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1. 发明授权

US07292742B2 Waveguides for performing enzymatic reactions 有权
标题翻译：用于进行酶反应的波导
公开(公告)号：US07292742B2
公开(公告)日：2007-11-06
申请号：US11670906
申请日：2007-02-02
申请人： Michael J. Levene , Jonas Korlach , Stephen W. Turner , Harold G. Craighead , Watt W. Webb
发明人： Michael J. Levene , Jonas Korlach , Stephen W. Turner , Harold G. Craighead , Watt W. Webb
IPC分类号： G02B6/00 , C12Q1/68 , G01N33/53 , C12M3/00
CPC分类号： C12Q1/25 , C12Q1/6825 , G01N21/47 , G01N21/6408 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/65 , G01N33/54373 , G01N2333/9015 , G01Q60/22 , G02B6/10 , G02B6/241
摘要： The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic energy of a frequency less than a cutoff frequency longitudinally through the core of the zero-mode waveguide. The analyte is positioned in the core of the zero-mode waveguide and is then subjected, in the core of the zero-mode wave guide, to activating electromagnetic radiation of a frequency less than the cut-off frequency under conditions effective to permit analysis of the analyte in an effective observation volume which is more compact than if the analysis were carried out in the absence of the zero-mode waveguide.
摘要翻译：本发明涉及用于分析分析物的方法和装置。该方法包括提供零模式波导，该零模式波导包括围绕芯的包层，其中覆层被配置为阻止频率小于截止频率的电磁能量沿纵向穿过零模式波导的芯的传播。分析物位于零模式波导的核心中，然后在零模式波导的核心中经受有效允许分析的条件下激活小于截止频率的频率的电磁辐射分析物在有效观察体积中比如果在没有零模式波导的情况下进行分析时更紧凑。

2. 发明授权

US07473361B2 Diffusion-based molecular separation in structured microfluidic devices 有权
标题翻译：结构化微流体装置中基于扩散的分子分离
公开(公告)号：US07473361B2
公开(公告)日：2009-01-06
申请号：US10306638
申请日：2002-11-27
申请人： Harold G. Craighead , Jennifer Gaudioso , Stephen W. Turner
发明人： Harold G. Craighead , Jennifer Gaudioso , Stephen W. Turner
IPC分类号： B01D63/00 , G01N7/10 , B01D61/00
CPC分类号： B01D17/0214 , B01D17/0217 , B01D17/045 , B01D17/06 , B01D17/08 , B01L3/502746 , B01L3/502753 , B01L2200/0647 , B01L2200/0652 , B01L2400/04 , B01L2400/0472 , B01L2400/086 , Y10T436/25
摘要： A microfluidic device has features that reduce the speed of flow of higher speed diffusing molecules. The features are used to separate various components of a mixture in the microfluidic device. The channel is sized to ensure laminar flow of the mixture to promote only diffusive mixing of the components. Wells extend from the channel. Components having higher diffusing velocities are slowed by the wells as the mixture proceeds through the channel. The result is that slower speed diffusing components exit the channel prior to the lower speed diffusing components. The device is formed by use of photolithographic techniques or other techniques capable of forming such features.
摘要翻译：微流体装置具有降低高速扩散分子的流速的特征。这些特征用于分离微流体装置中的混合物的各种组分。通道的大小可确保混合物的层流，以促进组分的扩散混合。井从通道延伸。当混合物通过通道进行时，具有较高扩散速度的组分被孔减慢。结果是较慢速度的扩散部件在低速扩散部件之前离开通道。该装置通过使用光刻技术或能够形成这种特征的其它技术形成。

3. 发明授权

US07316769B2 Length-dependent recoil separation of long molecules 有权
标题翻译：长分子长度依赖反冲分离
公开(公告)号：US07316769B2
公开(公告)日：2008-01-08
申请号：US10102268
申请日：2002-03-19
申请人： Harold G. Craighead , Stephen W. Turner
发明人： Harold G. Craighead , Stephen W. Turner
IPC分类号： G01N27/26 , B01D59/42 , C12N13/00
CPC分类号： G01N30/6052 , B01L3/502753 , B01L3/502761 , B01L2200/0663 , B01L2400/0409 , B01L2400/0415 , B01L2400/0487 , G01N30/02 , G01N30/6082 , G01N2030/285 , G01N2030/525 , G01N2030/527 , B01D15/34
摘要： Separation of long molecules by length is obtained by forcing such molecules to traverse a boundary between a low free-energy region and a high free-energy region. In one embodiment, the high free-energy region is a dense pillar region or other structure formed on a semiconductor substrate. One or more membranes are used in further embodiments. The low free-energy region is a larger chamber formed adjacent the high free-energy region. A recoil phase allows longer molecules not fully driven into the high free-energy region to recoil into the low free-energy region. In a further variation, the high free-energy region is a membrane having nanoscale holes.
摘要翻译：通过强迫这样的分子穿过低自由能区域和高自由能区域之间的边界来获得长分子长度的分离。在一个实施例中，高自由能区域是形成在半导体衬底上的致密柱状区域或其它结构。在另外的实施方案中使用一种或多种膜。低自由能区域是在高自由能区域附近形成的较大室。反冲阶段允许更长的分子不完全驱动到高自由能区域以反冲到低自由能区域。在另一变型中，高自由能区域是具有纳米孔的膜。

