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1. 发明申请

US20110124059A1 METHOD FOR PRODUCTION OF L-GLUTAMINE 有权
标题翻译： L-谷氨酰胺的生产方法
公开(公告)号：US20110124059A1
公开(公告)日：2011-05-26
申请号：US12439300
申请日：2007-08-30
申请人： Yugo Adachi , Mikiro Hayashi , Akihiro Senoo , Yoshiyuki Yonetani , Shin-ichi Hashimoto
发明人： Yugo Adachi , Mikiro Hayashi , Akihiro Senoo , Yoshiyuki Yonetani , Shin-ichi Hashimoto
IPC分类号： C12P13/14 , C12N1/21
CPC分类号： C12N9/1205 , C12N9/0008 , C12P13/14
摘要： According to the present invention, it is possible to provide a microorganism belonging to the genus Corynebacterium, wherein the activity of (1) a protein having the amino acid sequence shown by any one of SEQ ID NO:1 to 3, or (2) a protein having a homology of 80% or more to the amino acid sequence shown by any one of SEQ ID NO:1 to 3, and having substantially the same activity as the activity of a protein having the amino acid sequence shown by any one of SEQ ID NO:1 to 3, has been reduced or lost, and wherein the activity of (3) a protein having the amino acid sequence shown by SEQ ID NO:4, or (4) a protein having a homology of 80% or more to the amino acid sequence shown by SEQ ID NO:4, and having substantially the same activity as the activity of a protein having the amino acid sequence shown by SEQ ID NO:4, has been reduced or lost, and a process for producing L-glutamine using the microorganism and the like.
摘要翻译：根据本发明，可以提供属于棒状杆菌属的微生物，其中（1）具有SEQ ID NO：1〜3或（2）中任一项所示的氨基酸序列的蛋白质的活性，与SEQ ID NO：1〜3中任一项所示的氨基酸序列具有80％以上的同源性的蛋白质，并且具有与具有下述任一项所示的氨基酸序列的蛋白质的活性基本上相同的活性 SEQ ID NO：1至3已经被还原或丧失，并且其中（3）具有SEQ ID NO：4所示氨基酸序列的蛋白质的活性，或（4）具有80％同源性的蛋白质或更多地与SEQ ID NO：4所示的氨基酸序列相比，具有与SEQ ID NO：4所示的氨基酸序列的蛋白质的活性基本上相同的活性已被减少或丧失，使用微生物等的L-谷氨酰胺。

2. 发明授权

US08187843B2 Method for production of L-glutamine 有权
标题翻译： L-谷氨酰胺的生产方法
公开(公告)号：US08187843B2
公开(公告)日：2012-05-29
申请号：US12439300
申请日：2007-08-30
申请人： Yugo Adachi , Mikiro Hayashi , Akihiro Senoo , Yoshiyuki Yonetani , Shin-ichi Hashimoto
发明人： Yugo Adachi , Mikiro Hayashi , Akihiro Senoo , Yoshiyuki Yonetani , Shin-ichi Hashimoto
IPC分类号： C12P13/14
CPC分类号： C12N9/1205 , C12N9/0008 , C12P13/14
摘要： According to the present invention, it is possible to provide a microorganism belonging to the genus Corynebacterium, wherein the activity of (1) a protein having the amino acid sequence shown by any one of SEQ ID NO:1 to 3, or (2) a protein having a homology of 80% or more to the amino acid sequence shown by any one of SEQ ID NO:1 to 3, and having substantially the same activity as the activity of a protein having the amino acid sequence shown by any one of SEQ ID NO:1 to 3, has been reduced or lost, and wherein the activity of (3) a protein having the amino acid sequence shown by SEQ ID NO:4, or (4) a protein having a homology of 80% or more to the amino acid sequence shown by SEQ ID NO:4, and having substantially the same activity as the activity of a protein having the amino acid sequence shown by SEQ ID NO:4, has been reduced or lost, and a process for producing L-glutamine using the microorganism and the like.
摘要翻译：根据本发明，可以提供属于棒状杆菌属的微生物，其中（1）具有SEQ ID NO：1〜3或（2）中任一项所示的氨基酸序列的蛋白质的活性，与SEQ ID NO：1〜3中任一项所示的氨基酸序列具有80％以上的同源性的蛋白质，并且具有与具有下述任一项所示的氨基酸序列的蛋白质的活性基本上相同的活性 SEQ ID NO：1至3已经被还原或丧失，并且其中（3）具有SEQ ID NO：4所示氨基酸序列的蛋白质的活性，或（4）具有80％同源性的蛋白质或更多地与SEQ ID NO：4所示的氨基酸序列相比，具有与SEQ ID NO：4所示的氨基酸序列的蛋白质的活性基本上相同的活性已被减少或丧失，使用微生物等的L-谷氨酰胺。

