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1. 发明申请

US20070128687A1 Process for producing dipeptides 审中-公开
标题翻译：二肽生产方法
公开(公告)号：US20070128687A1
公开(公告)日：2007-06-07
申请号：US10580554
申请日：2004-11-26
申请人： Hajime Ikeda , Yugo Adachi , Yoshiyuki Yonetani , Shin-ichi Hashimoto , Makoto Yagasaki
发明人： Hajime Ikeda , Yugo Adachi , Yoshiyuki Yonetani , Shin-ichi Hashimoto , Makoto Yagasaki
IPC分类号： C12P21/06 , C12N1/20
CPC分类号： C12P21/02
摘要： The present invention provides a process for producing a dipeptide which comprises: allowing an enzyme source and a diketopiperazine wherein one or two kinds of α-amino acids are condensed with each other to be present in an aqueous medium, said enzyme source being a culture of a microorganism having the ability to produce a dipeptide from a diketopiperazine wherein two kinds of α-amino acids are condensed with each other or a treated matter of the culture; allowing the dipeptide to form and accumulate in the aqueous medium; and recovering the dipeptide from the aqueous medium (provided that the case in which the diketopiperazine is a diketopiperazine wherein aspartic acid and phenylalanine are condensed with each other and the dipeptide is aspartylphenylalanine is excluded).
摘要翻译：本发明提供一种生产二肽的方法，其包括：允许其中一种或两种α-氨基酸彼此缩合以存在于水性介质中的酶源和二酮哌嗪，所述酶源是具有从二酮哌嗪产生二肽的能力的微生物，其中两种α-氨基酸彼此缩合或培养物的处理物质; 允许二肽在水性介质中形成和积聚; 并从水性介质中回收二肽（条件是二酮哌嗪为二酮哌嗪的情况，其中天冬氨酸和苯丙氨酸彼此缩合，二肽为天冬氨酰苯丙氨酸）。

2. 发明申请

US20110124059A1 METHOD FOR PRODUCTION OF L-GLUTAMINE 有权
标题翻译： L-谷氨酰胺的生产方法
公开(公告)号：US20110124059A1
公开(公告)日：2011-05-26
申请号：US12439300
申请日：2007-08-30
申请人： Yugo Adachi , Mikiro Hayashi , Akihiro Senoo , Yoshiyuki Yonetani , Shin-ichi Hashimoto
发明人： Yugo Adachi , Mikiro Hayashi , Akihiro Senoo , Yoshiyuki Yonetani , Shin-ichi Hashimoto
IPC分类号： C12P13/14 , C12N1/21
CPC分类号： C12N9/1205 , C12N9/0008 , C12P13/14
摘要： According to the present invention, it is possible to provide a microorganism belonging to the genus Corynebacterium, wherein the activity of (1) a protein having the amino acid sequence shown by any one of SEQ ID NO:1 to 3, or (2) a protein having a homology of 80% or more to the amino acid sequence shown by any one of SEQ ID NO:1 to 3, and having substantially the same activity as the activity of a protein having the amino acid sequence shown by any one of SEQ ID NO:1 to 3, has been reduced or lost, and wherein the activity of (3) a protein having the amino acid sequence shown by SEQ ID NO:4, or (4) a protein having a homology of 80% or more to the amino acid sequence shown by SEQ ID NO:4, and having substantially the same activity as the activity of a protein having the amino acid sequence shown by SEQ ID NO:4, has been reduced or lost, and a process for producing L-glutamine using the microorganism and the like.
摘要翻译：根据本发明，可以提供属于棒状杆菌属的微生物，其中（1）具有SEQ ID NO：1〜3或（2）中任一项所示的氨基酸序列的蛋白质的活性，与SEQ ID NO：1〜3中任一项所示的氨基酸序列具有80％以上的同源性的蛋白质，并且具有与具有下述任一项所示的氨基酸序列的蛋白质的活性基本上相同的活性 SEQ ID NO：1至3已经被还原或丧失，并且其中（3）具有SEQ ID NO：4所示氨基酸序列的蛋白质的活性，或（4）具有80％同源性的蛋白质或更多地与SEQ ID NO：4所示的氨基酸序列相比，具有与SEQ ID NO：4所示的氨基酸序列的蛋白质的活性基本上相同的活性已被减少或丧失，使用微生物等的L-谷氨酰胺。

