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1. 发明授权

US07078204B2 Glucose-6-phosphate dehydrogenase 有权
标题翻译：葡萄糖-6-磷酸脱氢酶
公开(公告)号：US07078204B2
公开(公告)日：2006-07-18
申请号：US10312007
申请日：2001-06-15
申请人： Haruhiko Yokoi , Seiko Ando , Keiko Ochiai , Yoshiyuki Yonetani , Shin-ichi Hashimoto
发明人： Haruhiko Yokoi , Seiko Ando , Keiko Ochiai , Yoshiyuki Yonetani , Shin-ichi Hashimoto
IPC分类号： C12N9/04 , C12N1/20 , C12P21/04 , C12P13/04 , C07H21/04
CPC分类号： C12N9/0006 , C12P13/04 , C12P13/08 , C12Y101/01049
摘要： The present invention relates to a novel glucose-6-phosphate dehydrogenase (hereinafter referred to as “G6PD”) derived from a bacterium belonging to the genus Corynebacterium, a DNA encoding the enzyme, a recombinant DNA comprising the DNA, a transformant comprising the recombinant DNA, a transformant comprising the DNA on its chromosome, and a process for producing L-amino acid or G6PD which comprises culturing the transformant.According to the present invention, a modified G6PD and a DNA encoding the G6PD are obtained, and the productivity of L-amino acid by a microorganism can be improved by using the modified G6PD.
摘要翻译：本发明涉及一种衍生自属于棒状杆菌属的细菌的新型葡萄糖-6-磷酸脱氢酶（以下称为“G6PD”），编码该酶的DNA，包含该DNA的重组DNA，包含重组体 DNA，包含其染色体上的DNA的转化体，以及生产L-氨基酸或G6PD的方法，其包括培养转化体。根据本发明，获得了修饰的G6PD和编码G6PD的DNA，通过使用改良的G6PD可以提高微生物的L-氨基酸的生产率。

2. 发明申请

US20100062486A1 NOVEL PROTEIN AND DNA ENCODING THE PROTEIN 失效
标题翻译：新蛋白和DNA编码蛋白
公开(公告)号：US20100062486A1
公开(公告)日：2010-03-11
申请号：US12095244
申请日：2006-11-29
申请人： Shin-ichi Hashimoto , Yoshiyuki Yonetani , Masaki Maeda
发明人： Shin-ichi Hashimoto , Yoshiyuki Yonetani , Masaki Maeda
IPC分类号： C12P21/02 , C07K14/00 , C07H21/04 , C12N1/21 , C07C69/76 , C12P7/62 , C07D315/00
CPC分类号： C12P7/62 , C12N9/0006 , C12P7/42 , C12P17/06
摘要： The present invention provides a protein comprising the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3 (except for proteins of the amino acid sequences as shown in SEQ ID NOS: 4 to 6), and a process for industrially advantageously producing a compound that inhibits HMG-CoA reductase and has an action to decrease serum cholesterol, using DNA encoding the protein comprising the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3 (except for DNA encoding the protein comprising the amino acid sequence as shown in SEQ ID NO: 4).
摘要翻译：本发明提供了包含SEQ ID NO：1〜3中任一项所示的氨基酸序列的蛋白质（除了SEQ ID NO：4〜6所示的氨基酸序列的蛋白质）和工业上的工序有利地产生抑制HMG-CoA还原酶并具有降低血清胆固醇的作用的化合物，使用编码包含SEQ ID NO：1至3中任一项所示的氨基酸序列的蛋白的DNA（除了编码包含如SEQ ID NO：4所示的氨基酸序列）。

3. 发明申请

US20080261273A1 PROCESS FOR PRODUCING HMG-CoA REDUCTASE INHIBITORS 审中-公开
标题翻译：生产HMG-CoA还原酶抑制剂的方法
公开(公告)号：US20080261273A1
公开(公告)日：2008-10-23
申请号：US12125569
申请日：2008-05-22
申请人： Hirofumi ENDO , Yoshiyuki Yonetani , Hiroshi Mizoguchi , Shin-ichi Hashimoto , Akio Ozaki
发明人： Hirofumi ENDO , Yoshiyuki Yonetani , Hiroshi Mizoguchi , Shin-ichi Hashimoto , Akio Ozaki
IPC分类号： C12P21/00 , C12P7/62 , C12P17/06
CPC分类号： C12N9/0004 , C07K14/32 , C12P7/62 , C12P17/06
摘要： The present invention relates to processes for producing compounds by using a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a): wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl, or an alkali metal, and R2 represents a substituted or unsubstituted alkyl or substituted or unsubstituted aryl, or a ring-closed lactone from thereof.
摘要翻译：本发明涉及通过使用衍生自属于芽孢杆菌属的微生物的蛋白质来生产化合物的方法，其具有使由式（Ia）表示的化合物羟基化的活性：其中R 1表示氢原子，取代或未取代的烷基或碱金属，R 2表示取代或未取代的烷基或取代或未取代的芳基或其封闭的内酯。

