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1. 发明申请

US20060139997A1 Flash memory device 有权
标题翻译：闪存设备
公开(公告)号：US20060139997A1
公开(公告)日：2006-06-29
申请号：US11299063
申请日：2005-12-09
申请人： Hee Park , Kyeong Lee , Byung Park
发明人： Hee Park , Kyeong Lee , Byung Park
IPC分类号： G11C16/28 , G11C16/06 , G11C16/04
CPC分类号： G11C16/3418 , G11C16/0483 , G11C16/3427
摘要： A flash memory device comprises a first group of dummy memory cells disposed between source selection transistors, which are coupled to a source selection line, and memory cells coupled to a first wordline. The flash memory device further comprises a second group of dummy memory cells disposed between drain selection transistors, which are coupled to a drain selection line, and memory cells coupled to the last wordline. The flash memory device is configured to prevent program disturbance in deselected cell strings and degradation of programming/erasing speeds in a selected cell string.
摘要翻译：闪速存储器件包括设置在源选择晶体管之间的第一组虚拟存储器单元，其耦合到源选择线，以及耦合到第一字线的存储器单元。闪速存储器件还包括设置在漏极选择晶体管之间的第二组虚设存储器单元，其耦合到漏极选择线，以及耦合到最后一个字线的存储器单元。闪存器件被配置为防止未选择的单元串中的程序干扰以及所选单元串中编程/擦除速度的劣化。

2. 发明授权

US09180138B2 2′-fluoronucleosides 有权
标题翻译： 2'-核糖核苷
公开(公告)号：US09180138B2
公开(公告)日：2015-11-10
申请号：US13437676
申请日：2012-04-02
申请人： Raymond F. Schinazi , Dennis C. Liotta , Chung K. Chu , J. Jeffrey McAtee , Junxing Shi , Yongseok Choi , Kyeong Lee , Joon H. Hong
发明人： Raymond F. Schinazi , Dennis C. Liotta , Chung K. Chu , J. Jeffrey McAtee , Junxing Shi , Yongseok Choi , Kyeong Lee , Joon H. Hong
IPC分类号： A01N61/00 , A61K48/00 , A61K31/708 , C07D405/04 , C07D473/00 , C07H19/06 , C07H19/10 , C07H19/16 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , C07H1/00 , C07G3/00
CPC分类号： A61K31/7076 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/708 , C07D405/04 , C07D473/00 , C07H19/06 , C07H19/10 , C07H19/16
摘要： 2′-Fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: wherein Base is a purine or pyrimidine base; R1 is OH, H, OR3, N3, CN, halogen, CF3, lower alkyl, amino, loweralkylamino, di(lower)alkylamino, or alkoxy; R2 is H, phosphate, or a stabilized phosphate prodrug; acyl, or other pharmaceutically acceptable leaving benzyl, a lipid, an amino acid, peptide, or cholesterol; and R3 is acyl, alkyl, phosphate, or other pharmaceutically acceptable leaving group; or a pharmaceutically acceptable salt thereof.
摘要翻译：公开了可用于治疗乙型肝炎感染，丙型肝炎感染，HIV和异常细胞增殖（包括肿瘤和癌症）的2'-氟 - 核苷化合物。所述化合物具有以下通式：其中碱是嘌呤或嘧啶碱; R 1是OH，H，OR 3，N 3，CN，卤素，CF 3，低级烷基，氨基，低级烷基氨基，二（低级）烷基氨基或烷氧基; R2是H，磷酸盐或稳定的磷酸盐前药; 酰基或其它药学上可接受的苄基，脂质，氨基酸，肽或胆固醇; 烷基，磷酸酯或其它药学上可接受的离去基团; 或其药学上可接受的盐。

