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1. 发明授权

US09266962B2 Amino acid sequence presenting fusion polypeptide and its use 有权
标题翻译：氨基酸序列呈现融合多肽及其用途
公开(公告)号：US09266962B2
公开(公告)日：2016-02-23
申请号：US14112108
申请日：2012-05-04
申请人： Herbert Andres , David Casagolda Vallribera , Hartmut Duefel , Michael Gerg , Christian Scholz , Michael Schraeml
发明人： Herbert Andres , David Casagolda Vallribera , Hartmut Duefel , Michael Gerg , Christian Scholz , Michael Schraeml
IPC分类号： A61K39/00 , C07K16/40 , C07K16/22 , C12N9/90 , C07K16/12 , G01N33/74 , G01N33/573
CPC分类号： C07K16/22 , C07K14/475 , C07K14/65 , C07K16/1203 , C07K16/40 , C07K2317/34 , C07K2317/565 , C07K2317/92 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/23 , C07K2319/24 , C07K2319/35 , C07K2319/41 , C07K2319/43 , C12N9/90 , C12Y502/01008 , G01N33/573 , G01N33/74 , G01N2333/99
摘要： Herein is reported a fusion polypeptide according to formula (I): NH2—S2—X1—S1—COOH, wherein X1 comprises either a random amino acid sequence or an amino acid sequence derived from a first polypeptide, S2 and S1 are non-overlapping amino acid sequences derived from a second polypeptide, and denotes a peptide bond, wherein the second polypeptide is a polypeptide with peptidyl-prolyl cis/trans-isomerase activity (PPIase activity) or is derived from the FKBP-fold domain family, wherein X1 is inserted in place of the insert-in-flap-domain of the second polypeptide.
摘要翻译：本文报道了根据式（I）的融合多肽：NH2-S2-X1-S1-COOH，其中X1包含随机氨基酸序列或衍生自第一多肽的氨基酸序列，S2和S1不重叠衍生自第二多肽的氨基酸序列，并且表示肽键，其中第二多肽是具有肽基 - 脯氨酰顺/反异构酶活性（PPIase活性）或衍生自FKBP-折叠域家族的多肽，其中X1是插入第二多肽的插入片段结构域。

2. 发明申请

US20140178393A1 AMINO ACID SEQUENCE PRESENTING FUSION POLYPEPTIDE AND ITS USE 有权
标题翻译：氨基酸序列显示融合多肽及其用途
公开(公告)号：US20140178393A1
公开(公告)日：2014-06-26
申请号：US14112108
申请日：2012-05-04
申请人： Herbert Andres , David Casagolda Vallribera , Hartmut Duefel , Michael Gerg , Christian Scholz , Michael Schraeml
发明人： Herbert Andres , David Casagolda Vallribera , Hartmut Duefel , Michael Gerg , Christian Scholz , Michael Schraeml
IPC分类号： C12N9/90 , G01N33/573 , C07K16/40
CPC分类号： C07K16/22 , C07K14/475 , C07K14/65 , C07K16/1203 , C07K16/40 , C07K2317/34 , C07K2317/565 , C07K2317/92 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/23 , C07K2319/24 , C07K2319/35 , C07K2319/41 , C07K2319/43 , C12N9/90 , C12Y502/01008 , G01N33/573 , G01N33/74 , G01N2333/99
摘要： Herein is reported a fusion polypeptide according to formula (I): NH2—S2—X1—S1—COOH, wherein X1 comprises either a random amino acid sequence or an amino acid sequence derived from a first polypeptide, S2 and S1 are non-overlapping amino acid sequences derived from a second polypeptide, and denotes a peptide bond, wherein the second polypeptide is a polypeptide with peptidyl-prolyl cis/trans-isomerase activity (PPIase activity) or is derived from the FKBP-fold domain family, wherein X1 is inserted in place of the insert-in-flap-domain of the second polypeptide.
摘要翻译：本文报道了根据式（I）的融合多肽：NH2-S2-X1-S1-COOH，其中X1包含随机氨基酸序列或衍生自第一多肽的氨基酸序列，S2和S1不重叠衍生自第二多肽的氨基酸序列，并且表示肽键，其中第二多肽是具有肽基 - 脯氨酰顺/反异构酶活性（PPIase活性）或衍生自FKBP-折叠域家族的多肽，其中X1是插入第二多肽的插入片段结构域。

