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1. 发明申请

US20050230615A1 MALDI-IM-ortho-TOF mass spectrometry with simultaneous positive and negative mode detection 有权
标题翻译： MALDI-IM-ortho-TOF质谱联用正负模式检测
公开(公告)号：US20050230615A1
公开(公告)日：2005-10-20
申请号：US11025640
申请日：2004-12-29
申请人： Hiroshi Furutani , Michael Ugarov , Kimberly Prather , J. Schultz
发明人： Hiroshi Furutani , Michael Ugarov , Kimberly Prather , J. Schultz
IPC分类号： H01J49/00 , H01J49/16
CPC分类号： H01J49/0095 , B82Y10/00 , G01N27/622 , H01J49/0445 , H01J49/164 , H01J49/40 , Y10T436/24
摘要： An ion mobility/mass spectrometry method and instrument using aerosolized samples and dual positive and negative mode detection is described. Sample preparation methods are also described.
摘要翻译：描述了使用雾化样品和双正负模式检测的离子迁移/质谱法和仪器。还描述了样品制备方法。

2. 发明申请

US20060289746A1 Multi-beam ion mobility time-of-flight mass spectrometry with multi-channel data recording 有权
公开(公告)号：US20060289746A1
公开(公告)日：2006-12-28
申请号：US11441766
申请日：2006-05-26
申请人： Valeri Raznikov , J. Schultz , Thomas Egan , Michael Ugarov , Agnes Tempez , Gennadiy Savenkov , Vladislav Zelenov
发明人： Valeri Raznikov , J. Schultz , Thomas Egan , Michael Ugarov , Agnes Tempez , Gennadiy Savenkov , Vladislav Zelenov
IPC分类号： H01J49/00
CPC分类号： H01J49/009 , G01N27/622 , H01J49/40
摘要： The content of the invention comprises a concept of multi-beam ion pre-selection from a single sample, coordinated mobility (against the gas flow) separation, cooling ions in supersonic gas flow and mass separation of thus low divergent ions by single or plural compact high-resolution orthogonal time-of-flight mass spectrometers both linear or reflectron type with controlled collision-induced dissociation (CID) and multi-channel data recording for the optimization of sample use in the analysis, and obtaining as much useful information about the sample as possible in a reasonably short time.

3. 发明申请

US20060138317A1 Gold implantation/deposition of biological samples for laser desorption two and three dimensional depth profiling of biological tissues 有权
公开(公告)号：US20060138317A1
公开(公告)日：2006-06-29
申请号：US11231448
申请日：2005-09-21
申请人： J. Schultz , Michael Ugarov , Thomas Egan , Agnes Tempez , Yvon Le bayec , Serge Negra
发明人： J. Schultz , Michael Ugarov , Thomas Egan , Agnes Tempez , Yvon Le bayec , Serge Negra
IPC分类号： H01J49/00
CPC分类号： H01J49/164 , H01J49/0031 , H01J49/0418
摘要： The present invention enhances the laser desorption of biological molecular ions from surfaces by creating a surface localized MALDI particle matrix by ion implantation of low energy ionized clusters (gold, aluminum, etc.) or chemically derivatized clusters into the near surface region of the sample. MALDI analysis of the intact biomolecules on the surface or within a narrow subsurface region defined by the implantation range of the ions can then be performed by laser desorption into a mass spectrometer or, in a preferred embodiment, into a combined ion mobility orthogonal time of flight mass spectrometer.

4. 发明申请

US20050109931A1 Ion mobility TOF/MALDI/MS using drift cell alternating high and low electrical field regions 有权
标题翻译：离子迁移率TOF / MALDI / MS使用漂移电池交替高低电场区域
公开(公告)号：US20050109931A1
公开(公告)日：2005-05-26
申请号：US10969643
申请日：2004-10-20
申请人： J. Schultz , Valeri Raznikov , Thomas Egan , Michael Ugarov , Agnes Tempez
发明人： J. Schultz , Valeri Raznikov , Thomas Egan , Michael Ugarov , Agnes Tempez
IPC分类号： G01N20060101 , G01N27/64 , H01J49/00 , H01J49/40
CPC分类号： G01N27/622 , H01J49/0045
摘要： Improved ion focusing for an ion mobility drift cell allows for improved throughput for subsequent detection such as mass detection. Improved focusing is realized by the use of alternating regions of high and low electric fields in the ion mobility drift cell.
摘要翻译：用于离子迁移率漂移池的改进的离子聚焦允许用于后续检测（例如质量检测）的提高的生产量。通过在离子迁移率漂移池中使用高电场和低电场的交替区域来实现改进的聚焦。

