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1. 发明申请

US20060289747A1 Multi-beam ion mobility time-of-flight mass spectrometer with bipolar ion extraction and zwitterion detection 有权
标题翻译：具有双极离子提取和两性离子检测的多光束离子迁移率飞行时间质谱仪
公开(公告)号：US20060289747A1
公开(公告)日：2006-12-28
申请号：US11441768
申请日：2006-05-26
申请人： J. Schultz , Valeri Raznikov , Thomas Egan , Michael Ugarov , Agnes Tempez , Marina Raznikova , Valentin Tarasenko
发明人： J. Schultz , Valeri Raznikov , Thomas Egan , Michael Ugarov , Agnes Tempez , Marina Raznikova , Valentin Tarasenko
IPC分类号： H01J49/00
CPC分类号： H01J49/40 , G01N27/622 , H01J49/009
摘要： The present invention relates generally to instrumentation and methodology for the characterization of chemical samples in solutions or on a surface which is based on modified ionization methods with or without adjustable pH and controllable H-D exchange in solution, an improved ion mobility spectrometer (IMS), a multi-beam ion pre-selection of the initial flow, and coordinated mobility and mass ion separation and detection using a single or several independent time-of-flight mass spectrometers for different beams with methods for fragmenting ion mobility-separated ions and multi-channel data recording
摘要翻译：本发明一般涉及用于在溶液中或在表面上表征化学样品的仪器和方法，其基于在溶液中具有或不具有可调pH和可调节的HD交换的改进的离子化方法，改进的离子迁移谱仪（IMS），初始流动的多光束离子预选择，以及使用用于不同光束的单个或多个独立飞行时间质谱仪的协调迁移率和质量离子分离和检测，具有用于分离离子迁移率分离的离子和多通道的方法数据记录

2. 发明申请

US20060192104A1 Ion mobility TOF/MALDI/MS using drift cell alternating high and low electrical field regions 有权
公开(公告)号：US20060192104A1
公开(公告)日：2006-08-31
申请号：US11342716
申请日：2006-01-30
申请人： J. Schultz , Valeri Raznikov , Thomas Egan , Michael Ugarov , Agnes Tempez
发明人： J. Schultz , Valeri Raznikov , Thomas Egan , Michael Ugarov , Agnes Tempez
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： G01N27/622 , H01J49/0045
摘要： Improved ion focusing for an ion mobility drift cell allows for improved throughput for subsequent detection such as mass detection. Improved focusing is realized by the use of alternating regions of high and low electric fields in the ion mobility drift cell.

3. 发明申请

US20060289746A1 Multi-beam ion mobility time-of-flight mass spectrometry with multi-channel data recording 有权
公开(公告)号：US20060289746A1
公开(公告)日：2006-12-28
申请号：US11441766
申请日：2006-05-26
申请人： Valeri Raznikov , J. Schultz , Thomas Egan , Michael Ugarov , Agnes Tempez , Gennadiy Savenkov , Vladislav Zelenov
发明人： Valeri Raznikov , J. Schultz , Thomas Egan , Michael Ugarov , Agnes Tempez , Gennadiy Savenkov , Vladislav Zelenov
IPC分类号： H01J49/00
CPC分类号： H01J49/009 , G01N27/622 , H01J49/40
摘要： The content of the invention comprises a concept of multi-beam ion pre-selection from a single sample, coordinated mobility (against the gas flow) separation, cooling ions in supersonic gas flow and mass separation of thus low divergent ions by single or plural compact high-resolution orthogonal time-of-flight mass spectrometers both linear or reflectron type with controlled collision-induced dissociation (CID) and multi-channel data recording for the optimization of sample use in the analysis, and obtaining as much useful information about the sample as possible in a reasonably short time.

