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1. 发明授权

US5863800A Storage system for test elements 失效
标题翻译：测试元件存储系统
公开(公告)号：US5863800A
公开(公告)日：1999-01-26
申请号：US934779
申请日：1997-09-22
申请人： Heino Eikmeier , Klaus-Dieter Sacherer , Joerg Schreiber , Wilfried Schmid , Hans-Juergen Kuhr
发明人： Heino Eikmeier , Klaus-Dieter Sacherer , Joerg Schreiber , Wilfried Schmid , Hans-Juergen Kuhr
IPC分类号： G01N31/22 , B01L9/00 , B01L99/00 , B65D75/58 , B65D75/70 , B65D83/04 , G01N21/78 , G01N21/86 , G01N33/487 , G01N33/52 , G01N35/00 , G01N37/00 , G01N35/02
CPC分类号： G01N35/00732 , B01L9/52 , B01L99/00 , G01N21/8483 , G01N33/48778 , G01N35/00029 , B01L2300/0825 , G01N2035/00039 , G01N2035/00089 , G01N2035/00277 , G01N2035/00782 , Y10S435/808 , Y10S436/805 , Y10S436/808 , Y10T436/11 , Y10T436/112499 , Y10T436/114165
摘要： A systems for test elements used for clinical chemical analyses has several test elements, each of which is individually sealed to be impermeable to water vapor. The method provides for the removal of test elements and protects the test elements contained in it against effects from the outside.
摘要翻译：用于临床化学分析的测试元件的系统具有几个测试元件，每个测试元件被单独地密封以对水蒸汽是不可渗透的。该方法提供了去除测试元件并保护其中包含的测试元件免受外部影响。

2. 发明授权

US5645798A Test elements in sealed chambers for analyzing compounds contained in liquid samples 失效
标题翻译：用于分析液体样品中所含化合物的密封腔室中的测试元件
公开(公告)号：US5645798A
公开(公告)日：1997-07-08
申请号：US464405
申请日：1995-06-05
申请人： Joerg Schreiber , Wilfried Schmid , Hans-Juergen Kuhr , Heino Eikmeier , Klaus-Dieter Sacherer
发明人： Joerg Schreiber , Wilfried Schmid , Hans-Juergen Kuhr , Heino Eikmeier , Klaus-Dieter Sacherer
IPC分类号： G01N31/22 , B01L9/00 , B01L99/00 , B65D75/58 , B65D75/70 , B65D83/04 , G01N21/78 , G01N21/86 , G01N33/487 , G01N33/52 , G01N35/00 , G01N37/00 , G01N35/10
CPC分类号： G01N35/00732 , B01L9/52 , B01L99/00 , G01N21/8483 , G01N33/48778 , G01N35/00029 , B01L2300/0825 , G01N2035/00039 , G01N2035/00089 , G01N2035/00277 , G01N2035/00782 , Y10S435/808 , Y10S436/805 , Y10S436/808 , Y10T436/11 , Y10T436/112499 , Y10T436/114165
摘要： A system for analyzing sample liquids using dry reagents which is particularly suitable for the determination of clinical parameters. The system includes an analysis instrument containing the individually sealed test elements to carry out an analytical test. Shape and nature of the test elements were designed to match the analysis system. The system is particularly suitable for analyses where the available test elements exhibit a low storage stability when brought into contact with the environment.
摘要翻译：用于使用干试剂分析样品液体的系统，其特别适用于确定临床参数。该系统包括一个包含单独密封的测试元件进行分析测试的分析仪器。测试元素的形状和性质被设计为匹配分析系统。该系统特别适用于当可用的测试元件在与环境接触时表现出低的储存稳定性的分析。

