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    • 2. 发明授权
    • Antibacterial substance BE-24566B
    • 抗菌物质BE-24566B
    • US5334613A
    • 1994-08-02
    • US974460
    • 1992-11-12
    • Katsuhisa KojiriShigeru NakajimaAisaku FuseHiroyuki Suda
    • Katsuhisa KojiriShigeru NakajimaAisaku FuseHiroyuki Suda
    • C07D493/08C12P17/18A01N43/32C07D319/08
    • C07D493/08C12P17/181C12R1/465
    • Herein disclosed are an antibacterial substance: BE-24566B represented by the following structural formula (I): ##STR1## or a pharmaceutically acceptable salt thereof; and an antibacterial agent comprising, as an essential component, the foregoing antibacterial substance: BE-24566B or a pharmaceutically acceptable salt thereof. The antibacterial substance BE-24566B or pharmaceutically acceptable salts thereof can be prepared according to a method comprising the steps of inoculating an antibacterial substance: BE-24566B-producing microorganism or a variant thereof into a culture medium to cultivate the microorganism or variant, in particular the strain FERM BP-3994 or a variant thereof, and isolating the intracellularly and/or extracellularly produced antibacterial substance. The substance BE-24566B exhibits potent antibacterial effect on gram-positive bacteria represented by methicillin-resistant Staphylococcus aureus and, therefore, very useful as a therapeutic agent for treating a variety of infectious diseases caused by gram-positive bacteria.
    • 本文公开的是抗菌物质:由以下结构式(I)表示的BE-24566B:其中R 1,R 2, 以及作为必要成分的上述抗菌物质BE-24566B或其药学上可接受的盐的抗菌剂。 抗菌物质BE-24566B或其药学上可接受的盐可以根据包括以下步骤的方法制备:将抗菌物质:BE-24566B生产微生物或其变体接种到培养基中以培养微生物或变体,特别是 菌株FERM BP-3994或其变体,并分离细胞内和/或细胞外产生的抗菌物质。 物质BE-24566B对由耐甲氧西林金黄色葡萄球菌代表的革兰氏阳性细菌表现出强烈的抗菌作用,因此作为用于治疗由革兰氏阳性细菌引起的各种感染性疾病的治疗剂非常有用。
    • 4. 发明授权
    • Oxidation method providing parallel gas flow over substrates in a semiconductor process
    • 在半导体工艺中在衬底上提供平行气流的氧化方法
    • US08124181B2
    • 2012-02-28
    • US11907968
    • 2007-10-18
    • Kazuhide HasebeTakehiko FujitaShigeru NakajimaJun Ogawa
    • Kazuhide HasebeTakehiko FujitaShigeru NakajimaJun Ogawa
    • C23C16/40
    • H01L21/67109H01L21/02238H01L21/02255H01L21/31662
    • An oxidation method includes supplying oxidizing and deoxidizing gases to a process field by spouting the gases in lateral directions respectively from first and second groups of gas spouting holes. Each group of holes is disposed adjacent to target substrates on one side of the process field and arrayed over a length corresponding to the process field in a vertical direction. Gases are exhausted through an exhaust port disposed opposite to the first and second groups of gas spouting holes with the process field interposed therebetween and present over a length corresponding to the process field in the vertical direction. This causes the gases to flow along the surfaces of the target substrates, thus forming gas flows parallel with the target substrates. The process field is heated by a heater disposed around the process container to generate oxygen radicals and hydroxyl group radicals within the process field.
    • 氧化方法包括通过分别从第一和第二组气体喷射孔喷射气体在横向方向向工艺场提供氧化和脱氧气体。 每组孔与过程场一侧的目标衬底相邻设置,并且在垂直方向上排列在对应于过程场的长度上。 气体通过与第一和第二组气体喷射孔相对设置的排气口排出,其中过程场介于它们之间并且在垂直方向上存在超过对应于过程场的长度。 这使得气体沿着目标基板的表面流动,从而形成与目标基板平行的气体流。 工艺场由设置在加工容器周围的加热器加热,以在工艺场内产生氧自由基和羟基自由基。
    • 6. 发明申请
    • Valve Timing Control Apparatus
    • 气门正时控制装置
    • US20080163838A1
    • 2008-07-10
    • US11885761
    • 2006-02-10
    • Taiyu IwataKenji FujiwakiShigeru Nakajima
    • Taiyu IwataKenji FujiwakiShigeru Nakajima
    • F01L1/344
    • F01L1/022F01L1/3442F01L2001/34436F01L2001/34473F01L2001/34483
    • A valve timing control apparatus is provided having a locking mechanism that can minimize the accumulation of foreign material in a concave engagement part, can minimize the penetration of foreign material to the sliding parts of a locking member, and can reduce the sliding resistance of the locking member. A locking mechanism (5) is provided with a sliding groove (52) provided to an outer rotor (2); a locking member (53) capable of sliding along the sliding groove (52); and a concave engagement part (51) that is provided to the inner rotor (3), is formed to be capable of engaging with the locking member (53) in a state in which the phase of relative rotation is a lock phase, and has an inlet port (58) capable of introducing hydraulic fluid. Flow channels (57) for hydraulic fluid are provided to at least one of the sliding groove (52) and the locking member (53), are formed along the sliding direction of the locking member (53), and are communicatingly connected to the concave engagement part (51).
