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1. 发明授权

US5587474A Method for removing the protecting group for carboxyl group 失效
标题翻译：去除羧基保护基的方法
公开(公告)号：US5587474A
公开(公告)日：1996-12-24
申请号：US77383
申请日：1993-06-17
申请人： Kazuhiko Kondo , Hiroshi Horikawa , Tameo Iwasaki
发明人： Kazuhiko Kondo , Hiroshi Horikawa , Tameo Iwasaki
IPC分类号： C07D463/00 , C07D477/08 , C07D499/88 , C07D501/00 , C07D503/00 , C07D505/00 , C07D403/12
CPC分类号： C07D501/00 , C07D463/06 , C07D477/08 , C07D499/88 , C07D503/00 , C07D505/00 , Y02P20/55
摘要： A method for removing substituted or unsubstituted allyl group from .beta.-lactam compound having substituted or unsubstituted allyl group-protecting carboxyl group, which comprises treating said .beta.-lactam compound with palladium catalyst in the presence of allyl-scavenger in aqueous organic solvent, by which the substituted or unsubstituted group can be easily and effectively removed under moderate conditions so that the desired compound can be obtained in high yield at low cost.
摘要翻译：一种从具有取代或未取代的烯丙基保护羧基的β-内酰胺化合物中除去取代或未取代的烯丙基的方法，该方法包括在含有机溶剂的烯丙基清除剂存在下用钯催化剂处理所述β-内酰胺化合物，取代或未取代的基团可以在中等条件下容易且有效地除去，从而可以低成本高收率地获得所需化合物。

2. 发明授权

US5414081A Process for preparing .beta.-lactam derivative and synthetic intermediate thereof 失效
标题翻译：制备β-内酰胺衍生物及其合成中间体的方法
公开(公告)号：US5414081A
公开(公告)日：1995-05-09
申请号：US18407
申请日：1993-02-17
申请人： Hiroshi Horikawa , Kazuhiko Kondo , Tameo Iwasaki
发明人： Hiroshi Horikawa , Kazuhiko Kondo , Tameo Iwasaki
IPC分类号： C07D463/00 , C07D477/00 , C07D477/02 , C07D477/04 , C07D499/06 , C07D499/88 , C07D499/893 , C07D499/897 , C07D501/16 , C07D501/18 , C07D503/04 , C07D505/00 , C07D513/04 , C07D515/04 , C07D487/04
CPC分类号： C07D513/04 , C07D477/02 , C07D477/04 , C07D515/04
摘要： Disclosed is a process for preparing a .beta.-lactam compound represented by the formula: ##STR1## wherein R.sup.1 represents a hydroxy-substituted lower alkyl group or an amino group each of which may be protected; R.sup.2 represents hydrogen atom or an ester residue; X represents a methylene group which may be substituted by a lower alkyl group, sulfur atom or a group represented by the formula: --A--CH.sub.2 -- where A represents sulfur atom, oxygen atom or methylene group; and W represents an active ester residue of hydroxyl group, or a salt thereof, which comprises the steps of treating a 1-aza-3-thia-bicycloalkane compound represented by the formula: ##STR2## wherein R.sup.1, R.sup.2 and X have the same meanings as defined above, or a salt thereof with a base in the presence of a desulfurizing agent and then reacting the resulting compound with an active esterifying agent of hydroxyl group.
摘要翻译：公开了一种制备由下式表示的β-内酰胺化合物的方法：低级烷基或各自可被保护的氨基; R2表示氢原子或酯残基; X表示可以被低级烷基，硫原子或由下式表示的基团取代的亚甲基：-A-CH2-，其中A表示硫原子，氧原子或亚甲基; W表示羟基的活性酯残基或其盐，其包括如下步骤：处理由下式表示的1-氮杂-3-硫杂 - 双环烷烃化合物：其中R1，R2和X 具有与上述相同的含义，或其盐与脱碱剂存在下的碱，然后使所得化合物与羟基的活性酯化剂反应。