3. 发明授权

US5489414A System for analyzing compounds contained in liquid samples 失效
标题翻译：用于分析液体样品中所含化合物的系统
公开(公告)号：US5489414A
公开(公告)日：1996-02-06
申请号：US231712
申请日：1994-04-22
申请人： Joerg Schreiber , Wilfried Schmid , Hans-Juergen Kuhr , Heino Eikmeier , Klaus-Dieter Sacherer
发明人： Joerg Schreiber , Wilfried Schmid , Hans-Juergen Kuhr , Heino Eikmeier , Klaus-Dieter Sacherer
IPC分类号： G01N31/22 , B01L9/00 , B01L99/00 , B65D75/58 , B65D75/70 , B65D83/04 , G01N21/78 , G01N21/86 , G01N33/487 , G01N33/52 , G01N35/00 , G01N37/00 , G01N35/10
CPC分类号： G01N35/00732 , B01L9/52 , B01L99/00 , G01N21/8483 , G01N33/48778 , G01N35/00029 , B01L2300/0825 , G01N2035/00039 , G01N2035/00089 , G01N2035/00277 , G01N2035/00782 , Y10S435/808 , Y10S436/805 , Y10S436/808 , Y10T436/11 , Y10T436/112499 , Y10T436/114165
摘要： A system for analyzing sample liquids using dry reagents which is particularly suitable for the determination of clinical parameters. The system includes an analysis instrument containing the individually sealed test elements to carry out an analytical test. Shape and nature of the test elements were designed to match the analysis system. The system is particularly suitable for analyses where the available test elements exhibit a low storage stability when brought into contact with the environment.
摘要翻译：用于使用干试剂分析样品液体的系统，其特别适用于确定临床参数。该系统包括一个包含单独密封的测试元件进行分析测试的分析仪器。测试元素的形状和性质被设计为匹配分析系统。该系统特别适用于当可用的测试元件在与环境接触时表现出低的储存稳定性的分析。

4. 发明授权

US5720924A Storage system for test elements 失效
标题翻译：测试元件存储系统
公开(公告)号：US5720924A
公开(公告)日：1998-02-24
申请号：US609166
申请日：1996-03-01
申请人： Heino Eikmeier , Klaus-Dieter Sacherer , Joerg Schreiber , Wilfried Schmid , Hans-Juergen Kuhr
发明人： Heino Eikmeier , Klaus-Dieter Sacherer , Joerg Schreiber , Wilfried Schmid , Hans-Juergen Kuhr
IPC分类号： G01N31/22 , B01L9/00 , B01L99/00 , B65D75/58 , B65D75/70 , B65D83/04 , G01N21/78 , G01N21/86 , G01N33/487 , G01N33/52 , G01N35/00 , G01N37/00 , B01L3/00
CPC分类号： G01N35/00732 , B01L9/52 , B01L99/00 , G01N21/8483 , G01N33/48778 , G01N35/00029 , B01L2300/0825 , G01N2035/00039 , G01N2035/00089 , G01N2035/00277 , G01N2035/00782 , Y10S435/808 , Y10S436/805 , Y10S436/808 , Y10T436/11 , Y10T436/112499 , Y10T436/114165
摘要： The system has several test elements, each of which is individually sealed to be impermeable to water vapor. The system storing test elements facilitates removal of test elements and protects the test elements contained in it against effects from the outside.
摘要翻译：该系统具有几个测试元件，每个测试元件被单独密封以不透水蒸气。存储测试元件的系统有助于去除测试元件并保护其中包含的测试元件免受外部的影响。

5. 发明授权

US5505308A System for the storage of test elements 失效
标题翻译：用于存储测试元件的系统
公开(公告)号：US5505308A
公开(公告)日：1996-04-09
申请号：US295534
申请日：1994-08-25
申请人： Heino Eikmeier , Klaus-Dieter Sacherer
发明人： Heino Eikmeier , Klaus-Dieter Sacherer
IPC分类号： B65D43/22 , B01L99/00 , B65D43/26 , B65D81/26 , B65D83/08 , G01N31/22 , G01N33/487 , B65D85/67 , B65D51/04
CPC分类号： B01L99/00 , B65D43/26 , G01N33/48778
摘要： The invention is within the field of packaging and storing of test elements that are usually sensitive towards atmospheric humidity or water vapor. The invention concerns a system for the storage of test elements for the analysis of sample liquids in which two or more test elements are present in a storage container which can be sealed water-vapor tight and contains a desiccant inside.
摘要翻译：本发明在通常对大气湿度或水蒸汽敏感的测试元件的包装和存储领域内。本发明涉及一种用于存储用于分析样品液体的测试元件的系统，其中两个或更多个测试元件存在于存储容器中，该储存容器可以密封在水蒸汽上并在其中含有干燥剂。