5. 发明申请

US20050035284A1 Gold implantation/deposition of biological samples for laser desorption three dimensional depth profiling of tissues 有权
标题翻译：金子植入/沉积生物样品用于激光解吸三维组织的深度剖析
公开(公告)号：US20050035284A1
公开(公告)日：2005-02-17
申请号：US10861962
申请日：2004-06-04
申请人： J. Schultz , Michael Ugarov , Thomas Egan , Agnes Tempez , Yvon Le Bayec , Serge Della-Negra
发明人： J. Schultz , Michael Ugarov , Thomas Egan , Agnes Tempez , Yvon Le Bayec , Serge Della-Negra
IPC分类号： B01D59/44 , H01J20060101 , H01J49/00 , H01J49/04 , H01J49/16 , H01J49/40
CPC分类号： H01J49/164 , H01J49/0031 , H01J49/0418
摘要： The present invention enhances the laser desorption of biological molecular ions from surfaces by creating a surface localized MALDI particle matrix by ion implantation of low energy ionized clusters (gold, aluminum, etc.) or chemically derivatized clusters into the near surface region of the sample. MALDI analysis of the intact biomolecules on the surface or within a narrow subsurface region defined by the implantation range of the ions can then be performed by laser desorption into a mass spectrometer or, in a preferred embodiment, into a combined ion mobility orthogonal time of flight mass spectrometer.
摘要翻译：本发明通过将低能离子簇（金，铝等）或化学衍生的簇离子注入到样品的近表面区域中，形成表面定位的MALDI粒子基质来增强生物分子离子从表面的激光解吸附。然后可以通过激光解吸到质谱仪中或者在优选的实施方式中将离子迁移正交时间合并在离子迁移正交时间内的表面上或在由离子的注入范围限定的窄地下区域内的完整生物分子的MALDI分析质谱仪

6. 发明申请

US20060192104A1 Ion mobility TOF/MALDI/MS using drift cell alternating high and low electrical field regions 有权
公开(公告)号：US20060192104A1
公开(公告)日：2006-08-31
申请号：US11342716
申请日：2006-01-30
申请人： J. Schultz , Valeri Raznikov , Thomas Egan , Michael Ugarov , Agnes Tempez
发明人： J. Schultz , Valeri Raznikov , Thomas Egan , Michael Ugarov , Agnes Tempez
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： G01N27/622 , H01J49/0045
摘要： Improved ion focusing for an ion mobility drift cell allows for improved throughput for subsequent detection such as mass detection. Improved focusing is realized by the use of alternating regions of high and low electric fields in the ion mobility drift cell.

7. 发明申请

US20060024720A1 Multiplex data acquisition modes for ion mobility-mass spectrometry 有权
标题翻译：用于离子迁移率 - 质谱的多重数据采集模式
公开(公告)号：US20060024720A1
公开(公告)日：2006-02-02
申请号：US11191666
申请日：2005-07-27
申请人： John McLean , David Russell , Thomas Egan , Michael Ugarov , J. Schultz
发明人： John McLean , David Russell , Thomas Egan , Michael Ugarov , J. Schultz
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/48
CPC分类号： G01N33/6851 , B82Y30/00 , G01N27/622 , H01J49/0031 , H01J49/004
摘要： A method and apparatus for multiplexed data acquisition for gas-phase ion mobility coupled with mass spectrometry is described. Ion packets are injected into an ion mobility drift chamber at a rate faster than the ion mobility separation arrival time distribution. The convoluted arrival time distributions thus generated are deconvoluted by a mass spectrometer and post-processing algorithms.
摘要翻译：描述了一种与质谱耦合的气相离子迁移多路复用数据采集方法和装置。离子包以比离子迁移率分离到达时间分布更快的速率注入离子迁移率漂移室。由此产生的复杂到达时间分布由质谱仪和后处理算法解卷积。

