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1. 发明授权

US08940936B2 Aryloxy phenoxy acrylic compound having HIF-1 inhibition activity, method for preparing same, and pharmaceutical composition containing same as an active ingredient 有权
标题翻译：具有HIF-1抑制活性的芳氧基苯氧基丙烯酸化合物及其制备方法，以及含有它们作为活性成分的药物组合物
公开(公告)号：US08940936B2
公开(公告)日：2015-01-27
申请号：US13880642
申请日：2011-10-17
申请人： Kyeong Lee , Mi Sun Won , Hwan Mook Kim , Song Kyu Park , Kiho Lee , Ki Hoon Lee , Chang Woo Lee , Jung Joon Lee , Kyung Sook Chung , Bo Kyung Kim , Yinglan Jin , Seung-hee Lee
发明人： Kyeong Lee , Mi Sun Won , Hwan Mook Kim , Song Kyu Park , Kiho Lee , Ki Hoon Lee , Chang Woo Lee , Jung Joon Lee , Kyung Sook Chung , Bo Kyung Kim , Yinglan Jin , Seung-hee Lee
IPC分类号： C07C233/07 , A61K31/167 , C07C235/28 , C07C311/16 , C07D295/088
CPC分类号： A61K31/5375 , A61K9/0019 , A61K9/08 , A61K9/14 , A61K9/20 , A61K9/48 , A61K31/167 , A61K31/196 , A61K31/24 , A61K31/34 , A61K31/40 , A61K31/417 , A61K31/4409 , C07C233/07 , C07C235/28 , C07C311/16 , C07C311/46 , C07C317/40 , C07C2603/74 , C07D295/088
摘要： The present invention relates to a compound inhibiting HF-1 activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention demonstrates anticancer activity not by non-selective cytotoxicity but by inhibiting the activity of HIF-1, the transcription factor playing an important role in cancer cell growth and metastasis. Accordingly, the compound or the pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumors such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.
摘要翻译：本发明涉及抑制HF-1活性的化合物，其制备方法以及含有该化合物作为活性成分的药物组合物。本发明的化合物通过非选择性细胞毒性表现出抗癌活性，但通过抑制HIF-1的活性，该转录因子在癌细胞生长和转移中起重要作用。因此，根据本发明的化合物或其药学上可接受的盐抑制HIF-1活性，因此可以用作结肠癌，肝癌，胃癌和乳腺癌等实体瘤的治疗剂。此外，根据本发明的化合物或其药学上可接受的盐可以用作用于糖尿病性视网膜病变或关节炎的治疗剂的活性成分，当HIF-1的缺氧诱导的VEGF表达增加时，可能变差。

2. 发明申请

US20130237542A1 ARYLOXY PHENOXY ACRYLIC COMPOUND HAVING HIF-1 INHIBITION ACTIVITY, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ACTIVE INGREDIENT 有权
标题翻译：具有HIF-1抑制活性的芳族羟基丙烯酸酯化合物，其制备方法和含有活性成分的药物组合物
公开(公告)号：US20130237542A1
公开(公告)日：2013-09-12
申请号：US13880642
申请日：2011-10-17
申请人： Kyeong Lee , Mi Sun Won , Hwan Mook Kim , Song Kyu Park , Kiho Lee , Ki Hoon Lee , Chang Woo Lee , Jung Joon Lee , Kyung Sook Chung , Bo Kyung Kim , Yinglan Jin , Seung-hee Lee
发明人： Kyeong Lee , Mi Sun Won , Hwan Mook Kim , Song Kyu Park , Kiho Lee , Ki Hoon Lee , Chang Woo Lee , Jung Joon Lee , Kyung Sook Chung , Bo Kyung Kim , Yinglan Jin , Seung-hee Lee
IPC分类号： C07C235/28 , C07D295/088 , C07C311/16
CPC分类号： A61K31/5375 , A61K9/0019 , A61K9/08 , A61K9/14 , A61K9/20 , A61K9/48 , A61K31/167 , A61K31/196 , A61K31/24 , A61K31/34 , A61K31/40 , A61K31/417 , A61K31/4409 , C07C233/07 , C07C235/28 , C07C311/16 , C07C311/46 , C07C317/40 , C07C2603/74 , C07D295/088
摘要： The present invention relates to a compound inhibiting HF-1 activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention demonstrates anticancer activity not by non-selective cytotoxicity but by inhibiting the activity of HIF-1, the transcription factor playing an important role in cancer cell growth and metastasis. Accordingly, the compound or the pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumors such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.
摘要翻译：本发明涉及抑制HF-1活性的化合物，其制备方法以及含有该化合物作为活性成分的药物组合物。本发明的化合物通过非选择性细胞毒性表现出抗癌活性，但通过抑制HIF-1的活性，该转录因子在癌细胞生长和转移中起重要作用。因此，根据本发明的化合物或其药学上可接受的盐抑制HIF-1活性，因此可以用作结肠癌，肝癌，胃癌和乳腺癌等实体瘤的治疗剂。此外，根据本发明的化合物或其药学上可接受的盐可以用作用于糖尿病性视网膜病变或关节炎的治疗剂的活性成分，当HIF-1的缺氧诱导的VEGF表达增加时，可能变差。