3. 发明授权

US08067211B2 Method for production of L-glutamine 有权
标题翻译： L-谷氨酰胺的生产方法
公开(公告)号：US08067211B2
公开(公告)日：2011-11-29
申请号：US12159156
申请日：2006-12-27
申请人： Mikiro Hayashi , Masaki Maeda , Yoshiyuki Yonetani
发明人： Mikiro Hayashi , Masaki Maeda , Yoshiyuki Yonetani
IPC分类号： C12P13/14 , C12N1/20 , C07H21/04
CPC分类号： C12N9/93 , C12P13/14
摘要： A polypeptide comprising an amino acid sequence in which one or more amino acids are deleted, substituted or added in the amino acid sequence of a glutamine synthetase 2 derived from a microorganism belonging to a coryneform bacterium, wherein the coryneform bacterium producing the polypeptide has L-glutamine productivity, a DNA encoding the polypeptide, a recombinant DNA comprising the DNA, a microorganism comprising the DNA or the recombinant DNA, and a process for producing L-glutamine using the microorganism are provided.
摘要翻译：一种多肽，其包含氨基酸序列，其中一个或多个氨基酸被缺失，取代或添加在衍生自属于棒状杆菌型细菌的微生物的谷氨酰胺合成酶2的氨基酸序列中，其中产生多肽的棒状细菌具有L- 谷氨酰胺生产力，编码多肽的DNA，包含DNA的重组DNA，包含DNA或重组DNA的微生物，以及使用该微生物生产L-谷氨酰胺的方法。

4. 发明申请

US20100129867A1 METHOD FOR PRODUCING DIPEPTIDE 有权
标题翻译：生产二肽的方法
公开(公告)号：US20100129867A1
公开(公告)日：2010-05-27
申请号：US12594903
申请日：2008-04-04
申请人： Mikiro Hayashi , Kazuhiko Tabata , Makoto Yagasaki , Yoshiyuki Yonetani
发明人： Mikiro Hayashi , Kazuhiko Tabata , Makoto Yagasaki , Yoshiyuki Yonetani
IPC分类号： C12P21/00 , C12N1/21
CPC分类号： C07K14/195 , C07K5/06026 , C12P21/02
摘要： The invention provides a microorganism having an ability to produce a protein having a dipeptide synthesizing activity and in which an activity of the protein to transport a dipeptide in a microbial cell to the outside of the microbial cell is higher than that of a parental strain.
摘要翻译：本发明提供了具有产生具有二肽合成活性的蛋白质的能力的微生物，其中将微生物细胞中的二肽转运至微生物细胞外的蛋白质的活性高于亲本菌株的活性。

5. 发明授权

US08673590B2 Method for producing dipeptide 有权
标题翻译：二肽生产方法
公开(公告)号：US08673590B2
公开(公告)日：2014-03-18
申请号：US12594903
申请日：2008-04-04
申请人： Mikiro Hayashi , Kazuhiko Tabata , Makoto Yagasaki , Yoshiyuki Yonetani
发明人： Mikiro Hayashi , Kazuhiko Tabata , Makoto Yagasaki , Yoshiyuki Yonetani
IPC分类号： C07K5/06 , C07K14/195 , C12P21/02
CPC分类号： C07K14/195 , C07K5/06026 , C12P21/02
摘要： The invention provides a microorganism having an ability to produce a protein having a dipeptide synthesizing activity and in which an activity of the protein to transport a dipeptide in a microbial cell to theoutside of the microbial cell is higher than that of a parental strain.
摘要翻译：本发明提供了具有产生具有二肽合成活性的蛋白质的能力的微生物，其中将微生物细胞中的二肽转运到微生物细胞外侧的蛋白质的活性高于亲本菌株的活性。