4. 发明授权

US07247466B2 Amino acid racemase having low substrate specificity and process for producing racemic amino acid 有权
标题翻译：具有低底物特异性的氨基酸消旋酶和用于生产外消旋氨基酸的方法
公开(公告)号：US07247466B2
公开(公告)日：2007-07-24
申请号：US10506152
申请日：2003-02-28
申请人： Hajime Ikeda , Yoshiyuki Yonetani , Shin-ichi Hashimoto , Makoto Yagasaki , Kenji Soda
发明人： Hajime Ikeda , Yoshiyuki Yonetani , Shin-ichi Hashimoto , Makoto Yagasaki , Kenji Soda
IPC分类号： C07H21/04 , C12N9/90 , C12N15/74 , C12N1/21 , C12P21/06
CPC分类号： C12P13/04 , C12N9/90
摘要： The present invention provides a protein having low-substrate-specific amino acid racemase activity; DNA encoding the protein; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a process for producing the protein by using the transformant; and a process for producing a racemic amino acid which comprises allowing a culture of the transformant or a treated matter thereof as an enzyme source and an amino acid to be present in an aqueous medium to racemize the amino acid in the aqueous medium, and recovering the racemic amino acid from the aqueous medium.
摘要翻译：本发明提供了具有低底物特异性氨基酸消旋酶活性的蛋白质; 编码蛋白质的DNA; 包含DNA的重组DNA; 携带重组DNA的转化体; 通过使用转化体生产蛋白质的方法; 以及制备外消旋氨基酸的方法，其包括使转化体或其处理物质的培养物作为酶源，并且氨基酸存在于水性介质中以使水性介质中的氨基酸外消旋化，并回收来自水介质的外消旋氨基酸。

5. 发明授权

US08058037B2 Protein and DNA encoding the protein 失效
标题翻译：编码蛋白质的蛋白质和DNA
公开(公告)号：US08058037B2
公开(公告)日：2011-11-15
申请号：US12095244
申请日：2006-11-29
申请人： Shin-ichi Hashimoto , Yoshiyuki Yonetani , Masaki Maeda
发明人： Shin-ichi Hashimoto , Yoshiyuki Yonetani , Masaki Maeda
IPC分类号： C12P7/00 , C12P7/02
CPC分类号： C12P7/62 , C12N9/0006 , C12P7/42 , C12P17/06
摘要： The present invention provides a protein comprising the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3 (except for proteins of the amino acid sequences as shown in SEQ ID NOS: 4 to 6), and a process for industrially advantageously producing a compound that inhibits HMG-CoA reductase and has an action to decrease serum cholesterol, using DNA encoding the protein comprising the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3 (except for DNA encoding the protein comprising the amino acid sequence as shown in SEQ ID NO: 4).
摘要翻译：本发明提供了包含SEQ ID NO：1〜3中任一项所示的氨基酸序列的蛋白质（除了SEQ ID NO：4〜6所示的氨基酸序列的蛋白质）和工业上的工序有利地产生抑制HMG-CoA还原酶并具有降低血清胆固醇的作用的化合物，使用编码包含SEQ ID NO：1至3中任一项所示的氨基酸序列的蛋白的DNA（除了编码包含如SEQ ID NO：4所示的氨基酸序列）。