3. 发明申请

US20100113538A1 N-HYDROXY-4- BENZAMIDINE 2 ETHANSULFONIC ACID SALT, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 失效
标题翻译： N-羟基-4-苄基嘧啶2乙酸钠盐，其制备方法和包含其的药物组合物
公开(公告)号：US20100113538A1
公开(公告)日：2010-05-06
申请号：US12531807
申请日：2008-04-21
申请人： Jin Soo Lee , Soon Ki Cho , Seoung Kyoo Sung , Young Goo Jin , Jae Hoon Park , Bo Kyung Kim , Ja Hyun Cha , Eun Hee Cho , Jei Man Ryu
发明人： Jin Soo Lee , Soon Ki Cho , Seoung Kyoo Sung , Young Goo Jin , Jae Hoon Park , Bo Kyung Kim , Ja Hyun Cha , Eun Hee Cho , Jei Man Ryu
IPC分类号： A61K31/426 , C07D277/30 , A61P19/10 , A61P19/00 , A61P29/00 , A61P37/08
CPC分类号： C07D277/24
摘要： N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine 2 ethansulfonic acid salt, a process for the preparation thereof, a pharmaceutical composition for preventing and treating osteoporosis, bone fractures or allergic inflammatory diseases, comprising the same, and an oral formulation for preventing and treating osteoporosis, bone fractures or allergic inflammatory diseases, comprising the same are described.
摘要翻译： N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基}苄脒2乙磺酸盐，其制备方法，药物描述了用于预防和治疗骨质疏松症，骨折或过敏性炎性疾病的组合物，以及用于预防和治疗含有该组合物的骨质疏松症，骨折或过敏性炎性疾病的口服制剂。

4. 发明授权

US08039635B2 N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl) phenoxy]pentoxy} benzamidine 2 ethansulfonic acid salt, process for the preparation thereof and pharmaceutical composition comprising the same 失效
标题翻译： N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基}苄脒2乙磺酸盐，其制备方法和药物组合物，其包含一样
公开(公告)号：US08039635B2
公开(公告)日：2011-10-18
申请号：US12531807
申请日：2008-04-21
申请人： Jin Soo Lee , Soon Ki Cho , Seoung Kyoo Sung , Young Goo Jin , Jae Hoon Park , Bo Kyung Kim , Ja Hyun Cha , Eun Hee Cho , Jei Man Ryu
发明人： Jin Soo Lee , Soon Ki Cho , Seoung Kyoo Sung , Young Goo Jin , Jae Hoon Park , Bo Kyung Kim , Ja Hyun Cha , Eun Hee Cho , Jei Man Ryu
IPC分类号： A61K31/426 , C07D277/30
CPC分类号： C07D277/24
摘要： N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy} benzamidine 2 ethansulfonic acid salt, a process for the preparation thereof, a pharmaceutical composition for preventing and treating osteoporosis, bone fractures or allergic inflammatory diseases, comprising the same, and an oral formulation for preventing and treating osteoporosis, bone fractures or allergic inflammatory diseases, comprising the same are described.
摘要翻译： N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基}苄脒2乙磺酸盐，其制备方法，药物描述了用于预防和治疗骨质疏松症，骨折或过敏性炎性疾病的组合物，以及用于预防和治疗含有该组合物的骨质疏松症，骨折或过敏性炎性疾病的口服制剂。

