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1. 发明授权

US08815595B2 Substrate for forming a three-dimensional tissue construct and method of use 有权
标题翻译：用于形成三维组织结构的基材和使用方法
公开(公告)号：US08815595B2
公开(公告)日：2014-08-26
申请号：US12033324
申请日：2008-02-19
申请人： Hiroshi Iwanaga , Kentaro Shiratsuchi , Koji Nakazawa , Masatsugu Shimomura
发明人： Hiroshi Iwanaga , Kentaro Shiratsuchi , Koji Nakazawa , Masatsugu Shimomura
IPC分类号： C12M3/00
CPC分类号： C12N5/0068 , C12N5/0062 , C12N5/0671 , C12N5/0677 , C12N2533/30
摘要： The present invention provides a tissue construct-forming substrate for forming a three-dimensional tissue construct containing proliferating cells, the substrate including a porous film having through-holes, and the porous film having, on the surface of the film, a cell adhesive region capable of retaining cells and a cell non-adhesive region located at a peripheral region of the cell adhesive region, a tissue construct-forming kit comprising the above-mentioned tissue construct-forming substrate and a frame, and a method for forming the above-mentioned tissue construct.
摘要翻译：本发明提供了一种用于形成含有增殖细胞的三维组织构建体的组织构建体形成基底，所述基底包括具有通孔的多孔膜，并且所述多孔膜在所述膜的表面上具有细胞粘附区域能够保持细胞和位于细胞粘附区域的周边区域的细胞非粘合剂区域，包含上述组织构建体形成基材和框架的组织构建体形成试剂盒，以及形成上述组织构建体形成基板的方法，上述组织构建体。

2. 发明申请

US20070275156A1 Cell Growth Inhibiting Film, Medical Instrument and Digestive System Stent 审中-公开
标题翻译：细胞生长抑制膜，医疗器械和消化系统支架
公开(公告)号：US20070275156A1
公开(公告)日：2007-11-29
申请号：US10580648
申请日：2004-11-26
申请人： Masaru Tanaka , Masatsugu Shimomura , Yoshihide Toyokawa
发明人： Masaru Tanaka , Masatsugu Shimomura , Yoshihide Toyokawa
IPC分类号： A61L31/00 , A61L27/00
CPC分类号： A61L31/146
摘要： A cell growth inhibiting film including a resin and having a porous structure formed at least on its surface, a cell growth inhibiting method including causing the surface of a film including a resin and having a porous structure formed at least on its surface to contact cells to inhibit growth of the cells in the contact area, a medical instrument including a medical instrument substrate and a film including a resin and having a porous structure formed at least on its surface, in which the surface of the medical instrument substrate is entirely or partially covered with the film, and a digestive system stent including a stent substrate and a film including a resin and having a porous structure formed by through-holes with an average pore size of 0.1 to 20 μm and a coefficient of variation in pore size of 30% or less, in which the stent substrate is covered with the film. According to the present invention, a material exhibiting cell growth inhibitory effects without using a physiologically active substance and suitable for forming a medical instrument, and a digestive system stent which secures a digestive system tubular cavity in the body and allows a digestive fluid and digestive enzymes contained therein to pass through, but blocks cancer cells, can be provided.
摘要翻译：至少在其表面形成有具有多孔结构的树脂的细胞生长抑制膜，细胞生长抑制方法，包括使包含树脂的膜的表面至少在其表面形成的多孔结构的表面与细胞接触抑制接触区域中的细胞生长，包括医疗仪器基板的医疗器械和包括树脂的膜，并且至少在其表面上形成有多孔结构，其中医疗器械基板的表面完全或部分覆盖以及包括支架基板和包含树脂的薄膜的消化系统支架，并且具有通过平均孔径为0.1〜20μm的通孔形成的多孔结构，孔径的变异系数为30％或更少，其中支架基底被膜覆盖。根据本发明，不使用生理活性物质并且适于形成医疗器械的细胞生长抑制作用的材料，以及消化系统支架，其将消化系统管状空腔固定在体内并允许消化液和消化酶可以提供包含在其中的通道，但可以阻止癌细胞。