3. 发明申请

US20050181358A1 Soluble complex comprising a retroviral surface glycoprotein 有权
标题翻译：包含逆转录病毒表面糖蛋白的可溶性复合物
公开(公告)号：US20050181358A1
公开(公告)日：2005-08-18
申请号：US11088599
申请日：2005-03-24
申请人： Christian Scholz , Herbert Andres , Elke Faatz , Alfred Engel , Dorothea Sizmann
发明人： Christian Scholz , Herbert Andres , Elke Faatz , Alfred Engel , Dorothea Sizmann
IPC分类号： A61K39/00 , A61K47/48 , C07K14/16 , C12N9/90 , G01N33/543 , G01N33/569 , C12Q1/70 , C12P21/06
CPC分类号： G01N33/56988 , A61K39/00 , A61K47/64 , C07K14/005 , C07K2319/00 , C12N9/90 , C12N2740/16122 , G01N33/54306 , G01N33/56911 , G01N33/56983 , G01N2333/005 , G01N2333/16 , G01N2333/195 , G01N2469/20 , G01N2800/2821
摘要： The present invention relates to the diagnosis of HIV infections. It especially teaches the production of a soluble retroviral surface glycoprotein-(or transmembrane glycoprotein)-chaperone complex and the advantageous use of a chaperone-antigen complex especially in the detection of antibodies to HIV in immunoassays, preferably according to the double antigen bridge concept, or as an immunogen. The invention also discloses soluble complexes comprising a variant of HIV-1 gp41 or a variant of HIV-2 gp36, respectively, and a chaperone selected from the peptidyl-prolyl-isomerase class of chaperones. Variants comprising specific amino-acid substitutions in the N-helical domain of HIV-1 gp41 or of HIV-2 gp36, respectively, are also described.
摘要翻译：本发明涉及HIV感染的诊断。特别是教导了可溶性逆转录病毒表面糖蛋白（或跨膜糖蛋白） - 辅助复合物的产生，并且优选地根据双抗原桥概念，优选使用伴侣 - 抗原复合物，特别是在免疫测定中检测HIV抗体中，或作为免疫原。本发明还公开了分别包含HIV-1 gp41的变体或HIV-2 gp36的变体的可溶性复合物，以及选自分子伴侣的肽基 - 脯氨酰基异构酶类的伴侣。还描述了分别在HIV-1 gp41或HIV-2 gp36的N-螺旋结构域中包含特异性氨基酸取代的变体。

4. 发明授权

US07244819B2 Fusion polypeptides, vaccines and compositions of FKBP chaperones and target polypeptides 有权
标题翻译：融合多肽，疫苗和FKBP伴侣和靶多肽的组合物
公开(公告)号：US07244819B2
公开(公告)日：2007-07-17
申请号：US10179038
申请日：2002-06-24
申请人： Christian Scholz , Herbert Andres , Elke Faatz , Alfred Engel , Urban Schmitt , Ariuna Bazarsuren , Peter Schaarschmidt
发明人： Christian Scholz , Herbert Andres , Elke Faatz , Alfred Engel , Urban Schmitt , Ariuna Bazarsuren , Peter Schaarschmidt
IPC分类号： C01K1/00
CPC分类号： G01N33/56988 , A61K39/00 , A61K47/64 , C07K14/005 , C07K2319/00 , C12N9/90 , C12N2740/16122 , G01N33/54306 , G01N33/56911 , G01N33/56983 , G01N2333/005 , G01N2333/16 , G01N2333/195 , G01N2469/20
摘要： The present invention relates to the cloning and expression of foreign protein or polypeptides in bacteria, such as Escherichia coli. In particular, this invention relates to expression tools comprising a FKBP-type peptidyl prolyl isomerase selected from the group consisting of FkpA, SlyD, and trigger factor; methods of recombinant protein expression, the recombinant polypeptides thus obtained, as well as to the use of such polypeptides.
摘要翻译：本发明涉及在细菌如大肠杆菌中克隆和表达外源蛋白质或多肽。特别地，本发明涉及包含选自FkpA，SlyD和触发因子的FKBP型肽基脯氨酰异构酶的表达工具; 重组蛋白表达的方法，如此获得的重组多肽，以及这些多肽的用途。

