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1. 发明申请

US20090022822A1 EXTRACT OF OGALPI, ERECTILE DYSFUNCTION FANNING HEALTHY FOOD AND ERECTILE DYSFUNCTION TREATING AGENT CONTAINING THE SAME 有权
标题翻译： OGALPI的提取物，精神分裂症功能性食物健康食品和含有其的精神分裂症治疗剂
公开(公告)号：US20090022822A1
公开(公告)日：2009-01-22
申请号：US12240503
申请日：2008-09-29
申请人： Jung Joon Lee , Jeong-Hyung Lee , Young Soo Hong , Young Ho Kim , Young Deuk Chol
发明人： Jung Joon Lee , Jeong-Hyung Lee , Young Soo Hong , Young Ho Kim , Young Deuk Chol
IPC分类号： A61K36/82 , A61P15/10
CPC分类号： A23L33/105 , A21D2/14 , A21D2/36 , A21D13/80 , A23G1/48 , A23G3/48 , A23G4/068 , A23G9/42 , A23L2/52 , A61K36/254
摘要： The present invention relates to an alcohol extract of ogalpi, erectile dysfunction improving health food and a treating agent containing the same, more precisely, an alcohol extract of ogalpi having an effect of improving erectile dysfunction, erectile dysfunction improving health food and an erectile dysfunction treating agent containing the same. The alcohol extract of ogalpi of the present invention has a promoting effect of penile erectility, so that it can be effectively used for the improvement of erectile dysfunction.
摘要翻译：本发明涉及一种卵黄醇提取物，改善健康食品的勃起功能障碍及含有该成分的治疗剂，更准确地说，是具有改善勃起功能障碍，改善勃起功能障碍的健康食品和勃起功能障碍治疗的卵黄醇提取物含有相同的代理本发明的欧氏提取物具有阴茎勃起的促进作用，因此可以有效地用于改善勃起功能障碍。

2. 外观设计

USD683349S1 Exterior rim for a display device 有权
标题翻译：用于显示设备的外框
公开(公告)号：USD683349S1
公开(公告)日：2013-05-28
申请号：US29427318
申请日：2012-07-17
申请人： Young-Soo Hong , Eui-Seok Kim
设计人： Young-Soo Hong , Eui-Seok Kim

3. 发明授权

US08394799B2 Compounds that inhibit HIF-1 activity, the method for preparation thereof and the pharmaceutical composition containing them as an effective component 有权
标题翻译：抑制HIF-1活性的化合物，其制备方法和含有它们作为有效成分的药物组合物
公开(公告)号：US08394799B2
公开(公告)日：2013-03-12
申请号：US12306319
申请日：2007-07-03
申请人： Jung Joon Lee , Jeong-Hyung Lee , Kyeong Lee , Young-Soo Hong , B. K. Shanthaveerappa , Yinlan Jin , Jin Hwan Kim , Xuejun Jin
发明人： Jung Joon Lee , Jeong-Hyung Lee , Kyeong Lee , Young-Soo Hong , B. K. Shanthaveerappa , Yinlan Jin , Jin Hwan Kim , Xuejun Jin
IPC分类号： A61K31/5377 , A61K31/167 , A61K31/41 , A61K31/423 , A61P19/02 , C07C233/33 , C07D257/04 , C07D263/57 , C07D295/15
CPC分类号： C07C237/42 , C07C235/24 , C07C255/60 , C07C271/42 , C07C307/02 , C07C311/46 , C07C317/40 , C07C2603/74 , C07D213/38 , C07D213/75 , C07D213/79 , C07D213/80 , C07D213/81 , C07D235/12 , C07D257/04 , C07D263/56 , C07D307/52 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Disclosed herein are an HIF-1 inhibitor, a method for the preparation thereof, and a pharmaceutical composition comprising the same as an active ingredient. The HIF-1 inhibitor shows anticancer activity thanks to the inhibition activity against HIF-1, a transcription factor which plays an important role in the growth and metastasis of cancer, but not to general cytotoxicity. Thus, the HIF-inhibitor and a pharmaceutically acceptable salt thereof can be used as a therapeutic for various cancers such as liver cancer; stomach cancer and breast cancer. Also, the compound having inhibition activity against HIF-1 is useful in the treatment of diabetic retinopathy and arthritis, which are aggravated by HIF-1-mediated VEGF expression.
摘要翻译：本文公开了HIF-1抑制剂，其制备方法和包含其作为活性成分的药物组合物。 HIF-1抑制剂由于对HIF-1的抑制活性而显示出抗癌活性，HIF-1是在癌症的生长和转移中起重要作用的转录因子，而不是一般的细胞毒性。因此，HIF抑制剂及其药学上可接受的盐可以用作各种癌症如肝癌的治疗剂; 胃癌和乳腺癌。此外，对HIF-1具有抑制活性的化合物可用于治疗由HIF-1介导的VEGF表达而恶化的糖尿病性视网膜病变和关节炎。

