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1. 发明授权

US08280142B2 Predetermined site luminescence measuring method, predetermined site luminescence measuring apparatus, expression amount measuring method, and measuring apparatus 有权
标题翻译：预定位点发光测定方法，预定位点发光测定装置，表达量测定方法及测定装置
公开(公告)号：US08280142B2
公开(公告)日：2012-10-02
申请号：US13164208
申请日：2011-06-20
申请人： Hirobumi Suzuki , Yoko Ohashi , Kenji Kawasaki , Kiyotsugu Kojima , Kenichi Koyama , Akihiko Yoshikawa
发明人： Hirobumi Suzuki , Yoko Ohashi , Kenji Kawasaki , Kiyotsugu Kojima , Kenichi Koyama , Akihiko Yoshikawa
IPC分类号： G06K9/00
CPC分类号： G01N21/6428 , G01N21/6458 , G01N2021/6482 , G02B21/16 , G02B21/365
摘要： An object of the present invention is to provide a predetermined site luminescence measuring method and a predetermined site luminescence measuring apparatus, which allow for determining whether, when the luminescence from the predetermined site in live samples is measured, a photoprotein is localized at the predetermined site in the same ones as the samples. An predetermined site luminescence measuring apparatus 100 in the present invention is comprised of: a the sample 102 into which a fused fusion gene is introduced, the fusion gene being obtained by fusing a fluorescence-related gene that expresses a fluorescence protein in addition to a targeting base sequence and a luminescence-related gene; a container 103 for storing the sample 102, a stage 104 on which the container 103 is arranged; a luminescent image capturing unit 106 which captures a luminescent image of the sample 102 (the objective lens 106a to the CCD camera 106c, and the imaging lens 106f); a fluorescent image capturing unit 108 which captures a fluorescent image of the sample 102 (the objective lens 108a to shutter 108f); and an the information communication terminal 110.
摘要翻译：本发明的目的是提供一种预定的现场发光测量方法和预定的现场发光测量装置，其允许确定当测量活样品中来自预定部位的发光时，光蛋白定位在预定位置与样品相同。本发明的预定位点发光测定装置100包括：融合融合基因导入到其中的样品102，所述融合基因除了靶向外，还融合表达荧光蛋白的荧光相关基因碱基序列和发光相关基因; 用于存储样品102的容器103，设置容器103的载物台104; 捕获样品102（物镜106a到CCD照相机106c和成像透镜106f）的发光图像的发光图像捕获单元106。捕获样品102（物镜108a至快门108f）的荧光图像的荧光图像捕获单元108; 和信息通信终端110。

2. 发明申请

US20090274360A1 Predetermined Site Luminescence Measuring Method, Predetermined Site Luminescence Measuring Apparatus, Expression Amount Measuring Method, and Measuring Apparatus 有权
标题翻译：预定位点发光测量方法，预定位点发光测量装置，表达量测量方法和测量装置
公开(公告)号：US20090274360A1
公开(公告)日：2009-11-05
申请号：US11887468
申请日：2006-03-30
申请人： Hirobumi Suzuki , Yoko Ohashi , Kenji Kawasaki , Kiyotsugu Kojima , Kenichi Koyama , Akihiko Yoshikawa
发明人： Hirobumi Suzuki , Yoko Ohashi , Kenji Kawasaki , Kiyotsugu Kojima , Kenichi Koyama , Akihiko Yoshikawa
IPC分类号： G06T7/00 , G06K9/20
CPC分类号： G01N21/6428 , G01N21/6458 , G01N2021/6482 , G02B21/16 , G02B21/365
摘要： An object of the present invention is to provide a predetermined site luminescence measuring method and a predetermined site luminescence measuring apparatus, which allow for determining whether, when the luminescence from the predetermined site in live samples is measured, a photoprotein is localized at the predetermined site in the same ones as the samples. An predetermined site luminescence measuring apparatus 100 in the present invention is comprised of: a the sample 102 into which a fused fusion gene is introduced, the fusion gene being obtained by fusing a fluorescence-related gene that expresses a fluorescence protein in addition to a targeting base sequence and a luminescence-related gene; a container 103 for storing the sample 102, a stage 104 on which the container 103 is arranged; a luminescent image capturing unit 106 which captures a luminescent image of the sample 102 (the objective lens 106a to the CCD camera 106c, and the imaging lens 106f); a fluorescent image capturing unit 108 which captures a fluorescent image of the sample 102 (the objective lens 108a to shutter 108f); and an the information communication terminal 110.
摘要翻译：本发明的目的是提供一种预定的现场发光测量方法和预定的现场发光测量装置，其允许确定当测量活样品中来自预定部位的发光时，光蛋白定位在预定位置与样品相同。本发明的预定位点发光测定装置100包括：融合融合基因导入到其中的样品102，所述融合基因除了靶向外，还融合表达荧光蛋白的荧光相关基因碱基序列和发光相关基因; 用于存储样品102的容器103，设置容器103的载物台104; 捕获样品102（物镜106a到CCD照相机106c和成像透镜106f）的发光图像的发光图像捕获单元106。捕获样品102（物镜108a至快门108f）的荧光图像的荧光图像捕获单元108; 和信息通信终端110。