3. 发明授权

US08187843B2 Method for production of L-glutamine 有权
标题翻译： L-谷氨酰胺的生产方法
公开(公告)号：US08187843B2
公开(公告)日：2012-05-29
申请号：US12439300
申请日：2007-08-30
申请人： Yugo Adachi , Mikiro Hayashi , Akihiro Senoo , Yoshiyuki Yonetani , Shin-ichi Hashimoto
发明人： Yugo Adachi , Mikiro Hayashi , Akihiro Senoo , Yoshiyuki Yonetani , Shin-ichi Hashimoto
IPC分类号： C12P13/14
CPC分类号： C12N9/1205 , C12N9/0008 , C12P13/14
摘要： According to the present invention, it is possible to provide a microorganism belonging to the genus Corynebacterium, wherein the activity of (1) a protein having the amino acid sequence shown by any one of SEQ ID NO:1 to 3, or (2) a protein having a homology of 80% or more to the amino acid sequence shown by any one of SEQ ID NO:1 to 3, and having substantially the same activity as the activity of a protein having the amino acid sequence shown by any one of SEQ ID NO:1 to 3, has been reduced or lost, and wherein the activity of (3) a protein having the amino acid sequence shown by SEQ ID NO:4, or (4) a protein having a homology of 80% or more to the amino acid sequence shown by SEQ ID NO:4, and having substantially the same activity as the activity of a protein having the amino acid sequence shown by SEQ ID NO:4, has been reduced or lost, and a process for producing L-glutamine using the microorganism and the like.
摘要翻译：根据本发明，可以提供属于棒状杆菌属的微生物，其中（1）具有SEQ ID NO：1〜3或（2）中任一项所示的氨基酸序列的蛋白质的活性，与SEQ ID NO：1〜3中任一项所示的氨基酸序列具有80％以上的同源性的蛋白质，并且具有与具有下述任一项所示的氨基酸序列的蛋白质的活性基本上相同的活性 SEQ ID NO：1至3已经被还原或丧失，并且其中（3）具有SEQ ID NO：4所示氨基酸序列的蛋白质的活性，或（4）具有80％同源性的蛋白质或更多地与SEQ ID NO：4所示的氨基酸序列相比，具有与SEQ ID NO：4所示的氨基酸序列的蛋白质的活性基本上相同的活性已被减少或丧失，使用微生物等的L-谷氨酰胺。

4. 发明申请

US20070243581A1 Process for Producing Dipeptides 审中-公开
标题翻译：生产二肽的方法
公开(公告)号：US20070243581A1
公开(公告)日：2007-10-18
申请号：US11587004
申请日：2005-04-21
申请人： Shin-ichi Hashimoto , Kazuhiko Tabata , Ayako Noguchi , Yugo Adachi
发明人： Shin-ichi Hashimoto , Kazuhiko Tabata , Ayako Noguchi , Yugo Adachi
IPC分类号： C12P21/00 , C07H21/04 , C07K2/00
CPC分类号： C07K5/06043 , C07K5/06026 , C07K5/06078 , C07K5/12 , C12N9/00 , C12N9/93 , C12P21/02
摘要： The present invention provides: a protein having dipeptide-synthesizing activity or a protein for dipeptide synthesis; DNA encoding the protein having dipeptide-synthesizing activity or the protein for dipeptide synthesis; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a process for producing the protein having dipeptide-synthesizing activity; an enzymatic process for producing a dipeptide using the protein having dipeptide-synthesizing activity or the protein for dipeptide synthesis; and a process for producing a dipeptide using, as an enzyme source, a culture of a microorganism or a transformant having the ability to produce the protein having dipeptide-synthesizing activity or the protein for dipeptide synthesis, or the like.
摘要翻译：本发明提供：具有二肽合成活性的蛋白质或用于二肽合成的蛋白质; 编码具有二肽合成活性的蛋白质的DNA或二肽合成蛋白质; 包含DNA的重组DNA; 携带重组DNA的转化体; 制备具有二肽合成活性的蛋白质的方法; 使用具有二肽合成活性的蛋白质或用于二肽合成的蛋白质生产二肽的酶促方法; 以及使用具有产生具有二肽合成活性的蛋白质或二肽合成蛋白质的能力的微生物或转化体的培养物作为酶源来生产二肽的方法等。

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