4. 发明申请

US20050109931A1 Ion mobility TOF/MALDI/MS using drift cell alternating high and low electrical field regions 有权
标题翻译：离子迁移率TOF / MALDI / MS使用漂移电池交替高低电场区域
公开(公告)号：US20050109931A1
公开(公告)日：2005-05-26
申请号：US10969643
申请日：2004-10-20
申请人： J. Schultz , Valeri Raznikov , Thomas Egan , Michael Ugarov , Agnes Tempez
发明人： J. Schultz , Valeri Raznikov , Thomas Egan , Michael Ugarov , Agnes Tempez
IPC分类号： G01N20060101 , G01N27/64 , H01J49/00 , H01J49/40
CPC分类号： G01N27/622 , H01J49/0045
摘要： Improved ion focusing for an ion mobility drift cell allows for improved throughput for subsequent detection such as mass detection. Improved focusing is realized by the use of alternating regions of high and low electric fields in the ion mobility drift cell.
摘要翻译：用于离子迁移率漂移池的改进的离子聚焦允许用于后续检测（例如质量检测）的提高的生产量。通过在离子迁移率漂移池中使用高电场和低电场的交替区域来实现改进的聚焦。

5. 发明申请

US20060138317A1 Gold implantation/deposition of biological samples for laser desorption two and three dimensional depth profiling of biological tissues 有权
公开(公告)号：US20060138317A1
公开(公告)日：2006-06-29
申请号：US11231448
申请日：2005-09-21
申请人： J. Schultz , Michael Ugarov , Thomas Egan , Agnes Tempez , Yvon Le bayec , Serge Negra
发明人： J. Schultz , Michael Ugarov , Thomas Egan , Agnes Tempez , Yvon Le bayec , Serge Negra
IPC分类号： H01J49/00
CPC分类号： H01J49/164 , H01J49/0031 , H01J49/0418
摘要： The present invention enhances the laser desorption of biological molecular ions from surfaces by creating a surface localized MALDI particle matrix by ion implantation of low energy ionized clusters (gold, aluminum, etc.) or chemically derivatized clusters into the near surface region of the sample. MALDI analysis of the intact biomolecules on the surface or within a narrow subsurface region defined by the implantation range of the ions can then be performed by laser desorption into a mass spectrometer or, in a preferred embodiment, into a combined ion mobility orthogonal time of flight mass spectrometer.

6. 发明申请

US20050035284A1 Gold implantation/deposition of biological samples for laser desorption three dimensional depth profiling of tissues 有权
标题翻译：金子植入/沉积生物样品用于激光解吸三维组织的深度剖析
公开(公告)号：US20050035284A1
公开(公告)日：2005-02-17
申请号：US10861962
申请日：2004-06-04
申请人： J. Schultz , Michael Ugarov , Thomas Egan , Agnes Tempez , Yvon Le Bayec , Serge Della-Negra
发明人： J. Schultz , Michael Ugarov , Thomas Egan , Agnes Tempez , Yvon Le Bayec , Serge Della-Negra
IPC分类号： B01D59/44 , H01J20060101 , H01J49/00 , H01J49/04 , H01J49/16 , H01J49/40
CPC分类号： H01J49/164 , H01J49/0031 , H01J49/0418
摘要： The present invention enhances the laser desorption of biological molecular ions from surfaces by creating a surface localized MALDI particle matrix by ion implantation of low energy ionized clusters (gold, aluminum, etc.) or chemically derivatized clusters into the near surface region of the sample. MALDI analysis of the intact biomolecules on the surface or within a narrow subsurface region defined by the implantation range of the ions can then be performed by laser desorption into a mass spectrometer or, in a preferred embodiment, into a combined ion mobility orthogonal time of flight mass spectrometer.
摘要翻译：本发明通过将低能离子簇（金，铝等）或化学衍生的簇离子注入到样品的近表面区域中，形成表面定位的MALDI粒子基质来增强生物分子离子从表面的激光解吸附。然后可以通过激光解吸到质谱仪中或者在优选的实施方式中将离子迁移正交时间合并在离子迁移正交时间内的表面上或在由离子的注入范围限定的窄地下区域内的完整生物分子的MALDI分析质谱仪

