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1. 发明授权

US6156762A Indolomorphinan derivative and agent for curing and preventing cerebral disorder 失效
标题翻译：吲哚并吗啡喃衍生物和治疗和预防脑病的药剂
公开(公告)号：US6156762A
公开(公告)日：2000-12-05
申请号：US142794
申请日：1998-09-24
申请人： Hiroshi Nagase , Yoshifumi Imamura , Junichi Hirokawa , Susumu Matsuda , Yasushi Miyauchi
发明人： Hiroshi Nagase , Yoshifumi Imamura , Junichi Hirokawa , Susumu Matsuda , Yasushi Miyauchi
IPC分类号： C07D489/00 , C07D491/18 , C07D491/20 , A61K31/485 , C07D489/10
CPC分类号： C07D489/00
摘要： The present invention provides an indolomorphinan derivative or a pharmacologically acceptable acid addition salt thereof, and an agent for curing and preventing cerebral disorders composed of the derivative and salt thereof, which is represented by the following formula (I): ##STR1## [wherein R.sup.1 represents cyclopropylmethyl or the like; R.sup.2 and R.sup.3 each represent hydroxy methoxy, or the like; R.sup.4 represents hydrogen, methyl, benzyl, 3-isothiocyanatopropyl, or the like; and (R.sup.5).sub.m represents hydrogen, substituted benzo, or the like]. The compounds of the present invention have the excellent effect of preventing damage of the cerebral nerve cells. Therefore, the compounds of the present invention are useful as medicines used for curing and preventing various cerebral diseases such as cerebral stroke, traumatic cerebral diseases, cerebral edema, and cerebral neurodegenerative diseases, ameliorating aftereffects thereof, and preventing the recurrence thereof by inhibiting various ischemic, hemorrhagic or traumatic cerebral disorders, and damages of the cerebral nerve cells caused by various nerve degenerations.
摘要翻译： PCT No.PCT / JP98 / 00092 Sec。 371日期：1998年9月24日 102（e）1998年9月24日PCT PCT 1998年1月13日PCT公布。公开号WO98 / 31684 日期：1998年7月23日本发明提供吲哚并吗啡衍生物或其药理学上可接受的酸加成盐，以及由下式（I）表示的由其衍生物和盐组成的脑病的治疗和预防剂：其中R1表示环丙基甲基等; R2和R3各自表示羟基甲氧基等; R4代表氢，甲基，苄基，3-异硫氰基丙基等; 和（R 5）m表示氢，取代的苯并或类似物]。本发明的化合物具有防止脑神经细胞损伤的优异效果。因此，本发明的化合物可用作治疗和预防各种脑疾病如脑中风，创伤性脑病，脑水肿和脑神经变性疾病的药物，改善其后遗症，并通过抑制各种缺血性疾病预防其复发，出血性或创伤性脑病，以及由各种神经变性引起的脑神经细胞损伤。

