专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070199078A1 Antibody fragments specific for human carcinoembryonic antigen (CEA) 审中-公开
标题翻译：针对人癌胚抗原（CEA）特异的抗体片段
公开(公告)号：US20070199078A1
公开(公告)日：2007-08-23
申请号：US11731442
申请日：2007-03-30
申请人： Jorge Cowley , Marta Avila , Freya Freyre Almeida , Boris Castro , Hanssel Garcia , Lourdes Navarro , Luis Lopez , Jose Alvarez , Raquel Segui
发明人： Jorge Cowley , Marta Avila , Freya Freyre Almeida , Boris Castro , Hanssel Garcia , Lourdes Navarro , Luis Lopez , Jose Alvarez , Raquel Segui
IPC分类号： A61K51/00 , C12N5/06 , A61K39/395
CPC分类号： C07K14/22 , C07K16/3007 , C07K2317/622 , C07K2317/626
摘要： The invention refers to mono- and divalent (diabody) single chain Fv (scFv) antibody fragments, obtained by recombinant DNA techniques from the anti-carcinoembryonic antigen (CEA) monoclonal antibody (Mab) CB/ior-CEA. 1. This antibody has high affinity for CEA and is employed in the diagnosis and follow-up of human colorectal tumors. As the original Mab, the monovalent fragment and the diabody exhibit high affinity for human CEA and recognize an epitope dependent of carbohydrate conservation. The monovalent scFv fragment and the diabody have affinity constants for CEA of (5.0±0.4)×109 L mol−1 and (2.8±0.3)×1010 L mol−1, respectively. These two fragments do not show cross reactivity with human normal cells and tissues, exception made of the normal colonic mucosa, where CEA is occasionally present. The fragments can be produced through the expression in recombinant microorganisms, starting from the cloning of the encoding variable region nucleic acid sequences obtained from the hybridoma that produces Mab CB/ior-CEA.1. As the original Mab, the monovalent scFv and the diabody have the ability to identify in vivo cells that produce human CEA and grow as tumors in mice. The monovalent scFv and the diabody have a molecular size 5 and 2.5 times lower, respectively, than the mouse Mab, and do not have Fc domains, fact this that confers them the potential to better penetrate tissues in vivo and to be less immunogenic in man.
摘要翻译：本发明涉及通过来自抗癌胚抗原（CEA）单克隆抗体（Mab）CB / i-CEA的重组DNA技术获得的单价和二价（双抗体）单链Fv（scFv）抗体片段。该抗体对CEA具有高亲和力，用于诊断和追踪人结肠直肠肿瘤。作为原始的Mab，单价片段和双抗体对人CEA表现出高亲和力，并识别依赖于碳水化合物保护的表位。单价scFv片段和双抗体对于（5.0±0.4）×10 9 L mol -1 -1和（2.8±0.3）×10 10 -1的CEA具有亲和力常数， / SUP> L mol 。这两个片段不显示与人正常细胞和组织的交叉反应性，例外是正常结肠粘膜，其中CEA偶尔存在。通过从产生Mab CB / i-CEA.1的杂交瘤获得的编码可变区核酸序列的克隆开始，可以通过重组微生物中的表达产生片段。作为原始的Mab，单价scFv和双抗体具有鉴定产生人CEA的体内细胞并在小鼠中作为肿瘤生长的能力。单价scFv和双抗体分别具有比小鼠Mab低5和2.5倍的分子量，并且不具有Fc结构域，事实上，这赋予它们在体内更好地穿透组织的潜力并且在人中具有较少的免疫原性。