4. 发明授权

US08304448B2 Method for the treatment of metabolic disorder containing benzazole derivatives as an active ingredient 有权
标题翻译：用于治疗含有苯并唑衍生物作为活性成分的代谢紊乱的方法
公开(公告)号：US08304448B2
公开(公告)日：2012-11-06
申请号：US12442895
申请日：2007-09-27
申请人： Hyun Sun Lee , Kyeong Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Rho , Jeong Hyung Lee , Young Soo Hong , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
发明人： Hyun Sun Lee , Kyeong Lee , Jung Joon Lee , Young Kook Kim , Mun-Chual Rho , Jeong Hyung Lee , Young Soo Hong , Hye-Ran Park , Chul-Ho Lee , Yongseok Choi
IPC分类号： A61K31/40 , A61K31/405
CPC分类号： A61K31/423
摘要： Disclosed is a composition for the prevention and treatment of metabolic diseases, which comprises a benzazole derivative as an active ingredient. The benzazole derivative has inhibitory activity against DGAT (diacylglycerol acyltransferase), which causes metabolic diseases such as obesity and diabetes in the process of lipid metabolism. With the ability to effectively control lipid metabolism and energy metabolism, thus, the composition is useful in the prevention and treatment of metabolic diseases, such as obesity and diabetes.
摘要翻译：公开了用于预防和治疗代谢疾病的组合物，其包含作为有效成分的苯并唑衍生物。苯并唑衍生物对脂质代谢过程中引起代谢性疾病如肥胖和糖尿病的DGAT（二酰基甘油酰基转移酶）具有抑制活性。具有有效控制脂质代谢和能量代谢的能力，因此，该组合物可用于预防和治疗诸如肥胖症和糖尿病的代谢疾病。