2. 发明授权

US06172078B2 Quinolinomorphinane derivatives and medicinal use thereof 失效
标题翻译：喹啉吗啡烷衍生物及其医药用途
公开(公告)号：US06172078B2
公开(公告)日：2001-01-09
申请号：US09194538
申请日：1999-01-13
申请人： Hiroshi Nagase , Yoshifumi Imamura , Hiroshi Ohno , Masanobu Kaneeda , Susumu Matsuda , Yasushi Miyauchi
发明人： Hiroshi Nagase , Yoshifumi Imamura , Hiroshi Ohno , Masanobu Kaneeda , Susumu Matsuda , Yasushi Miyauchi
IPC分类号： C07D51500
CPC分类号： C07D489/00
摘要： The present invention provides a quinolinomorphinan derivative or a pharmacologically acceptable acid addition salt thereof, and an agent for curing or preventing cerebral disorders composed of the derivative and salt thereof, which is represented by the following formula (I): (wherein R1 represents cyclopropylmethyl or the like; R2 and R3 independently represent hydroxy, methoxy, or the like; R4 represents hydrogen, methyl, amino or the like; and (R5)m represents hydrogen, substituted benzo, or the like. The compounds of the present invention prevent damages of the cerebral nerve cells and are useful as medicine for curing or preventing various cerebral diseases such as cerebral stroke, traumatic cerebral diseases, cerebral edema, and cerebral neurodegenerative diseases. The compounds of the present invention also ameliorate the after-effects of these diseases and prevent the recurrence of these diseases by inhibiting various ischemic, hemorrhagic or traumatic cerebral disorders, and damages of the cerebral nerve cells caused by various nerve degenerations.
摘要翻译：本发明提供喹啉吗啡喃衍生物或其药理学上可接受的酸加成盐，以及由下式（I）表示的用于治疗或预防由其衍生物和盐组成的脑病的药剂:(其中R1表示环丙基甲基或 R 2和R 3独立地表示羟基，甲氧基等; R 4表示氢，甲基，氨基等;（R 5）m表示氢，取代的苯并或类似物，本发明化合物可以防止损害的脑神经细胞，可用作治疗或预防各种脑疾病如脑中风，创伤性脑疾病，脑水肿和脑神经变性疾病的药物，本发明的化合物还可以改善这些疾病的后遗症和通过抑制各种缺血性，出血性或创伤性脑病，预防这些疾病的复发，以及d 大脑神经细胞由各种神经变性引起的药物。

3. 发明授权

US6147084A Brain cell protective agent 失效
标题翻译：脑细胞保护剂
公开(公告)号：US6147084A
公开(公告)日：2000-11-14
申请号：US262791
申请日：1999-03-04
申请人： Hiroshi Nagase , Yoshifumi Imamura , Takashi Endo , Susumu Matsuda , Yasushi Miyauchi
发明人： Hiroshi Nagase , Yoshifumi Imamura , Takashi Endo , Susumu Matsuda , Yasushi Miyauchi
IPC分类号： A61K31/485 , C07D489/00 , C07D491/08
CPC分类号： A61K31/485 , C07D489/00
摘要： The present invention relates to a novel brain cell protective agent having for its active ingredient a morphinan derivative represented with Compound 1 ##STR1## or pharmacologically acceptable acid addition salt thereof. The compounds used in the present invention were found to have excellent defensive effects against brain nerve cell necrosis in both in vitro and in vivo pharmacological evaluations, and can be used as useful preventive and therapeutic agents of ischemic brain disorders, brain nerve cell disorders and dementia.
摘要翻译：本发明涉及一种新颖的脑细胞保护剂，其具有由化合物1表示的吗啡喃衍生物或其药理学上可接受的酸加成盐。发现本发明中使用的化合物在体外和体内药理学评价中对脑神经细胞坏死具有优异的防御作用，并且可以用作缺血性脑病，脑神经细胞病症和痴呆的有用的预防和治疗剂。

4. 发明授权

US5972953A Brain cell protective agent 失效
公开(公告)号：US5972953A
公开(公告)日：1999-10-26
申请号：US745041
申请日：1996-11-07
申请人： Hiroshi Nagase , Yoshifumi Imamura , Takashi Endo , Susumu Matsuda , Yasushi Miyauchi
发明人： Hiroshi Nagase , Yoshifumi Imamura , Takashi Endo , Susumu Matsuda , Yasushi Miyauchi
IPC分类号： A61K31/485 , C07D489/00
CPC分类号： A61K31/485 , C07D489/00
摘要： The present invention relates to a novel brain cell protective agent having for its active ingredient a morphinan derivative represented with Compound 1 ##STR1## or pharmacologically acceptable acid addition salt thereof. The compounds used in the present invention were found to have excellent defensive effects against brain nerve cell necrosis in both in vitro and in vivo pharmacological evaluations, and can be used as useful preventive and therapeutic agents of ischemic brain disorders, brain nerve cell disorders and dementia.