6. 发明授权

US07470528B2 DNA encoding hydroxylase 失效
标题翻译：编码羟化酶的DNA
公开(公告)号：US07470528B2
公开(公告)日：2008-12-30
申请号：US11352308
申请日：2006-02-13
申请人： Hirofumi Endo , Yoshiyuki Yonetani , Hiroshi Mizoguchi , Shin-ichi Hashimoto , Akio Ozaki
发明人： Hirofumi Endo , Yoshiyuki Yonetani , Hiroshi Mizoguchi , Shin-ichi Hashimoto , Akio Ozaki
IPC分类号： C12N15/00 , C12N5/10 , C12N1/21 , C12P21/00 , C07H21/00 , C12N9/02 , C07K14/00
CPC分类号： C12N9/0004 , C07K14/32 , C12P7/62 , C12P17/06
摘要： The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a): wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl, or an alkali metal, and R2 represents a substituted or unsubstituted alkyl or a substituted or unsubstituted aryl, or a ring-closed lactone form thereof; a DNA encoding the protein; and a recombinant DNA comprising the DNA.
摘要翻译：本发明涉及一种衍生自属于芽孢杆菌属的微生物的蛋白质，其具有使由式（Ia）表示的化合物羟化的活性：其中R1表示氢原子，取代或未取代的烷基或碱金属并且R 2表示取代或未取代的烷基或取代或未取代的芳基或其封闭的内酯形式; 编码蛋白质的DNA; 和包含DNA的重组DNA。

7. 发明授权

US08187843B2 Method for production of L-glutamine 有权
标题翻译： L-谷氨酰胺的生产方法
公开(公告)号：US08187843B2
公开(公告)日：2012-05-29
申请号：US12439300
申请日：2007-08-30
申请人： Yugo Adachi , Mikiro Hayashi , Akihiro Senoo , Yoshiyuki Yonetani , Shin-ichi Hashimoto
发明人： Yugo Adachi , Mikiro Hayashi , Akihiro Senoo , Yoshiyuki Yonetani , Shin-ichi Hashimoto
IPC分类号： C12P13/14
CPC分类号： C12N9/1205 , C12N9/0008 , C12P13/14
摘要： According to the present invention, it is possible to provide a microorganism belonging to the genus Corynebacterium, wherein the activity of (1) a protein having the amino acid sequence shown by any one of SEQ ID NO:1 to 3, or (2) a protein having a homology of 80% or more to the amino acid sequence shown by any one of SEQ ID NO:1 to 3, and having substantially the same activity as the activity of a protein having the amino acid sequence shown by any one of SEQ ID NO:1 to 3, has been reduced or lost, and wherein the activity of (3) a protein having the amino acid sequence shown by SEQ ID NO:4, or (4) a protein having a homology of 80% or more to the amino acid sequence shown by SEQ ID NO:4, and having substantially the same activity as the activity of a protein having the amino acid sequence shown by SEQ ID NO:4, has been reduced or lost, and a process for producing L-glutamine using the microorganism and the like.
摘要翻译：根据本发明，可以提供属于棒状杆菌属的微生物，其中（1）具有SEQ ID NO：1〜3或（2）中任一项所示的氨基酸序列的蛋白质的活性，与SEQ ID NO：1〜3中任一项所示的氨基酸序列具有80％以上的同源性的蛋白质，并且具有与具有下述任一项所示的氨基酸序列的蛋白质的活性基本上相同的活性 SEQ ID NO：1至3已经被还原或丧失，并且其中（3）具有SEQ ID NO：4所示氨基酸序列的蛋白质的活性，或（4）具有80％同源性的蛋白质或更多地与SEQ ID NO：4所示的氨基酸序列相比，具有与SEQ ID NO：4所示的氨基酸序列的蛋白质的活性基本上相同的活性已被减少或丧失，使用微生物等的L-谷氨酰胺。

8. 发明授权

US07666653B2 Low-substrate-specific amino acid racemase and process for producing racemic amino acid 失效
标题翻译：低底物特异性氨基酸消旋酶及其制备外消旋氨基酸的方法
公开(公告)号：US07666653B2
公开(公告)日：2010-02-23
申请号：US11808186
申请日：2007-06-07
申请人： Hajime Ikeda , Yoshiyuki Yonetani , Shin-ichi Hashimoto , Makoto Yagasaki , Kenji Soda
发明人： Hajime Ikeda , Yoshiyuki Yonetani , Shin-ichi Hashimoto , Makoto Yagasaki , Kenji Soda
IPC分类号： C07H21/04 , C12N9/90 , C12N15/74 , C12N1/21 , C12P21/06
CPC分类号： C12P13/04 , C12N9/90
摘要： The present invention provides a protein having low-substrate-specific amino acid racemase activity; DNA encoding the protein; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a process for producing the protein by using the transformant; and a process for producing a racemic amino acid which comprises allowing a culture of the transformant or a treated matter thereof as an enzyme source and an amino acid to be present in an aqueous medium to racemize the amino acid in the aqueous medium, and recovering the racemic amino acid from the aqueous medium.
摘要翻译：本发明提供了具有低底物特异性氨基酸消旋酶活性的蛋白质; 编码蛋白质的DNA; 包含DNA的重组DNA; 携带重组DNA的转化体; 通过使用转化体生产蛋白质的方法; 以及制备外消旋氨基酸的方法，其包括使转化体或其处理物质的培养物作为酶源，并且氨基酸存在于水性介质中以使水性介质中的氨基酸外消旋化，并回收来自水介质的外消旋氨基酸。