8. 发明申请

US20060289747A1 Multi-beam ion mobility time-of-flight mass spectrometer with bipolar ion extraction and zwitterion detection 有权
标题翻译：具有双极离子提取和两性离子检测的多光束离子迁移率飞行时间质谱仪
公开(公告)号：US20060289747A1
公开(公告)日：2006-12-28
申请号：US11441768
申请日：2006-05-26
申请人： J. Schultz , Valeri Raznikov , Thomas Egan , Michael Ugarov , Agnes Tempez , Marina Raznikova , Valentin Tarasenko
发明人： J. Schultz , Valeri Raznikov , Thomas Egan , Michael Ugarov , Agnes Tempez , Marina Raznikova , Valentin Tarasenko
IPC分类号： H01J49/00
CPC分类号： H01J49/40 , G01N27/622 , H01J49/009
摘要： The present invention relates generally to instrumentation and methodology for the characterization of chemical samples in solutions or on a surface which is based on modified ionization methods with or without adjustable pH and controllable H-D exchange in solution, an improved ion mobility spectrometer (IMS), a multi-beam ion pre-selection of the initial flow, and coordinated mobility and mass ion separation and detection using a single or several independent time-of-flight mass spectrometers for different beams with methods for fragmenting ion mobility-separated ions and multi-channel data recording
摘要翻译：本发明一般涉及用于在溶液中或在表面上表征化学样品的仪器和方法，其基于在溶液中具有或不具有可调pH和可调节的HD交换的改进的离子化方法，改进的离子迁移谱仪（IMS），初始流动的多光束离子预选择，以及使用用于不同光束的单个或多个独立飞行时间质谱仪的协调迁移率和质量离子分离和检测，具有用于分离离子迁移率分离的离子和多通道的方法数据记录

9. 发明授权

US08633436B2 Data acquisition modes for ion mobility time-of-flight mass spectrometry 有权
标题翻译：离子迁移时间质谱的数据采集模式
公开(公告)号：US08633436B2
公开(公告)日：2014-01-21
申请号：US13335059
申请日：2011-12-22
申请人： Michael Ugarov
发明人： Michael Ugarov
IPC分类号： H01J49/00
CPC分类号： G01N27/62 , H01J49/0031 , H01J49/40
摘要： Methods, apparatus and systems for acquiring spectrometric data from analyte ions implement a combination of drift-type ion mobility (IM) separation and time-of-flight mass spectrometry (TOF MS). Both separation techniques are carried out in tandem while applying mass filtering with a wide window of ion isolation. One mode of operation entails utilizing a mass filter to limit ion packets to ions in a selected m/z range that remains constant over the entire course of data acquisition. Another mode entails utilizing the mass filter to limit ion packets to an m/z range that varies over the course of data acquisition.
摘要翻译：用于从分析物离子获取光谱数据的方法，装置和系统实现漂移型离子迁移率（IM）分离和飞行时间质谱（TOF MS）的组合。两种分离技术都是串联进行的，同时采用广泛的离子隔离窗口进行质量过滤。一种操作模式需要利用质量过滤器将离子包限制在选择的m / z范围内的离子，其在整个数据采集过程中保持恒定。另一种模式需要利用质量过滤器将离子包限制到在数据采集过程中变化的m / z范围。

10. 发明授权

US08481963B2 Ion slicer with accelleration and decelleration optics 有权
标题翻译：离子切片机，具有激光和脱光光学元件
公开(公告)号：US08481963B2
公开(公告)日：2013-07-09
申请号：US13406157
申请日：2012-02-27
申请人： Harvey D. Loucks, Jr. , James L. Bertsch , Michael Ugarov , William E. Barry , Yevgeny Kaplun
发明人： Harvey D. Loucks, Jr. , James L. Bertsch , Michael Ugarov , William E. Barry , Yevgeny Kaplun
IPC分类号： H01J37/147 , H01J37/04 , G21K1/04 , H01J49/06
CPC分类号： H01J37/045 , G21K1/04 , H01J37/147 , H01J49/067
摘要： Described herein is an ion slicer that: a) accelerates an ion beam towards a first electrode comprising an ion entrance slit, where the first electrode blocks a portion of ions with high displacement from the axis of the ion beam, thereby slicing the ion beam; and then b) decelerates the ion beam after it is sliced.
摘要翻译：本文描述的是一种离子切片机，其特征在于：a）将离子束加速至包括离子入口狭缝的第一电极，其中第一电极阻挡离子束轴线高位移的一部分离子，从而切割离子束; 然后b）在离子束切片后减速。

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