5. 发明授权

US07170840B2 Information recording method 有权
标题翻译：信息记录方式
公开(公告)号：US07170840B2
公开(公告)日：2007-01-30
申请号：US11171355
申请日：2005-07-01
申请人： Hidehiko Kando , Takeshi Maeda , Hiroyuki Minemura , Tsuyoshi Toda , Yasushi Miyauchi , Mitsuhide Miyamoto
发明人： Hidehiko Kando , Takeshi Maeda , Hiroyuki Minemura , Tsuyoshi Toda , Yasushi Miyauchi , Mitsuhide Miyamoto
IPC分类号： G11B5/76
CPC分类号： G11B7/1267 , G11B7/00456 , G11B7/0062 , G11B7/00736
摘要： An information recording method in which an energy beam is irradiated to a recording medium and a basic recording pattern is generated. The basic recording pattern has a first power level provides a first state and a second power level providing a second state. Based upon a period of a recording timing generating clock in a recording mode, and a relative velocity of the energy beam and the recording medium, there is formed a first sequence of the second state and the first state based upon parameters as a first small recording pattern, a second sequence which starts with the first state and ends with the first state as a second small recording pattern, a state in which the second small recording pattern follows said the small recording pattern as the basic recording pattern, and a state in which the basic recording patterns are repeated as a recording pattern.
摘要翻译：一种信号记录方法，其中能量束照射到记录介质上并产生基本记录图案。基本记录模式具有第一功率电平提供提供第二状态的第一状态和第二功率电平。基于记录模式下的记录定时产生时钟的周期和能量束和记录介质的相对速度，基于作为第一小记录的参数形成第二状态和第一状态的第一序列图案，以第一状态开始并以第一状态结束为第二小记录图案的第二序列，第二小记录图案跟随小记录图案作为基本记录图案的状态，以及其中作为记录图案重复基本记录图案。

6. 发明授权

US06954941B2 Information recording medium and information recording device 失效
标题翻译：信息记录介质和信息记录装置
公开(公告)号：US06954941B2
公开(公告)日：2005-10-11
申请号：US10653161
申请日：2003-09-03
申请人： Makoto Miyamoto , Junko Ushiyama , Keikichi Ando , Yumiko Anzai , Akemi Hirotsune , Motoyasu Terao , Tetsuya Nishida , Yasushi Miyauchi , Mitsuhide Miyamoto
发明人： Makoto Miyamoto , Junko Ushiyama , Keikichi Ando , Yumiko Anzai , Akemi Hirotsune , Motoyasu Terao , Tetsuya Nishida , Yasushi Miyauchi , Mitsuhide Miyamoto
IPC分类号： G11B7/007 , G11B7/24 , G11B7/24079 , G11B7/243 , G11B7/253 , G11B7/2534 , G11B7/257 , G11B7/2578 , G11B11/105 , G11B5/84
CPC分类号： G11B7/2578 , G11B7/007 , G11B7/00718 , G11B7/24 , G11B7/24079 , G11B7/252 , G11B7/2534 , G11B11/10584 , G11B11/10586 , G11B2007/24306 , G11B2007/24308 , G11B2007/2431 , G11B2007/24312 , G11B2007/24314 , G11B2007/24316 , G11B2007/25706 , G11B2007/25708 , G11B2007/2571 , G11B2007/25711 , G11B2007/25713 , G11B2007/25715 , G11B2007/25716 , G11B2007/25718
摘要： This invention relates to an information-recording medium that is used for recording information through radiation of energy beam. The information recording medium has a groove-shaped information recording track and is provided with a recording layer, one or more kinds of heat sink control layers and heat sink layers. A sum of film thickness of the more than one kind of recording layer is equal to or less than a step between information recording tracks, and a sum of film thickness of one or more kinds of heat sink control layers is more than a groove depth of the information recording track. With this configuration, no cross-erase is produced even if the information-recording medium is applied for a high density recording with the track pitch being 70% or less.
摘要翻译：本发明涉及一种用于通过能量束辐射记录信息的信息记录介质。信息记录介质具有凹槽状信息记录轨迹，并且设置有记录层，一种或多种散热器控制层和散热层。多于一种记录层的膜厚的总和等于或小于信息记录道之间的台阶，并且一种或多种散热器控制层的膜厚之和大于沟槽深度信息记录轨道。利用这种配置，即使将信息记录介质应用于轨道间距为70％或更小的高密度记录，也不产生交叉擦除。

