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1. 发明申请

US20080318000A1 SANDWICH PANEL 有权
标题翻译：三菱面板
公开(公告)号：US20080318000A1
公开(公告)日：2008-12-25
申请号：US12137710
申请日：2008-06-12
申请人： Hiroshi HORIGOME , Yasunobu Tanaka , Masaaki Hirai , Hiroshi Tanaka
发明人： Hiroshi HORIGOME , Yasunobu Tanaka , Masaaki Hirai , Hiroshi Tanaka
IPC分类号： B32B3/12
CPC分类号： E04C2/365 , B32B3/12 , B32B5/02 , B32B2260/046 , B32B2262/101 , B32B2262/106 , B32B2307/50 , B32B2307/542 , B32B2307/546 , B32B2307/718 , B32B2605/003 , B32B2605/18 , Y10T428/1314 , Y10T428/24149 , Y10T428/24744 , Y10T428/249953 , Y10T428/254
摘要： There is provided a lightweight sandwich panel of exceptional utility, which satisfies the flexural strength and in-plane shear strength requirements for an inner wall material used in aircraft. The sandwich panel comprises a laminating material in which a plurality of fiber bodies_is laminated, and a surface material, the laminating material and the surface material being laminated in the stated order from the inside to the outside on the upper and lower surfaces of a hollow columnar core. The laminating material comprises at least four unidirectional fiber bodies each of which has fibers aligned in a uniform direction and is laminated so that each of the fiber directions thereof is at approximately 0 , +45°, −45°, and 90°, respectively, in relation to one edge of the sandwich panel. The unidirectional fiber bodies are stitched together using a stitching yarn.
摘要翻译：提供了一种特殊用途的轻质夹芯板，其满足飞机内壁材料的弯曲强度和平面内剪切强度要求。夹层板包括层压材料，其中多个纤维体层叠，并且表面材料，层压材料和表面材料在中空柱体的上表面和下表面上以从内向外的顺序层叠核心。层压材料包括至少四个单向纤维体，每个纤维体具有沿均匀方向排列的纤维，并被层压，使得其纤维方向分别在大约0°，+ 45°，-45°和90°。相对于夹心板的一个边缘。单向纤维体使用缝合线缝合在一起。

2. 发明授权

US08334042B2 Sandwich panel 有权
标题翻译：三明治板
公开(公告)号：US08334042B2
公开(公告)日：2012-12-18
申请号：US12137710
申请日：2008-06-12
申请人： Hiroshi Horigome , Yasunobu Tanaka , Masaaki Hirai , Hiroshi Tanaka
发明人： Hiroshi Horigome , Yasunobu Tanaka , Masaaki Hirai , Hiroshi Tanaka
IPC分类号： B32B3/12 , B32B3/26
CPC分类号： E04C2/365 , B32B3/12 , B32B5/02 , B32B2260/046 , B32B2262/101 , B32B2262/106 , B32B2307/50 , B32B2307/542 , B32B2307/546 , B32B2307/718 , B32B2605/003 , B32B2605/18 , Y10T428/1314 , Y10T428/24149 , Y10T428/24744 , Y10T428/249953 , Y10T428/254
摘要： There is provided a lightweight sandwich panel of exceptional utility, which satisfies the flexural strength and in-plane shear strength requirements for an inner wall material used in aircraft. The sandwich panel comprises a laminating material in which a plurality of fiber bodies is laminated, and a surface material, the laminating material and the surface material being laminated in the stated order from the inside to the outside on the upper and lower surfaces of a hollow columnar core. The laminating material comprises at least four unidirectional fiber bodies each of which has fibers aligned in a uniform direction and is laminated so that each of the fiber directions thereof is at approximately 0°, +45°, −45°, and 90°, respectively, in relation to one edge of the sandwich panel. The unidirectional fiber bodies are stitched together using a stitching yarn.
摘要翻译：提供了一种特殊用途的轻质夹芯板，其满足飞机内壁材料的弯曲强度和平面内剪切强度要求。夹层板包括层压材料，其中多个纤维体层叠，并且表面材料，层压材料和表面材料在中空的上表面和下表面上以从内向外的顺序层叠柱状核。层压材料包括至少四个单向纤维体，每个单向纤维体具有沿均匀方向排列的纤维，并被层压，使得其每个纤维方向分别在大约0°，+ 45°，-45°和90° 相对于夹心板的一个边缘。使用缝合线将单向纤维体缝合在一起。