5. 发明授权

US08426167B2 Methods for producing fusion polypeptides or enhancing expression of fusion polypeptides 有权
公开(公告)号：US08426167B2
公开(公告)日：2013-04-23
申请号：US11786847
申请日：2007-04-13
申请人： Christian Scholz , Herbert Andres , Elke Faatz , Alfred Engel , Urban Schmitt , Ariuna Bazarsuren , Peter Schaarschmidt
发明人： Christian Scholz , Herbert Andres , Elke Faatz , Alfred Engel , Urban Schmitt , Ariuna Bazarsuren , Peter Schaarschmidt
IPC分类号： C12P21/04
CPC分类号： G01N33/56988 , A61K39/00 , A61K47/64 , C07K14/005 , C07K2319/00 , C12N9/90 , C12N2740/16122 , G01N33/54306 , G01N33/56911 , G01N33/56983 , G01N2333/005 , G01N2333/16 , G01N2333/195 , G01N2469/20
摘要： The present invention relates to the cloning and expression of foreign protein or polypeptides in bacteria, such as Escherichia coli. In particular, this invention relates to expression tools comprising a FKBP-type peptidyl prolyl isomerase selected from the group consisting of FkpA, SlyD, and trigger factor; methods of recombinant protein expression, the recombinant polypeptides thus obtained, as well as to the use of such polypeptides.

6. 发明申请

US20090028893A1 Methods for producing fusion polypeptides or enhancing expression of fusion polypeptides 有权
标题翻译：用于产生融合多肽或增强融合多肽表达的方法
公开(公告)号：US20090028893A1
公开(公告)日：2009-01-29
申请号：US11786847
申请日：2007-04-13
申请人： Christian Scholz , Herbert Andres , Elke Faatz , Alfred Engel , Urban Schmitt , Ariuna Bazarsuren , Peter Schaarschmidt
发明人： Christian Scholz , Herbert Andres , Elke Faatz , Alfred Engel , Urban Schmitt , Ariuna Bazarsuren , Peter Schaarschmidt
IPC分类号： A61K39/00 , C12P21/02
CPC分类号： G01N33/56988 , A61K39/00 , A61K47/64 , C07K14/005 , C07K2319/00 , C12N9/90 , C12N2740/16122 , G01N33/54306 , G01N33/56911 , G01N33/56983 , G01N2333/005 , G01N2333/16 , G01N2333/195 , G01N2469/20
摘要： The present invention relates to the cloning and expression of foreign protein or polypeptides in bacteria, such as Escherichia coli. In particular, this invention relates to expression tools comprising a FKBP-type peptidyl prolyl isomerase selected from the group consisting of FkpA, SlyD, and trigger factor; methods of recombinant protein expression, the recombinant polypeptides thus obtained, as well as to the use of such polypeptides.
摘要翻译：本发明涉及在细菌如大肠杆菌中克隆和表达外源蛋白质或多肽。特别地，本发明涉及包含选自FkpA，SlyD和触发因子的FKBP型肽基脯氨酰异构酶的表达工具; 重组蛋白表达的方法，如此获得的重组多肽，以及这些多肽的用途。