    • 一种气门正时控制装置,其具有锁定机构,该锁定机构可使外部材料在凹形接合部分中的积聚最小化,能够最大限度地减少外部材料对锁定构件的滑动部分的渗透,并且可以降低锁定的滑动阻力 会员。 锁定机构(5)设置有设置在外转子(2)上的滑动槽(52); 能够沿着滑动槽(52)滑动的锁定构件(53)。 以及设置在所述内转子(3)上的凹形卡合部(51),能够以相对旋转相位为锁定相的状态与所述卡定部件(53)卡合, 能够引入液压流体的入口(58)。 用于液压流体的流动通道(57)设置在滑动槽(52)和锁定构件(53)中的至少一个上,沿着锁定构件(53)的滑动方向形成,并且连通地连接到凹部 接合部(51)。
    • 8. 发明申请
    • Valve opening-closing timing control device
    • 阀门开闭正时控制装置
    • US20050087713A1
    • 2005-04-28
    • US10927393
    • 2004-08-27
    • Yoshiyuki KawaiMasaki KobayashiShigeru Nakajima
    • Yoshiyuki KawaiMasaki KobayashiShigeru Nakajima
    • F01L1/34F01L1/344F16K35/00
    • F01L1/3442F01L1/022F01L2001/34453F01L2001/34483
    • A valve opening-closing timing control device includes a housing member rotating together with one of a cam shaft and a crank shaft of a combustion engine, a rotor member rotatably attached to said housing member; and rotating together with the other of said crank shaft and said cam shaft, a hydraulic pressure chamber formed between said housing member and said rotor member, the hydraulic pressure chamber being divided into an advance angle hydraulic chamber and a retard angle hydraulic chamber by a vane integrally provided with said rotor member, a lock mechanism including a lock member movably provided at the housing member and a receiving portion formed at said rotor member for receiving the lock member, whereby the lock mechanism restricts a relative rotation between the rotor member and the housing member by advancing the lock member into the receiving portion and allows the relative rotation between the rotor member and the housing member by retracting the lock member from the receiving portion, a hydraulic pressure circuit for supplying hydraulic fluid to said advance angle hydraulic chamber, said retard angle hydraulic chamber, and said lock mechanism, and a projecting portion formed at a bottom of said receiving portion and including a top end face smaller than a sectional area of said lock member.
    • 一种开阀正时控制装置,包括与内燃机的凸轮轴和曲轴中的一个一起旋转的壳体构件,可旋转地附接到所述壳体构件的转子构件; 并与所述曲轴和所述凸轮轴中的另一个一起旋转,形成在所述壳体构件和所述转子构件之间的液压室,所述液压室被叶片分为前进角液压室和延迟角液压室 与所述转子构件一体设置的锁定机构,包括可移动地设置在所述壳体构件上的锁定构件和形成在所述转子构件处的用于接收所述锁定构件的容纳部的锁定机构,由此所述锁定机构限制所述转子构件与所述壳体之间的相对旋转 构件,其通过使所述锁定构件进入所述接收部,并且通过使所述锁定构件从所述接收部收回而允许所述转子构件与所述壳体构件之间的相对旋转;液压回路,用于向所述提前角液压室供给液压流体,所述延迟 角度液压室和所述锁定机构,以及形成在其上的突出部分 所述接收部分的底部包括小于所述锁定构件的截面面积的顶端面。
    • 10. 发明授权
    • Switching valve
    • 切换阀
    • US5878782A
    • 1999-03-09
    • US703873
    • 1996-08-27
    • Shigeru Nakajima
    • Shigeru Nakajima
    • F01L1/34F01L1/344F16K11/07F16K31/06F15B13/044
    • F16K31/0613F01L1/3442F16K11/0716F01L2001/34426Y10T137/86622Y10T137/86702
    • A switching valve has a cylindrical housing including a bore, an inlet port, a first inlet-outlet port, and a second inlet-outlet port which open to the hollow. A valve member slidably disposed in the bore has a ringed groove around its periphery. The valve member can open or block a portion between the groove and the first inlet-outlet port and a portion between the groove and the second inlet-outlet port. The groove formed outside the valve member always communicates with the inlet port and can communicate with the first and second inlet-outlet ports. A single drain port is formed within the valve member so that the single drain port can communicate with the first and second inlet-outlet ports. The valve member is caused to slide by a solenoid.
    • 切换阀具有圆柱形壳体,该圆柱形壳体包括孔,入口,第一入口 - 出口和向中空开口的第二入口 - 出口。 可滑动地设置在孔中的阀构件具有围绕其周边的环形槽。 阀构件可以打开或阻挡凹槽和第一入口 - 出口之间的部分以及凹槽和第二入口 - 出口之间的部分。 形成在阀构件外部的凹槽总是与入口连通并且可以与第一和第二入口 - 出口连通。 单个排出口形成在阀构件内,使得单个排出口能够与第一和第二入口 - 出口连通。 阀构件被螺线管滑动。