6. 发明授权

US5188966A Test carrier with separation means for analyzing a sample fluid 失效
标题翻译：具有分析手段的测试载体用于分析样品流体
公开(公告)号：US5188966A
公开(公告)日：1993-02-23
申请号：US654110
申请日：1991-02-12
申请人： Heino Eikmeier , Anselm Rothe
发明人： Heino Eikmeier , Anselm Rothe
IPC分类号： G01N31/22 , G01N33/52
CPC分类号： G01N33/525 , Y10S435/805 , Y10S435/97
摘要： Test carrier for analyzing a sample fluid with several test layers which form a sample fluid transport path and contain a reagent system which reacts with the sample fluid to produce a detectable signal. The test carrier includes a reservoir layer of absorbent material, a detection layer arranged in the fluid transport path downstream the reservoir layer, in which a detectable signal is formed, and a separating layer arranged between the reservoir layer and the detection layer. The separating layer makes a two-step process possible. Fluid contact between the reservoir layer and the detection layer arises only with pressure loading of the layer assembly of the reservoir layer, separating layer and detection layer. A more uniform optical detection signal, and consequently better accuracy, can be achieved because the separating layer is made up of a hydrophilic material, wich is in the form of a lattice-shaped structure, in which the mean width of the lattice openings is more than 0.05 mm, and the threads from which the lattice-shaped structure is formed are multi-filament.
摘要翻译：用于分析具有几个测试层的样品流体的测试载体，其形成样品流体输送路径并且包含与样品流体反应以产生可检测信号的试剂系统。测试载体包括吸收材料的储存层，布置在储存层下游的流体输送路径中的检测层，其中形成可检测信号，以及布置在储层和检测层之间的分离层。分离层使两步过程成为可能。储层与检测层之间的流体接触仅在储层的层组件，分离层和检测层的压力负载下才产生。可以实现更均匀的光学检测信号，因此更好的精度，因为分离层由格子状结构形式的亲水材料组成，其中格子孔的平均宽度更多并且形成格子状结构的丝是多丝的。

7. 发明授权

US5132208A Test carrier for the analysis of a sample liquid 失效
标题翻译：用于分析样品液体的试验载体
公开(公告)号：US5132208A
公开(公告)日：1992-07-21
申请号：US189782
申请日：1988-05-03
申请人： Helmut Freitag , Hans-Erich Wilk , Anselm Rothe , Heino Eikmeier
发明人： Helmut Freitag , Hans-Erich Wilk , Anselm Rothe , Heino Eikmeier
IPC分类号： G01N31/22 , C12Q1/00 , G01N33/52 , G01N33/543
CPC分类号： G01N33/525
摘要： The present invention provides a test carrier for the analysis of a sample liquid and especially of a body fluid, having a porous test layer (8, 13) which contains a solid component (9, 17), wherein the solid component (9, 17) is coated with a protein which is insoluble in the sample liquid under the test conditions. A process for the production of this test layer is also disclosed, wherein the protein is dissolved in a solvent under conditions under which the solubility of the protein is sufficiently high in order to dissolve a certain minimum amount of the protein, the solid component of the test layer is contracted with the solution and the solubility is reduced to such an extent that the component is coated by the precipitating protein.
摘要翻译：本发明提供了一种用于分析样品液体，特别是体液的测试载体，其具有含有固体组分（9,17）的多孔测试层（8,13），其中固体组分（9,17））在测试条件下涂覆有不溶于样品液体的蛋白质。还公开了用于生产该测试层的方法，其中将蛋白质溶解在溶解有蛋白质的溶解度足够高以便溶解某些最低量的蛋白质的条件下，将固体成分试验层与溶液一起收缩，溶解度降低至组分被沉淀蛋白包被的程度。

8. 发明授权

US08628721B2 System for measuring an analyte concentration of a body fluid sample 有权
标题翻译：用于测量体液样品的分析物浓度的系统
公开(公告)号：US08628721B2
公开(公告)日：2014-01-14
申请号：US12638347
申请日：2009-12-15
申请人： Christoph Eisenhardt , Heino Eikmeier
发明人： Christoph Eisenhardt , Heino Eikmeier
IPC分类号： G01N33/48
CPC分类号： A61B5/14532 , A61B2560/0223 , A61B2560/0475 , A61B2562/0295 , G01N33/48771 , G01N33/48792 , G06F19/00
摘要： A system is provided for measuring an analyte concentration in a body fluid sample, comprising at least one cartridge that contains consumables for multiple measurements, a data carrier affixed to the cartridge that contains calibration information for the consumables, a hand-held device including a reading facility for receiving a cartridge of this type and for reading its data carrier, a measuring facility for measuring the result of a detection reaction, and a processor for controlling the measuring facility and for analysis of a measuring signal. At least one replaceable data storage unit is further provided in which supplementary data is stored. The data storage unit functions in combination with calibration information from the data carrier and is used by the processor to determine whether the consumables of the inserted cartridge renders a reliable measurement of analyte concentration.
摘要翻译：提供了一种用于测量体液样品中的分析物浓度的系统，包括至少一个包含用于多次测量的消耗品的盒，固定到所述盒的数据载体，其包含所述消耗品的校准信息，包括读数的手持装置用于接收这种类型的盒并用于读取其数据载体的设备，用于测量检测反应结果的测量设备，以及用于控制测量设备和用于分析测量信号的处理器。还提供至少一个可更换数据存储单元，其中存储有补充数据。数据存储单元与来自数据载体的校准信息组合起来，并由处理器使用以确定插入的盒的消耗品是否可靠地测量分析物浓度。