2. 发明申请

US20200337933A1 ASSISTIVE DEVICE FOR PATIENTS WITH SOMATOSENSATION DEFICIENCY 审中-公开
公开(公告)号：US20200337933A1
公开(公告)日：2020-10-29
申请号：US16858302
申请日：2020-04-24
申请人： Luis Lopez , Arizona Board of Regents on behalf of Arizona State University , Dignity Health
发明人： Thomas Sugar , Luis Lopez , Lee Griffith , Robin Parmentier , Saivimal Sridar , Pham Huy Nguyen , Jeremy Palmiscno , Will Meredith
IPC分类号： A61H1/02
摘要： A soft wearable medical device may comprise a force actuation system at least partially disposed in a glove assembly. The force actuation system may be a passive or active actuation system. The force actuation system may be configured to adjust a grip of a patient during use of the soft wearable medical device. The soft wearable medical device may further comprise a force indication system including a plurality of force sensors and a light array, each force sensor disposed in a finger of the glove assembly and the light array mounted to the glove assembly.

3. 发明授权

US10486300B2 Tool holder 有权
公开(公告)号：US10486300B2
公开(公告)日：2019-11-26
申请号：US15823800
申请日：2017-11-28
申请人： Luis Lopez
发明人： Luis Lopez
IPC分类号： B25H3/00 , B25H3/04 , F16B1/00
CPC分类号： B25H3/003 , B25H3/04 , F16B2001/0035
摘要： A device includes a body portion including: a top portion, a bottom portion, a first track, a ledge connected to the bottom portion and multiple through-holes. A first magnet element is disposed within the first track.

4. 发明申请

US20070128729A1 Method for the identification and relative quantification of proteins based on the selective isolation of RRnK peptides for the simplification of complex mixtures of proteins 审中-公开
标题翻译：基于选择性分离RRnK肽的蛋白质鉴定和相对定量的方法，用于简化蛋白质的复杂混合物
公开(公告)号：US20070128729A1
公开(公告)日：2007-06-07
申请号：US11603975
申请日：2006-11-22
申请人： Aniel Puente , Luis Lopez , Jeovanis Valdes , Lazaro Nunes , Vladimir Perez , Jorge Fernandez Dorta-Duque , Felix Modesto Gil , Gabriel Ramon Palomares , Yassel Gomez
发明人： Aniel Puente , Luis Lopez , Jeovanis Valdes , Lazaro Nunes , Vladimir Perez , Jorge Fernandez Dorta-Duque , Felix Modesto Gil , Gabriel Ramon Palomares , Yassel Gomez
IPC分类号： G01N33/00
CPC分类号： G01N33/6848 , G01N33/6842
摘要： A method based on the selective isolation of peptides originated by the cleavage at the C-terminal end of the arginine residues and do not possess lysine inside their sequences (péptidos RRnK), is described. The method is based on the blocking of amino groups of the LEP peptides and the separation of the RRnK peptides and the modified peptides by using a chromatography column or a chemical reaction of the modified peptides with a solid support. The method simplifies the complex mixtures of peptides by isolating selectively an average of 4 peptides/protein and it guarantees a coverage of 88% of the proteomes, its specificity and selectivity are very high (>95%), it is compatible with different types of isotopic labeling (13C, 18O or 15N) and it is useful for the determination of the differential expression of proteins without the necessity of using the two-dimensional electrophoresis.
摘要翻译：描述了基于精氨酸残基的C末端切割而不是其序列内的赖氨酸（péptidosRRnK）的肽的选择性分离的方法。该方法基于LEP肽的氨基封闭和通过使用色谱柱或修饰的肽与固体支持物的化学反应分离RRnK肽和修饰的肽。该方法通过选择性分离4个肽/蛋白质的平均值来简化肽的复杂混合物，并且其保证88％的蛋白质组的覆盖率，其特异性和选择性非常高（> 95％），它与不同类型的同位素标记（“13”，“18”或“15”），可用于测定蛋白质的差异表达，而无需使用二维电泳。