3. 发明申请

US20130071467A1 RETINOID-LIPOSOMES FOR TREATING FIBROSIS 有权
标题翻译：用于治疗纤维化的假体 - 脂质体
公开(公告)号：US20130071467A1
公开(公告)日：2013-03-21
申请号：US13492594
申请日：2012-06-08
申请人： Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Violetta Akopian , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nahum , Hagar Kalinski , Igor Mett , Kenjiro Minomi , Wenbin Ying , Yun Liu
发明人： Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Violetta Akopian , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nahum , Hagar Kalinski , Igor Mett , Kenjiro Minomi , Wenbin Ying , Yun Liu
IPC分类号： A61K9/127 , A61K31/713
CPC分类号： A61K9/1271 , A61K9/127 , A61K31/713 , C07H21/02 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2320/32 , C12N2320/52
摘要： What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPINH1_45a (SEQ ID NOS: 98 and 165), and SERPINH1_51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 expression, including fibrosis.
摘要翻译：描述的是包含包含有义链和反义链的双链核酸分子的药物组合物，其中有义链和反义链选自描述为SERPINH1_2的寡核苷酸（SEQ ID NO：60和127），SERPINH1_45a（SEQ ID NO： NOS：98和165）和SERPINH1_51（SEQ ID NO：101和168）和包含类视黄醇和脂质囊泡的混合物的药物载体，以及使用这些药物组合物治疗与hsp47表达相关的疾病的方法，包括纤维化。

4. 发明授权

US08216558B2 Polymer coating of cells 失效
标题翻译：细胞的聚合物涂层
公开(公告)号：US08216558B2
公开(公告)日：2012-07-10
申请号：US12690011
申请日：2010-01-19
申请人： Sang Van , Yasunobu Tanaka , Lei Yu
发明人： Sang Van , Yasunobu Tanaka , Lei Yu
IPC分类号： A61K8/72
CPC分类号： C08G69/10 , A61K31/765 , A61K35/36 , A61K35/44 , A61K35/545 , A61K47/59 , A61K47/595 , A61K47/6901 , A61L27/18 , A61L27/34 , A61L27/3834 , A61L27/54 , A61L2300/64 , C08G69/02 , C08G69/08 , C08G73/028 , C12N5/0068 , C12N2533/30 , Y10T70/437 , C08L77/00
摘要： Polymers and methods of making them are described. The polymers may be used to coat living cells. The polymer-coated cells are useful in cell therapy applications.
摘要翻译：描述了聚合物及其制备方法。聚合物可用于包衣活细胞。聚合物涂覆的细胞可用于细胞治疗应用。

5. 发明授权

US07674452B2 Polymer coating of cells 失效
标题翻译：细胞的聚合物涂层
公开(公告)号：US07674452B2
公开(公告)日：2010-03-09
申请号：US11359811
申请日：2006-02-22
申请人： Sang Van , Yasunobu Tanaka , Lei Yu
发明人： Sang Van , Yasunobu Tanaka , Lei Yu
IPC分类号： A61Q7/00
CPC分类号： C08G69/10 , A61K31/765 , A61K35/36 , A61K35/44 , A61K35/545 , A61K47/59 , A61K47/595 , A61K47/6901 , A61L27/18 , A61L27/34 , A61L27/3834 , A61L27/54 , A61L2300/64 , C08G69/02 , C08G69/08 , C08G73/028 , C12N5/0068 , C12N2533/30 , Y10T70/437 , C08L77/00
摘要： Polymers and methods of making them are described. The polymers may be used to coat living cells. The polymer-coated cells are useful in cell therapy applications.
摘要翻译：描述了聚合物及其制备方法。聚合物可用于包衣活细胞。聚合物涂覆的细胞可用于细胞治疗应用。

6. 发明授权

US07125709B2 Culture device and method for eukaryotic cell transfection 失效
标题翻译：用于真核细胞转染的培养装置和方法
公开(公告)号：US07125709B2
公开(公告)日：2006-10-24
申请号：US10775341
申请日：2004-02-10
申请人： Yasunobu Tanaka , Lei Yu , Shouping Ji
发明人： Yasunobu Tanaka , Lei Yu , Shouping Ji
IPC分类号： C12M1/00 , C12M1/16
CPC分类号： C12N5/0068 , C12N2510/00 , C12N2533/18 , C12N2533/54
摘要： A cell culture device for transfecting a eukaryotic cell is disclosed. The cell culture/transfection device may be a multiwell plate or slide which has been coated with a metal salt such as CaCl2. Methods of using the cell culture device to transfect mammalian cells and/or to monitor cell transfection are described. Kits are also described which include the cell transfection device, eukaryotic cells to be transformed and nucleic acid for transformation.
摘要翻译：公开了用于转染真核细胞的细胞培养装置。细胞培养/转染装置可以是已经涂覆有金属盐如CaCl 2 2的多孔板或载玻片。描述了使用细胞培养装置转染哺乳动物细胞和/或监测细胞转染的方法。还描述了包括细胞转染装置，待转化的真核细胞和用于转化的核酸的试剂盒。