6. 发明申请

US20120322115A1 PROCESS FOR PRODUCTION OF L-GLUTAMINE OR L-GLUTAMIC ACID 有权
标题翻译：生产L-谷氨酰胺或L-谷氨酸的方法
公开(公告)号：US20120322115A1
公开(公告)日：2012-12-20
申请号：US13520947
申请日：2011-01-07
申请人： Mikiro Hayashi , Kazuhiko Tabata , Yoshiyuki Yonetani
发明人： Mikiro Hayashi , Kazuhiko Tabata , Yoshiyuki Yonetani
IPC分类号： C12P13/14
CPC分类号： C12P13/14
摘要： Provided is an efficient process for producing L-glutamine or L-glutamic acid using a microorganism. L-glutamine or L-glutamic acid is produced by culturing in a medium a microorganism in which has an ability to produce L-glutamine or L-glutamic acid, and in which an ability to form a superhelical double-stranded DNA is decreased compared with that of the parent strain, producing and accumulating L-glutamine or L-glutamic acid in the medium, and recovering L-glutamine or L-glutamic acid from the medium.
摘要翻译：提供使用微生物生产L-谷氨酰胺或L-谷氨酸的有效方法。通过在具有L-谷氨酰胺或L-谷氨酸生产能力的微生物培养基中培养L-谷氨酰胺或L-谷氨酸，其中形成超螺旋双链DNA的能力与在培养基中产生和积累L-谷氨酰胺或L-谷氨酸，从培养基中回收L-谷氨酰胺或L-谷氨酸。

7. 发明授权

US08703447B2 Process for production of L-glutamine or L-glutamic acid 有权
标题翻译： L-谷氨酰胺或L-谷氨酸的生产方法
公开(公告)号：US08703447B2
公开(公告)日：2014-04-22
申请号：US13520947
申请日：2011-01-07
申请人： Mikiro Hayashi , Kazuhiko Tabata , Yoshiyuki Yonetani
发明人： Mikiro Hayashi , Kazuhiko Tabata , Yoshiyuki Yonetani
IPC分类号： C12P13/14 , C12P13/04
CPC分类号： C12P13/14
摘要： Provided is an efficient process for producing L-glutamine or L-glutamic acid using a microorganism. L-glutamine or L-glutamic acid is produced by culturing in a medium a microorganism in which has an ability to produce L-glutamine or L-glutamic acid, and in which an ability to form a superhelical double-stranded DNA is decreased compared with that of the parent strain, producing and accumulating L-glutamine or L-glutamic acid in the medium, and recovering L-glutamine or L-glutamic acid from the medium.
摘要翻译：提供了使用微生物生产L-谷氨酰胺或L-谷氨酸的有效方法。通过在具有L-谷氨酰胺或L-谷氨酸生产能力的微生物培养基中培养L-谷氨酰胺或L-谷氨酸，其中形成超螺旋双链DNA的能力与在培养基中产生和积累L-谷氨酰胺或L-谷氨酸，从培养基中回收L-谷氨酰胺或L-谷氨酸。

8. 发明申请

US20100184163A1 METHOD FOR PRODUCTION OF L-GLUTAMINE 有权
标题翻译： L-谷氨酰胺的生产方法
公开(公告)号：US20100184163A1
公开(公告)日：2010-07-22
申请号：US12159156
申请日：2006-12-27
申请人： Mikiro Hayashi , Masaki Maeda , Yoshiyuki Yonetani
发明人： Mikiro Hayashi , Masaki Maeda , Yoshiyuki Yonetani
IPC分类号： C12N1/20 , C07H21/04 , C12N9/00 , C12P13/14
CPC分类号： C12N9/93 , C12P13/14
摘要： A polypeptide comprising an amino acid sequence in which one or more amino acids are deleted, substituted or added in the amino acid sequence of a glutamine synthetase 2 derived from a microorganism belonging to a coryneform bacterium, wherein the coryneform bacterium producing the polypeptide has L-glutamine productivity, a DNA encoding the polypeptide, a recombinant DNA comprising the DNA, a microorganism comprising the DNA or the recombinant DNA, and a process for producing L-glutamine using the microorganism are provided.
摘要翻译：一种多肽，其包含氨基酸序列，其中一个或多个氨基酸被缺失，取代或添加在衍生自属于棒状杆菌型细菌的微生物的谷氨酰胺合成酶2的氨基酸序列中，其中产生多肽的棒状细菌具有L- 谷氨酰胺生产力，编码多肽的DNA，包含DNA的重组DNA，包含DNA或重组DNA的微生物，以及使用该微生物生产L-谷氨酰胺的方法。