5. 发明授权

US07309504B2 Extract of Acanthopanax koreanum for the treatment or prevention of hepatitis or the liver protective drug 失效
标题翻译：刺五加提取物用于治疗或预防肝炎或肝脏保护性药物
公开(公告)号：US07309504B2
公开(公告)日：2007-12-18
申请号：US10502140
申请日：2003-01-24
申请人： Jung Joon Lee , Jeong-Hyung Lee , Young Soo Hong , Young Ho Kim , Jeong Bum Nam , Dong Hwan Shon , Hang Sub Kim
发明人： Jung Joon Lee , Jeong-Hyung Lee , Young Soo Hong , Young Ho Kim , Jeong Bum Nam , Dong Hwan Shon , Hang Sub Kim
IPC分类号： A61K36/25 , A61K36/00
CPC分类号： A61K36/254
摘要： The disclosure concerns an extract of Acanthopanax koreanum and its use. More particularly, it concerns the extract of Acanthopanax koreanum comprising 1) the extract of Acanthopanax koreanum extracted from water, 2) among the water extract, the extract of Acanthopanax koreanum only containing ethanol insoluble part obtained by precipitating ethanol, 3) among the ethanol insoluble part, the extract of Acanthopanax koreanum containing polysaccaride with a molecular weight larger than range of 12,000˜14,000, or 4) among the ethanol insoluble part, the extract of Acanthopanax koreanum containing polysaccaride with a molecular weight larger than 100,000, which is respectively obtained from the root or stem of Acanthopanax koreanum. The extract of the present invention shows a high inhibitory activity against hepatitis and protects the liver, and thus, can be used for the treatment or prevention of hepatitis, or as a liver protective drug.
摘要翻译：本公开涉及刺五加的提取物及其用途。更具体地说，涉及刺五加提取物，其包括1）从水中提取的刺五加提取物，2）在水提取物中，仅含有通过沉淀乙醇获得的乙醇不溶部分的刺五加的提取物，3）乙醇不溶性一部分含有分子量大于12,000〜14,000范围的多糖的刺五加提取物，或4）在乙醇不溶部分中，含有分子量大于100,000的多糖的刺五加提取物分别从刺五加的根或茎。本发明的提取物显示出对肝炎的高抑制活性并保护肝脏，因此可用于治疗或预防肝炎，或用作肝保护药物。

6. 发明申请

US20090306078A1 COMPOUNDS THAT INHIBIT HIF-1 ACTIVITY, THE METHOD FOR PREPARATION THEREOF AND THE PHARMACEUTICAL COMPOSITION CONTAINING THEM AS AN EFFECTIVE COMPONENT 有权
标题翻译：抑制HIF-1活性的化合物，其制备方法和作为有效成分的药物组合物
公开(公告)号：US20090306078A1
公开(公告)日：2009-12-10
申请号：US12306319
申请日：2007-07-03
申请人： Jung Joon Lee , Jeong-Hyung Lee , Kyeong Lee , Young-Soo Hong , B.K. Shanthaveerappa , Yinlan Jin , Jin Hwan Kim , Xuejun Jin
发明人： Jung Joon Lee , Jeong-Hyung Lee , Kyeong Lee , Young-Soo Hong , B.K. Shanthaveerappa , Yinlan Jin , Jin Hwan Kim , Xuejun Jin
IPC分类号： A61K31/5377 , C07C233/33 , A61K31/167 , A61K31/41 , C07D257/04 , C07D295/15 , A61K31/423 , C07D263/57 , A61P19/02
CPC分类号： C07C237/42 , C07C235/24 , C07C255/60 , C07C271/42 , C07C307/02 , C07C311/46 , C07C317/40 , C07C2603/74 , C07D213/38 , C07D213/75 , C07D213/79 , C07D213/80 , C07D213/81 , C07D235/12 , C07D257/04 , C07D263/56 , C07D307/52 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Disclosed herein are an HIF-1 inhibitor, a method for the preparation thereof, and a pharmaceutical composition comprising the same as an active ingredient. The HIF-1 inhibitor shows anticancer activity thanks to the inhibition activity against HIF-1, a transcription factor which plays an important role in the growth and metastasis of cancer, but not to general cytotoxicity. Thus, the HIF-inhibitor and a pharmaceutically acceptable salt thereof can be used as a therapeutic for various cancers such as liver cancer; stomach cancer and breast cancer. Also, the compound having inhibition activity against HIF-1 is useful in the treatment of diabetic retinopathy and arthritis, which are aggravated by HIF-1-mediated VEGF expression.
摘要翻译：本文公开了HIF-1抑制剂，其制备方法和包含其作为活性成分的药物组合物。 HIF-1抑制剂由于对HIF-1的抑制活性而显示出抗癌活性，HIF-1是在癌症的生长和转移中起重要作用的转录因子，而不是一般的细胞毒性。因此，HIF抑制剂及其药学上可接受的盐可以用作各种癌症如肝癌的治疗剂; 胃癌和乳腺癌。此外，对HIF-1具有抑制活性的化合物可用于治疗由HIF-1介导的VEGF表达而恶化的糖尿病性视网膜病变和关节炎。