3. 发明授权

US07986824B2 Predetermined site luminescence measuring method, predetermined site luminescence measuring apparatus, expression amount measuring method, and measuring apparatus 有权
标题翻译：预定位点发光测定方法，预定位点发光测定装置，表达量测定方法及测定装置
公开(公告)号：US07986824B2
公开(公告)日：2011-07-26
申请号：US11887468
申请日：2006-03-30
申请人： Hirobumi Suzuki , Yoko Ohashi , Kenji Kawasaki , Kiyotsugu Kojima , Kenichi Koyama , Akihiko Yoshikawa
发明人： Hirobumi Suzuki , Yoko Ohashi , Kenji Kawasaki , Kiyotsugu Kojima , Kenichi Koyama , Akihiko Yoshikawa
IPC分类号： G06K9/00
CPC分类号： G01N21/6428 , G01N21/6458 , G01N2021/6482 , G02B21/16 , G02B21/365
摘要： An object of the present invention is to provide a predetermined site luminescence measuring method and a predetermined site luminescence measuring apparatus, which allow for determining whether, when the luminescence from the predetermined site in live samples is measured, a photoprotein is localized at the predetermined site in the same ones as the samples. An predetermined site luminescence measuring apparatus 100 in the present invention is comprised of: a the sample 102 into which a fused fusion gene is introduced, the fusion gene being obtained by fusing a fluorescence-related gene that expresses a fluorescence protein in addition to a targeting base sequence and a luminescence-related gene; a container 103 for storing the sample 102, a stage 104 on which the container 103 is arranged; a luminescent image capturing unit 106 which captures a luminescent image of the sample 102 (the objective lens 106a to the CCD camera 106c, and the imaging lens 106f); a fluorescent image capturing unit 108 which captures a fluorescent image of the sample 102 (the objective lens 108a to shutter 108f); and an the information communication terminal 110.
摘要翻译：本发明的目的是提供一种预定的现场发光测量方法和预定的现场发光测量装置，其允许确定当测量活样品中来自预定部位的发光时，光蛋白定位在预定位置与样品相同。本发明的预定位点发光测定装置100包括：融合融合基因导入到其中的样品102，所述融合基因除了靶向外，还融合表达荧光蛋白的荧光相关基因碱基序列和发光相关基因; 用于存储样品102的容器103，设置容器103的载物台104; 捕获样品102（物镜106a到CCD照相机106c和成像透镜106f）的发光图像的发光图像捕获单元106。捕获样品102（物镜108a至快门108f）的荧光图像的荧光图像捕获单元108; 和信息通信终端110。