7. 发明授权

US06650608B2 Information recording medium, information recording method and information recording apparatus 有权
公开(公告)号：US06650608B2
公开(公告)日：2003-11-18
申请号：US10293327
申请日：2002-11-14
申请人： Yasushi Miyauchi , Motoyasu Terao , Akemi Hirotsune , Hiroyuki Minemura , Harukazu Miyamoto
发明人： Yasushi Miyauchi , Motoyasu Terao , Akemi Hirotsune , Hiroyuki Minemura , Harukazu Miyamoto
IPC分类号： G11B700
CPC分类号： G11B7/126 , G11B7/00454 , G11B7/006 , G11B7/00745 , G11B7/013 , G11B7/24 , G11B20/1217 , G11B2020/10898 , G11B2020/1232 , G11B2020/1277 , G11B2020/1287 , G11B2020/1288 , G11B2020/1298 , G11B2220/216 , G11B2220/2537
摘要： A recording medium having a dummy signal area on at least one side of a recording area is used and information is recorded with a dummy signal added to at least one of the leading and trailing sides in the recorded information signal. The user data area remains unaffected by repeated overwriting so that recorded user data is reproduced correctly. In particular, the wave form distortion caused by fluidization of a recording film remains at the dummy signal area and does not affect the user data area, so that the reproduction of the target information (user data) is assured.

8. 发明授权

US06430134B1 Information recording method and apparatus 有权
标题翻译：信息记录方法和装置
公开(公告)号：US06430134B1
公开(公告)日：2002-08-06
申请号：US09949640
申请日：2001-09-12
申请人： Harukazu Miyamoto , Hiroyuki Minemura , Yasushi Miyauchi
发明人： Harukazu Miyamoto , Hiroyuki Minemura , Yasushi Miyauchi
IPC分类号： G11B700
CPC分类号： G11B20/1217 , G11B7/0045 , G11B7/00454 , G11B7/006 , G11B7/00718 , G11B7/00745 , G11B7/013 , G11B20/10009 , G11B20/12 , G11B2020/10898 , G11B2020/1285 , G11B2020/1287 , G11B2020/1288 , G11B2220/216 , G11B2220/2537
摘要： An information recording method for recording information on a rewritable recording medium including recording first synchronizing signal information in a first synchronizing signal portion on the rewritable recording medium, recording second synchronizing signal information in a second synchronizing signal portion following the first synchronizing signal portion on the rewritable recording medium, and recording data information in a data portion of the rewritable recording medium after the second synchronizing signal portion by forming marks in the data portion, wherein the data information corresponds to both ends of each of the record marks. A length of the first synchronizing signal portion changes and a start position of the first synchronizing signal portion changes, and a change of the start position of the first synchronizing signal portion is smaller than a change of the length of the first synchronizing signal portion.
摘要翻译：一种用于在可重写记录介质上记录信息的信息记录方法，包括在可重写记录介质上的第一同步信号部分中记录第一同步信号信息，在可重写的第一同步信号部分之后的第二同步信号部分中记录第二同步信号信息记录介质，并且通过在数据部分中形成标记，在第二同步信号部分之后的可重写记录介质的数据部分中记录数据信息，其中数据信息对应于每个记录标记的两端。第一同步信号部分的长度改变并且第一同步信号部分的开始位置改变，并且第一同步信号部分的开始位置的改变小于第一同步信号部分的长度的变化。