3. 发明授权

US5359059A Process for preparing carbapenem derivatives 失效
标题翻译：碳青霉烯衍生物的制备方法
公开(公告)号：US5359059A
公开(公告)日：1994-10-25
申请号：US100460
申请日：1993-08-02
申请人： Tameo Iwasaki , Kazuhiko Kondo , Hiroshi Horikawa
发明人： Tameo Iwasaki , Kazuhiko Kondo , Hiroshi Horikawa
IPC分类号： C07D477/00 , C07D477/04 , C07D487/04 , C07D499/00
CPC分类号： C07D477/04
摘要： Process for preparing carbapenem derivative of the formula [I], which comprises subjecting azetidinone compound of the formula [II] to intramolecular cyclization reaction together with elimination reaction of the group of --SR.sup.4, followed by re-adding said group of --SR.sup.4 to the 2-position of the carbapenem skeleton of the intramolecularly cyclized compound, which is industrially useful as process for preparing carbapenem antimicrobials or synthetic intermediate therefor. ##STR1## wherein R.sup.1 is protected or unprotected hydroxy-substituted lower alkyl group, R.sup.2 is hydrogen atom or ester residue, R.sup.3 is hydrogen atom or lower alkyl group, and the group of --SR.sup.4 is group which can be used as substituent at 2-position of the carbapenem antimicrobials.
摘要翻译：制备式[I]的碳青霉烯衍生物的方法，其包括将式[II]的氮杂环丁酮化合物与-SR 4基团的消除反应一起分子内环化反应，然后将所述-SR 4基团重新加入到分子内环化化合物的碳青霉烯骨架的2-位，其在工业上可用作制备碳青霉烯类抗微生物剂或其合成中间体的方法。其中R 1为被保护或未被保护的羟基取代的低级烷基，R 2为氢原子或酯残基，R 3为氢原子或低级烷基，-SR 4为基团其可用作碳青霉烯类抗微生物剂的2-位上的取代基。

4. 发明授权

US5208348A Mercaptan compound 失效
标题翻译：硫醇化合物
公开(公告)号：US5208348A
公开(公告)日：1993-05-04
申请号：US913506
申请日：1992-07-14
申请人： Tameo Iwasaki , Kazuhiko Kondo , Hiroshi Horikawa , Totaro Yamaguchi , Tadahiro Matsushita
发明人： Tameo Iwasaki , Kazuhiko Kondo , Hiroshi Horikawa , Totaro Yamaguchi , Tadahiro Matsushita
IPC分类号： C07D477/20
CPC分类号： C07D477/20
摘要： A mercaptan compound of the formula ##STR1## wherein R.sup.3 is a hydrogen atom or a lower alkyl group, or a salt thereof.
摘要翻译：其中R3是氢原子或低级烷基的式“IMAGE”的硫醇化合物或其盐。

5. 发明授权

US5153187A 1-Methylcarbapenem derivatives and process for preparation thereof 失效
标题翻译： 1-甲基胆碱衍生物及其制备方法
公开(公告)号：US5153187A
公开(公告)日：1992-10-06
申请号：US755884
申请日：1991-09-06
申请人： Tameo Iwasaki , Kazuhiko Kondo , Hiroshi Horikawa , Totaro Yamaguchi , Tadahiro Matsushita
发明人： Tameo Iwasaki , Kazuhiko Kondo , Hiroshi Horikawa , Totaro Yamaguchi , Tadahiro Matsushita
IPC分类号： A61K31/40 , A61K31/397 , A61P31/04 , C07D207/24 , C07D477/00 , C07D477/20
CPC分类号： C07D477/20 , Y02P20/55
摘要： 1-Methylcarbapenem derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen atom or a hydroxy-protecting group, R.sup.2 is hydrogen atom or an ester residue, R.sup.3 is hydrogen atom or a lower alkyl group, or salts thereof, which have excellent antimicrobial activities and are useful as an antimicrobial drug.

6. 发明授权

US5260438A Method for removing the protecting group for hydroxy group 失效
标题翻译：去除羟基保护基的方法
公开(公告)号：US5260438A
公开(公告)日：1993-11-09
申请号：US52680
申请日：1993-04-27
申请人： Hiroshi Horikawa , Kazuhiko Kondo , Tameo Iwasaki
发明人： Hiroshi Horikawa , Kazuhiko Kondo , Tameo Iwasaki
IPC分类号： C07D205/08 , C07D463/00 , C07D477/02 , C07D499/88 , C07D501/00 , C07D503/00 , C07D505/00 , C07D487/00 , C07D487/04 , C07D487/08 , C07D499/00
CPC分类号： C07D503/00 , C07D205/08 , C07D463/06 , C07D477/02 , C07D499/88 , C07D501/00 , C07D505/00 , Y02P20/55
摘要： A method for removing tri-substituted silyl group from .beta.-lactam compound having a tri-substituted silyl group-protecting hydroxy group, which comprises treating with an acid and a fluoride selected from alkali metal fluoride, alkaline earth metal fluoride and hydrogenfluoride of organic or inorganic amine, by which the tri-substituted silyl group can be easily and effectively removed under moderate conditions so that the desired compound can be obtained in high yield at low cost.
摘要翻译：一种从具有三取代甲硅烷基保护羟基的β-内酰胺化合物中除去三取代甲硅烷基的方法，该方法包括用酸和选自碱金属氟化物，碱土金属氟化物和有机氟化氢的氟化物无机胺，通过其可以在中等条件下容易且有效地除去三取代甲硅烷基，从而可以低成本高收率地获得所需化合物。