3. 发明申请

US20060183222A1 Method for culturing neurons, neuron culture substrate, neurons, neuron system, and method for manufacturing neuron system 审中-公开
标题翻译：培养神经元，神经元培养基质，神经元，神经元系统和神经元系统制造方法
公开(公告)号：US20060183222A1
公开(公告)日：2006-08-17
申请号：US11354874
申请日：2006-02-16
申请人： Kosuke Kuwabara , Akihiro Miyauchi , Masatsugu Shimomura , Masaru Tanaka , Hiroshi Yabu , Akinori Tsuruma
发明人： Kosuke Kuwabara , Akihiro Miyauchi , Masatsugu Shimomura , Masaru Tanaka , Hiroshi Yabu , Akinori Tsuruma
IPC分类号： C12N5/08 , C12M3/00
CPC分类号： C12N5/0619 , C12M25/00 , C12M35/00 , C12N2533/30
摘要： There is provided a method for controlling morphological growth of neurons by specifically controlling the surface configuration of a substrate. There is also provided a neuron culture substrate necessary for application of the method and neurons controlled in morphological growth. The method for culturing neurons include, providing a culture medium and neurons on a cell culture substrate 1 and culturing the neurons in corresponding culture conditions, wherein the culture surface of the cell culture substrate 1 has a plurality of protrusions 4, and the shape, interval or both is controlled to control morphological growth of the neurons.
摘要翻译：提供了通过特异性地控制基底的表面构型来控制神经元的形态生长的方法。还提供了应用该方法所需的神经元培养基质和形态生长控制的神经元。培养神经元的方法包括在细胞培养基质1上提供培养基和神经元，并在相应的培养条件下培养神经元，其中细胞培养基质1的培养表面具有多个突起4，形状间隔或者两者被控制以控制神经元的形态生长。

4. 发明申请

US20050109390A1 Photoelectric conversion device and solar cell comprising same 审中-公开
标题翻译：光电转换装置和包含该光电转换装置的太阳能电池
公开(公告)号：US20050109390A1
公开(公告)日：2005-05-26
申请号：US10927015
申请日：2004-08-27
申请人： Masatsugu Shimomura , Sachiko Matsushita , Nobuko Fukuda , Takashi Isoshima , Masahiko Hara
发明人： Masatsugu Shimomura , Sachiko Matsushita , Nobuko Fukuda , Takashi Isoshima , Masahiko Hara
IPC分类号： H01L31/04 , H01G9/20 , H01L31/00
CPC分类号： H01G9/2031 , H01G9/2059 , H01L51/0086 , Y02E10/542
摘要： Disclosed is a high-efficiency photoelectric conversion device which comprises a photonic crystal consisting essentially of a photoelectric conversion substance, and a light-emitting dye contained inside the photonic crystal, and in which the photonic crystal has a periodic structure that retards the light emission by the light-emitting dye.
摘要翻译：公开了一种高效光电转换装置，其包括基本上由光电转换物质组成的光子晶体和包含在光子晶体内部的发光染料，其中光子晶体具有通过以下方式延迟发光的周期性结构发光染料。

5. 发明授权

US07799378B2 Process for producing micropillar structure 有权
标题翻译：微柱结构生产工艺
公开(公告)号：US07799378B2
公开(公告)日：2010-09-21
申请号：US10536589
申请日：2003-11-27
申请人： Masaru Tanaka , Masatsugu Shimomura , Masafumi Takebayashi , Hiroshi Yabu
发明人： Masaru Tanaka , Masatsugu Shimomura , Masafumi Takebayashi , Hiroshi Yabu
IPC分类号： B05D5/00 , B05D7/24 , B05D3/10 , B05D3/12 , B29C41/12 , B29C41/36 , B29D28/00 , C12M3/00 , C08J9/00
CPC分类号： B01D69/06 , B29C59/022 , B29C59/026 , B29C2059/023 , B29K2105/0073 , B29L2007/008 , B29L2031/608 , B29L2031/755 , B29L2031/756
摘要： A solution having a polymer dissolved in a hydrophobic organic solvent is cast on a substrate, said organic solvent is evaporated in a moist atmosphere to condense moisture contained in an atmosphere prevailing on a surface of said cast solution into micro-droplets, said micro-droplets are dispersed on the surface of said cast solution or in said cast solution into a close-packed structure, said micro-droplets, condensed and dispersed on the surface of said cast solution or in said cast solution, are evaporated to obtain a porous honeycomb structure with said droplets used as casts, and said porous honeycomb structure is at least bisected by peeling in a thickness direction, thereby obtaining honeycomb structures wherein micro-pillars or anisotropic micro-pillars are regularly formed and arranged by said bisection on the peeled sections.
摘要翻译：将溶解在疏水性有机溶剂中的聚合物的溶液浇铸在基材上，将所述有机溶剂在潮湿气氛中蒸发以将包含在所述流延溶液表面上的气氛中的水分浓缩成微滴，所述微滴分散在所述流延溶液的表面或所述流延溶液中形成紧密堆积的结构，所述微滴在所述流延溶液或所述流延溶液的表面上被冷凝并分散，得到多孔蜂窝结构体其中所述小滴用作铸件，并且所述多孔蜂窝结构通过在厚度方向上的剥离至少被二等分，从而获得其中微柱或各向异性微柱规则地形成并且通过在剥离部分上的所述二等分布置的蜂窝结构。

