12 , B29K2001/00
摘要： The present invention provides a microchannel chip having microchannels fabricated without using an original such as a mold. The microchannel chip of the present invention comprises at least an upper substrate and a lower substrate, the upper substrate and the lower substrate being bonded together, characterized in that at least one non-bonding thin-film layer is formed on the bonding side of at least one substrate and that opposite ends of the non-bonding thin-film layer are each connected to a port open to the atmosphere. When a positive pressure is applied through one port, the area that corresponds to the non-bonding thin-film layer inflates to create a gap that can function as a microchannel, with the result that a liquid and/or a gas can be transferred from one port to the other.
摘要翻译：本发明提供一种微通道芯片，其具有在不使用诸如模具的原件的情况下制造的微通道。本发明的微通道芯片至少包括上基板和下基板，上基板和下基板接合在一起，其特征在于，在接合侧的至少一个非接合薄膜层上形成至少一个非接合薄膜层至少一个衬底，并且非粘合薄膜层的相对端分别连接到对大气开放的端口。当通过一个端口施加正压力时，对应于非粘结薄膜层的区域膨胀以产生可用作微通道的间隙，结果是液体和/或气体可以从一个端口到另一个端口。

2. 发明申请

US20090202391A1 MICRO PASSAGE CHIP AND FLUID TRANSFERRING METHOD 有权
标题翻译：微通道芯片和流体传输方法
公开(公告)号：US20090202391A1
公开(公告)日：2009-08-13
申请号：US12307403
申请日：2007-07-04
申请人： Hisashi Hagiwara , Yoshinori Mishina
发明人： Hisashi Hagiwara , Yoshinori Mishina
IPC分类号： B01J19/00 , F17D3/00
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00837 , B01J2219/0086 , B01J2219/00889 , B01J2219/00891 , B01L3/50273 , B01L2200/12 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2300/12 , B01L2400/0481 , B01L2400/0633 , B01L2400/0672 , F04B43/043 , Y10T137/0318 , Y10T137/0324 , Y10T137/0352 , Y10T137/0396 , Y10T137/1624 , Y10T428/24612
摘要： There is provided by the present invention a novel micro passage chip having such a structure that a fluid can be transferred without using a physical or mechanical squeezing means that is applied from above the substrate of the micro passage chip. The micro passage chip of the present invention comprises at least a first substrate, a second substrate, and an intermediate substrate interposed between the first substrate and the second substrate and is characterized in that a first non-adhesive thin-film layer is formed on at least one of the mating sides of the first substrate and the intermediate substrate and at least one port for fluids that is in contact with the first non-adhesive thin-film layer and which is open to the outer surface of the first substrate is provided in any position on the first non-adhesive thin-film layer, and that at least a portion of a second non-adhesive thin-film layer whose length is either the same as or different from that of the first non-adhesive thin-film layer is formed on at least one of the mating sides of the second substrate and the intermediate substrate such that it lies either above or under the first non-adhesive thin-film layer, with the intermediate substrate lying in between, and a pressurizing port that is in contact with the second non-adhesive thin-film layer and which is open to the outer surface of the first or the second substrate is provided in at least one area on the second non-adhesive thin-film layer.
摘要翻译：本发明提供了一种新颖的微通道芯片，具有这样一种结构，可以在不使用从微通道芯片的基板上方施加的物理或机械挤压装置的情况下传送流体。本发明的微通道芯片至少包括插入在第一基板和第二基板之间的第一基板，第二基板和中间基板，其特征在于，在第一基板，第二基板和第二基板之间形成第一非粘性薄膜层第一基板和中间基板的配合侧中的至少一个以及与第一非粘合薄膜层接触并且与第一基板的外表面开口的流体的至少一个端口设置在在第一非粘合薄膜层上的任何位置，以及长度与第一非粘性薄膜层的长度相同或不同的第二非粘性薄膜层的至少一部分形成在第二基板和中间基板的至少一个配合侧上，使得其位于第一非粘合薄膜层的上方或下方，中间基板位于其间，并且在第二非粘合薄膜层上的至少一个区域上设置与第二非粘合薄膜层接触且与第一或第二基板的外表面开口的加压口。

