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1. 发明授权

US06248777B1 Remedies for peripheral circulation disturbances 失效
标题翻译：外周循环障碍的补救措施
公开(公告)号：US06248777B1
公开(公告)日：2001-06-19
申请号：US09380376
申请日：1999-09-01
申请人： Hiroshi Koga , Hisanori Takanashi , Eiji Kumagai
发明人： Hiroshi Koga , Hisanori Takanashi , Eiji Kumagai
IPC分类号： A61K3135
CPC分类号： C07D311/58
摘要： It is an object of the present invention to provide novel therapeutic agents for peripheral vascular disease. The present invention provides pharmaceutical compositions comprising a benzopyran or benzoxazine derivative of the general formula (1): wherein; R1 represents a hydrogen atom, a lower alkyl group or an aryl group, or R1 directly couples with Q or R11 to form a single bond; R2represents a substituted or unsubstituted amino group, a saturated or unsaturated heterocyclic group, A—O—or —C(═X)Y; Q represents ═N—, N+—O−or C(R11)R12; R3 and R4 each represent a hydrogen atom, a lower alkyl group or a substituted lower alkyl group having a halogen atom or a lower alkoxy group as a substituent or the like; and R5 and R6 each represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower haloalkyl group or the like; and a pharmaceutically acceptable carrier.
摘要翻译：本发明的目的是提供用于外周血管疾病的新治疗剂。本发明提供了包含通式（1）的苯并吡喃或苯并恶嗪衍生物的药物组合物：其中：R 1表示氢原子，低级烷基或芳基，或R 1与Q或R 11直接键合形成单键; R 2表示取代或未取代的氨基，饱和或不饱和杂环基，AO或-C（= X）Y; Q表示= N- ，N + -O-或C（R 11）R 12; R 3和R 4各自表示氢原子，低级烷基或具有卤素原子或低级烷氧基作为取代基的取代的低级烷基等; R 5和R 6各自表示氢原子，卤素原子，低级烷基，低级卤代烷基等; 和药学上可接受的载体。

2. 发明授权

US5658888A Erythromycin derivatives 失效
标题翻译：红霉素衍生物
公开(公告)号：US5658888A
公开(公告)日：1997-08-19
申请号：US318814
申请日：1994-10-19
申请人： Hiroshi Koga , Tsutomu Sato , Hisanori Takanashi
发明人： Hiroshi Koga , Tsutomu Sato , Hisanori Takanashi
IPC分类号： C07D407/00 , C07H17/08 , A61K31/00 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P1/00 , A61P1/12 , A61P43/00 , C07M17/08
CPC分类号： C07H17/08
摘要： Compounds represented by the general formula: ##STR1## wherein R.sub.1 is a hydrogen atom or an acyl group; R.sub.2 and R.sub.3 may be the same or different, and each represents a hydrogen atom, hydroxyl group, acyloxy group or amino group, or, in combination, they represent .dbd.O or .dbd.NOR.sub.10, where R.sub.10 represents a hydrogen atom or lower alkyl group;R.sub.4 represents a hydrogen atom or lower alkyl group; andY represents --NR.sub.5 R.sub.6 or --N.sup.+ R.sub.7 R.sub.8 R.sub.9 X.sup.-, where R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 may be the same or different, and each represents a hydrogen atom or an unsubstituted or substituted lower alkyl group, lower alkenyl group, lower alkinyl group, cycloalkyl group or 3-7-membered heterocyclic group comprising an oxygen atom, nitrogen atom or sulphur atom as an heteroatom, and X represents an anion, where R.sub.5 and R.sub.6, or R.sub.7 and R.sub.8 may form an azacycloalkyl group together with the neighboring nitrogen atom, respectively, and salts thereof.These compounds and their salts are subject to a remarkably lower degree of decomposition by gastric acid than are the publicly known erythromycin derivatives of the prior art, and have an excellent enterolinesis stimulating action.
摘要翻译： PCT No.PCT / JP93 / 00702 Sec。 371日期：1994年10月19日 102（e）日期1994年10月19日PCT提交1993年5月26日PCT公布。出版物WO93 / 24509 日期1993年12月9日化合物由通式表示的化合物：酰基; R2和R3可以相同或不同，各自表示氢原子，羟基，酰氧基或氨基，或者组合表示= O或= NOR10，其中R10表示氢原子或低级烷基; R4代表氢原子或低级烷基; 并且Y表示-NR5R6或-N + R7R8R9X-，其中R5，R6，R7，R8和R9可以相同或不同，并且各自表示氢原子或未取代或取代的低级烷基，低级烯基，低级炔基基团，环烷基或包含氧原子，氮原子或硫原子作为杂原子的3-7元杂环基，X表示阴离子，其中R 5和R 6或R 7和R 8可以与相邻的基团一起形成氮杂环烷基氮原子及其盐。与现有技术中公知的红霉素衍生物相比，这些化合物及其盐受胃酸分解程度明显降低，具有优异的肠溶激素作用。