7. 发明授权

US06962982B2 Soluble complexes of target proteins and peptidyl prolyl isomerase chaperones and methods of making and using them 有权
标题翻译：靶蛋白和肽基脯氨酰异构酶伴侣的可溶性复合物及其制备和使用方法
公开(公告)号：US06962982B2
公开(公告)日：2005-11-08
申请号：US10179905
申请日：2002-06-24
申请人： Christian Scholz , Herbert Andres , Elke Faatz , Alfred Engel , Dorothea Sizmann
发明人： Christian Scholz , Herbert Andres , Elke Faatz , Alfred Engel , Dorothea Sizmann
IPC分类号： A61K39/00 , A61K47/48 , C07K14/16 , C12N9/90 , G01N33/543 , G01N33/569 , A61K38/24 , C07K14/00
CPC分类号： G01N33/56988 , A61K39/00 , A61K47/64 , C07K14/005 , C07K2319/00 , C12N9/90 , C12N2740/16122 , G01N33/54306 , G01N33/56911 , G01N33/56983 , G01N2333/005 , G01N2333/16 , G01N2333/195 , G01N2469/20 , G01N2800/2821
摘要： The present invention relates to the diagnosis of HIV infections. It especially teaches the production of a soluble retroviral surface glycoprotein- (or transmembrane glycoprotein)-chaperone complex and the advantageous use of a chaperone-antigen complex especially in the detection of antibodies to HIV in immunoassays, preferably according to the double antigen bridge concept, or as an immunogen. The invention also discloses soluble complexes comprising a variant of HIV-1 gp41 or a variant of HIV-2 gp36, respectively, and a chaperone selected from the peptidyl-prolyl-isomerase class of chaperones. Variants comprising specific amino-acid substitutions in the N-helical domain of HIV-1 gp41 or of HIV-2 gp36, respectively, are also described.
摘要翻译：本发明涉及HIV感染的诊断。特别是教导了可溶性逆转录病毒表面糖蛋白（或跨膜糖蛋白） - 辅助复合物的产生，并且优选地根据双抗原桥概念，优选使用伴侣 - 抗原复合物，特别是在免疫测定中检测HIV抗体中，或作为免疫原。本发明还公开了分别包含HIV-1 gp41的变体或HIV-2 gp36的变体的可溶性复合物，以及选自分子伴侣的肽基 - 脯氨酰基异构酶类的伴侣。还描述了分别在HIV-1 gp41或HIV-2 gp36的N-螺旋结构域中包含特异性氨基酸取代的变体。

8. 发明授权

US07244575B2 Soluble complex comprising a retroviral surface glycoprotein 有权
标题翻译：包含逆转录病毒表面糖蛋白的可溶性复合物
公开(公告)号：US07244575B2
公开(公告)日：2007-07-17
申请号：US11088599
申请日：2005-03-24
申请人： Christian Scholz , Herbert Andres , Elke Faatz , Alfred Engel , Dorothea Sizmann
发明人： Christian Scholz , Herbert Andres , Elke Faatz , Alfred Engel , Dorothea Sizmann
IPC分类号： C07K14/00 , G01N33/53
CPC分类号： G01N33/56988 , A61K39/00 , A61K47/64 , C07K14/005 , C07K2319/00 , C12N9/90 , C12N2740/16122 , G01N33/54306 , G01N33/56911 , G01N33/56983 , G01N2333/005 , G01N2333/16 , G01N2333/195 , G01N2469/20 , G01N2800/2821
摘要： The present invention relates to the diagnosis of HIV infections. It especially teaches the production of a soluble retroviral surface glycoprotein-(or transmembrane glycoprotein)-chaperone complex and the advantageous use of a chaperone-antigen complex especially in the detection of antibodies to HIV in immunoassays, preferably according to the double antigen bridge concept, or as an immunogen. The invention also discloses soluble complexes comprising a variant of HIV-1 gp41 or a variant of HIV-2 gp36, respectively, and a chaperone selected from the peptidyl-prolyl-isomerase class of chaperones. Variants comprising specific amino-acid substitutions in the N-helical domain of HIV-1 gp41 or of HIV-2 gp36, respectively, are also described.
摘要翻译：本发明涉及HIV感染的诊断。它特别教导了可溶性逆转录病毒表面糖蛋白（或跨膜糖蛋白） - 辅助复合物的产生，并且优选地根据双抗原桥概念，优选使用伴侣 - 抗原复合物，特别是在免疫测定中检测HIV抗体中，或作为免疫原。本发明还公开了分别包含HIV-1 gp41的变体或HIV-2 gp36的变体的可溶性复合物，以及选自分子伴侣的肽基 - 脯氨酰基异构酶类的伴侣。还描述了分别在HIV-1 gp41或HIV-2 gp36的N-螺旋结构域中包含特异性氨基酸取代的变体。

