专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07211644B1 Diagnostic markers of human female infertility 有权
标题翻译：人类女性不孕症的诊断标志物
公开(公告)号：US07211644B1
公开(公告)日：2007-05-01
申请号：US09674254
申请日：1999-04-29
申请人： Siamak Tabibzadeh
发明人： Siamak Tabibzadeh
IPC分类号： C01K1/00
CPC分类号： C07K7/08 , A61K38/00
摘要： Methods and reagents for the diagnosis of female infertility, prognostic indicators for female infertility, compounds for the treatment of female infertility, compounds and methods for contraception. Methods and compounds are based on the levels of ebaf in endometrial tissue. Methods for diagnosing endometrial receptivity and bleeding function by screening a biological sample such as an endometrial tissue sample, or bodily fluid for the presence of ebaf. A contraceptive compound containing an effective amount of ebaf and a pharmaceutically acceptable carrier. A diagnostic kit for timing contraception containing reagents for screening a sample for the presence of ebaf. A method of treating endometrial irregularities by down-regulating the expression of ebaf.
摘要翻译：女性不育症的诊断方法和试剂，女性不育症的预后指标，治疗女性不孕症的化合物，化合物和避孕方法。方法和化合物是基于子宫内膜组织中ebaf的水平。通过筛选生物样本例如子宫内膜组织样本或体液来测定子宫内膜容受性和出血功能的方法。包含有效量的ebaf和药学上可接受的载体的避孕化合物。一种用于定时避孕的诊断试剂盒，含有用于筛选样品以存在ebaf的试剂。通过下调ebaf的表达来治疗子宫内膜不规则的方法。

2. 发明授权

US07253256B2 Polypeptides encoded by a nucleic acid are expressed in esophageal and kidney tumor 有权
标题翻译：由核酸编码的多肽在食管和肾肿瘤中表达
公开(公告)号：US07253256B2
公开(公告)日：2007-08-07
申请号：US10063549
申请日：2002-05-02
申请人： Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , William I. Wood
发明人： Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , William I. Wood
IPC分类号： C01K1/00 , C01K14/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4748 , C07K14/705 , C07K14/82 , C07K16/18 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3053 , C07K16/40 , C07K2319/30 , C12N5/06 , Y10S530/866
摘要： The present invention is directed to novel polypeptides encoded by nucleic acids that are differently expressed in esophageal and kidney tumors.
摘要翻译：本发明涉及由在食道和肾脏肿瘤中不同表达的核酸编码的新型多肽。

3. 发明授权

US07576183B2 Structure-based receptor MIMICS targeted against bacterial superantigen toxins 失效
标题翻译：针对细菌超抗原毒素的基于结构的受体MIMICS
公开(公告)号：US07576183B2
公开(公告)日：2009-08-18
申请号：US10746959
申请日：2003-12-24
申请人： Goutam Gupta , Elizabeth Hong-Geller , Patrick R. Shiflett , Nancy M. Lehnert
发明人： Goutam Gupta , Elizabeth Hong-Geller , Patrick R. Shiflett , Nancy M. Lehnert
IPC分类号： C01K16/00 , C01K1/00 , G01N33/53
CPC分类号： C07K14/70539 , A61K38/00 , A61K39/00 , C07K14/7051 , C07K2319/00
摘要： The invention provides therapeutic compositions useful in the treatment of bacterial superantigen mediated conditions, such as Toxic Shock Syndrome. The compositions comprise genetically engineered bifunctional polypeptides containing a specific T-cell receptor binding domain and a specific MHC class II receptor binding domain, each targeting non-overlapping epitopes on a superantigen molecule against which they are designed. The anti-superantigen “receptor mimetics” or “chimeras” are rationally designed to recreate the modality of superantigen binding directly to both the TCR and the MHC-II receptor, and are capable of acting as decoys for superantigen binding, effectively out-competing the host T-cell and MHC-II receptors, the natural host receptors.
摘要翻译：本发明提供治疗组合物，其可用于治疗细菌超抗原介导的病症，例如有毒性休克综合症。所述组合物包含含有特异性T细胞受体结合结构域和特异性MHC II类受体结合结构域的遗传工程改造的双功能多肽，每个靶向它们设计在其上的超抗原分子上的非重叠表位。合成设计抗超抗原“受体模拟物”或“嵌合体”，以重新形成超抗原结合直接与TCR和MHC-II受体结合的模式，并且能够作为超抗原结合的诱饵，有效地竞争宿主T细胞和MHC-II受体，天然宿主受体。