9. 发明申请

US20110015511A1 SYSTEMS AND METHODS FOR OPTIMIZING INSULIN DOSAGE 有权
标题翻译：用于优化胰岛素剂量的系统和方法
公开(公告)号：US20110015511A1
公开(公告)日：2011-01-20
申请号：US12818310
申请日：2010-06-18
申请人： Steven Bousamra , Stefan Weinert , Juergen Rasch-Menges , P. Douglas Walling , John F. Price , Heino Eikmeier , Birgit Kraeling , Karl Werner , Ulrich Porsch
发明人： Steven Bousamra , Stefan Weinert , Juergen Rasch-Menges , P. Douglas Walling , John F. Price , Heino Eikmeier , Birgit Kraeling , Karl Werner , Ulrich Porsch
IPC分类号： A61B5/145 , G06F19/00 , G01N33/48 , G09B23/28
CPC分类号： A61B5/0002 , A61B5/05 , A61B5/14532 , A61B5/14546 , A61M31/00 , A61M2230/201 , C12Q1/006 , G06F19/00 , G06F19/3418 , G06F19/3456 , G16H10/20 , G16H10/40 , G16H20/17 , G16H80/00
摘要： Embodiments of a testing method suitable for diabetic persons to optimize their administered insulin dosage comprise collecting one or more sampling sets of biomarker data, wherein each sampling set comprises a sufficient plurality of non-adverse sampling instances and wherein each sampling instance comprises an acceptable biomarker reading at a single point in time recorded upon compliance with adherence criteria, determining a biomarker sampling parameter from each sampling set, comparing the biomarker sampling parameter to a target biomarker range, calculating an insulin adjustment parameter associated with the biomarker sampling parameter if the biomarker sampling parameter falls outside the target biomarker range, adjusting the insulin dosage by the insulin adjustment parameter if the biomarker sampling parameter falls outside the target biomarker range and if the insulin dosage does not exceed maximum dosage, and exiting the testing method if the adjusted insulin dosage is optimized. The insulin dosage is optimized when one or more biomarker sampling parameters fall within a target biomarker range.
摘要翻译：适于糖尿病患者优化其施用的胰岛素剂量的测试方法的实施方案包括收集一个或多个生物标志物数据的采样组，其中每个采样组包括足够多个非不良采样实例，并且其中每个采样实例包括可接受的生物标志物读数在符合遵守标准的单个时间点上，从每个采样组确定生物标志物采样参数，将生物标志物采样参数与目标生物标志物范围进行比较，计算与生物标志物采样参数相关联的胰岛素调节参数，如果生物标志物采样参数如果生物标志物采样参数落在目标生物标志物范围之外，并且如果胰岛素剂量不超过最大剂量，并且如果调整的胰岛素剂量是最佳的则退出测试方法，则超出目标生物标志物范围，通过胰岛素调节参数调整胰岛素剂量 zed。当一个或多个生物标志物采样参数落入目标生物标志物范围内时，胰岛素剂量被优化。

10. 发明申请

US20050207938A1 Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：US20050207938A1
公开(公告)日：2005-09-22
申请号：US10891073
申请日：2004-07-15
申请人： Masaaki Hanawa , Isao Yamazaki , Hitoshi Tokieda , Masaharu Nishida , Masaki Shiba , Heino Eikmeier , Dietmar Kappelhoff , Christoph Mollers , Stephan Sattler
发明人： Masaaki Hanawa , Isao Yamazaki , Hitoshi Tokieda , Masaharu Nishida , Masaki Shiba , Heino Eikmeier , Dietmar Kappelhoff , Christoph Mollers , Stephan Sattler
IPC分类号： G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10
CPC分类号： G01N35/1002 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/114998
摘要： An automatic analyzer is disclosed that dispenses a sample and a reagent into each of a plurality of reaction vessels to allow them to react with each other, and that measures the liquid formed as a result of the reaction. This automatic analyzer includes a first reagent storage case for storing the reagent to be used for the reaction, a second reagent storage case for storing the reagent for supplemental purpose, and a reagent conveying unit for conveying the reagent from the second reagent storage case to the first reagent storage case.
摘要翻译：公开了一种自动分析仪，其将样品和试剂分配到多个反应容器中的每一个中以允许它们彼此反应，并且测量由于反应而形成的液体。该自动分析装置具备存储反应用试剂的第一试剂储存箱，补充试剂的第二试剂储存箱和第二试剂储存箱的试剂输送单元，第一试剂储存盒。

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