3. 发明申请

US20110120867A1 MICRO-CHANNEL CHIP FOR ELECTROPHORESIS AND METHOD FOR ELECTROPHORESIS 审中-公开
标题翻译：用于电泳的微通道芯片和电泳方法
公开(公告)号：US20110120867A1
公开(公告)日：2011-05-26
申请号：US12674481
申请日：2008-08-22
申请人： Yoshinori Mishina , Hisashi Hagiwara
发明人： Yoshinori Mishina , Hisashi Hagiwara
IPC分类号： B01D57/02
CPC分类号： G01N27/44791 , G01N27/44743
摘要： The micro-channel chip for electrophoresis of the present invention comprises a first substrate formed of a gas-permeable material and a second substrate formed of a gas-permeable or a gas-impermeable material, the first and the second substrate being glued together, the mating surface of either one of the first and second substrates having a sample-feeding channel having a port at both ends and an electrophoretic channel also having a port at both ends, the sample-feeding channel and the electrophoretic channel being allowed to communicate with each other via a narrower channel having a smaller cross-sectional area than those two channels. The micro-channel chip for electrophoresis of the present invention requires only one power source to perform electrophoresis and can use samples with minimum waste of their quantity.
摘要翻译：本发明的电泳用微通道芯片包括由透气性材料形成的第一基板和由透气性或气体不可渗透材料形成的第二基板，第一和第二基板被胶合在一起，第一基板和第二基板中的任一个的配合表面具有在两端具有端口的采样馈送通道和在两端具有端口的电泳通道，允许采样馈送通道和电泳通道与每个另一个通过具有比两个通道更小的横截面面积的较窄通道。本发明的电泳用微通道芯片仅需要一个电源来进行电泳，并且可以以最少的数量浪费使用样品。

4. 发明授权

US08147774B2 Micro passage chip and fluid transferring method 有权
标题翻译：微通道芯片和流体转移方法
公开(公告)号：US08147774B2
公开(公告)日：2012-04-03
申请号：US12307403
申请日：2007-07-04
申请人： Hisashi Hagiwara , Yoshinori Mishina
发明人： Hisashi Hagiwara , Yoshinori Mishina
IPC分类号： B01L3/00 , B32B3/00 , F16K17/40 , F16K3/00 , F17D1/00 , G01N33/00 , F17D1/16 , G01L27/00 , G01F19/00
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00837 , B01J2219/0086 , B01J2219/00889 , B01J2219/00891 , B01L3/50273 , B01L2200/12 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2300/12 , B01L2400/0481 , B01L2400/0633 , B01L2400/0672 , F04B43/043 , Y10T137/0318 , Y10T137/0324 , Y10T137/0352 , Y10T137/0396 , Y10T137/1624 , Y10T428/24612
摘要： There is provided by the present invention a novel micro passage chip having such a structure that a fluid can be transferred without using a physical or mechanical squeezing means that is applied from above the substrate of the micro passage chip. The micro passage chip of the present invention comprises at least a first substrate, a second substrate, and an intermediate substrate interposed between the first substrate and the second substrate and is characterized in that a first non-adhesive thin-film layer is formed on at least one of the mating sides of the first substrate and the intermediate substrate and at least one port for fluids that is in contact with the first non-adhesive thin-film layer and which is open to the outer surface of the first substrate is provided in any position on the first non-adhesive thin-film layer, and that at least a portion of a second non-adhesive thin-film layer whose length is either the same as or different from that of the first non-adhesive thin-film layer is formed on at least one of the mating sides of the second substrate and the intermediate substrate such that it lies either above or under the first non-adhesive thin-film layer, with the intermediate substrate lying in between, and a pressurizing port that is in contact with the second non-adhesive thin-film layer and which is open to the outer surface of the first or the second substrate is provided in at least one area on the second non-adhesive thin-film layer.
摘要翻译：本发明提供了一种新颖的微通道芯片，具有这样一种结构，可以在不使用从微通道芯片的基板上方施加的物理或机械挤压装置的情况下传送流体。本发明的微通道芯片至少包括插入在第一基板和第二基板之间的第一基板，第二基板和中间基板，其特征在于，在第一基板，第二基板和第二基板之间形成第一非粘性薄膜层第一基板和中间基板的配合侧中的至少一个以及与第一非粘合薄膜层接触并且与第一基板的外表面开口的流体的至少一个端口设置在在第一非粘合薄膜层上的任何位置，以及长度与第一非粘性薄膜层的长度相同或不同的第二非粘性薄膜层的至少一部分形成在第二基板和中间基板的至少一个配合侧上，使得其位于第一非粘合薄膜层的上方或下方，中间基板位于其间，并且在第二非粘合薄膜层上的至少一个区域上设置与第二非粘合薄膜层接触且与第一或第二基板的外表面开口的加压口。