9. 发明申请

US20070128687A1 Process for producing dipeptides 审中-公开
标题翻译：二肽生产方法
公开(公告)号：US20070128687A1
公开(公告)日：2007-06-07
申请号：US10580554
申请日：2004-11-26
申请人： Hajime Ikeda , Yugo Adachi , Yoshiyuki Yonetani , Shin-ichi Hashimoto , Makoto Yagasaki
发明人： Hajime Ikeda , Yugo Adachi , Yoshiyuki Yonetani , Shin-ichi Hashimoto , Makoto Yagasaki
IPC分类号： C12P21/06 , C12N1/20
CPC分类号： C12P21/02
摘要： The present invention provides a process for producing a dipeptide which comprises: allowing an enzyme source and a diketopiperazine wherein one or two kinds of α-amino acids are condensed with each other to be present in an aqueous medium, said enzyme source being a culture of a microorganism having the ability to produce a dipeptide from a diketopiperazine wherein two kinds of α-amino acids are condensed with each other or a treated matter of the culture; allowing the dipeptide to form and accumulate in the aqueous medium; and recovering the dipeptide from the aqueous medium (provided that the case in which the diketopiperazine is a diketopiperazine wherein aspartic acid and phenylalanine are condensed with each other and the dipeptide is aspartylphenylalanine is excluded).
摘要翻译：本发明提供一种生产二肽的方法，其包括：允许其中一种或两种α-氨基酸彼此缩合以存在于水性介质中的酶源和二酮哌嗪，所述酶源是具有从二酮哌嗪产生二肽的能力的微生物，其中两种α-氨基酸彼此缩合或培养物的处理物质; 允许二肽在水性介质中形成和积聚; 并从水性介质中回收二肽（条件是二酮哌嗪为二酮哌嗪的情况，其中天冬氨酸和苯丙氨酸彼此缩合，二肽为天冬氨酰苯丙氨酸）。

10. 发明授权

US06946270B1 Process for producing HMG-CoA reductase inhibitors 失效
标题翻译：生产HMG-CoA还原酶抑制剂的方法
公开(公告)号：US06946270B1
公开(公告)日：2005-09-20
申请号：US09868924
申请日：2000-01-20
申请人： Shin-ichi Hashimoto , Yoshiyuki Yonetani , Akio Ozaki
发明人： Shin-ichi Hashimoto , Yoshiyuki Yonetani , Akio Ozaki
IPC分类号： C12P7/62 , C12P17/06
CPC分类号： C12P17/06 , C12P7/62
摘要： The present invention relates to a process for producing a compound (II-a) or a compound (II-b), each of which is a hydroxylated product of a compound represented by the formula (I-a) (hereinafter referred to as compound (I-a)): wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl, or an alkali metal, and R2 represents a substituted or unsubstituted alkyl, or a substituted or unsubstituted aryl; or a ring-closed lactone form thereof (hereinafter referred to as compound (I-b)). wherein the process comprises: treating the compound (I-a) or compound (I-b) in an aqueous medium comprising with a microorganism acting to hydroxylate compound (I-a) or compound (I-b), having no ability to sporulate and showing no hyphal growth, a culture of the microorganism, or a treated product of the culture, as an enzyme source; and collecting a hydroxylated product of compound (I-a) or compound (I-b) from the aqueous medium.
摘要翻译：本发明涉及一种制备化合物（II-a）或化合物（II-b）的方法，其中每种化合物是由式（Ia）表示的化合物的羟基化产物（以下称为化合物（Ia ））：其中R 1表示氢原子，取代或未取代的烷基或碱金属，R 2表示取代或未取代的烷基，或取代或未取代的烷基，未取代的芳基; 或其封闭的内酯形式（以下称为化合物（I-b））。其中所述方法包括：在水性介质中处理化合物（Ia）或化合物（Ib），所述水性介质包含微生物作用于羟化化合物（Ia）或化合物（Ib）的微生物，其不具有孢子形成和不显示菌丝生长的能力，的微生物或培养物的处理产物作为酶源; 并从水性介质中收集化合物（I-a）或化合物（I-b）的羟基化产物。

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