4. 发明申请

US20100227316A1 LUMINESCENSE MEASURING APPARATUS AND LUMINESCENSE MEASURING METHOD 审中-公开
标题翻译：光泽测量仪器和光度测量方法
公开(公告)号：US20100227316A1
公开(公告)日：2010-09-09
申请号：US12159198
申请日：2006-12-26
申请人： Hirobumi Suzuki , Yoko Ohashi , Chiaki Sato , Morinao Fukuoka , Akihiro Namba
发明人： Hirobumi Suzuki , Yoko Ohashi , Chiaki Sato , Morinao Fukuoka , Akihiro Namba
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： G01N21/6458 , G02B21/0088
摘要： There is provided a novel luminescence measuring apparatus that enables measuring a luminescence amount or a luminescence intensity from plural living biological samples, such as tissues, cells, and biological individuals, into which a gene expressing a luminescent protein has been introduced, individually for the respective biological samples. The inventive luminescence measuring apparatus comprises an image acquisition portion that acquires a luminescence image of biological samples; a measurement region determination portion that determines at least one measurement region in the luminescence image; and a luminescence measurement portion that measures the luminescence amount or luminescence intensity in the determined measurement region; thereby measuring the luminescence amount or luminescence intensity individually by the biological sample(s) included in the measurement region. Irrespective of an efficiency of transfer of a luminescent protein gene into a cell, etc., it becomes possible to execute a luminescence measurement successfully while observing only biological samples having a gene expression.
摘要翻译：提供了一种新颖的发光测量装置，其能够分别测量来自已经引入了表达发光蛋白质的基因的多个生物体生物样品（例如组织，细胞和生物个体）的发光量或发光强度生物样品。本发明的发光测量装置包括获取生物样品的发光图像的图像获取部分; 确定所述发光图像中的至少一个测量区域的测量区域确定部分; 以及测量所测定的测定区域的发光量或发光强度的发光测定部，从而通过测量区域中包含的生物样品分别测量发光量或发光强度。无论将发光蛋白质基因转移到细胞等中的效率如何，可以在仅观察具有基因表达的生物样品的同时成功地进行发光测定。

5. 发明授权

US08174686B2 Focal position determining method, focal position determining apparatus, feeble light detecting apparatus and feeble light detecting method 有权
标题翻译：焦点位置确定方法，焦点位置确定装置，微弱光检测装置和微弱光检测方法
公开(公告)号：US08174686B2
公开(公告)日：2012-05-08
申请号：US12058150
申请日：2008-03-28
申请人： Akihiro Namba , Hirobumi Suzuki , Hiroshi Ishiwata
发明人： Akihiro Namba , Hirobumi Suzuki , Hiroshi Ishiwata
IPC分类号： G01J1/00 , G01B9/00 , G01B11/14 , G02B7/04 , G02B27/40 , G02B27/64 , G03B3/00
CPC分类号： G01N21/6458 , G02B21/244 , G02B21/245
摘要： A focal position determining method determines a focal position of an objective lens focused on an observed target region in a specimen. The focal position determining method includes measuring any one of the focal position of the objective lens at a near point and the focal position of the objective lens at a far point or both so as to determine the focal position of the objective lens focused on the observed target region based on the measured focal position.
摘要翻译：焦点位置确定方法确定聚焦在样本中的观察目标区域上的物镜的焦点位置。焦点位置确定方法包括测量物体在近点处的焦点位置和物镜在远点处的焦点位置中的任何一个或两者，以便确定聚焦在观察到的物体上的物镜的焦点位置基于测量的焦点位置的目标区域。

