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    • 9. 发明授权
    • Production process of cross-linked polysuccinimide resin
    • 交联聚琥珀酰亚胺树脂的生产工艺
    • US06346569B1
    • 2002-02-12
    • US09514954
    • 2000-02-28
    • Yoshihiro IrizatoMakoto SukegawaToshio KatohHiroaki TamataniAkinori NagatomoMasaru Wada
    • Yoshihiro IrizatoMakoto SukegawaToshio KatohHiroaki TamataniAkinori NagatomoMasaru Wada
    • C08J324
    • C08G73/1092
    • A process is disclosed for producing with good productivity a cross-linked polyaspartic acid resin having biodegradability and high water absorbency. The process features inclusion of one of the following steps: (a) a polysuccinimide, which has been brought into a dispersed state by a dispersant, and a cross-linking agent are reacted to produce the cross-linked polyaspartic acid resin; (b) imide rings of a cross-linked polysuccinimide are subjected to a hydrolysis reaction while controlling a swelling degree of a resulting gel, whereby the cross-linked polyaspartic acid resin is produced; and (c) a gel of a cross-linked polysuccinimide, which has been obtained by reacting a cross-linking agent to a solution of a polysuccinimide in an organic solvent, is disintegrated to subject imide rings of the cross-linked polysuccinimide to a hydrolysis reaction, so that the cross-linked polyaspartic acid resin is produced. The process may also include one or both of the following steps as needed: (d) a gel of the cross-linked polyaspartic acid resin is washed with water and/or a water-miscible organic solvent; and (e) the polysuccinimide is produced using a basic amino acid as a cross-linking agent.
    • 公开了一种具有生物降解性和高吸水性的交联聚天冬氨酸树脂以高生产率生产的方法。 该方法包括以下步骤之一:(a)已经通过分散剂进入分散状态的聚琥珀酰亚胺和交联剂反应生成交联聚天冬氨酸树脂; (b)交联聚琥珀酰亚胺的酰亚胺环进行水解反应同时控制所得凝胶的溶胀度,从而制得交联聚天冬氨酸树脂; 和(c)通过使交联剂与聚琥珀酰亚胺在有机溶剂中的溶液反应而获得的交联聚琥珀酰亚胺的凝胶被分解以使交联的聚琥珀酰亚胺的酰亚胺环进行水解 反应,制成交联聚天冬氨酸树脂。 该方法还可以根据需要包括以下步骤中的一种或两种:(d)用水和/或水混溶性有机溶剂洗涤交联聚天冬氨酸树脂的凝胶; 和(e)使用碱性氨基酸作为交联剂制备聚琥珀酰亚胺。