5. 发明申请

US20080057274A1 MICRO-CHANNEL CHIP AND A PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：微通道芯片及其制造方法
公开(公告)号：US20080057274A1
公开(公告)日：2008-03-06
申请号：US11751763
申请日：2007-05-22
申请人： Hisashi Hagiwara , Yoshinori Mishina
发明人： Hisashi Hagiwara , Yoshinori Mishina
IPC分类号： B32B3/00 , B05D5/12 , C23F1/00
CPC分类号： B01L3/502738 , B01L2200/10 , B01L2200/12 , B01L2300/0816 , B01L2300/087 , B01L2400/0487 , B01L2400/0638 , F16K99/0001 , Y10T428/24612
摘要： A micro-channel chip comprising at least an upper substrate, a lower substrate, and an intermediate substrate interposed between the upper substrate and the lower substrate, at least one non-adhesive thin-film layer for a micro-channel being linearly formed on one mating side which is selected from among the mating sides of the upper substrate and the intermediate substrate and the mating sides of the lower substrate and the intermediate substrate, at least two ports being provided on the non-adhesive thin-film layer for a micro-channel, at least one non-adhesive thin-film layer for a shutter channel being linearly formed on the mating side opposite the mating side on which the non-adhesive thin-film layer for a micro-channel is formed such that it intersects the non-adhesive thin-film layer for a micro-channel by passing beneath or over the latter, with the intermediate substrate lying in between, and a pressure supply port for inflating that part of the substrate which corresponds to the non-adhesive thin-film layer for a shutter channel being provided in at least one area on the non-adhesive thin-film layer for a shutter channel.
摘要翻译：一种微通道芯片，其至少包括上基板，下基板和介于上基板和下基板之间的中间基板，至少一个用于微通道的非粘性薄膜层线形地形成在一个从上基板和中间基板的配合侧和下基板和中间基板的配合侧中选择的配合侧，至少两个端口设置在非粘合薄膜层上，至少一个用于快门通道的非粘性薄膜层线性地形成在与配合侧相对的配合侧上，在该配合侧上形成用于微通道的非粘性薄膜层，通过使后者的下方或上方通过中间基板位于其间的用于微通道的粘合薄膜层和用于使基板的对应于用于快门通道的非粘性薄膜层设置在用于快门通道的非粘性薄膜层上的至少一个区域中。

6. 发明授权

US08741231B2 Flow passage control mechanism for microchip 有权
公开(公告)号：US08741231B2
公开(公告)日：2014-06-03
申请号：US14082356
申请日：2013-11-18
申请人： Minoru Asogawa , Hisashi Hagiwara , Tohru Hiramatsu
发明人： Minoru Asogawa , Hisashi Hagiwara , Tohru Hiramatsu
IPC分类号： G01N15/06
CPC分类号： B01L3/502738 , B01L3/50273 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , G01N35/1095 , G01N2035/00158 , G01N2035/1034 , Y10T137/8593 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A channel control mechanism for a microchip has a laminated structure formed of members including elastic members, and includes: a sample reservoir for packing a sample therein; a reaction reservoir in which mixture and reaction of the sample are performed; and a channel formed in a middle layer of the laminated structure, for bringing the sample reservoir and the reaction reservoir into communication with each other. The channel control mechanism performs the reaction and analysis in such a manner that the sample is delivered into the reaction reservoir through the channel. A shutter channel (pressurizing channel) is provided in a layer different from a layer in which the channel is formed so that the pressurizing channel partially overlaps the channel. The channel is closed through applying a pressurized medium to the shutter channel (pressurizing channel), and the channel is opened through releasing a pressure of the pressurized medium.