3. 发明授权

US08940936B2 Aryloxy phenoxy acrylic compound having HIF-1 inhibition activity, method for preparing same, and pharmaceutical composition containing same as an active ingredient 有权
标题翻译：具有HIF-1抑制活性的芳氧基苯氧基丙烯酸化合物及其制备方法，以及含有它们作为活性成分的药物组合物
公开(公告)号：US08940936B2
公开(公告)日：2015-01-27
申请号：US13880642
申请日：2011-10-17
申请人： Kyeong Lee , Mi Sun Won , Hwan Mook Kim , Song Kyu Park , Kiho Lee , Ki Hoon Lee , Chang Woo Lee , Jung Joon Lee , Kyung Sook Chung , Bo Kyung Kim , Yinglan Jin , Seung-hee Lee
发明人： Kyeong Lee , Mi Sun Won , Hwan Mook Kim , Song Kyu Park , Kiho Lee , Ki Hoon Lee , Chang Woo Lee , Jung Joon Lee , Kyung Sook Chung , Bo Kyung Kim , Yinglan Jin , Seung-hee Lee
IPC分类号： C07C233/07 , A61K31/167 , C07C235/28 , C07C311/16 , C07D295/088
CPC分类号： A61K31/5375 , A61K9/0019 , A61K9/08 , A61K9/14 , A61K9/20 , A61K9/48 , A61K31/167 , A61K31/196 , A61K31/24 , A61K31/34 , A61K31/40 , A61K31/417 , A61K31/4409 , C07C233/07 , C07C235/28 , C07C311/16 , C07C311/46 , C07C317/40 , C07C2603/74 , C07D295/088
摘要： The present invention relates to a compound inhibiting HF-1 activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention demonstrates anticancer activity not by non-selective cytotoxicity but by inhibiting the activity of HIF-1, the transcription factor playing an important role in cancer cell growth and metastasis. Accordingly, the compound or the pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumors such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.
摘要翻译：本发明涉及抑制HF-1活性的化合物，其制备方法以及含有该化合物作为活性成分的药物组合物。本发明的化合物通过非选择性细胞毒性表现出抗癌活性，但通过抑制HIF-1的活性，该转录因子在癌细胞生长和转移中起重要作用。因此，根据本发明的化合物或其药学上可接受的盐抑制HIF-1活性，因此可以用作结肠癌，肝癌，胃癌和乳腺癌等实体瘤的治疗剂。此外，根据本发明的化合物或其药学上可接受的盐可以用作用于糖尿病性视网膜病变或关节炎的治疗剂的活性成分，当HIF-1的缺氧诱导的VEGF表达增加时，可能变差。

4. 发明申请

US20130237542A1 ARYLOXY PHENOXY ACRYLIC COMPOUND HAVING HIF-1 INHIBITION ACTIVITY, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ACTIVE INGREDIENT 有权
标题翻译：具有HIF-1抑制活性的芳族羟基丙烯酸酯化合物，其制备方法和含有活性成分的药物组合物
公开(公告)号：US20130237542A1
公开(公告)日：2013-09-12
申请号：US13880642
申请日：2011-10-17
申请人： Kyeong Lee , Mi Sun Won , Hwan Mook Kim , Song Kyu Park , Kiho Lee , Ki Hoon Lee , Chang Woo Lee , Jung Joon Lee , Kyung Sook Chung , Bo Kyung Kim , Yinglan Jin , Seung-hee Lee
发明人： Kyeong Lee , Mi Sun Won , Hwan Mook Kim , Song Kyu Park , Kiho Lee , Ki Hoon Lee , Chang Woo Lee , Jung Joon Lee , Kyung Sook Chung , Bo Kyung Kim , Yinglan Jin , Seung-hee Lee
IPC分类号： C07C235/28 , C07D295/088 , C07C311/16
CPC分类号： A61K31/5375 , A61K9/0019 , A61K9/08 , A61K9/14 , A61K9/20 , A61K9/48 , A61K31/167 , A61K31/196 , A61K31/24 , A61K31/34 , A61K31/40 , A61K31/417 , A61K31/4409 , C07C233/07 , C07C235/28 , C07C311/16 , C07C311/46 , C07C317/40 , C07C2603/74 , C07D295/088
摘要： The present invention relates to a compound inhibiting HF-1 activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention demonstrates anticancer activity not by non-selective cytotoxicity but by inhibiting the activity of HIF-1, the transcription factor playing an important role in cancer cell growth and metastasis. Accordingly, the compound or the pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumors such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.
摘要翻译：本发明涉及抑制HF-1活性的化合物，其制备方法以及含有该化合物作为活性成分的药物组合物。本发明的化合物通过非选择性细胞毒性表现出抗癌活性，但通过抑制HIF-1的活性，该转录因子在癌细胞生长和转移中起重要作用。因此，根据本发明的化合物或其药学上可接受的盐抑制HIF-1活性，因此可以用作结肠癌，肝癌，胃癌和乳腺癌等实体瘤的治疗剂。此外，根据本发明的化合物或其药学上可接受的盐可以用作用于糖尿病性视网膜病变或关节炎的治疗剂的活性成分，当HIF-1的缺氧诱导的VEGF表达增加时，可能变差。

