会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 2. 发明授权
    • Charge pump with a programmable pump current and system
    • 带有可编程泵电流和系统的电荷泵
    • US5362990A
    • 1994-11-08
    • US70186
    • 1993-06-02
    • Jose AlvarezHector SanchezGianfranco Gerosa
    • Jose AlvarezHector SanchezGianfranco Gerosa
    • H03L7/093H03L7/089H03L7/107H03L7/183H03K3/01H03K5/13H03L5/00
    • H03L7/183H03L7/0898H03L7/107H03L2207/04
    • A charge pump has a reference circuitry (18, 20, 22), a first parallel current path (16), at least one second parallel current path (16), a mirror circuit (46), a sourcing circuitry (60, 62) and a sinking circuitry (50, 54, 66, 68). The first and the at least one second parallel current path sink current from a first node responsive to a predetermined voltage generated by the reference circuitry. The at least one second current path also operates responsive to a control signal. The mirror circuit generates a second predetermined voltage responsive to the total current sunk from the first node. The sourcing circuitry and the sinking circuitry sourcing and sinking a current from the output node, respectively, responsive to the second predetermined voltage and to a control signal. The disclosed charge pump may be incorporated into a phase locked loop circuit where constant stability parameters are desired.
    • 电荷泵具有参考电路(18,20,22),第一并联电流路径(16),至少一个第二并联电流路径(16),镜电路(46),源电路(60,62) 和下沉电路(50,54,66,68)。 响应于由参考电路产生的预定电压,第一和至少一个第二并联电流路径从第一节点吸收电流。 所述至少一个第二电流路径也响应于控制信号而起作用。 镜电路响应于从第一节点下降的总电流产生第二预定电压。 源电路和吸收电路分别根据第二预定电压和控制信号从输出节点发出和吸收电流。 所公开的电荷泵可以并入到需要恒定稳定性参数的锁相环电路中。
    • 5. 发明申请
    • Antibody fragments specific for human carcinoembryonic antigen (CEA)
    • 针对人癌胚抗原(CEA)特异的抗体片段
    • US20070199078A1
    • 2007-08-23
    • US11731442
    • 2007-03-30
    • Jorge CowleyMarta AvilaFreya Freyre AlmeidaBoris CastroHanssel GarciaLourdes NavarroLuis LopezJose AlvarezRaquel Segui
    • Jorge CowleyMarta AvilaFreya Freyre AlmeidaBoris CastroHanssel GarciaLourdes NavarroLuis LopezJose AlvarezRaquel Segui
    • A61K51/00C12N5/06A61K39/395
    • C07K14/22C07K16/3007C07K2317/622C07K2317/626
    • The invention refers to mono- and divalent (diabody) single chain Fv (scFv) antibody fragments, obtained by recombinant DNA techniques from the anti-carcinoembryonic antigen (CEA) monoclonal antibody (Mab) CB/ior-CEA. 1. This antibody has high affinity for CEA and is employed in the diagnosis and follow-up of human colorectal tumors. As the original Mab, the monovalent fragment and the diabody exhibit high affinity for human CEA and recognize an epitope dependent of carbohydrate conservation. The monovalent scFv fragment and the diabody have affinity constants for CEA of (5.0±0.4)×109 L mol−1 and (2.8±0.3)×1010 L mol−1, respectively. These two fragments do not show cross reactivity with human normal cells and tissues, exception made of the normal colonic mucosa, where CEA is occasionally present. The fragments can be produced through the expression in recombinant microorganisms, starting from the cloning of the encoding variable region nucleic acid sequences obtained from the hybridoma that produces Mab CB/ior-CEA.1. As the original Mab, the monovalent scFv and the diabody have the ability to identify in vivo cells that produce human CEA and grow as tumors in mice. The monovalent scFv and the diabody have a molecular size 5 and 2.5 times lower, respectively, than the mouse Mab, and do not have Fc domains, fact this that confers them the potential to better penetrate tissues in vivo and to be less immunogenic in man.