9. 发明授权

US06278680B1 Initial crystallization method of recording media and device thereof 有权
标题翻译：记录介质的初始结晶方法及其装置
公开(公告)号：US06278680B1
公开(公告)日：2001-08-21
申请号：US09275424
申请日：1999-03-24
申请人： Yasushi Miyauchi , Eiji Sahota , Shin Matsumoto , Kazuhiro Soga , Motoyasu Terao
发明人： Yasushi Miyauchi , Eiji Sahota , Shin Matsumoto , Kazuhiro Soga , Motoyasu Terao
IPC分类号： G11B712
CPC分类号： G11B7/268 , G11B7/00557 , G11B7/26
摘要： An initial crystallization method of a recording medium such as a phase-change optical disk, which comprises forming a light spot composed of at least two flat elliptical beam spots each having a long axis direction and a short axis direction and irradiating a rotating recording medium with the light spot such that the long axis direction of the beam spots becomes other direction than the parallel direction to the track direction of the recording medium, wherein the above-described light spot has at least two peaks of light intensity in the short axis direction and the interval of said two peaks of light intensity is 10 &mgr;m or smaller but not smaller than 2 &mgr;m, and a device for carrying out the initial crystallization method. By the initial crystallization method and the device thereof, the initial crystallization of the recording film of the recording medium can be surely carried out at a high speed without causing non-uniformity.
摘要翻译：一种诸如相变光盘的记录介质的初始结晶方法，包括形成由至少两个具有长轴方向和短轴方向的平坦椭圆形光束点组成的光斑，并且将旋转记录介质照射光斑使得光斑的长轴方向成为与记录介质的轨迹方向平行的方向以外的方向，其中上述光点在短轴方向上具有至少两个光强度的峰值，以及所述两个光强度峰值的间隔为10μm或更小但不小于2μm，以及用于进行初始结晶方法的装置。通过初始结晶方法及其装置，记录膜的初始结晶可以高速地可靠地进行记录介质，而不会引起不均匀。

10. 发明授权

US06232035B1 Information recording medium and information memory apparatus 失效
标题翻译：信息记录介质和信息存储装置
公开(公告)号：US06232035B1
公开(公告)日：2001-05-15
申请号：US09228943
申请日：1999-01-12
申请人： Akemi Hirotsune , Motoyasu Terao , Yasushi Miyauchi
发明人： Akemi Hirotsune , Motoyasu Terao , Yasushi Miyauchi
IPC分类号： G11B1100
CPC分类号： G11B7/243 , G11B7/24 , G11B7/2531 , G11B7/2534 , G11B7/258 , G11B2007/24306 , G11B2007/24312 , G11B2007/24314 , G11B2007/24316 , Y10S430/146
摘要： An information storage medium includes a substrate, a thin film formed on the substrate and having a reflectance changed by a phase change caused by irradiation of an energy beam irradiated via the substrate and a first reflective layer and a second reflective layer on the film directly or via an intermediate layer. The thin film includes one of In3SbTe2, In35Sb32Te33, In31Sb26Te43 and Ag—In—Sb—Te. The first reflective layer and the second reflective layer are piled up in the recited order from a thin film side with the first reflective layer consisting of a material having an attenuation factor k of 2 or less and selected from a group of silicon based materials and the second reflective layer consisting of a material having an attenuation factor k of at least 3.
摘要翻译：信息存储介质包括：基板，形成在基板上的薄膜，具有通过经由基板照射的能量束的照射引起的相位变化的反射率以及膜上的第一反射层和第二反射层直接或经由中间层。薄膜包括In3SbTe2，In35Sb32Te33，In31Sb26Te43和Ag-In-Sb-Te之一。第一反射层和第二反射层从薄膜一侧按顺序堆积，第一反射层由衰减因子k为2以下的材料组成，并选自硅基材料和第二反射层由衰减系数k至少为3的材料构成。

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