5. 发明申请

US20090306078A1 COMPOUNDS THAT INHIBIT HIF-1 ACTIVITY, THE METHOD FOR PREPARATION THEREOF AND THE PHARMACEUTICAL COMPOSITION CONTAINING THEM AS AN EFFECTIVE COMPONENT 有权
标题翻译：抑制HIF-1活性的化合物，其制备方法和作为有效成分的药物组合物
公开(公告)号：US20090306078A1
公开(公告)日：2009-12-10
申请号：US12306319
申请日：2007-07-03
申请人： Jung Joon Lee , Jeong-Hyung Lee , Kyeong Lee , Young-Soo Hong , B.K. Shanthaveerappa , Yinlan Jin , Jin Hwan Kim , Xuejun Jin
发明人： Jung Joon Lee , Jeong-Hyung Lee , Kyeong Lee , Young-Soo Hong , B.K. Shanthaveerappa , Yinlan Jin , Jin Hwan Kim , Xuejun Jin
IPC分类号： A61K31/5377 , C07C233/33 , A61K31/167 , A61K31/41 , C07D257/04 , C07D295/15 , A61K31/423 , C07D263/57 , A61P19/02
CPC分类号： C07C237/42 , C07C235/24 , C07C255/60 , C07C271/42 , C07C307/02 , C07C311/46 , C07C317/40 , C07C2603/74 , C07D213/38 , C07D213/75 , C07D213/79 , C07D213/80 , C07D213/81 , C07D235/12 , C07D257/04 , C07D263/56 , C07D307/52 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Disclosed herein are an HIF-1 inhibitor, a method for the preparation thereof, and a pharmaceutical composition comprising the same as an active ingredient. The HIF-1 inhibitor shows anticancer activity thanks to the inhibition activity against HIF-1, a transcription factor which plays an important role in the growth and metastasis of cancer, but not to general cytotoxicity. Thus, the HIF-inhibitor and a pharmaceutically acceptable salt thereof can be used as a therapeutic for various cancers such as liver cancer; stomach cancer and breast cancer. Also, the compound having inhibition activity against HIF-1 is useful in the treatment of diabetic retinopathy and arthritis, which are aggravated by HIF-1-mediated VEGF expression.
摘要翻译：本文公开了HIF-1抑制剂，其制备方法和包含其作为活性成分的药物组合物。 HIF-1抑制剂由于对HIF-1的抑制活性而显示出抗癌活性，HIF-1是在癌症的生长和转移中起重要作用的转录因子，而不是一般的细胞毒性。因此，HIF抑制剂及其药学上可接受的盐可以用作各种癌症如肝癌的治疗剂; 胃癌和乳腺癌。此外，对HIF-1具有抑制活性的化合物可用于治疗由HIF-1介导的VEGF表达而恶化的糖尿病性视网膜病变和关节炎。

6. 发明申请

US20150291509A1 NOVEL BIPHENYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY DISEASES OR AUTOIMMUNE DISEASES COMPRISING THE SAME AS ACTIVE INGREDIENT 有权
标题翻译：新颖的联苯衍生物或药物可接受的盐，以及用于预防或治疗包含其作为活性成分的炎症性疾病或自身免疫性疾病的药物组合物
公开(公告)号：US20150291509A1
公开(公告)日：2015-10-15
申请号：US14237256
申请日：2012-08-06
申请人： Chang Hoon Lee , Kyeong Lee
发明人： Chang Hoon Lee , Kyeong Lee
IPC分类号： C07C233/47 , C07D295/195
CPC分类号： C07C233/47 , C07D295/192 , C07D295/195
摘要： The present invention relates to a novel biphenyl derivative or a pharmaceutically acceptable salt thereof, a pharmaceutical composition for preventing or treating inflammatory diseases or autoimmune diseases comprising the same as an active ingredient, and methods for treating inflammatory disease or autoimmune diseases with the pharmaceutical composition. Novel biphenyl derivatives according to the present invention promote the phagocytosis of macrophages and inhibit the chemotaxis to exhibit excellent inflammation terminating and anti-inflammatory effects and thus can be effectively used as therapeutic agents for inflammatory diseases or autoimmune diseases.
摘要翻译：本发明涉及一种新型的联苯衍生物或其药学上可接受的盐，用于预防或治疗炎性疾病的药物组合物或包含其作为活性成分的自身免疫性疾病，以及用药物组合物治疗炎性疾病或自身免疫性疾病的方法。根据本发明的新型联苯衍生物促进巨噬细胞的吞噬作用并抑制趋化性表现出优异的炎症终止和抗炎作用，因此可以有效地用作炎性疾病或自身免疫性疾病的治疗剂。