4. 发明授权

US07179891B2 Physiologically active complex 失效
标题翻译：生理活性复合物
公开(公告)号：US07179891B2
公开(公告)日：2007-02-20
申请号：US10668178
申请日：2003-09-24
申请人： Tadanori Mayumi , Yasuo Tsutsumi , Shinsaku Nakagawa , Hakuo Ikegami
发明人： Tadanori Mayumi , Yasuo Tsutsumi , Shinsaku Nakagawa , Hakuo Ikegami
IPC分类号： C01K1/00 , A61K45/00
CPC分类号： C07K14/525 , A61K47/60
摘要： Disclosed is a physiologically active complex which comprises a proteinaceous part with TNF activity and a high molecular part bound artificially to the N-terminus of the proteinaceous part. The proteinaceous part in the complex has the amino acid sequence of SEQ ID NO:2 where Xaa is a member selected from the group consisting of asparagine, alanine, arginine, serine, threonine, proline, methionine, and leucine; while the high molecular part in the complex is a homopolymer of polyethylene glycol, copolymer of polyethylene glycol, or a derivative thereof.
摘要翻译：公开了一种生理活性配合物，其包含具有TNF活性的蛋白质部分和与蛋白质部分的N末端人工结合的高分子部分。复合物中的蛋白质部分具有SEQ ID NO：2的氨基酸序列，其中Xaa是选自天冬酰胺，丙氨酸，精氨酸，丝氨酸，苏氨酸，脯氨酸，甲硫氨酸和亮氨酸的成员; 而络合物中的高分子部分是聚乙二醇的均聚物，聚乙二醇或其衍生物的共聚物。

5. 发明授权

US07358228B2 Methods of treating pain using neurotrophic factors 有权
标题翻译：使用神经营养因子治疗疼痛的方法
公开(公告)号：US07358228B2
公开(公告)日：2008-04-15
申请号：US11614599
申请日：2006-12-21
申请人： Dinah W. Y. Sah , Teit E. Johansen , Anthony Rossomando
发明人： Dinah W. Y. Sah , Teit E. Johansen , Anthony Rossomando
IPC分类号： A01N37/18 , A61K38/00 , C01K1/00 , C01K14/00 , C01K17/00
CPC分类号： C07K14/48 , A61K38/00 , C07K14/475
摘要： The invention relates to neublastin neurotrophic factor polypeptides, nucleic acids encoding neublastin polypeptides, and antibodies that bind specifically to neublastin polypeptides, as well as methods of making and methods of using the same.
摘要翻译：本发明涉及新斯的斯顿神经营养因子多肽，编码新斯的斯多肽的核酸，以及特异性结合到新斯普霉素多肽的抗体，以及其制备方法及其使用方法。

6. 发明授权

US07256261B2 Polypeptides encoded by a nucleic acid over expressed in normal stomach normal skin and kidney tumor 有权
标题翻译：由正常胃正常皮肤和肾脏肿瘤中过表达的核酸编码的多肽
公开(公告)号：US07256261B2
公开(公告)日：2007-08-14
申请号：US10063545
申请日：2002-05-02
申请人： Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , William I. Wood
发明人： Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , William I. Wood
IPC分类号： C01K1/00 , C01K14/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4748 , C07K14/705 , C07K14/82 , C07K16/18 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3053 , C07K16/40 , C07K2319/30 , C12N5/06 , Y10S530/866
摘要： The present invention is directed to novel polypeptides encoded by nucleic acids that are differentially expressed in kidney, stomach, and melanoma tumors.
摘要翻译：本发明涉及由肾，胃和黑素瘤肿瘤中差异表达的核酸编码的新型多肽。