4. 发明授权

US07833398B2 Length-dependent recoil separation of long molecules 有权
标题翻译：长分子长度依赖反冲分离
公开(公告)号：US07833398B2
公开(公告)日：2010-11-16
申请号：US11938141
申请日：2007-11-09
申请人： Harold G. Craighead , Stephen W. Turner
发明人： Harold G. Craighead , Stephen W. Turner
IPC分类号： B01D59/42
CPC分类号： G01N30/6052 , B01L3/502753 , B01L3/502761 , B01L2200/0663 , B01L2400/0409 , B01L2400/0415 , B01L2400/0487 , G01N30/02 , G01N30/6082 , G01N2030/285 , G01N2030/525 , G01N2030/527 , B01D15/34
摘要： Separation of long molecules by length is obtained by forcing such molecules to traverse a boundary between a low free-energy region and a high free-energy region. In one embodiment, the high free-energy region is a dense pillar region or other structure formed on a semiconductor substrate. One or more membranes are used in further embodiments. The low free-energy region is a larger chamber formed adjacent the high free-energy region. A recoil phase allows longer molecules not fully driven into the high free-energy region to recoil into the low free-energy region. In a further variation, the high free-energy region is a membrane having nanoscale holes.
摘要翻译：通过强迫这样的分子穿过低自由能区域和高自由能区域之间的边界来获得长分子长度的分离。在一个实施例中，高自由能区域是形成在半导体衬底上的致密柱状区域或其它结构。在另外的实施方案中使用一种或多种膜。低自由能区域是在高自由能区域附近形成的较大室。反冲阶段允许更长的分子不完全驱动到高自由能区域以反冲到低自由能区域。在另一变型中，高自由能区域是具有纳米孔的膜。

5. 发明授权

US07181122B1 Zero-mode waveguides 有权
标题翻译：零模式波导
公开(公告)号：US07181122B1
公开(公告)日：2007-02-20
申请号：US11313971
申请日：2005-12-20
申请人： Michael J. Levene , Jonas Korlach , Stephen W. Turner , Harold G. Craighead , Watt W. Webb
发明人： Michael J. Levene , Jonas Korlach , Stephen W. Turner , Harold G. Craighead , Watt W. Webb
IPC分类号： G02B6/10
CPC分类号： C12Q1/25 , C12Q1/6825 , G01N21/47 , G01N21/6408 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/65 , G01N33/54373 , G01N2333/9015 , G01Q60/22 , G02B6/10 , G02B6/241
摘要： The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic energy of a frequency less than a cutoff frequency longitudinally through the core of the zero-mode waveguide. The analyte is positioned in the core of the zero-mode waveguide and is then subjected, in the core of the zero-mode waveguide, to activating electromagnetic radiation of a frequency less than the cut-off frequency under conditions effective to permit analysis of the analyte in an effective observation volume which is more compact than if the analysis were carried out in the absence of the zero-mode waveguide.
摘要翻译：本发明涉及用于分析分析物的方法和装置。该方法包括提供零模式波导，该零模式波导包括围绕芯的包层，其中覆层被配置为阻止频率小于截止频率的电磁能量沿纵向穿过零模式波导的芯的传播。分析物被定位在零模式波导的核心中，然后在零模式波导的核心中经受有效地允许分析的条件下激活小于截止频率的频率的电磁辐射分析物的有效观察体积比如果在没有零模式波导的情况下进行分析时更紧凑。

