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    • 8. 发明授权
    • Methods of fabricating a collagen lenticule precursor for modifying the
cornea
    • 制造用于修饰角膜的胶原微透镜前体的方法
    • US5288436A
    • 1994-02-22
    • US855367
    • 1992-03-20
    • Yung S. LiuKeith P. ThompsonRaymond P. GailitisSeth R. BanksGary C. Taylor
    • Yung S. LiuKeith P. ThompsonRaymond P. GailitisSeth R. BanksGary C. Taylor
    • A61F2/14B29D11/00B29D11/02
    • B29D11/00009A61F2/14A61F2/142A61L27/24B29D11/00105B29D11/023
    • A lenticule is bonded to the eye as part of its formation process by curing or final curing the lenticule on the eye. Such lenticules provide a smooth transition from the body of the lenticule to Bowman's layer on which the lenticule is disposed. The lenticule at the time its material or precursor is placed on the eye may vary from being essentially all viscous collagen which flows and must be molded to obtain a desired lenticule configuration to a substantially stable preform which holds its own shape. Such preformed lenticules may be formed using an appropriate mold and photopolymerization or other partial curing techniques to pre-cure the lenticule material to an appropriate stage for application to the eye. In one method, such a partially cured lenticule precursor is formed in layers by depositing a quantity of curable viscous collagen in an anterior surface mold, partially curing the viscous collagen, and repeatedly depositing and partially curing subsequent collagen layers until a preform having a desired thickness has been formed.
    • 通过固化或最终固化眼睛上的微透镜将微透镜结合到眼睛,作为其形成过程的一部分。 这种微透镜提供从微透镜的主体到设置有微透镜的Bowman层的平滑过渡。 当它的材料或前体放置在眼睛上时,微透镜可能与基本上所有流动并且必须模制的粘性胶原变化,以获得所需的微透镜结构到保持其自身形状的基本稳定的预成型件。 可以使用适当的模具和光聚合或其它部分固化技术来形成这种预制的微透镜,以将微透镜材料预固化到适用于眼睛的阶段。 在一种方法中,通过在前表面模具中沉积一定量的可固化粘性胶原蛋白,部分固化粘性胶原蛋白,并重复沉积和部分固化后续胶原蛋白层,直到形成具有所需厚度的预制件,从而形成这种部分固化的微透镜前体 已经形成。