6. 发明申请

US20100051871A1 FLUORESCENT FILM 审中-公开
标题翻译：荧光膜
公开(公告)号：US20100051871A1
公开(公告)日：2010-03-04
申请号：US12530782
申请日：2008-03-13
申请人： Mina Han , Masahiko Hara , Keiko Fukasawa , Masatsugu Shimomura
发明人： Mina Han , Masahiko Hara , Keiko Fukasawa , Masatsugu Shimomura
IPC分类号： C09K11/06 , C09K11/02
CPC分类号： C09K11/02 , C08K5/23 , C09B29/0003 , C09B29/12 , C09K11/06 , C09K2211/1007 , C09K2211/1014
摘要： Disclosed is a fluorescent film containing an azobenzene derivative represented by the general formula (I) below and a binder. (In the general formula (I), R1 represents a hydrogen atom or the like; Ar1 and Ar2 independently represent an optionally substituted arylene group or aromatic heterocyclic ring; X represents an alkylene group which may contain a heteroatom; X1 represents —NH— or the like; Y represents a hydrogen atom or the like; a represents an integer of 0-2; m and n independently represent an integer of 1-8, and when m and n are integers of not less than 2, a plurality of Ar1's and Ar2's may be the same as or different from each other.)
摘要翻译：公开了含有下述通式（I）表示的偶氮苯衍生物和粘合剂的荧光膜。（通式（I）中，R 1表示氢原子等; Ar 1和Ar 2分别表示可以具有取代基的亚芳基或芳香族杂环，X表示可以含有杂原子的亚烷基，X 1表示-NH-或 Y表示氢原子等; a表示0〜2的整数，m和n分别表示1-8的整数，当m和n为2以上的整数时，多个Ar 1的并且Ar2可以彼此相同或不同。）

7. 发明授权

US06855408B2 Composite metal material and method for manufacturing the same, etched metal material and method for manufacturing the same and electrolytic capacitor 失效
标题翻译：复合金属材料及其制造方法，蚀刻金属材料及其制造方法和电解电容器
公开(公告)号：US06855408B2
公开(公告)日：2005-02-15
申请号：US10351500
申请日：2003-01-27
申请人： Masatsugu Shimomura , Masaru Tanaka , Hiroshi Yabu , Masafumi Takebayashi , Ryuji Monden , Tamami Koyama , Yoshikazu Hosoda , Masashi Sakaguchi
发明人： Masatsugu Shimomura , Masaru Tanaka , Hiroshi Yabu , Masafumi Takebayashi , Ryuji Monden , Tamami Koyama , Yoshikazu Hosoda , Masashi Sakaguchi
IPC分类号： H01G9/04 , H01G9/055 , B32B3/26
CPC分类号： H01G9/055 , Y10T428/24157 , Y10T428/24165 , Y10T428/249953 , Y10T428/249967 , Y10T428/24997 , Y10T428/249977 , Y10T428/249979 , Y10T428/249986 , Y10T428/24999 , Y10T428/31678
摘要： A composite metallic material 1 according to the invention is used for, e.g., electrolytic capacitors, and includes a metallic material substrate 10 and a high polymer thin layer 11 having a fine pattern 12 formed on at least one surface of the substrate 10 by self-organization. This high polymer thin film 11 is formed by, for example, drying hydrophobic organic solvent solution of high polymer compound. By subjecting this composite metallic material 1 to etching processing, etching pits are formed uniformly with high density based on the fine pattern.
摘要翻译：根据本发明的复合金属材料1用于例如电解电容器，并且包括金属材料基板10和具有通过自对准形成在基板10的至少一个表面上的精细图案12的高聚合物薄层11，组织。该高分子薄膜11例如通过干燥高分子化合物的疏水性有机溶剂溶液而形成。通过使该复合金属材料1进行蚀刻处理，基于精细图案，以高密度均匀地形成蚀刻凹坑。