6. 发明授权

US07013054B2 Waveguides for performing spectroscopy with confined effective observation volumes 有权
标题翻译：用限制有效观察体积进行光谱的波导
公开(公告)号：US07013054B2
公开(公告)日：2006-03-14
申请号：US11151807
申请日：2005-06-13
申请人： Michael J. Levene , Jonas Korlach , Stephen W. Turner , Harold G. Craighead , Watt W. Webb
发明人： Michael J. Levene , Jonas Korlach , Stephen W. Turner , Harold G. Craighead , Watt W. Webb
IPC分类号： G02B6/00
CPC分类号： C12Q1/25 , C12Q1/6825 , G01N21/47 , G01N21/6408 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/65 , G01N33/54373 , G01N2333/9015 , G01Q60/22 , G02B6/10 , G02B6/241
摘要： The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic energy of a frequency less than a cutoff frequency longitudinally through the core of the zero-mode waveguide. The analyte is positioned in the core of the zero-mode waveguide and is then subjected, in the core of the zero-mode waveguide, to activating electromagnetic radiation of a frequency less than the cut-off frequency under conditions effective to permit analysis of the analyte in an effective observation volume which is more compact than if the analysis were carried out in the absence of the zero-mode waveguide.
摘要翻译：本发明涉及用于分析分析物的方法和装置。该方法包括提供零模式波导，该零模式波导包括围绕芯的包层，其中覆层被配置为阻止频率小于截止频率的电磁能量沿纵向穿过零模式波导的芯的传播。分析物被定位在零模式波导的核心中，然后在零模式波导的核心中经受有效地允许分析的条件下激活小于截止频率的频率的电磁辐射分析物的有效观察体积比如果在没有零模式波导的情况下进行分析时更紧凑。

7. 发明授权

US06917726B2 Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes 有权
标题翻译：零模式包层波导用于执行有限的有效观察体积的光谱
公开(公告)号：US06917726B2
公开(公告)日：2005-07-12
申请号：US10259268
申请日：2002-09-27
申请人： Michael J. Levene , Jonas Korlach , Stephen W. Turner , Harold G. Craighead , Watt W. Webb
发明人： Michael J. Levene , Jonas Korlach , Stephen W. Turner , Harold G. Craighead , Watt W. Webb
IPC分类号： G01N21/47 , G01N21/64 , G01N21/65 , G01Q60/18 , G02B6/10 , G02B6/24 , G02B6/00
CPC分类号： C12Q1/25 , C12Q1/6825 , G01N21/47 , G01N21/6408 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/65 , G01N33/54373 , G01N2333/9015 , G01Q60/22 , G02B6/10 , G02B6/241
摘要： The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic energy of a frequency less than a cutoff frequency longitudinally through the core of the zero-mode waveguide. The analyte is positioned in the core of the zero-mode waveguide and is then subjected, in the core of the zero-mode waveguide, to activating electromagnetic radiation of a frequency less than the cut-off frequency under conditions effective to permit analysis of the analyte in an effective observation volume which is more compact than if the analysis were carried out in the absence of the zero-mode waveguide.
摘要翻译：本发明涉及用于分析分析物的方法和装置。该方法包括提供零模式波导，该零模式波导包括围绕芯的包层，其中覆层被配置为阻止频率小于截止频率的电磁能量沿纵向穿过零模式波导的芯的传播。分析物被定位在零模式波导的核心中，然后在零模式波导的核心中经受有效地允许分析的条件下激活小于截止频率的频率的电磁辐射分析物的有效观察体积比如果在没有零模式波导的情况下进行分析时更紧凑。

8. 发明授权

US06753200B2 Monolithic nanofluid sieving structures for DNA manipulation 有权
标题翻译：用于DNA操作的单片纳米流体筛选结构
公开(公告)号：US06753200B2
公开(公告)日：2004-06-22
申请号：US09905027
申请日：2001-07-13
申请人： Harold G. Craighead , Stephen W. Turner
发明人： Harold G. Craighead , Stephen W. Turner
IPC分类号： H01L2100
CPC分类号： H01L21/00 , B01L3/00 , B01L3/502707 , B01L3/502715 , B01L2200/12 , B01L2300/0654 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2300/1827 , B01L2400/086 , G01N27/44791 , G01N30/02 , G01N30/6095 , G01N2030/285 , B01D15/34
摘要： A new technique for fabricating two-dimensional and three-dimensional fluid microchannels for molecular studies includes fabricating a monolithic unit using planar processing techniques adapted from semiconductor electronics fabrication. A fluid gap between a floor layer (12) and a ceiling layer (20) is provided by an intermediate patterned sacrificial layer (14) which is removed by a wet chemical etch. The process may be used to produce a structure such as a filter or artificial gel by using Electron beam lithography to define a square array of 100 nm holes (30) in the sacrificial layer. CVD silicon nitride (54) is applied over the sacrificial layer and enters the array of holes to produce closely spaced pillars. The sacrificial layer can be removed with a wet chemical etch trough access holes in the ceiling layer, after which the access holes are sealed with VLTO silicon dioxide (64).
摘要翻译：用于分子研究的用于制造二维和三维流体微通道的新技术包括使用适于半导体电子器件制造的平面处理技术来制造单片单元。地板层（12）和天花板层（20）之间的流体间隙由中间图案化的牺牲层（14）提供，其通过湿化学蚀刻去除。该方法可以用于通过使用电子束光刻来在牺牲层中限定100nm孔（30）的正方形阵列来产生诸如过滤器或人造凝胶的结构。 CVD氮化硅（54）施加在牺牲层上并进入孔阵列以产生紧密间隔的柱。牺牲层可以通过湿法化学蚀刻去除顶层中的通孔，然后用VLTO二氧化硅（64）密封进入孔。