7. 发明授权

US08394799B2 Compounds that inhibit HIF-1 activity, the method for preparation thereof and the pharmaceutical composition containing them as an effective component 有权
标题翻译：抑制HIF-1活性的化合物，其制备方法和含有它们作为有效成分的药物组合物
公开(公告)号：US08394799B2
公开(公告)日：2013-03-12
申请号：US12306319
申请日：2007-07-03
申请人： Jung Joon Lee , Jeong-Hyung Lee , Kyeong Lee , Young-Soo Hong , B. K. Shanthaveerappa , Yinlan Jin , Jin Hwan Kim , Xuejun Jin
发明人： Jung Joon Lee , Jeong-Hyung Lee , Kyeong Lee , Young-Soo Hong , B. K. Shanthaveerappa , Yinlan Jin , Jin Hwan Kim , Xuejun Jin
IPC分类号： A61K31/5377 , A61K31/167 , A61K31/41 , A61K31/423 , A61P19/02 , C07C233/33 , C07D257/04 , C07D263/57 , C07D295/15
CPC分类号： C07C237/42 , C07C235/24 , C07C255/60 , C07C271/42 , C07C307/02 , C07C311/46 , C07C317/40 , C07C2603/74 , C07D213/38 , C07D213/75 , C07D213/79 , C07D213/80 , C07D213/81 , C07D235/12 , C07D257/04 , C07D263/56 , C07D307/52 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Disclosed herein are an HIF-1 inhibitor, a method for the preparation thereof, and a pharmaceutical composition comprising the same as an active ingredient. The HIF-1 inhibitor shows anticancer activity thanks to the inhibition activity against HIF-1, a transcription factor which plays an important role in the growth and metastasis of cancer, but not to general cytotoxicity. Thus, the HIF-inhibitor and a pharmaceutically acceptable salt thereof can be used as a therapeutic for various cancers such as liver cancer; stomach cancer and breast cancer. Also, the compound having inhibition activity against HIF-1 is useful in the treatment of diabetic retinopathy and arthritis, which are aggravated by HIF-1-mediated VEGF expression.
摘要翻译：本文公开了HIF-1抑制剂，其制备方法和包含其作为活性成分的药物组合物。 HIF-1抑制剂由于对HIF-1的抑制活性而显示出抗癌活性，HIF-1是在癌症的生长和转移中起重要作用的转录因子，而不是一般的细胞毒性。因此，HIF抑制剂及其药学上可接受的盐可以用作各种癌症如肝癌的治疗剂; 胃癌和乳腺癌。此外，对HIF-1具有抑制活性的化合物可用于治疗由HIF-1介导的VEGF表达而恶化的糖尿病性视网膜病变和关节炎。

8. 发明授权

US08304448B2 Method for the treatment of metabolic disorder containing benzazole derivatives as an active ingredient 有权
标题翻译：用于治疗含有苯并唑衍生物作为活性成分的代谢紊乱的方法
公开(公告)号：US08304448B2
公开(公告)日：2012-11-06
申请号：US12442895
申请日：2007-09-27
申请人： Hyun Sun Lee , Kyeong Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Rho , Jeong Hyung Lee , Young Soo Hong , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
发明人： Hyun Sun Lee , Kyeong Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Rho , Jeong Hyung Lee , Young Soo Hong , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
IPC分类号： A61K31/40 , A61K31/405
CPC分类号： A61K31/423
摘要： Disclosed is a composition for the prevention and treatment of metabolic diseases, which comprises a benzazole derivative as an active ingredient. The benzazole derivative has inhibitory activity against DGAT (diacylglycerol acyltransferase), which causes metabolic diseases such as obesity and diabetes in the process of lipid metabolism. With the ability to effectively control lipid metabolism and energy metabolism, thus, the composition is useful in the prevention and treatment of metabolic diseases, such as obesity and diabetes.
摘要翻译：公开了用于预防和治疗代谢疾病的组合物，其包含作为有效成分的苯并唑衍生物。苯并唑衍生物对脂质代谢过程中引起代谢性疾病如肥胖和糖尿病的DGAT（二酰基甘油酰基转移酶）具有抑制活性。具有有效控制脂质代谢和能量代谢的能力，因此，该组合物可用于预防和治疗诸如肥胖症和糖尿病的代谢疾病。