3. 发明授权

US08522026B2 Automatic authentication method and system in print process 有权
公开(公告)号：US08522026B2
公开(公告)日：2013-08-27
申请号：US11842931
申请日：2007-08-21
申请人： Hiroshi Koga
发明人： Hiroshi Koga
IPC分类号： G06F21/00
CPC分类号： G06F21/608
摘要： This invention provides an automatic authentication method and system in a print process, which can obviate the need for user's input operations of the user ID and password and can improve security since authentication is automatically done based on print information embedded in a file or information from an application program without any user's input.In a print process that requires user authentication, a printer driver extracts information related to an application and/or a document for the print process as attribute information, and user authentication is made by comparing the attribute information with information stored in a user registration information database of a server. If user authentication has succeeded, the printer driver controls a printer to print, and the server manages and stores accounting information and the like for respective departments in a department management information database.

4. 发明授权

US08035841B2 Print control apparatus and method, and print system 有权
公开(公告)号：US08035841B2
公开(公告)日：2011-10-11
申请号：US12985243
申请日：2011-01-05
申请人： Yasuhiro Kujirai , Hiroshi Koga , Shigeki Kuroda , Shinichi Yamamura , Kazunori Masaki
发明人： Yasuhiro Kujirai , Hiroshi Koga , Shigeki Kuroda , Shinichi Yamamura , Kazunori Masaki
IPC分类号： G06K15/00 , G06F3/00 , H04N1/32
CPC分类号： G06F3/1285 , G06F3/1222 , G06F3/1238 , G06F3/1262 , G06F21/608
摘要： In this invention, a combined job obtained by combining a plurality of jobs is authenticated as a single job. According to the arrangement of this invention, when print jobs are to be spooled, these jobs are transferred from a dispatcher to a spooler where the jobs are combined. Upon reception of a print instruction, the print job is read out from a spool file, transferred from a despooler to a graphic engine again, and transferred from the dispatcher to a printer driver. At this time, the printer driver issues an authentication request in printing to a job accounting client. Thus, only one authentication request suffices for one combined job.

5. 发明授权

US5977167A Benzopyran and benzoxazine derivatives 失效
标题翻译：苯并吡喃和苯并恶嗪衍生物
公开(公告)号：US5977167A
公开(公告)日：1999-11-02
申请号：US26127
申请日：1998-02-19
申请人： Hiroshi Koga , Haruhiko Sato , Takenori Ishizawa , Hiroyuki Nabata
发明人： Hiroshi Koga , Haruhiko Sato , Takenori Ishizawa , Hiroyuki Nabata
IPC分类号： C07D311/22 , C07D311/68 , C07D405/04 , C07D405/12 , C07D413/04 , C07D417/04 , A61K31/35
CPC分类号： C07D405/04 , C07D311/22 , C07D311/68 , C07D405/12 , C07D413/04 , C07D417/04
摘要： Novel benzopyran and benzoxazine derivatives represented by the general formula: wherein R.sub.1 and R.sub.2 represent a lower haloalkyl group, R.sub.3 represents a hydrogen atom, etc., R.sub.4 represents a heterocyclic group or A--O-- wherein A represents a cyclic structure, etc., R.sub.5 and R.sub.6 represent a lower haloalkyl, X represents .dbd.N--, N.fwdarw.O, etc, are disclosed. These compounds exhibit K.sup.+ channel opening activating and can be widely used as an anti-asthma drug, an anti-epilepsy drug, etc.
摘要翻译：新的苯并吡喃和苯并恶嗪衍生物由以下通式表示：其中R1和R2代表低级卤代烷基，R3代表氢原子等，R4代表杂环基或AO-，其中A代表环状结构等，R5和 R6表示低级卤代烷基，X表示= N-，N-→O等。这些化合物显示K +通道开启活化，可广泛用作抗哮喘药，抗癫痫药等。