9. 发明授权

US09248381B2 Method of purifying a dicarboxylic acid 有权
标题翻译：纯化二羧酸的方法
公开(公告)号：US09248381B2
公开(公告)日：2016-02-02
申请号：US13358943
申请日：2012-01-26
申请人： Thomas Chad Walker , Stephen W. Turner , Jay William Landwehr , Douglas da Silva Rosa , Mark Elliot Durchholz
发明人： Thomas Chad Walker , Stephen W. Turner , Jay William Landwehr , Douglas da Silva Rosa , Mark Elliot Durchholz
IPC分类号： C07C51/43 , C07C51/44 , C07C51/34 , B01D3/12 , B01D1/22 , B01D3/04
CPC分类号： B01D3/12 , B01D1/22 , B01D3/04 , C07C51/34 , C07C51/43 , C07C51/44 , C07C55/02 , C07C55/10 , C07C55/14 , C07C55/18 , C07C55/20 , C07C55/21
摘要： A process for purifying a dicarboxylic acid that is derived from the mixed oxidation products from an ozonization of a mixture containing an ethylenically unsaturated compound having between 6 to 24 carbons, the process includes distilling the mixed oxidation products to provide a first distillate, and a second distillate, where the second distillate includes the dicarboxylic acid and impurity acids, partitioning the second distillate between water and a organic solvent, separating the organic solvent layer from the water layer, lowering the temperature of the water layer to crystallize at least a portion of the dicarboxylic acid, separating the crystallized dicarboxylic acid solid, melting the crystallized dicarboxylic acid, and distilling the liquid dicarboxylic acid to provide a purified dicarboxylic acid.
摘要翻译：从含有6〜24个碳原子的烯键式不饱和化合物的混合物的臭氧化而得到的来自混合氧化物的二羧酸的方法，该方法包括蒸馏混合氧化产物以提供第一馏出物，第二馏分馏出物，其中第二馏出物包括二羧酸和杂质酸，将第二馏出物在水和有机溶剂之间分配，将有机溶剂层与水层分离，降低水层的温度以使至少一部分二羧酸，分离结晶二羧酸固体，熔融结晶的二羧酸，蒸馏液体二羧酸，得到纯化的二羧酸。

10. 发明申请

US20110134752A1 MULTILINK TRAFFIC SHAPING 审中-公开
标题翻译： MULTILINK交通形象
公开(公告)号：US20110134752A1
公开(公告)日：2011-06-09
申请号：US13029181
申请日：2011-02-17
申请人： Uros PRESTOR , Raghu Subramanian , Stephen W. Turner
发明人： Uros PRESTOR , Raghu Subramanian , Stephen W. Turner
IPC分类号： H04L12/26
CPC分类号： H04L47/10 , H04L45/00 , H04L45/24 , H04L47/125 , H04L47/22 , H04L47/34
摘要： A method for performing multilink communications may include applying a quality-of-service (QoS) policy to incoming traffic, where the QoS policy operates to identify a first portion and a second portion of the incoming traffic. The method may include fragmenting the first portion of the incoming traffic into a group of fragments. The method may include sequencing the group of fragments and the second portion of the incoming traffic into a sequenced flow, where the sequencing causes the second portion to be interleaved among the group of fragments so that the sequenced flow can be made available to a first link and a second link as multilink traffic, where the first link carries a first portion of the multilink traffic and the second link carries a second portion of the multilink traffic.
摘要翻译：用于执行多链路通信的方法可以包括将QoS质量策略应用于输入流量，其中QoS策略用于识别输入流量的第一部分和第二部分。该方法可以包括将输入业务的第一部分分段成一组分段。该方法可以包括对进入的业务组中的组和第二部分进行排序成顺序流，其中排序使第二部分在该组分组之间进行交织，使得顺序流可以被提供给第一链路以及作为多链路业务的第二链路，其中所述第一链路携带所述多链路业务的第一部分，并且所述第二链路承载所述多链路业务的第二部分。

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