6. 发明授权

US07630065B2 Low-light specimen image pickup unit and low-light specimen image pickup apparatus 有权
标题翻译：低光标本摄像单元和低光标本摄像装置
公开(公告)号：US07630065B2
公开(公告)日：2009-12-08
申请号：US11884822
申请日：2006-02-16
申请人： Hirobumi Suzuki , Shinichi Dosaka
发明人： Hirobumi Suzuki , Shinichi Dosaka
IPC分类号： G02B21/36 , G01N21/64 , G01N21/00
CPC分类号： G02B21/361 , G02B13/22 , G02B21/16 , H04N5/2254
摘要： In order to be able to take an image of a specimen emitting low light in a short exposure time by a cooled CCD at about 0° C., a low-light specimen image pickup unit has an imaging optical system forming a specimen image of a specimen having a point light source emitting a low light, and the low-light specimen image pickup unit further has an image pickup unit having a plurality of pixels receiving incident light, for taking an image corresponding to the specimen image. In the low-light specimen image pickup unit, the imaging optical system is telecentric to a side of the specimen image of the imaging optical system, and condenses the low light emitted from the point light source to form an Airy disk of a size which is substantially the same as a pixel of the pixels, or which is smaller than the pixel. Here, the pixel receives the low light emitted from the point light source.
摘要翻译：为了能够在约0℃下通过冷却的CCD拍摄在短曝光时间内发射低光的样本的图像，低光标本图像拾取单元具有成像光学系统，其形成一个具有发射低光的点光源的样本，并且所述低光标本摄像单元还具有具有接收入射光的多个像素的摄像单元，用于拍摄与所述标本图像相对应的图像。在低光标本摄像单元中，成像光学系统对成像光学系统的样本图像的一侧是远心的，并且将从点光源发射的低光会聚，形成尺寸为基本上与像素的像素相同，或者小于像素。这里，像素接收从点光源发出的低光。

7. 发明授权

US09287058B2 Accumulator device 有权
标题翻译：蓄电池装置
公开(公告)号：US09287058B2
公开(公告)日：2016-03-15
申请号：US14005472
申请日：2012-02-27
申请人： Nobuo Ando , Teruaki Tezuka , Yuu Watanabe , Makoto Taguchi , Kenji Kojima , Takashi Chiba , Hirobumi Suzuki
发明人： Nobuo Ando , Teruaki Tezuka , Yuu Watanabe , Makoto Taguchi , Kenji Kojima , Takashi Chiba , Hirobumi Suzuki
IPC分类号： H01G9/00 , H01G11/26 , H01G11/22 , H01M4/02 , H01M10/04 , H01M10/42 , H01G11/50 , H01G11/06 , H01G11/70 , H01M10/0525
CPC分类号： H01G11/26 , H01G11/06 , H01G11/22 , H01G11/50 , H01G11/70 , H01M4/02 , H01M10/0431 , H01M10/0525 , H01M10/42 , H01M2004/021 , H01M2010/4292 , Y02E60/13 , Y02T10/7011 , Y02T10/7022
摘要： An accumulator device which provides a high energy density and high output power is provided. The accumulator device (D) includes a positive electrode in which a positive electrode layer (A) is formed, a negative electrode in which a negative electrode layer (B) is formed, and an electrolytic solution (C). The accumulator device is characterized by satisfying that 1.02≦WA/WB≦2.08 and that 390 μm≦TA≦750 μm, where WA is the weight of the positive electrode layer (A), WB is the weight of the negative electrode layer (B), and TA is the thickness of the positive electrode in which the positive electrode layer (A) is formed.
摘要翻译：提供了提供高能量密度和高输出功率的蓄电池装置。蓄电装置（D）包括形成有正极层（A）的正电极，形成有负极层（B）的负极和电解液（C）。蓄电装置的特征在于满足1.02＆nlE; WA / WB＆nlE; 2.08以及390μm＆nlE; TA＆nlE;750μm，其中WA是正极层（A）的重量，WB是负极层的重量 B），TA是形成正极层（A）的正极的厚度。

8. 发明申请

US20100247446A1 METHOD AND SYSTEM FOR ANALYZING OPTICAL SIGNAL 审中-公开
标题翻译：用于分析光信号的方法和系统
公开(公告)号：US20100247446A1
公开(公告)日：2010-09-30
申请号：US12724795
申请日：2010-03-16
申请人： Hirobumi Suzuki
发明人： Hirobumi Suzuki
IPC分类号： A61K49/00 , C12Q1/68 , C12M3/00 , A61P43/00
CPC分类号： C12Q1/6897 , C12Q2523/313 , C12Q2563/103
摘要： The present invention is related to a method of analyzing an optical signal which analyzes a signal substance induced by a photosensitive protein, includes the steps of introducing a gene which expresses a luminescent probe to analyze the signal substance into an organism sample, emitting a stimulus light to activate the photosensitive protein, and detecting an optical signal emitted by the organism sample.
摘要翻译：本发明涉及一种分析由感光性蛋白质诱导的信号物质的光信号的分析方法，其特征在于，包括以下步骤：引入表达发光探针的基因，将信号物质分析成生物样品，发射刺激光激活感光性蛋白质，检测生物样品发出的光信号。