7. 发明授权

US5157436A Apparatus for making a color proof 失效
标题翻译：用于制作色彩的装置
公开(公告)号：US5157436A
公开(公告)日：1992-10-20
申请号：US706150
申请日：1991-05-28
申请人： Masahide Akisada , Kazuya Fujimoto , Takatugu Kusayanagi , Yasunobu Tanaka
发明人： Masahide Akisada , Kazuya Fujimoto , Takatugu Kusayanagi , Yasunobu Tanaka
IPC分类号： G03B27/30
CPC分类号： G03B27/30
摘要： An apparatus for making a color proof. An original loading portion having a loading opening provided for loading the original is disposed side by side at an exposure portion so that a carriage may be substantially horizontally moved between the exposure position of the exposure portion and the copy exchange position of corresponding to the loading opening. When the original is exchanged and recharged, the loading opening is open by a lid member and when the carriage is positioned to the copy exchange position, the original is placed. Since the exposure portion and the like are not disposed upwardly of the original loading portion, the exposure unit and the like are not mounted with the result that the lid member can be made compact and lightweight while exchange of the original can be eased. In addition, the carriage is not withdrawn into the working space allowed for the operators.
摘要翻译：用于制作色彩的装置。具有用于装载原件的装载开口的原始装载部分并排设置在曝光部分，使得滑架可以在曝光部分的曝光位置和对应于装载开口的复印更换位置之间基本上水平移动。当原件被更换和充电时，装载开口由盖构件打开，并且当托架被定位到复印交换位置时，放置原件。由于曝光部分等没有设置在原始装载部分的上方，曝光单元等不被安装，从而可以使得盖构件可以被制造成紧凑轻便，同时可以更换原稿。此外，运输工具不会撤回运营商允许的工作空间。

8. 发明授权

US4914835A Method of and apparatus for drying photographic light-sensitive material in photographic processing machine 失效
标题翻译：摄影处理机中照相感光材料的干燥方法和装置
公开(公告)号：US4914835A
公开(公告)日：1990-04-10
申请号：US172687
申请日：1988-03-23
申请人： Junichi Kose , Yoshiyasu Matsuzaki , Motoharu Komori , Nobuyuki Seto , Miyuki Endo , Kimitaka Kameoka , Takashi Naoi , Yasunobu Tanaka , Tomoyuki Takiue
发明人： Junichi Kose , Yoshiyasu Matsuzaki , Motoharu Komori , Nobuyuki Seto , Miyuki Endo , Kimitaka Kameoka , Takashi Naoi , Yasunobu Tanaka , Tomoyuki Takiue
IPC分类号： F26B13/10 , F26B21/10 , G03D15/02
CPC分类号： F26B13/10 , F26B21/10 , G03D15/022
摘要： In a method of drying a photographic light-sensitive material by use of drying air, the amount of light-sensitive material which can be processed within a predetermined time at a set temperature of the drying air is compared with the totalized amount of the light-sensitive material to be actually processed within the predetermined time, and, on the basis of the result of this comparison, the set temperature of the drying air can be adjusted. An apparatus for drying photographic light-sensitive material by use of drying air is arranged so that the amount of light-sensitive material to be actually processed within a predetermined time is detected by a detecting sensor and the thus-detected amount is compared with the amount of light-sensitive material which can be dried. If the amount of light-sensitive material to be actually processed exceeds the amount of light-sensitive material which can be processed, such a display is conducted that the apparatus is not ready for insertion of further light-sensitive material. Accordingly, the light-sensitive material can consistently be dried at a proper drying temperature.
摘要翻译：在通过使用干燥空气干燥摄影感光材料的方法中，将可在干燥空气的设定温度下的预定时间内处理的感光材料的量与发光材料的合计量进行比较，在预定时间内实际处理的敏感材料，并且基于该比较的结果，可以调节干燥空气的设定温度。通过使用干燥空气来对照相感光材料进行干燥的装置，通过检测传感器检测在预定时间内实际处理的感光材料的量，并将这样检测的量与量的可以干燥的感光材料。如果实际处理的感光材料的量超过可以处理的感光材料的量，则进行这样的显示，使得该装置未准备好插入另外的感光材料。因此，感光材料可以在适当的干燥温度下始终干燥。

