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1. 发明授权

US4360682A Stabilizing caprolactones with dihydroxybenzenes 失效
标题翻译：用二羟基苯稳定己内酯
公开(公告)号：US4360682A
公开(公告)日：1982-11-23
申请号：US148869
申请日：1980-05-12
申请人： Herbert Klenk , Rolf Wirthwein , Helmut Waldmann , Hermann Seifert
发明人： Herbert Klenk , Rolf Wirthwein , Helmut Waldmann , Hermann Seifert
IPC分类号： C07D313/04 , C07D315/00
CPC分类号： C07D315/00
摘要： Caprolactones such as .epsilon.-caprolactone are stabilized against discoloration with dihydroxybenzenes such as hydroquinone or compounds of the formula ##STR1## in which R.sub.1 is alkyl of 1 to 8 carbon atoms, andR.sub.2 is hydrogen or alkyl of 1 to 8 carbon atoms.Even the presence of air is not detrimental.
摘要翻译：己内酯如ε-己内酯通过二羟基苯如氢醌或其中R 1为1至8个碳原子的烷基，且R 2为氢或1至8个碳原子的烷基的式“IMAGE”的化合物稳定化。即使空气的存在也不是有害的。

2. 发明授权

US4341709A Preparation of .epsilon.-caprolactone 失效
标题翻译： ε-己内酯的制备
公开(公告)号：US4341709A
公开(公告)日：1982-07-27
申请号：US150260
申请日：1980-05-15
申请人： Willi Hofen , Herbert Klenk , Gerd Schreyer , Otto Weiberg , Helmut Waldmann , Hermann Seifert , Karl-Hermann Reissinger , Wolfgang Swodenk
发明人： Willi Hofen , Herbert Klenk , Gerd Schreyer , Otto Weiberg , Helmut Waldmann , Hermann Seifert , Karl-Hermann Reissinger , Wolfgang Swodenk
IPC分类号： C07D313/04 , C07D315/00 , C07D313/02
CPC分类号： C07D315/00
摘要： A process for the preparation of .epsilon.-caprolactone comprising:(a) reacting cyclohexanone with a solution of perpropionic acid in an organic solvent at a molar ratio of cyclohexanone;perpropionic acid of about 1.1-5:1 at a temperature of about 10.degree. to 80.degree. C. to form a reaction mixture consisting essentially of .epsilon.-caprolactone, propionic acid and organic solvent,(b) distilling the reaction mixture from (a) in a first distillation unit to obtain a distillate comprising the organic solvent and a distillation residue,(c) introducing the distillation residue from (b) at a point into a second distillation unit to obtain a distillate comprising propionic acid and unreacted cyclohexanone, removing from the second distillation unit, separately from one another and at a point below the point of introduction into the second distillation unit, .epsilon.-caprolactone and any high-boiling constituents, and,(d) distilling in a third distillation unit the distillate from (c) to obtain a distillate consisting essentially of propionic acid and a distillation residue comprising a mixture of propionic acid and cyclohexanone.
摘要翻译：一种制备ε-己内酯的方法，包括：（a）使环己酮与过丙酸在有机溶剂中的溶液以环己酮的摩尔比约1.1-5:1的约0.1〜5:1的摩尔比在约10℃〜形成基本上由ε-己内酯，丙酸和有机溶剂组成的反应混合物，（b）在第一蒸馏单元中将反应混合物从（a）中蒸馏，得到包含有机溶剂和蒸馏残余物的馏出物（c）在一点将来自（b）的蒸馏残余物引入第二蒸馏单元以获得包含丙酸和未反应的环己酮的馏出物，从第二蒸馏单元彼此分离并在低于引入第二蒸馏装置，ε-己内酯和任何高沸点组分，和（d）在第三蒸馏装置中蒸馏出馏出物（c）得到基本上由丙酸组成的馏出物和包含丙酸和环己酮的混合物的蒸馏残渣。

3. 发明授权

US4313879A Process for the manufacture of very pure .epsilon.-caprolactone 失效
标题翻译：用于制造非常纯的ε-己内酯的方法
公开(公告)号：US4313879A
公开(公告)日：1982-02-02
申请号：US179622
申请日：1980-08-20
申请人： Herbert Klenk , Rolf Wirthwein , Gerd Siekmann , Wulf Schwerdtel
发明人： Herbert Klenk , Rolf Wirthwein , Gerd Siekmann , Wulf Schwerdtel
IPC分类号： C07D313/04 , C07D315/00
CPC分类号： C07D315/00
摘要： The invention relates to a process for the production of .epsilon.-caprolactone having a purity of 99.9% and increased color and storage stability which comprises feeding .epsilon.-caprolactone, which has been made by reacting cyclohexanone with a solution of a percarboxylic acid, into a first distillation unit, operating at 0.1 to 500 mbars and drawing off as the top product a mixture consisting of .epsilon.-caprolactone and lower-boiling impurities, feeding the bottom product of said first distillation unit into a second distillation unit, operating at 0.1 to 500 mbars and then drawing off the pure .epsilon.-caprolactone as the top product. The .epsilon.-caprolactone is useful as an intermediate for the production of known useful compounds such as polyesterols which are subsequently converted to polyurethanes.
摘要翻译：本发明涉及一种生产纯度为99.9％，颜色和储存稳定性提高的ε-己内酯的方法，包括将环己酮与过羧酸反应制得的ε-己内酯进料到第一蒸馏单元，操作为0.1至500mbar，并作为顶部产物抽出由ε-己内酯和低沸点杂质组成的混合物，将所述第一蒸馏单元的底部产物进料到第二蒸馏单元中，操作为0.1至500mbar 然后取出纯ε-己内酯作为顶级产品。 ε-己内酯可用作生产已知有用化合物如聚酯的中间体，随后将其转化为聚氨酯。