9. 发明授权

US08551696B2 Rubella E1 envelope protein variants and their use in detection of anti-rubella antibodies 有权
标题翻译：风疹E1包膜蛋白变体及其在抗风疹抗体检测中的应用
公开(公告)号：US08551696B2
公开(公告)日：2013-10-08
申请号：US12793134
申请日：2010-06-03
申请人： Christian Scholz , Ralf Bollhagen , Alfred Engel , Elke Faatz , Peter Schaarschmidt , Barbara Upmeier , Toralf Zarnt
发明人： Christian Scholz , Ralf Bollhagen , Alfred Engel , Elke Faatz , Peter Schaarschmidt , Barbara Upmeier , Toralf Zarnt
IPC分类号： C12Q1/70 , A61K39/20 , C12N7/01
CPC分类号： G01N33/56983 , C07K14/005 , C07K2319/35 , C12N2770/36222 , G01N2333/19 , G01N2469/20
摘要： The invention relates to soluble rubella E1 antigens and variants of these antigens. The antigens contain amino acids 201 to 432 or 169 to 432 and are lacking amino acids 453 to 481 as well as at least the amino acids 143 to 164. They further contain a region spanning two disulfide-bridges. The invention also relates to a recombinant DNA molecule encoding the rubella E1 antigens, the expression of rubella E1 antigens as chaperone fusion proteins and their use in a method of detecting antibodies against rubella in a sample.
摘要翻译：本发明涉及可溶性风疹E1抗原和这些抗原的变体。抗原含有氨基酸201至432或169至432，并且缺少氨基酸453至481以及至少氨基酸143至164.它们还包含横跨两个二硫键的区域。本发明还涉及编码风疹E1抗原的重组DNA分子，风疹E1抗原作为伴侣融合蛋白的表达，以及它们在检测样品中风疹抗体的方法中的用途。

10. 发明申请

US20130150646A1 Method for the Operation of a Radiotherapy System and a Radiotherapy System 有权
标题翻译：放射治疗系统和放射治疗系统的运行方法
公开(公告)号：US20130150646A1
公开(公告)日：2013-06-13
申请号：US13684463
申请日：2012-11-23
申请人： Christian Scholz
发明人： Christian Scholz
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/1047
摘要： A method for calculating local part radiation doses in a radiotherapy system for applying a total radiation dose in a target volume with several beams is provided. The method includes determining at least one first control plane for controlling the dosing of the beams, determining at least one second control plane for controlling the positioning of the beams, and allocating beams to the first and second control planes. The method also includes, for at least one side of a first control plane, calculating in isolation of the corresponding local part radiation doses of all the beams allocated to the first control plane.
摘要翻译：提供了一种用于计算放射治疗系统中的局部部分放射剂量的方法，用于在具有多个光束的目标体积中施加总辐射剂量。该方法包括确定至少一个第一控制平面以控制光束的计量，确定用于控制光束定位的至少一个第二控制平面，以及将光束分配给第一和第二控制平面。该方法还包括对于第一控制平面的至少一侧，隔离地分配分配给第一控制平面的所有光束的对应局部部分辐射剂量。

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