7. 发明授权

US07244819B2 Fusion polypeptides, vaccines and compositions of FKBP chaperones and target polypeptides 有权
标题翻译：融合多肽，疫苗和FKBP伴侣和靶多肽的组合物
公开(公告)号：US07244819B2
公开(公告)日：2007-07-17
申请号：US10179038
申请日：2002-06-24
申请人： Christian Scholz , Herbert Andres , Elke Faatz , Alfred Engel , Urban Schmitt , Ariuna Bazarsuren , Peter Schaarschmidt
发明人： Christian Scholz , Herbert Andres , Elke Faatz , Alfred Engel , Urban Schmitt , Ariuna Bazarsuren , Peter Schaarschmidt
IPC分类号： C01K1/00
CPC分类号： G01N33/56988 , A61K39/00 , A61K47/64 , C07K14/005 , C07K2319/00 , C12N9/90 , C12N2740/16122 , G01N33/54306 , G01N33/56911 , G01N33/56983 , G01N2333/005 , G01N2333/16 , G01N2333/195 , G01N2469/20
摘要： The present invention relates to the cloning and expression of foreign protein or polypeptides in bacteria, such as Escherichia coli. In particular, this invention relates to expression tools comprising a FKBP-type peptidyl prolyl isomerase selected from the group consisting of FkpA, SlyD, and trigger factor; methods of recombinant protein expression, the recombinant polypeptides thus obtained, as well as to the use of such polypeptides.
摘要翻译：本发明涉及在细菌如大肠杆菌中克隆和表达外源蛋白质或多肽。特别地，本发明涉及包含选自FkpA，SlyD和触发因子的FKBP型肽基脯氨酰异构酶的表达工具; 重组蛋白表达的方法，如此获得的重组多肽，以及这些多肽的用途。

8. 发明授权

US6048700A Antigenic preparations and the isolation of such preparations 失效
标题翻译：抗原制剂和这些制剂的分离
公开(公告)号：US6048700A
公开(公告)日：2000-04-11
申请号：US478046
申请日：1995-06-07
申请人： Pavel Novotny , Juan Antonio Montaraz Crespo , Juraj Ivanyi , Jaroslava Novotny
发明人： Pavel Novotny , Juan Antonio Montaraz Crespo , Juraj Ivanyi , Jaroslava Novotny
IPC分类号： A61K39/095 , A61K31/00 , A61K39/00 , A61K39/02 , A61K39/085 , A61K39/09 , A61K39/10 , A61P31/00 , A61P31/04 , C07K1/00 , C07K1/18 , C07K1/22 , C07K14/235 , C12N9/88 , C12P21/00 , C12P21/04 , G01N33/53 , G01N33/531 , C01K1/00
CPC分类号： C07K14/235 , C12N9/88 , A61K39/00 , Y10S530/806 , Y10S530/825
摘要： The invention provides a vaccine containing a proteinaceous material derived from the outer membrane of Bordetella pertussis, wherein the proteinaceous material is characterized by a relative molecular weight of about 67,000 to 73,000, preferably 69,000, as determined by 12% (w/w) polyacrylamide gel electrophoresis and a proline:glutamic acid ratio of about 1:1 as determined by amino acid analysis, in a pharmaceutically acceptable carrier or adjuvant. The invention also provides a method of inducing an immune response in an individual involving administering the vaccine of the invention to an individual.
摘要翻译：本发明提供一种含有衍生自百日咳博德特氏菌外膜的蛋白质物质的疫苗，其中蛋白质物质的特征在于通过12％（w / w）聚丙烯酰胺凝胶测定的相对分子量为约67,000至73,000，优选为69,000 电泳，脯氨酸：通过氨基酸分析确定的约1：1的谷氨酸比例，在药学上可接受的载体或佐剂中。本发明还提供了在个体中诱导免疫应答的方法，其涉及向个体施用本发明的疫苗。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式