8. 发明授权

US5871915A Method for detecting nucleic acid polymer 失效
标题翻译：检测核酸聚合物的方法
公开(公告)号：US5871915A
公开(公告)日：1999-02-16
申请号：US595206
申请日：1996-02-01
申请人： Kunihara Ijiro , Masatsugu Shimomura
发明人： Kunihara Ijiro , Masatsugu Shimomura
IPC分类号： C12Q1/68 , G01N33/536 , G01N33/566 , G01N33/567
CPC分类号： B82Y30/00 , B82Y15/00 , C12Q1/68 , C12Q1/6825 , C12Q1/6834
摘要： The present invention has an object to provide an easy method for detecting a nucleic acid polymer in aqueous phase.The present invention provides a method for detecting the amount of nucleic acid polymer, which comprises the steps of modifying an intercalator to be amphiphilic by using a hydrophobic group, spreading the amphiphilic intercalator on an aqueous solution containing a nucleic acid polymer to form a monolayer of said nucleic acid polymer and said amphiphilic intercalator at the gas-water interface, and measuring surface pressures per unit area of said monolayer.
摘要翻译：本发明的目的是提供一种在水相中检测核酸聚合物的简单方法。本发明提供了一种用于检测核酸聚合物的量的方法，其包括以下步骤：通过使用疏水基团将嵌合剂修饰为两亲性的步骤，将两亲嵌入剂扩散到含有核酸聚合物的水溶液上以形成单层所述核酸聚合物和所述两亲嵌入剂在气 - 水界面处，并测量所述单层的每单位面积的表面压力。

9. 发明授权

US08685264B2 Slide member and method for the production thereof 有权
标题翻译：滑动构件及其制造方法
公开(公告)号：US08685264B2
公开(公告)日：2014-04-01
申请号：US13822138
申请日：2011-09-12
申请人： Masataka Kaido , Atsushi Suzuki , Masatsugu Shimomura , Hiroshi Yabu , Yuji Hirai
发明人： Masataka Kaido , Atsushi Suzuki , Masatsugu Shimomura , Hiroshi Yabu , Yuji Hirai
IPC分类号： B44C1/22 , C03C15/00 , C03C25/68 , C23F1/00
CPC分类号： F16C33/02 , F16C33/103 , F16C33/14 , F16C2220/60 , F16C2240/40 , F16C2240/44
摘要： A slide member includes a substrate that is made of a metal material and has a sliding surface with a plurality of microdimples formed therein. Each of the microdimple has a circular opening, the microdimples are arranged in regular intervals in a hexagonal close-packed configuration, and the area ratio of the openings of all the microdimples to the entire sliding surface is in the range of 50 to 80%.
摘要翻译：滑动构件包括由金属材料制成并且具有形成有多个微型微粒的滑动面的基板。每个微型微型物具有圆形开口，微型粉末以六边形紧密构造的规则间隔布置，并且所有微小的微孔的开口面积与整个滑动面的面积比在50％至80％的范围内。

10. 发明申请

US20130168351A1 SLIDE MEMBER AND METHOD FOR THE PRODUCTION THEREOF 有权
标题翻译：滑动构件及其制造方法
公开(公告)号：US20130168351A1
公开(公告)日：2013-07-04
申请号：US13822138
申请日：2011-09-12
申请人： Masataka Kaido , Atsushi Suzuki , Masatsugu Shimomura , Hiroshi Yabu , Yuji Hirai
发明人： Masataka Kaido , Atsushi Suzuki , Masatsugu Shimomura , Hiroshi Yabu , Yuji Hirai
IPC分类号： F16C33/02
CPC分类号： F16C33/02 , F16C33/103 , F16C33/14 , F16C2220/60 , F16C2240/40 , F16C2240/44
摘要： A slide member includes a substrate that is made of a metal material and has a sliding surface with a plurality of microdimples formed therein. Each of the microdimple has a circular opening, the microdimples are arranged in regular intervals in a hexagonal close-packed configuration, and the area ratio of the openings of all the microdimples to the entire sliding surface is in the range of 50 to 80%.
摘要翻译：滑动构件包括由金属材料制成并且具有形成有多个微型微粒的滑动面的基板。每个微型微型物具有圆形开口，微型粉末以六边形紧密构造的规则间隔布置，并且所有微小的微孔的开口面积与整个滑动面的面积比在50％至80％的范围内。

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