4. 发明授权

US5455264A RS-thioctic acid with novel morphology 失效
标题翻译： RS-硫辛酸具有新颖的形态
公开(公告)号：US5455264A
公开(公告)日：1995-10-03
申请号：US134695
申请日：1993-10-12
申请人： Thomas Beisswenger , Horst Bethge , Joachim Goede , Frank Hubner , Klaus Huthmacher , Herbert Klenk , Roland Moller
发明人： Thomas Beisswenger , Horst Bethge , Joachim Goede , Frank Hubner , Klaus Huthmacher , Herbert Klenk , Roland Moller
IPC分类号： C07D339/04 , A61K31/385
CPC分类号： C07D339/04
摘要： RS-thioctic acid with a novel morphology which is obtained by a recrystallization process.
摘要翻译：具有通过重结晶过程获得的新型形态的RS-硫辛酸。

5. 发明授权

US4326056A Process for the production of 4-amino-6-tert. butyl-3-mercapto-1,2,4-triazin-5-one 失效
标题翻译：制备4-氨基-6-叔丁氧基羰基的方法。丁基-3-巯基-1,2,4-三嗪-5-酮
公开(公告)号：US4326056A
公开(公告)日：1982-04-20
申请号：US266147
申请日：1981-05-22
申请人： Axel Kleemann , Bernd Lehamnn , Herbert Klenk
发明人： Axel Kleemann , Bernd Lehamnn , Herbert Klenk
IPC分类号： C07D253/06 , C07D253/075
CPC分类号： C07D253/075
摘要： 4-amino-6-tert.butyl-3-mercapto-1,2,4-triazin-5-one of the formula ##STR1## is produced by reacting pivaloyl cyanide and isobutylene in the presence of acetic acid and sulfuric acid, hydrolyzing the reaction mixture in the presence of water and reacting the trimethyl pyruvic acid formed with thiocarbohydrazide. The triazinone is an important intermediate product in the synthesis of the known herbicide 4-amino-6-tert.butyl-3-methylmercapto-1,2,4-triazin-5-one.
摘要翻译：通过在乙酸和硫酸的存在下使新戊酰氰和异丁烯反应制备式“IMAGE”的4-氨基-6-叔丁基-3-巯基-1,2,4-三嗪-5-酮，水解反应混合物在水存在下反应，并与硫代碳酰肼形成的三甲基丙酮酸反应。三嗪酮是合成已知除草剂4-氨基-6-叔丁基-3-甲基巯基-1,2,4-三嗪-5-酮的重要中间产物。

6. 发明授权

US5760268A Production and use of salts of 6, 8-bis (amidiniumthio) -octanoic acid 失效
标题翻译：制备和使用6,8-双（脒硫代） - 辛酸的盐
公开(公告)号：US5760268A
公开(公告)日：1998-06-02
申请号：US786053
申请日：1997-01-21
申请人： Thomas Beisswenger , Rainer Gewald , Alfred Olbrich , Horst Bethge , Frank Hubner , Klaus Huthmacher , Herbert Klenk , Roland Moller , Stephan Rautenberg , Gerhard Sator
发明人： Thomas Beisswenger , Rainer Gewald , Alfred Olbrich , Horst Bethge , Frank Hubner , Klaus Huthmacher , Herbert Klenk , Roland Moller , Stephan Rautenberg , Gerhard Sator
IPC分类号： C07C319/02 , C07C323/52 , C07C335/32 , C07D339/04
CPC分类号： C07D339/04 , C07C319/02 , C07C335/32
摘要： The invention relates to the production and purification of salts of 6,8-bis(amidiniumthio) octanoic acid, its enantiomers (+)-6,8-bis(amidiniumthio)octanoic acid and (-)-6,8-bis (amidiniumthio)octanoic acid and of the esters of these compounds as well as to their use to produce dihydrolipoic acid and .alpha.-lipoic acid.
摘要翻译：本发明涉及6,8-双（脒硫）辛酸及其对映体（+） - 6,8-双（脒硫）辛酸和（ - ） - 6,8-双（脒硫））辛酸和这些化合物的酯，以及它们用于产生二氢硫辛酸和α-硫辛酸的用途。