7. 发明授权

US5589592A Process for preparing .beta.-lactam derivative and synthetic intermediate 失效
标题翻译：制备β-内酰胺衍生物和合成中间体的方法
公开(公告)号：US5589592A
公开(公告)日：1996-12-31
申请号：US393395
申请日：1995-04-07
申请人： Hiroshi Horikawa , Kazuhiko Kondo
发明人： Hiroshi Horikawa , Kazuhiko Kondo
IPC分类号： C07D463/00 , C07D477/00 , C07D477/02 , C07D477/04 , C07D499/06 , C07D499/88 , C07D499/893 , C07D499/897 , C07D501/16 , C07D501/18 , C07D503/04 , C07D505/00 , C07D513/04 , C07D515/04
CPC分类号： C07D513/04 , C07D477/02 , C07D477/04 , C07D515/04
摘要： Disclosed is a process for preparing a .beta.-lactam compound represented by the formula: ##STR1## wherein R.sup.1 represents a hydroxy-substituted lower alkyl group or an amino group each of which may be protected; R.sup.2 represents hydrogen atom or an ester residue; X represents a methylene group which may be substituted by a lower alkyl group, sulfur atom or a group represented by the formula: --A--CH.sub.2 -- where A represents sulfur atom, oxygen atom or methylene group; and W represents an active ester residue of hydroxyl group,or a salt thereof, which comprises the steps of treating a 1-aza-3-thia-bicycloalkane compound represented by the formula: ##STR2## wherein R.sup.1, R.sup.2 and X have the same meanings as defined above, or a salt thereof with a base in the presence of a desulfurizing agent and then reacting the resulting compound with an active esterifying agent of hydroxyl group.
摘要翻译：公开了一种制备由下式表示的β-内酰胺化合物的方法：其中R 1表示羟基取代的低级烷基或各自可被保护的氨基; R2表示氢原子或酯残基; X表示可以被低级烷基，硫原子或由下式表示的基团取代的亚甲基：-A-CH2-，其中A表示硫原子，氧原子或亚甲基; W表示羟基的活性酯残基或其盐，其包括如下步骤：处理由下式表示的1-氮杂-3-硫杂 - 双环烷烃化合物：其中R1，R2和X 具有与上述相同的含义，或其盐与脱碱剂存在下的碱，然后使所得化合物与羟基的活性酯化剂反应。

8. 发明申请

US20100192888A1 High strength aluminum alloy casting and method of production of same 有权
标题翻译：高强度铝合金铸造及其生产方法相同
公开(公告)号：US20100192888A1
公开(公告)日：2010-08-05
申请号：US12798288
申请日：2010-04-01
申请人： Kouji Yamada , Tomoyuki Hatano , Susumu Miyakawa , Hiromi Takagi , Hiroshi Horikawa , Akio Hashimoto
发明人： Kouji Yamada , Tomoyuki Hatano , Susumu Miyakawa , Hiromi Takagi , Hiroshi Horikawa , Akio Hashimoto
IPC分类号： C22C21/04 , F04C18/02 , F01L1/34 , F16D65/00
CPC分类号： C22C21/04 , C22F1/043
摘要： A high strength aluminum alloy casting obtained by casting an aluminum alloy comprised of 7.5 to 11.5 wt % of Si, 3.8 to 4.8 wt % of Cu, 0.45 to 0.65 wt % of Mg, 0.4 to 0.7 wt % of Fe, 0.35 to 0.45 wt % of Mn, and the balance of Al and not more than 0.2 wt % of unavoidable impurities, wherein this aluminum alloy has 0.1 to 0.3 wt % of Ag added to it or contains 0.1 to 1.0 wt % of at least one element selected from the group of second additive elements comprised of Rb, K, Ba, Sr, Zr, Nb, Ta, V, and Pd and rare earth elements, and a method of production of a high strength aluminum alloy casting comprising the steps of filling a melt of an aluminum alloy in a mold to obtain a casting, taking out the aluminum alloy casting from the mold, solubilizing the high strength aluminum alloy casting by heating in a temperature range of 495 to 505° C. for 2 to 6 hours, quenching the high strength aluminum alloy casting after the solubilization, and age hardening the high strength aluminum alloy casting by heating in a temperature range of 160 to 220° C. for 2 to 6 hours after quenching.
摘要翻译：通过铸造由7.5〜11.5重量％的Si，3.8〜4.8重量％的Cu，0.45〜0.65重量％的Mg，0.4〜0.7重量％的Fe，0.35〜0.45重量％的铝构成的高强度铝合金铸件的Mn，余量为Al和不大于0.2重量％的不可避免的杂质，其中该铝合金添加0.1至0.3重量％的Ag或含有0.1至1.0重量％的至少一种选自由Rb，K，Ba，Sr，Zr，Nb，Ta，V和Pd以及稀土元素组成的第二添加元素组，以及制造高强度铝合金铸造的方法，包括以下步骤：在模具中获得铝合金以获得铸件，从模具中取出铝合金铸件，通过在495至505℃的温度范围内加热将高强度铝合金铸件溶解2至6小时，淬火高强度铝合金铸造后溶解，并且老化硬化高强度铝合金cas 在160-220℃的温度范围内加热淬火2至6小时。