9. 发明申请

US20100173196A1 POLYMER COMPOSITION, PASTE FOR USE IN ELECTRODE FOR SECONDARY BATTERY, AND ELECTRODE FOR SECONDARY BATTERY 审中-公开
标题翻译：聚合物组合物，用于二次电池的电极中的电极和用于二次电池的电极
公开(公告)号：US20100173196A1
公开(公告)日：2010-07-08
申请号：US12729571
申请日：2010-03-23
申请人： Kazuaki Itou , Takeshi Mogi , Hirobumi Suzuki , Akira Nishikawa
发明人： Kazuaki Itou , Takeshi Mogi , Hirobumi Suzuki , Akira Nishikawa
IPC分类号： H01M4/62 , H01M4/90 , H01B1/12
CPC分类号： C08L27/16 , C08L33/06 , C08L33/14 , H01G11/38 , H01M4/621 , H01M4/623 , Y02E60/13 , C08L2666/04
摘要： A paste for a secondary battery electrode, comprising an electrode active material and a polymer composition comprising (a) a fluorine-containing polymer and (b) a functional group-containing polymer which contains a structural unit originating from an alkyl (meth)acrylate and a structural unit originating from at least one monomer selected from the group consisting of a sulfonic acid group-containing unsaturated monomer, an amide group-containing unsaturated monomer, and a sulfonic acid group and amide group-containing unsaturated monomer is provided.
摘要翻译：一种二次电池用电极用糊料，其特征在于，包含电极活性物质和聚合物组合物，所述聚合物组合物含有（a）含氟聚合物和（b）含有来自（甲基）丙烯酸烷基酯的结构单元的官能团聚合物，和提供了源自选自含磺酸基的不饱和单体，含酰胺基的不饱和单体和磺酸基团和含酰胺基的不饱和单体中的至少一种单体的结构单元。

10. 发明申请

US20090239147A1 POLYMER COMPOSITION, PASTE FOR USE IN ELECTRODE FOR SECONDARY BATTERY, AND ELECTRODE FOR SECONDARY BATTERY 审中-公开
标题翻译：聚合物组合物，用于二次电池的电极中的电极和用于二次电池的电极
公开(公告)号：US20090239147A1
公开(公告)日：2009-09-24
申请号：US12278095
申请日：2007-02-02
申请人： Kazuaki Itou , Takeshi Mogi , Hirobumi Suzuki , Akira Nishikawa
发明人： Kazuaki Itou , Takeshi Mogi , Hirobumi Suzuki , Akira Nishikawa
IPC分类号： H01M4/62 , C08L27/16 , H01B1/12
CPC分类号： C08L27/16 , C08L33/06 , C08L33/14 , H01G11/38 , H01M4/621 , H01M4/623 , Y02E60/13 , C08L2666/04
摘要： A polymer composition comprising (a) a fluorine-containing polymer and (b) a functional group-containing polymer which contains a structural unit originating from an alkyl (meth)acrylate and a structural unit originating from at least one monomer selected from the group consisting of a sulfonic acid group-containing unsaturated monomer, an amide group-containing unsaturated monomer, and a sulfonic acid group and amide group-containing unsaturated monomer is provided.
摘要翻译：一种聚合物组合物，其包含（a）含氟聚合物和（b）含官能团的聚合物，其含有源自（甲基）丙烯酸烷基酯的结构单元和来自至少一种选自以下的单体的结构单元：的含磺酸基的不饱和单体，含酰胺基的不饱和单体和磺酸基和含酰胺基的不饱和单体。

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