7. 发明授权

US5426249A Process for the simultaneous production of 1,2- and 1,3-propanediol 失效
标题翻译：同时生产1,2-和1,3-丙二醇的方法
公开(公告)号：US5426249A
公开(公告)日：1995-06-20
申请号：US151389
申请日：1993-11-12
申请人： Thomas Haas , Armin Neher , Dietrich Arntz , Herbert Klenk , Walter Girke
发明人： Thomas Haas , Armin Neher , Dietrich Arntz , Herbert Klenk , Walter Girke
IPC分类号： C07C31/20 , C07C29/136 , C07C29/141 , C07C29/145 , C07C45/52 , C07C45/64 , C07C47/22 , C07C49/17
CPC分类号： C07C29/141 , C07C29/145 , C07C45/52 , C07C45/64 , Y02P20/52
摘要： A process is described for the simultaneous production of 1,2- and 1,3-propanediol from glycerol. The process involves the reaction stages (a) dehydration of glycerol by feeding a gaseous glycerol-water mixture with 10 to 40 wt % glycerol at 250.degree. to 340.degree. C. over a solid catalyst with an H.sub.0 value (Hammett acidity function) of less than 2, preferably between -3 and -8.2, (b) hydration of the acrolein contained in the reaction mixture of stage (a), and (c) catalytic hydrogenation of the reaction mixture, containing 3-hydroxypropionaldehyde and hydroxyacetone, of stage (b). Two valuable products, namely 1,2- and 1,3-propanediol, can be obtained simultaneously and in high total yield from glycerol in a simple process.
摘要翻译：描述了从甘油同时生产1,2-和1,3-丙二醇的方法。该方法包括反应阶段（a）通过在250℃至340℃下通过在H 2值（哈米特酸度函数）较小的固体催化剂上加入含有10至40重量％甘油的气态甘油 - 水混合物来脱水甘油（b）使步骤（a）的反应混合物中所含的丙烯醛水合，（c）含有3-羟基丙醛和羟基丙酮的反应混合物的催化氢化 b）。两个有价值的产物，即1,2-和1,3-丙二醇，可以在一个简单的过程中同时获得，并以高的总收率由甘油获得。

8. 发明授权

US4914208A Optically active salts of a substituted thiazolidine-4-carboxylate and 3-chloro-2-hydroxypropyltrimethyl ammonium, their preparation and use 失效
标题翻译：取代噻唑烷-4-羧酸酯和3-氯-2-羟丙基三甲基铵的光学活性盐，其制备和用途
公开(公告)号：US4914208A
公开(公告)日：1990-04-03
申请号：US262722
申请日：1988-10-17
申请人： Harald Jakob , Klaus Huthmacher , Herbert Klenk , Axel Kleemann , Gunes Giray
发明人： Harald Jakob , Klaus Huthmacher , Herbert Klenk , Axel Kleemann , Gunes Giray
IPC分类号： C07B57/00 , C07C67/00 , C07C213/00 , C07C213/04 , C07C215/40 , C07D277/06
CPC分类号： C07C215/40 , C07D277/06
摘要： The invention relates to the preparation of optically active salts of the general formula ##STR1## from which the corresponding optically active 3-chloro-2-hydroxypropyltrimethyl ammonium chloride can be obtained by treatment with mineral acid.The L(-) form of this compound is a valuable component for the synthesis of L(-) carnitine.
摘要翻译：本发明涉及制备通式（I）的光学活性盐，通过用无机酸处理可得到相应的光学活性3-氯-2-羟丙基三甲基氯化铵。该化合物的L（ - ）形式是合成L（ - ）肉碱的有价值的成分。

9. 发明授权

US4716247A Process for the production of thiosemicarbazide 失效
标题翻译：硫代氨基脲生产工艺
公开(公告)号：US4716247A
公开(公告)日：1987-12-29
申请号：US462973
申请日：1983-02-01
申请人： Axel Kleemann , Herbert Klenk , Wolfgang Schulz
发明人： Axel Kleemann , Herbert Klenk , Wolfgang Schulz
IPC分类号： C07C337/06 , C01B21/093 , C01C3/20 , C07C67/00 , C07C325/00 , C07C159/00
CPC分类号： C07C331/02 , C07C335/40 , C07C337/06
摘要： To produce thiosemicarbazide hydrazine is reacted with hydrogen cyanide and sulfur to form hydrazine thiocyanate, and this is then converted into the thiosemicarbazide at an elevated temperature. Advantageously, the reaction is carried out in a polar solvent.
摘要翻译：将氨基硫脲肼与氰化氢和硫反应形成硫氰酸肼，然后在升高的温度下将其转化为氨基硫脲。有利地，反应在极性溶剂中进行。

10. 发明授权

US4117008A Process for the production of benzoyl cyanide (II) 失效
标题翻译：苄基氰化物（Ⅱ）生产方法
公开(公告)号：US4117008A
公开(公告)日：1978-09-26
申请号：US802945
申请日：1977-06-02
申请人： Herbert Klenk , Heribert Offermanns
发明人： Herbert Klenk , Heribert Offermanns
IPC分类号： C07C255/40 , C07C20060101 , C07C63/06 , C07C67/00 , C07C253/00 , C07C253/16 , C07C255/56
CPC分类号： C07C253/16
摘要： Benzoyl cyanide is made by reacting benzoic anhydride with an alkali cyanide in an inert organic solvent.

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