9. 发明授权

US06921441B2 Super-elastic titanium alloy for medical uses 失效
标题翻译：超弹性钛合金用于医疗用途
公开(公告)号：US06921441B2
公开(公告)日：2005-07-26
申请号：US10396917
申请日：2003-03-25
申请人： Toyonobu Tanaka , Hiroshi Horikawa , Shuichi Miyazaki , Hideki Hosoda
发明人： Toyonobu Tanaka , Hiroshi Horikawa , Shuichi Miyazaki , Hideki Hosoda
IPC分类号： A61L27/00 , A61L27/06 , A61L27/50 , A61L29/00 , A61M25/01 , C22C14/00 , C22F1/00 , C22F1/02 , C22F1/18
CPC分类号： C22F1/183 , A61L27/06 , A61L27/50 , A61L2400/16 , C22C14/00 , C22F1/006
摘要： A super-elastic titanium alloy for medical use consisting essentially of: a molybdenum (Mo) as a β stabilizer element of titanium (Ti): from 2 to 12 at %; an α stabilizer element of the titanium (Ti): from 0.1 to 14 at %; and the balance being titanium (Ti) and inevitable impurities. The α stabilizer element is at least one element selected from the group consisting of aluminum (Al), gallium (Ga) and germanium (Ge).
摘要翻译：用于医疗用途的超弹性钛合金基本上由以下组成：钼（Mo）作为钛（Ti）的β稳定剂元素：2至12原子％; 钛（Ti）的α稳定剂元素：0.1至14原子％; 余量为钛（Ti）和不可避免的杂质。 α稳定剂元素是选自由铝（Al），镓（Ga）和锗（Ge）组成的组中的至少一种元素。

10. 发明授权

US06508803B1 Niti-type medical guide wire and method of producing the same 有权
标题翻译： Niti型医用导丝及其制造方法
公开(公告)号：US06508803B1
公开(公告)日：2003-01-21
申请号：US09581521
申请日：2000-07-06
申请人： Hiroshi Horikawa , Kaisuke Shiroyama , Kengo Mitose
发明人： Hiroshi Horikawa , Kaisuke Shiroyama , Kengo Mitose
IPC分类号： A61M2500
CPC分类号： C22F1/006 , A61M25/09 , B21F7/00 , B21F9/00 , B21F9/005
摘要： A medical guidewire comprised of an NiTi-based alloy having a high elasticity over a wide range of strain, excellent straightness, and preferable shape and characteristics of a stress-strain curve in a tensile test. The wire is obtained by applying a predetermined tension to a cold drawn NiTi-based alloy wire and mechanical straightening it under conditions of a predetermined torsional shear strain and temperature and shows superior pushability, torque transmission, and reinsertability as a medical guidewire, so is preferable for a catheter guidewire, endoscope guidewire, etc.
摘要翻译：一种医用导线，其由在宽范围应变下具有高弹性的NiTi基合金，优异的直线性以及拉伸试验中的应力 - 应变曲线的优选形状和特性组成。通过在预定的扭转剪切应变和温度的条件下将预定的张力施加到冷拉伸的NiTi基合金丝并机械矫直来获得线，并且作为医疗导线显示出优异的推挤性，扭矩传递和可重新插入性，因此优选用于导管导丝，内窥镜导丝等

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