7. 发明申请

US20090318806A1 ULTRASONOGRAPH 有权
公开(公告)号：US20090318806A1
公开(公告)日：2009-12-24
申请号：US11915884
申请日：2006-05-25
申请人： Hiroshi Kanai , Hideyuki Hasegawa , Hisashi Hagiwara
发明人： Hiroshi Kanai , Hideyuki Hasegawa , Hisashi Hagiwara
IPC分类号： A61B8/14
CPC分类号： A61B8/0858 , A61B5/02007 , A61B5/7221 , A61B5/7239 , A61B8/463 , A61B8/485 , G01S7/52042 , G01S7/5205 , G01S7/52077
摘要： An ultrasonic diagnostic apparatus according to the present invention includes: a transmitting section that generates a drive signal to drive a probe in order to transmit an ultrasonic wave toward a subject to be deformed periodically under stress; a receiving section for receiving an echo, produced when the ultrasonic wave is reflected from the subject, at the probe to generate a received echo signal; a computing section for figuring out a thickness change waveform, representing a variation in distance between two arbitrary measuring points on the subject, based on the received echo signal; and a reference waveform generating section for outputting a reference waveform. The apparatus obtains subject's internal information by comparing the thickness change waveform and the reference waveform to each other.
摘要翻译：根据本发明的超声波诊断装置包括：发送部，其产生用于驱动探头的驱动信号，以便在应力下周期性地朝向被摄体发送超声波; 接收部，其在所述探头处接收在所述超声波从所述被检体反射时产生的回波，以产生接收到的回波信号; 计算部，用于根据所接收的回波信号求出厚度变化波形，表示被检体上两个任意的测量点之间的距离的变化; 以及用于输出参考波形的参考波形生成部。该装置通过将厚度变化波形和参考波形相互比较来获得被摄体的内部信息。

8. 发明授权

US07569016B2 Ultrasonic diagnostic apparatus 有权
标题翻译：超声波诊断仪
公开(公告)号：US07569016B2
公开(公告)日：2009-08-04
申请号：US10562550
申请日：2004-07-02
申请人： Yoshinobu Watanabe , Yoshinao Tannaka , Takao Suzuki , Hisashi Hagiwara
发明人： Yoshinobu Watanabe , Yoshinao Tannaka , Takao Suzuki , Hisashi Hagiwara
IPC分类号： A61B8/00
CPC分类号： A61B8/0858 , A61B5/02007 , A61B5/1075 , A61B8/463 , A61B8/543
摘要： There are provided transmission means (1) for transmitting an ultrasonic signal from a surface of a skin of a subject toward a blood vessel (21) of the subject, reception means (3) for receiving a reflected ultrasonic echo and converting the ultrasonic echo into an electric signal to obtain the ultrasonic echo signal in a depth direction from the surface of the skin, movement detection means (5) for analyzing a phase of the ultrasonic echo signal in a direction traversing the blood vessel to calculate a movement amount in each of a plurality of regions including a blood vessel wall and a vicinity of the blood vessel wall, analysis means (7) for analyzing a state of the blood vessel based on a variation in the calculated movement amount in each of the regions, boundary position detection means (8) for detecting a boundary position between the blood vessel wall and a blood flow region of the blood vessel based on a result of the analysis by the analysis means, and stability judgment means (15) for comparing the detected boundary position with a detection result in a previous cycle.
摘要翻译：提供了用于从受试者的皮肤表面向对象的血管（21）发送超声信号的发送装置（1），用于接收反射的超声回波并将超声回波转换成从皮肤表面获得深度方向的超声波回波信号的电信号，用于在穿过血管的方向上分析超声波回波信号的相位的运动检测装置（5），计算出每个包括血管壁和血管壁附近的多个区域，分析装置（7），用于基于每个区域中计算的移动量的变化来分析血管的状态，边界位置检测装置（8），用于基于分析装置的分析结果检测血管壁与血管的血流区域之间的边界位置，以及稳定性判断平均值 s（15），用于将检测到的边界位置与先前循环中的检测结果进行比较。