7. 发明申请

US20080275039A1 Geldanamycin Derivatives and the Method for Biosynthesis Thereof 审中-公开
标题翻译：格尔德霉素衍生物及其生物合成方法
公开(公告)号：US20080275039A1
公开(公告)日：2008-11-06
申请号：US11573503
申请日：2005-08-11
申请人： Jung Joon Lee , Young Soo Hong , Dongho Lee , Jeong-Hyung Lee , Kwang-Soo Sung
发明人： Jung Joon Lee , Young Soo Hong , Dongho Lee , Jeong-Hyung Lee , Kwang-Soo Sung
IPC分类号： A61K31/5377 , C07D225/06 , C07H21/04 , C12N1/20 , C12P17/10 , C12N15/64 , A61P31/04 , A61P37/06 , A61P35/00 , A61P31/12 , A61P31/10
CPC分类号： C07D225/06
摘要： The present invention relates to geldanamycin derivatives, benzoquinone ansamycin biosynthesized by gene manipulation of Streptomyces hygroscopicus subsp. duamyceticus and the method producing them, more particularly to a geldanamycin O-carbamoyl transferase gene(gel8)-inactive mutant, the method producing it and geldanamycin derivatives, 4,5-dihydro-7-O-descarbamoyl-7-hydroxy geldanamycin and 4,5-dihydro-7-O-descarbamoyl-7-hydroxy-17-O-demethyl geldanamycin. Since geldanamycin derivatives of the present invention suppress Hsp90 like geldanamycin, they can effectively be used for antibiotic, antifungal, antiviral, anti-inflammatory and antitumor agents and an immune suppressant.
摘要翻译：本发明涉及通过吸湿链霉菌subsp。的基因操作生物合成的格尔德霉素衍生物，苯醌安莎霉素。杜马霉素及其制备方法，更具体地涉及格尔德霉素O-氨基甲酰基转移酶基因（gel8） - 活性突变体，其制备方法和格尔德霉素衍生物，4,5-二氢-7-O-氨基甲酰基-7-羟基格尔德霉素和4 ，5-二氢-7-O-氨基甲酰基-7-羟基-17-O-脱甲基格尔德霉素。由于本发明的格尔德霉素衍生物抑制类似格尔德霉素的Hsp90，因此它们可以有效地用于抗生素，抗真菌剂，抗病毒剂，抗炎剂和抗肿瘤剂和免疫抑制剂。

8. 发明申请

US20050233876A1 Doctor underpants 审中-公开
标题翻译：医生内裤
公开(公告)号：US20050233876A1
公开(公告)日：2005-10-20
申请号：US10521344
申请日：2003-07-16
申请人： Young-Soo Hong
发明人： Young-Soo Hong
IPC分类号： A41B9/02 , A63B21/02
CPC分类号： A41B9/02 , A61H19/32 , A61H2201/1253 , A61H2201/1628 , A61H2201/165
摘要： This invention relates to an inside structure of a male underpants for kinematically moving a penis. The inside structure of the underpants comprises comprises a waistband 110, a penis cord 120 for lifting a lower muscle of the penis positioned between the penis and a scrotum, penis supporting cords 130a, 130b, connected to either side of the penis cord 120, and penis exercising cords 140a, 140b positioned between the penis supporting cords 130a, 130b. The invention has a simple constitution, and thus may be easily manufactured. The invention provides healthful underpants having a pleasant wearing feeling by giving a pleasant stimulation to the lower muscle of the penis and kinematically moving the penis.
摘要翻译：本发明涉及用于运动学运动阴茎的男性内裤的内部结构。内裤的内部结构包括腰带110，用于提升位于阴茎和阴囊之间的阴茎的下部肌肉的阴茎绳120，阴茎支撑绳130a，130b，连接到阴茎帘线120的任一侧和阴茎锻炼位于阴茎支撑绳130a，130b之间的绳索140a，140b。本发明具有简单的结构，因此可以容易地制造。本发明通过对阴茎的下部肌肉进行愉悦的刺激并且运动地移动阴茎来提供健康的内裤，其具有愉悦的穿着感。