9. 发明申请

US20100173863A1 2-Fluoronucleosides 有权
标题翻译： 2-氟核苷
公开(公告)号：US20100173863A1
公开(公告)日：2010-07-08
申请号：US12510083
申请日：2009-07-27
申请人： Raymond F. Schinazi , Dennis C. Liotta , Chung K. Chu , J. Jeffrey McAtee , Junxing Shi , Yongseok Choi , Kyeong Lee , Joon H. Hong
发明人： Raymond F. Schinazi , Dennis C. Liotta , Chung K. Chu , J. Jeffrey McAtee , Junxing Shi , Yongseok Choi , Kyeong Lee , Joon H. Hong
IPC分类号： A61K31/7052 , A61K31/7064 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61P31/14
CPC分类号： A61K31/7076 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/708 , C07D405/04 , C07D473/00 , C07H19/06 , C07H19/10 , C07H19/16
摘要： 2′-Fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: wherein Base is a purine or pyrimidine base; R1 is OH, H, OR3, N3, CN, halogen, CF3, lower alkyl, amino, loweralkylamino, di(lower)alkylamino, or alkoxy; R2 is H, phosphate, or a stabilized phosphate prodrug; acyl, or other pharmaceutically acceptable leaving benzyl, a lipid, an amino acid, peptide, or cholesterol; and R3 is acyl, alkyl, phosphate, or other pharmaceutically acceptable leaving group; or a pharmaceutically acceptable salt thereof.
摘要翻译：公开了可用于治疗乙型肝炎感染，丙型肝炎感染，HIV和异常细胞增殖（包括肿瘤和癌症）的2'-氟 - 核苷化合物。所述化合物具有以下通式：其中碱是嘌呤或嘧啶碱; R 1是OH，H，OR 3，N 3，CN，卤素，CF 3，低级烷基，氨基，低级烷基氨基，二（低级）烷基氨基或烷氧基; R2是H，磷酸盐或稳定的磷酸盐前药; 酰基或其它药学上可接受的苄基，脂质，氨基酸，肽或胆固醇; 烷基，磷酸酯或其它药学上可接受的离去基团; 或其药学上可接受的盐。

10. 发明申请

US20050105864A1 Waveguide type optical device using large 3rd non-linear optical material and method for operating the same 有权
标题翻译：使用大型第3非线性光学材料的波导型光学器件及其操作方法
公开(公告)号：US20050105864A1
公开(公告)日：2005-05-19
申请号：US10987709
申请日：2004-11-12
申请人： Taek-Sung Lee , Kyeong Lee , Won-Mok Kim , Byung-Ki Cheong , In-Ho Kim
发明人： Taek-Sung Lee , Kyeong Lee , Won-Mok Kim , Byung-Ki Cheong , In-Ho Kim
IPC分类号： G02B6/12 , G02F1/35 , G02B6/00
CPC分类号： G02F1/3517 , G02B2006/12142 , G02B2006/12145 , G02B2006/12147 , G02F1/3521
摘要： Disclosed is a waveguide type optical device utilizing a nonlinear refractive index change according to a large 3rd order nonlinear optical phenomenon. The waveguide type optical device includes a signal beam waveguide through which a signal beam propagates; and a pump beam waveguide through which a pump beam propagates, wherein the pump beam waveguide is disposed adjacent to the signal beam waveguide so that the pump beam can be coupled to the signal beam waveguide, the signal beam waveguide is made of nonlinear optical materials with large 3rd order nonlinear optical property and the pump beam waveguide is made of linear optical materials, and the wavelength range of the signal beam is different from that of the pump beam. By such a structure, the pump beam is coupled to one arm of the signal beam waveguide, thereby generating a 3rd nonlinear phenomenon on one arm of the waveguide through which the signal beam passes. Therefore, the waveguide optical device which implements an all-optical communication device operating as an optical device and can be integrated is provided.
摘要翻译：公开了一种使用根据大的3阶非线性光学现象的非线性折射率变化的波导型光学器件。波导型光学器件包括信号光束波导，信号光束通过该波导波导传播; 以及泵浦光束通过其传播的泵浦波导，其中所述泵浦波导与所述信号光束波导相邻设置，使得所述泵浦波束可以耦合到所述信号波导管，所述信号波束波导由非线性光学材料制成，大的3阶非线性光学特性和泵浦波导由线性光学材料制成，信号光束的波长范围与泵浦光束的波长范围不同。通过这种结构，泵浦光束耦合到信号光束波导的一个臂，从而在信号光束通过的波导的一个臂上产生第三非线性现象。因此，提供了实现作为光学装置工作并可以集成的全光通信装置的波导光学装置。

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