    • 本发明涉及通过来自抗癌胚抗原(CEA)单克隆抗体(Mab)CB / i-CEA的重组DNA技术获得的单价和二价(双抗体)单链Fv(scFv)抗体片段。 该抗体对CEA具有高亲和力,用于诊断和追踪人结肠直肠肿瘤。 作为原始的Mab,单价片段和双抗体对人CEA表现出高亲和力,并识别依赖于碳水化合物保护的表位。 单价scFv片段和双抗体对于(5.0±0.4)×10 9 L mol -1 -1和(2.8±0.3)×10 10 -1的CEA具有亲和力常数, / SUP> L mol 。 这两个片段不显示与人正常细胞和组织的交叉反应性,例外是正常结肠粘膜,其中CEA偶尔存在。 通过从产生Mab CB / i-CEA.1的杂交瘤获得的编码可变区核酸序列的克隆开始,可以通过重组微生物中的表达产生片段。 作为原始的Mab,单价scFv和双抗体具有鉴定产生人CEA的体内细胞并在小鼠中作为肿瘤生长的能力。 单价scFv和双抗体分别具有比小鼠Mab低5和2.5倍的分子量,并且不具有Fc结构域,事实上,这赋予它们在体内更好地穿透组织的潜力并且在人中具有较少的免疫原性 。
    • 8. 发明授权
    • Real-time disk system
    • 实时磁盘系统
    • US5396339A
    • 1995-03-07
    • US803502
    • 1991-12-06
    • John SternJose AlvarezLuigi GalloDouglas J. George
    • John SternJose AlvarezLuigi GalloDouglas J. George
    • G11B27/034G11B27/32G11B27/34H04N5/765H04N5/781H04N5/917H04N5/92H04N5/926H04N5/956H04N7/01H04N9/804H04N9/87G11B7/00
    • H04N7/0112G11B27/034G11B27/34H04N5/765H04N5/781H04N5/917H04N5/9205H04N5/9261H04N9/87G11B2220/415G11B27/329H04N5/956H04N9/804
    • A real-time disk system (10) stores and plays back D1 digital 10-bit 4:2:2 component video and audio signals from magnetic storage disks (12). The system (10) has a main channel subsystem (14) with an associated smooth motion option (16) and a second or key channel option subsystem (18) with an associated smooth motion option (20). Serial and parallel D1 digital video inputs (30) and (32) and outputs (34) and (36) are connected to each of the channels (14) and (18) and to control subsystem (22). In the main channel (14), the serial and parallel D1 input (30) is connected through an input board (60) to a video processing board (62). The video board (62) is connected by a bidirectional, 11.times.2 wide bus (64) to disk arrays (66) and (68). Digital video signal information is stored and retrieved in parallel to and from the disk arrays (66) and (68) without requiring any serial to parallel or parallel to serial conversion. Smooth motion option (20) processes a group of video fields by creating a plurality of additional fields between two original fields in the group of video fields by a combination of motion adaptive interpolation and frame repetition.
    • 实时盘系统(10)存储并播放来自磁存储盘(12)的D1数字10位4:2:2分量视频和音频信号。 系统(10)具有具有相关联的平滑运动选项(16)的主通道子系统(14)和具有相关联的平滑运动选项(20)的第二或键通道选项子系统(18)。 串行和并行D1数字视频输入(30)和(32)和输出(34)和(36)连接到每个通道(14)和(18)和控制子系统(22)。 在主通道(14)中,串行和并行D1输入(30)通过输入板(60)连接到视频处理板(62)。 视频板(62)通过双向11x2宽的总线(64)连接到磁盘阵列(66)和(68)。 数字视频信号信息与磁盘阵列(66)和(68)并行存储和检索,而不需要串行到并行或并行串行转换。 平滑运动选项(20)通过运动自适应内插和帧重复的组合在视频场组中的两个原始场之间创建多个附加场来处理一组视频场。