9. 发明授权

US06894073B2 Use of diterpene compound as a therapeutic agent of inflammation, immune disease or cancer 失效
标题翻译：使用双萜化合物作为炎症，免疫疾病或癌症的治疗剂
公开(公告)号：US06894073B2
公开(公告)日：2005-05-17
申请号：US10450217
申请日：2001-12-12
申请人： Jung-Joon Lee , Jeong-Hyung Lee , Hang-Sub Kim , Young-Soo Hong , Bang-Yeon Hwang
发明人： Jung-Joon Lee , Jeong-Hyung Lee , Hang-Sub Kim , Young-Soo Hong , Bang-Yeon Hwang
IPC分类号： A61K31/122 , C07C45/78 , C07C49/743 , C07D493/08 , A61K31/352 , C07C49/115 , C07C49/215 , C07D311/78
CPC分类号： C07D493/08 , A61K31/122 , C07C45/78 , C07C49/743
摘要： The disclosure concerns novel use of diterpene compound as a therapeutic agent of inlfammation, immune disease or cancer. More particularly, the present invention relates to novel use of diterpene compound that include kamebanin, kamebacetal A, kamebakaurin, and exisanin A, which would be effective for the treatment inflammation, immune disease or cancer by inhibiting the production of nitric oxide, prostaglandin, and TNF-a1 through the suppression of NF-k B activity.
摘要翻译：本公开涉及双萜化合物作为炎症，免疫疾病或癌症的治疗剂的新用途。更具体地说，本发明涉及二萜化合物的新用途，其中包括kamebanin，kamebacetal A，kamebakaurin和exisanin A，这对于通过抑制一氧化氮，前列腺素和通过抑制NF-κB活性，TNF-α1A。

10. 发明授权

US06770671B2 7,8-dihydro-xanthenone-8-carboxylic acid derivative and novel microbe producing the same 失效
标题翻译： 7,8-二氢呫吨酮-8-羧酸衍生物及其生产新颖的微生物
公开(公告)号：US06770671B2
公开(公告)日：2004-08-03
申请号：US10220724
申请日：2002-09-04
申请人： Jung Joon Lee , Jeong-Hyung Lee , Hang Sub Kim , Young-Soo Hong , Yun Joo Park
发明人： Jung Joon Lee , Jeong-Hyung Lee , Hang Sub Kim , Young-Soo Hong , Yun Joo Park
IPC分类号： A61K3135
CPC分类号： C12R1/66 , C07D311/86 , C12P17/06
摘要： Disclosed are a novel compound represented by the following chemical formula (1), useful for the prophylaxis and treatment of angiogenic diseases, its production, and a novel microorganism producing the same. Aspergillus sp. Y80118 isolated from soil was found to produce 7,8-dihydro-1,7-dihydroxy-3-hydroxymethyl-xanthenone-8-carboxylic acid methylester which inhibits VEGF-induced proliferation of HUVEC, angiogenesis in CAM assay, and tumor growth. The novel compound can be effectively used for the medical treatment of anigiogenic diseases, including cancers, rheumatoid arthritis, and diabetic retinopathy.
摘要翻译：公开了由以下化学式（1）表示的新型化合物，其用于预防和治疗血管生成疾病及其生产，以及生产该新化合物的新型微生物。曲霉菌发现从土壤中分离的Y80118产生抑制VEGF诱导的HUVEC增殖，CAM测定中的血管发生和肿瘤生长的7,8-二氢-1,7-二羟基-3-羟甲基 - 呫吨酮-8-羧酸甲酯。该新型化合物可有效地用于治疗致病性疾病，包括癌症，类风湿性关节炎和糖尿病性视网膜病变。

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