9. 发明授权

US09011903B2 Cationic lipids for therapeutic agent delivery formulations 有权
标题翻译：用于治疗剂递送配方的阳离子脂质
公开(公告)号：US09011903B2
公开(公告)日：2015-04-21
申请号：US13492650
申请日：2012-06-08
申请人： Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Zheng Hou , John A. Gaudette , Violetta Akopian , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Yasunobu Tanaka , Priya Karmali , Sridhar C. Nagarajan
发明人： Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Zheng Hou , John A. Gaudette , Violetta Akopian , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Yasunobu Tanaka , Priya Karmali , Sridhar C. Nagarajan
IPC分类号： A61K31/225 , C07C69/34 , A61K9/127 , A61K31/7052 , A61K47/18 , A61K9/00 , A61K9/10 , A61K31/713 , C12N15/113
CPC分类号： C07C237/08 , A61K9/0019 , A61K9/10 , A61K9/1271 , A61K31/713 , A61K47/186 , A61K47/543 , C07C323/60 , C07C333/04 , C12N15/113
摘要： Here described are compounds of formula I: wherein R1 and R2 is independently selected from a group consisting of C10 to C18 alkyl, C12 to C18 alkenyl, and oleyl group; wherein R3 and R4 are independently selected from a group consisting of C1 to C6 alkyl, and C2 to C6 alkanol; wherein X is selected from a group consisting of —CH2—, —S—, and —O— or absent; wherein Y is selected from —(CH2)n, —S(CH2)n, —O(CH2)n—, thiophene, —SO2(CH2)n—, and ester, wherein n=1-4; wherein a=1-4; wherein b=1-4; wherein c=1-4; and wherein Z is a counterion; as well as compositions and pharmaceutical formulations including compounds of formula I which are useful for the delivery of therapeutic agents; and methods of using these compositions and formulations.
摘要翻译：这里描述的是式I化合物：其中R 1和R 2独立地选自C 10至C 18烷基，C 12至C 18烯基和油基; 其中R3和R4独立地选自C1-C6烷基和C2-C6链烷醇; 其中X选自-CH 2 - ， - S-和-O-或不存在; 其中Y选自 - （CH 2）n，-S（CH 2）n，-O（CH 2）n - ，噻吩，-SO 2（CH 2）n - 和酯，其中n = 1-4; 其中a = 1-4; 其中b = 1-4; 其中c = 1-4; 并且其中Z是抗衡离子; 以及包含可用于递送治疗剂的式I化合物的组合物和药物制剂; 以及使用这些组合物和制剂的方法。

10. 发明授权

US08710209B2 Modulation of HSP47 expression 有权
标题翻译：调节HSP47表达
公开(公告)号：US08710209B2
公开(公告)日：2014-04-29
申请号：US12963600
申请日：2010-12-08
申请人： Xiaomei Jin , Lei Yu , Hirokazu Takahashi , Yasunobu Tanaka , Yoshiro Niitsu , Elena Feinstein , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett , Shai Erlich , Elizabeth C. Squiers , Ning Chen
发明人： Xiaomei Jin , Lei Yu , Hirokazu Takahashi , Yasunobu Tanaka , Yoshiro Niitsu , Elena Feinstein , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett , Shai Erlich , Elizabeth C. Squiers , Ning Chen
IPC分类号： C07H21/04
CPC分类号： C12N15/113 , A61K31/713 , C12N2310/11 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/32 , C12N2310/321 , C12N2310/33 , C12N2310/531 , C12N2320/30 , C12N2310/3521
摘要： Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.
摘要翻译：本文提供用于调节靶基因，特别是热休克蛋白47（hsp47）的表达的组合物，方法和试剂盒。组合物，方法和试剂盒可以包括核酸分子（例如，短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）或短发夹RNA（shRNA））），其调节编码hsp47的基因，例如编码人hsp47的基因。本文公开的组合物和方法也可用于治疗与hsp47相关的病症和病症，例如肝纤维化，肺纤维化，腹膜纤维化和肾纤维化。

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