6. 发明授权

US5878194A Method and device for outputting multicolor document 失效
标题翻译：用于输出多色文档的方法和装置
公开(公告)号：US5878194A
公开(公告)日：1999-03-02
申请号：US441668
申请日：1995-05-15
申请人： Hiroshi Koga
发明人： Hiroshi Koga
IPC分类号： B41J29/38 , B41J2/485 , B41J2/525 , G06K15/00 , G06T1/00 , H04N1/46
CPC分类号： G06K15/00 , G06K2215/004 , G06K2215/0065 , G06K2215/0094
摘要： There is provided a multicolor document output device including a designating circuit to designate an output position of a character; an output format setting circuit to set an output format of character information which is output to the designated position; a color setting circuit to set an output color of the character information which is output to the designated position; an input circuit to input document information to be output; and an output controller to control so as to output the document information on the basis of the set output format and the set output color. An area is designated by the number of lines and the number of columns of a character to be output. The output color can be easily matched with the input document data.
摘要翻译：提供了一种多色文档输出装置，其包括指定字符的输出位置的指定电路; 输出格式设置电路，用于设置输出到指定位置的字符信息的输出格式; 颜色设置电路，用于设置输出到指定位置的字符信息的输出颜色; 输入要输出的文档信息的输入电路; 以及输出控制器，用于根据设定的输出格式和设定的输出颜色来控制输出文档信息。区域由要输出的字符的行数和列数指定。输出颜色可以很容易地与输入的文档数据匹配。

7. 发明授权

US4732906A Dioxolobenzizoxazole derivatives 失效
标题翻译：二氧代苯并恶唑衍生物
公开(公告)号：US4732906A
公开(公告)日：1988-03-22
申请号：US840680
申请日：1986-03-18
申请人： Hiroshi Koga , Takashi Dan , Haruhiko Sato , Etsuro Onuma
发明人： Hiroshi Koga , Takashi Dan , Haruhiko Sato , Etsuro Onuma
IPC分类号： A61K31/357 , A61K31/42 , A61P7/10 , C07D261/00 , C07D317/00 , C07D498/04 , C07D261/20
CPC分类号： C07D498/04
摘要： Dioxolobenzisoxazole derivatives of the formula ##STR1## wherein R.sub.1 is a phenyl group which may be substituted with a halogen atom, a lower alkyl group having 1-3 carbon atoms or a lower haloalkyl group, or a thienyl group; R.sub.2 is a hydrogen atom or a lower alkyl group having 1-4 carbon atoms; and X and Y which may be the same or different represent a hydrogen atom or a halogen atom, as well as non-toxic salts thereof wherein R.sub.2 is a hydrogen atom, a process for preparing the same and a pharmaceutical composition containing the same are disclosed.The derivatives have diuretic and uricosuric activities and, therefore, are useful as a drug for treating hyperuricemia or hypertension.
摘要翻译：其中R 1是可以被卤素原子取代的苯基，具有1-3个碳原子的低级烷基或低级卤代烷基，或噻吩基的式Ⅱ的二氧代联苯并恶唑衍生物; R2是氢原子或具有1-4个碳原子的低级烷基; 和可以相同或不同的X和Y表示氢原子或卤素原子，以及其中R2是氢原子的无毒盐，其制备方法和含有它们的药物组合物。衍生物具有利尿和尿酸活性，因此可用作治疗高尿酸血症或高血压的药物。