5. 发明申请

US20100249402A1 NOVEL BENZAMIDINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OSTEPOROSIS COMPRISING THE SAME 审中-公开
标题翻译：新型苯扎明衍生物，其制备方法和用于预防或治疗包含其的药物组合物的药物组合物
公开(公告)号：US20100249402A1
公开(公告)日：2010-09-30
申请号：US12670814
申请日：2008-07-28
申请人： Jei Man Ryu , Jin Soo Lee , Young Goo Jin , Jae Hoon Park , Bo Kyung Kim , Dae Yeon Won , Yun-Ha Hwang , Ki Yoon Kim , Sae Kwang Ku
发明人： Jei Man Ryu , Jin Soo Lee , Young Goo Jin , Jae Hoon Park , Bo Kyung Kim , Dae Yeon Won , Yun-Ha Hwang , Ki Yoon Kim , Sae Kwang Ku
IPC分类号： C07D417/02 , C07D413/02
CPC分类号： C07D277/22 , C07D277/28 , C07D277/40 , C07D417/06
摘要： The present invention relates to novel benzamidine derivatives, a process for the preparation thereof and a pharmaceutical composition for preventing or treating osteoporosis comprising the same. The benzamidine derivatives of the present invention effectively inhibit osteoclast differentiation at an extremely low concentration, and thus can be advantageously used for the prevention and treatment of osteoporosis.
摘要翻译：本发明涉及新的苄脒衍生物，其制备方法和用于预防或治疗包含其的骨质疏松症的药物组合物。本发明的苄脒衍生物以极低的浓度有效抑制破骨细胞分化，因此可有利地用于预防和治疗骨质疏松症。

6. 发明授权

US07149181B2 Apparatus and method for re-transmitting erroneous packet data 有权
标题翻译：用于重传错误分组数据的装置和方法
公开(公告)号：US07149181B2
公开(公告)日：2006-12-12
申请号：US09801682
申请日：2001-03-09
申请人： Bo Kyung Kim
发明人： Bo Kyung Kim
IPC分类号： H04L12/56
CPC分类号： H04L1/188
摘要： An apparatus and method for re-transmitting erroneous packet data is disclosed. Each of the physical layers of the system includes a buffer, a timer, a controller, and a radio frequency unit. The buffer temporarily stores transmitted data in the form of a final data frame capable of being transmitted on a transmission line without any processing. The timer is a time counter adapted to limit the time, for which the transmission end waits for an acknowledgment to a transmission of data after the data transmission is made. If no acknowledgment signal is received when the timer expires the buffered data in the physical layer is re-transmitted. This reduces the data transmission delay resulting from the inter-layer movement of data generated during a re-transmission of erroneous data, and the transmission delay of packet data resulting from overhead time.
摘要翻译：公开了重传错误分组数据的装置和方法。系统的每个物理层包括缓冲器，定时器，控制器和射频单元。缓冲器临时存储能够在传输线上传输的最终数据帧形式的发送数据，而不进行任何处理。定时器是一种时间计数器，适用于限制传输结束在进行数据传输之后等待数据传输确认的时间。如果在定时器到期时没有接收到确认信号，物理层中缓存的数据被重新发送。这减少了在错误数据的重新传输期间产生的数据的层间移动以及由开销时间产生的分组数据的传输延迟所导致的数据传输延迟。

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