7. 发明授权

US06992284B2 Ion mobility TOF/MALDI/MS using drift cell alternating high and low electrical field regions 有权
标题翻译：离子迁移率TOF / MALDI / MS使用漂移电池交替高低电场区域
公开(公告)号：US06992284B2
公开(公告)日：2006-01-31
申请号：US10969643
申请日：2004-10-20
申请人： J. Albert Schultz , Valeri Raznikov , Thomas F. Egan , Michael V. Ugarov , Agnes Tempez
发明人： J. Albert Schultz , Valeri Raznikov , Thomas F. Egan , Michael V. Ugarov , Agnes Tempez
IPC分类号： B01D59/44
CPC分类号： G01N27/622 , H01J49/0045
摘要： Improved ion focusing for an ion mobility drift cell allows for improved throughput for subsequent detection such as mass detection. Improved focusing is realized by the use of alternating regions of high and low electric fields in the ion mobility drift cell.
摘要翻译：用于离子迁移率漂移池的改进的离子聚焦允许用于后续检测（例如质量检测）的提高的生产量。通过在离子迁移率漂移池中使用高电场和低电场的交替区域来实现改进的聚焦。

8. 发明授权

US08581494B2 Discharge lamp for GDS with an axial magnetic field 有权
标题翻译：具有轴向磁场的GDS放电灯
公开(公告)号：US08581494B2
公开(公告)日：2013-11-12
申请号：US13147906
申请日：2010-02-10
申请人： Mihai Ganciu-Petcu , Virgil Mircea Udrea , Agnes Tempez , Patrick Chapon
发明人： Mihai Ganciu-Petcu , Virgil Mircea Udrea , Agnes Tempez , Patrick Chapon
IPC分类号： H01J7/24
CPC分类号： H01J61/02 , G01N21/67 , G01N21/68
摘要： A glow discharge spectrometer discharge lamp includes: a lamp body having a vacuum enclosure connected to pump elements and to injector elements for injecting an inert gas into the enclosure; a hollow cylindrical first electrode of longitudinal axis X-X′; a second electrode for receiving a sample for analysis and for holding the sample facing one end of the cylindrical electrode; electric field generator including an applicator for applying to the terminals of the electrodes an electric field that is continuous, pulsed, radiofrequency, or hybrid, and suitable for generating a glow discharge plasma in the presence of the gas; coupler elements for coupling the discharge lamp to a spectrometer suitable for measuring at least one component of the plasma; and magnetic field generator elements for generating a magnetic field having field lines oriented along the axis X-X′, the magnetic field being uniform in orientation and in intensity over an area of the sample that is not less than the inside area of the hollow cylindrical electrode as projected along the direction X-X′.
摘要翻译：辉光放电光谱仪放电灯包括：具有连接到泵元件的真空外壳的灯体和用于将惰性气体注入外壳的注射器元件; 纵轴X-X'的中空圆柱形第一电极; 第二电极，用于接收用于分析的样品并保持面向所述圆柱形电极的一端的样品; 电场发生器，其包括用于向电极的端子施加连续，脉冲，射频或混合的电场的施加器，并且适用于在存在气体的情况下产生辉光放电等离子体; 用于将放电灯耦合到适于测量等离子体的至少一种组分的光谱仪的耦合器元件; 以及用于产生具有沿着X-X'轴定向的场线的磁场的磁场发生器元件，所述磁场在样品的区域上的取向均匀且强度不小于中空圆柱体的内部区域电极沿X-X'方向投影。