9. 发明授权

US08859241B2 Process for production of L-amino acid 有权
标题翻译：生产L-氨基酸的方法
公开(公告)号：US08859241B2
公开(公告)日：2014-10-14
申请号：US13520954
申请日：2011-01-07
申请人： Mikiro Hayashi , Kazuhiko Tabata
发明人： Mikiro Hayashi , Kazuhiko Tabata
IPC分类号： C12P13/04 , C12N9/00 , C12N1/20 , C12N15/00 , C07H21/02 , C12P13/14 , C12R1/19
CPC分类号： C12P13/04 , C12P13/14 , C12R1/19 , C12Y301/02012
摘要： Provided is a novel process for producing an L-amino acid using a microorganism belonging to the genus Escherichia. According to the present invention, a process for producing an L-amino acid comprising; culturing a microorganism in which an activity of the protein of any of the following [1]-[3] is increased compared with that of the parent strain in a medium, producing and accumulating the L-amino acid in the medium, and recovering the L-amino acid from the medium: [1] a protein comprising the amino acid sequence shown in SEQ ID NO: 2 [2] a protein consisting of an amino acid sequence in which one or more amino acids are deleted, substituted or added in the amino acid sequence shown in SEQ ID NO: 2, and having YeiG activity [3] a protein consisting of an amino acid sequence having 80% or more homology to the amino acid sequence shown in SEQ ID NO: 2, and having YeiG activity.
摘要翻译：提供了使用属于埃希氏菌属的微生物来生产L-氨基酸的新方法。根据本发明，制备L-氨基酸的方法包括：培养下述[1] - [3]中任一项所述的蛋白质的活性与培养基中的亲本菌株相比增加的微生物，培养基中产生和积累L-氨基酸，并回收来自培养基的L-氨基酸：[1]包含SEQ ID NO：2所示氨基酸序列的蛋白质[2]一种蛋白质，其由一个或多个氨基酸缺失，取代或加入的氨基酸序列组成 SEQ ID NO：2所示的氨基酸序列，并且具有YeiG活性[3]由与SEQ ID NO：2所示的氨基酸序列具有80％以上同源性的氨基酸序列组成的蛋白质，并具有YeiG活性。

10. 发明申请

US20060228712A1 Novel polynucleotides 有权
标题翻译：新型多核苷酸
公开(公告)号：US20060228712A1
公开(公告)日：2006-10-12
申请号：US10805394
申请日：2004-03-22
申请人： Satoshi Nakagawa , Hiroshi Mizoguchi , Seiko Ando , Mikiro Hayashi , Keiko Ochiai , Haruhiko Yokoi , Naoko Tateishi , Akihiro Senoh , Masato Ikeda , Akio Ozaki
发明人： Satoshi Nakagawa , Hiroshi Mizoguchi , Seiko Ando , Mikiro Hayashi , Keiko Ochiai , Haruhiko Yokoi , Naoko Tateishi , Akihiro Senoh , Masato Ikeda , Akio Ozaki
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12P19/34 , C12N9/00 , C12M1/34 , C12N15/74 , C12N1/21
CPC分类号： C12N9/93 , C07K14/34 , C12N9/0004 , C12P13/08 , C12R1/15 , C12Y101/01003 , C12Y604/01001
摘要： Novel polynucleotides derived from microorganisms belonging to coryneform bacteria and fragments thereof, polypeptides encoded by the polynucleotides and fragments thereof, polynucleotide arrays comprising the polynucleotides and fragments thereof, recording media in which the nucleotide sequences of the polynucleotide and fragments thereof have been recorded which are readable in a computer, and use of them.
摘要翻译：衍生自属于棒状细菌的微生物及其片段的新型多核苷酸，由多核苷酸及其片段编码的多肽，包含多核苷酸及其片段的多核苷酸阵列，其中记录了多核苷酸及其片段的核苷酸序列是可读的记录介质在电脑中，并使用它们。

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