8. 发明授权

US4398029A Quinoline carboxylic acid derivatives and process for the preparation 失效
标题翻译：喹啉羧酸衍生物及其制备方法
公开(公告)号：US4398029A
公开(公告)日：1983-08-09
申请号：US236168
申请日：1981-02-20
申请人： Tsutomu Irikura , Hiroshi Koga , Satoshi Murayama
发明人： Tsutomu Irikura , Hiroshi Koga , Satoshi Murayama
IPC分类号： C07D215/56 , C07D401/04 , A61K31/47 , A61K31/535 , C07D413/04
CPC分类号： C07D401/04 , C07D215/56
摘要： This invention relates to new compounds of value as antibacterial agent. More particularly, it relates to quinoline carboxylic acid derivatives, the hydrates and the salts thereof.
摘要翻译：本发明涉及作为抗菌剂的价值的新化合物。更具体地，涉及喹啉羧酸衍生物，水合物及其盐。

9. 发明授权

US08939631B2 Controlling device with an insulating portion 有权
标题翻译：具有绝缘部分的控制装置
公开(公告)号：US08939631B2
公开(公告)日：2015-01-27
申请号：US13390990
申请日：2010-08-25
申请人： Noriya Uchiumi , Hidefumi Harada , Hiroshi Koga
发明人： Noriya Uchiumi , Hidefumi Harada , Hiroshi Koga
IPC分类号： F21V7/04 , H05K9/00
CPC分类号： H05K9/0067
摘要： A control apparatus is provided with a substrate disposed inside a main case and on which light sources are mounted. A surface panel in which light-source display windows are formed at positions opposite the light sources, is also disposed in the main case. The outer rim of the surface of the surface panel facing the main case is affixed to the front-surface rim of the main case with an insulating part sandwiched therebetween.
摘要翻译：控制装置设置有设置在主壳体内部并且安装有光源的基板。在主壳体中也设置有在与光源相对的位置处形成光源显示窗的表面面板。表面板的面向主壳体的表面的外缘被固定到主壳体的前表面边缘，绝缘部分夹在其间。

10. 发明申请

US20090022904A1 METHOD FOR MODIFYING ORGANIC FIBER CORD 审中-公开
标题翻译：修改有机纤维丝的方法
公开(公告)号：US20090022904A1
公开(公告)日：2009-01-22
申请号：US11912399
申请日：2006-04-05
申请人： Toshihiro Yotsumoto , Hiroshi Koga
发明人： Toshihiro Yotsumoto , Hiroshi Koga
IPC分类号： B05D3/06
CPC分类号： D06M10/003 , C08J7/08 , C08J7/123 , D02G3/48 , D06M10/001 , D06M10/08 , D06M10/10 , D06M15/41 , D06M15/55 , D06M15/693 , D06M2200/50
摘要： A method for modifying an organic fiber cord according to the invention comprises the step (A) of dipping the organic fiber cord (10) into an adhesive, the step (B) of drying the dipped organic fiber cord and the step (C) of heat-treating the dried organic fiber cord to modify it, and is characterized in that the drying step (B) is conducted by irradiating microwaves to the dipped organic fiber cord and/or the heat-treating step (C) is conducted by irradiating far-infrared rays to the dried organic fiber cord.
摘要翻译：根据本发明的改性有机纤维帘线的方法包括将有机纤维帘线（10）浸入粘合剂中的步骤（A），将浸渍有机纤维帘线干燥的步骤（B）和步骤（C）对干燥的有机纤维帘线进行热处理以进行改性，其特征在于，通过向浸渍的有机纤维帘线照射微波进行干燥工序（B），和/或热处理工序（C） - 红外线到干燥的有机纤维帘线。

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