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    • 7. 发明申请
    • THERAPEUTIC AGENT FOR CANCER, AND METHOD FOR DETERMINING PROGNOSIS OF CANCER
    • 癌症治疗剂及确定癌症预防方法
    • US20140335090A1
    • 2014-11-13
    • US14009026
    • 2012-03-30
    • Soken TsuchiyaGozoh TsujimotoKazuharu ShimizuYutaka ShimadaKazuhiro Tsukada
    • Soken TsuchiyaGozoh TsujimotoKazuharu ShimizuYutaka ShimadaKazuhiro Tsukada
    • C07K16/28G01N33/574
    • C07K16/2863C07K16/30C07K2317/24C07K2317/34C07K2317/73G01N33/57407G01N33/57446G01N2333/71G01N2800/52
    • Disclosed are a novel therapeutic agent for cancer such as esophageal squamous cell carcinoma, a method for predicting the prognosis of cancer, and a method for detecting, or predicting the prognosis of, cancer such as esophageal squamous cell carcinoma using a sample that can be collected less invasively. The therapeutic agent for cancer comprises as an effective component an antibody that undergoes antigen-antibody reaction with FGFRL1 to suppress the growth of cancer cells, or an antigen-binding fragment thereof. The method for predicting the prognosis of cancer comprises investigating the expression level of FGFRL1 in a cancer tissue separated from a living body, and, in this method, a high expression level of FGFRL1 indicates poor prognosis. The method for detecting cancer comprises measuring FGFRL1 or a fragment thereof extracted from a body tissue, or FGFRL1 or a fragment thereof in blood separated from a living body, and, in this method, a higher concentration of FGFRL1 or the fragment thereof contained therein than the concentration of FGFRL1 or the fragment thereof in the tissue or blood of a healthy individual indicates the presence of cancer.
    • 公开了一种用于癌症的新型治疗剂,例如食管鳞状细胞癌,预测癌症预后的方法,以及使用可以收集的样品来检测或预测癌症如食管鳞状细胞癌的预后的方法 较少侵略 癌症治疗剂包括与FGFRL1进行抗原抗体反应以抑制癌细胞生长的抗体或其抗原结合片段作为有效成分。 用于预测癌症预后的方法包括研究从活体分离的癌组织中FGFRL1的表达水平,并且在该方法中,FGFRL1的高表达水平表示不良预后。 用于检测癌症的方法包括测量从活体分离的血液中从身体组织提取的FGFRL1或其片段或FGFRL1或其片段,并且在该方法中,FGFRL1或其片段含有的浓度高于 健康个体的组织或血液中的FGFRL1或其片段的浓度表示存在癌症。