5. 发明授权

US09100940B2 System and method for extended wireless access gateway service provider Wi-Fi offload 有权
标题翻译：用于扩展无线接入网关服务提供商Wi-Fi卸载的系统和方法
公开(公告)号：US09100940B2
公开(公告)日：2015-08-04
申请号：US13305010
申请日：2011-11-28
申请人： Marco C. Centemeri , Luis Lopez , Anand Oswal , Steve Wood , William Wan
发明人： Marco C. Centemeri , Luis Lopez , Anand Oswal , Steve Wood , William Wan
IPC分类号： H04W76/02 , H04W92/02
CPC分类号： H04L67/141 , H04W48/16 , H04W76/11 , H04W76/12 , H04W88/16 , H04W92/02
摘要： A method is provided in one example embodiment and includes receiving a dynamic host configuration protocol (DHCP) discovery signal at a wireless network element from a customer premise equipment; requesting that a data session be established at a gateway; receiving an Internet protocol (IP) address; and communicating the IP address to the customer premise equipment.
摘要翻译：在一个示例实施例中提供了一种方法，并且包括在客户驻地设备的无线网络元件处接收动态主机配置协议（DHCP）发现信号; 请求在网关建立数据会话; 接收互联网协议（IP）地址; 并将IP地址传送到客户驻地设备。

6. 发明申请

US20130138823A1 SYSTEM AND METHOD FOR EXTENDED WIRELESS ACCESS GATEWAY SERVICE PROVIDER WI-FI OFFLOAD 有权
标题翻译：用于扩展无线接入网关服务提供商无线上网的系统和方法
公开(公告)号：US20130138823A1
公开(公告)日：2013-05-30
申请号：US13305010
申请日：2011-11-28
申请人： Marco C. Centemeri , Luis Lopez , Anand Oswal , Steve Wood , William Wan
发明人： Marco C. Centemeri , Luis Lopez , Anand Oswal , Steve Wood , William Wan
IPC分类号： G06F15/16 , H04W24/00
CPC分类号： H04L67/141 , H04W48/16 , H04W76/11 , H04W76/12 , H04W88/16 , H04W92/02
摘要： A method is provided in one example embodiment and includes receiving a dynamic host configuration protocol (DHCP) discovery signal at a wireless network element from a customer premise equipment; requesting that a data session be established at a gateway; receiving an Internet protocol (IP) address; and communicating the IP address to the customer premise equipment.
摘要翻译：在一个示例实施例中提供了一种方法，并且包括在客户驻地设备的无线网络元件处接收动态主机配置协议（DHCP）发现信号; 请求在网关建立数据会话; 接收互联网协议（IP）地址; 并将IP地址传送到客户驻地设备。

7. 发明申请

US20190160648A1 TOOL HOLDER 审中-公开
公开(公告)号：US20190160648A1
公开(公告)日：2019-05-30
申请号：US15823800
申请日：2017-11-28
申请人： Luis Lopez
发明人： Luis Lopez
IPC分类号： B25H3/00
摘要： A device includes a body portion including: a top portion, a bottom portion, a first track, a ledge connected to the bottom portion and multiple through-holes. A first magnet element is disposed within the first track.

8. 发明申请

US20090236179A1 PORTABLE AND MECHANIZED ELEVATED HUNTING STAND 审中-公开
标题翻译：便携式和机械式高空作战台
公开(公告)号：US20090236179A1
公开(公告)日：2009-09-24
申请号：US12052400
申请日：2008-03-20
申请人： Luis Lopez
发明人： Luis Lopez
IPC分类号： A01M31/02
CPC分类号： A01M31/02
摘要： A portable hunting stand that can be elevated is described. The hunting stand may be trailer mounted for towing to a desired site. The trailer may have multiple jack stands or similar devices to level the trailer on uneven ground. The hunting stand can be raised from ground level without requiring the user to climb steps or a ladder. The hunting stand can use various types of motors or mechanical devices to raise the stand above the ground surface, including hydraulic pumps and motors.
摘要翻译：描述了可升高的便携式狩猎架。狩猎台可以是拖车安装用于牵引到所需的地点。拖车可以具有多个插座或类似的装置，以使拖车在不平坦的地面上平坦。狩猎架可以从地面升起，而不需要用户爬梯子或梯子。狩猎台可以使用各种类型的电机或机械装置将地面上的支架升高，包括液压泵和电机。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式