9. 发明申请

US20070213614A1 ULTRASONIC DIAGNOSTIC APPARATUS 审中-公开
标题翻译：超声诊断设备
公开(公告)号：US20070213614A1
公开(公告)日：2007-09-13
申请号：US11574140
申请日：2005-08-30
申请人： Takao Suzuki , Hisashi Hagiwara , Makoto Kato
发明人： Takao Suzuki , Hisashi Hagiwara , Makoto Kato
IPC分类号： A61B8/08
CPC分类号： A61B8/08 , A61B5/02007 , A61B8/0858 , A61B8/463 , A61B8/485 , G01S7/52026 , G01S7/52038 , G01S7/52042 , G01S7/52071 , G01S7/52074 , G01S7/52087 , G01S15/8954
摘要： An ultrasonic diagnostic apparatus according to the present invention includes: a transmitting section for driving an ultrasonic probe that transmits an ultrasonic wave toward a subject's tissue; a receiving section for receiving a reflected wave, produced by getting the ultrasonic wave reflected by the tissue of the organism, through the ultrasonic probe to generate a received signal; a plurality of filters for extracting multiple signal components, belonging to mutually different frequency bands, from the received signal; a plurality of phase detecting sections for detecting the respective phases of the multiple signal components; and a tissue tracking section for tracking the motion of the subject's tissue on the basis of the phases, thereby outputting tracking information.
摘要翻译：根据本发明的超声波诊断装置包括：发送部分，用于驱动向对象组织发送超声波的超声波探头; 接收部，其通过超声波探头接收由生物体的组织反射的超声波产生的反射波，生成接收信号; 多个滤波器，用于从接收信号中提取属于相互不同的频带的多个信号分量; 多个相位检测部分，用于检测多个信号分量的各个相位; 以及组织跟踪部分，用于基于相位跟踪对象组织的运动，从而输出跟踪信息。

10. 发明申请

US20070161900A1 Ultrasonic doppler blood flow measuring device 有权
标题翻译：超声多普勒血流测量装置
公开(公告)号：US20070161900A1
公开(公告)日：2007-07-12
申请号：US10572428
申请日：2004-10-15
申请人： Hisashi Hagiwara
发明人： Hisashi Hagiwara
IPC分类号： A61B8/00
CPC分类号： A61B8/06 , G01S15/8981
摘要： A technology for performing the filter processing of blood flow velocity data having aliasing by only common filter processing means and common addition and subtraction means and actualizing image display of smooth blood flow velocity is disclosed. According to this technology, when performing image display of the blood flow velocity of blood within a subject biological body using an ultrasonic wave Doppler method, the difference values of data D33 of an arbitrary focus point and data D32 and D34 of points spatially prior and subsequent to this focus point are calculated in the pre-processing unit (difference calculating unit) 41. Then, in the filtering unit 42, after filter processing is performed on these difference values, data D39 after filter processing and data D33 of the arbitrary focus point are added in the post-processing unit (addition processing unit) 43. In this way, a filter processing can be performed under the assumption that the velocity difference is smaller than the velocity difference generated by the aliasing phenomenon, and filter processing of the blood flow velocity value in the sound ray direction of the ultrasonic waves can be performed without being influenced by aliasing.
摘要翻译：公开了一种用于仅通过公共滤波处理装置和普通加法和减法装置执行具有混叠的血流速度数据的滤波处理并实现平滑血流速度的图像显示的技术。根据该技术，当使用超声波多普勒方法进行对象生物体内的血液的血流速度的图像显示时，任意焦点的数据D 33与空间上的点D 32和D 34的差值在预处理单元（差分计算单元）41中计算该焦点之前和之后。然后，在滤波部42中，对这些差分值进行滤波处理后，滤波处理后的数据D39和任意对焦点的数据D 33被添加到后处理部（相加处理部）43。以这种方式，可以在速度差小于由混叠现象产生的速度差的假设下进行滤波处理，并且可以执行超声波的声束射线方向上的血流速度值的滤波处理不受混叠的影响。

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