9. 发明申请

US20110291567A1 DISCHARGE LAMP FOR GDS WITH AN AXIAL MAGNETIC FIELD 有权
标题翻译：放电灯用于具有轴向磁场的GDS
公开(公告)号：US20110291567A1
公开(公告)日：2011-12-01
申请号：US13147906
申请日：2010-02-10
申请人： Mihai Ganciu-Petcu , Virgil Mircea Udrea , Agnes Tempez , Patrick Chapon
发明人： Mihai Ganciu-Petcu , Virgil Mircea Udrea , Agnes Tempez , Patrick Chapon
IPC分类号： H05H1/24 , H01J29/76
CPC分类号： H01J61/02 , G01N21/67 , G01N21/68
摘要： A glow discharge spectrometer discharge lamp includes: a lamp body having a vacuum enclosure connected to pump elements and to injector elements for injecting an inert gas into the enclosure; a hollow cylindrical first electrode of longitudinal axis X-X′; a second electrode for receiving a sample for analysis and for holding the sample facing one end of the cylindrical electrode; electric field generator including an applicator for applying to the terminals of the electrodes an electric field that is continuous, pulsed, radiofrequency, or hybrid, and suitable for generating a glow discharge plasma in the presence of the gas; coupler elements for coupling the discharge lamp to a spectrometer suitable for measuring at least one component of the plasma; and magnetic field generator elements for generating a magnetic field having field lines oriented along the axis X-X′, the magnetic field being uniform in orientation and in intensity over an area of the sample that is not less than the inside area of the hollow cylindrical electrode as projected along the direction X-X′.
摘要翻译：辉光放电光谱仪放电灯包括：具有连接到泵元件的真空外壳的灯体和用于将惰性气体注入外壳的注射器元件; 纵轴X-X'的中空圆柱形第一电极; 第二电极，用于接收用于分析的样品并保持面向所述圆柱形电极的一端的样品; 电场发生器，其包括用于向电极的端子施加连续，脉冲，射频或混合的电场的施加器，并且适用于在存在气体的情况下产生辉光放电等离子体; 用于将放电灯耦合到适于测量等离子体的至少一种组分的光谱仪的耦合器元件; 以及用于产生具有沿着轴线XX'定向的场线的磁场的磁场发生器元件，所述磁场在样品的不小于中空圆柱形电极的内部区域的取向和强度上是均匀的，作为沿着XX'方向投影。

10. 发明授权

US06989528B2 Gold implantation/deposition of biological samples for laser desorption three dimensional depth profiling of tissues 有权
标题翻译：金子植入/沉积生物样品用于激光解吸三维组织的深度剖析
公开(公告)号：US06989528B2
公开(公告)日：2006-01-24
申请号：US10861962
申请日：2004-06-04
申请人： J. Albert Schultz , Michael V. Ugarov , Thomas F. Egan , Agnes Tempez , Yvon Le Beyec , Serge Della-Negra
发明人： J. Albert Schultz , Michael V. Ugarov , Thomas F. Egan , Agnes Tempez , Yvon Le Beyec , Serge Della-Negra
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/164 , H01J49/0031 , H01J49/0418
摘要： The present invention enhances the laser desorption of biological molecular ions from surfaces by creating a surface localized MALDI particle matrix by ion implantation of low energy ionized clusters (gold, aluminum, etc.) or chemically derivatized clusters into the near surface region of the sample. MALDI analysis of the intact biomolecules on the surface or within a narrow subsurface region defined by the implantation range of the ions can then be performed by laser desorption into a mass spectrometer or, in a preferred embodiment, into a combined ion mobility orthogonal time of flight mass spectrometer.
摘要翻译：本发明通过将低能离子簇（金，铝等）或化学衍生的簇离子注入到样品的近表面区域中，形成表面定位的MALDI粒子基质来增强生物分子离子从表面的激光解吸附。然后可以通过激光解吸到质谱仪中或者在优选的实施方式中将离子迁移正交时间合并在离子迁移正交时间内的表面上或在由离子的注入范围限定的窄地下区域内的完整生物分子的MALDI分析质谱仪

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