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1. 发明授权

US08774892B2 Electrode configuration and measuring device for measuring the electrical activity in electrically active tissue 有权
标题翻译：用于测量电活动组织中的电活动的电极配置和测量装置
公开(公告)号：US08774892B2
公开(公告)日：2014-07-08
申请号：US12763374
申请日：2010-04-20
申请人： Detlef Behrend , Klaus-Peter Schmitz , Hans Wilhelm Pau , Katrin Sternberg , Wolfram Schmidt
发明人： Detlef Behrend , Klaus-Peter Schmitz , Hans Wilhelm Pau , Katrin Sternberg , Wolfram Schmidt
IPC分类号： A61B5/0492
CPC分类号： A61B5/0492 , A61B5/121 , A61B5/6815 , A61B5/6817 , A61B5/6838 , A61B5/6848 , A61B5/6849 , A61B2562/125
摘要： An electrode arrangement for sensing electrical activity in target tissue is described. A support electrode has an elongate electrode body with a base end and a penetrating end for insertion into the target tissue. A fixation electrode has an elongate electrode body with a base end and a penetrating end at an angle to the electrode body. The electrodes are joined together with their electrode bodies in parallel so that the penetrating end of the fixation electrode penetrates a fixed distance into the target tissue so that at least one of the electrodes senses electrical activity in the target tissue.
摘要翻译：描述了用于感测靶组织中的电活动的电极装置。支撑电极具有细长电极体，其具有基端和用于插入目标组织的穿透端。固定电极具有细长电极体，其具有基端和与电极体成角度的贯通端。电极与其电极体平行连接在一起，使得固定电极的穿透端穿过目标组织的固定距离，使得至少一个电极感测目标组织中的电活动。

2. 发明授权

US08280480B2 Stapedius muscle electrode 有权
标题翻译：脚趾肌电极
公开(公告)号：US08280480B2
公开(公告)日：2012-10-02
申请号：US12527263
申请日：2008-02-19
申请人： Hans Wilhelm Pau , Detlef Behrend , Wolfram Schmidt , Klaus-Peter Schmitz
发明人： Hans Wilhelm Pau , Detlef Behrend , Wolfram Schmidt , Klaus-Peter Schmitz
IPC分类号： A61B5/04
CPC分类号： A61B5/0492 , A61B5/6817 , A61N1/0541
摘要： The invention relates to a stapedius muscle electrode array for detecting the action elements generated when a human stapedius muscle is contracted. Said array comprises an electrode (2, 2′, 2″) that is adapted for bipolar discharge and is to be attached to a human stapedius muscle. The electrode has two flexible, elastic, electrically conducting elongate elements (2a, 2b), each of which has a distal (4a, 4b) and a proximal end (17a, 17b) and is helically preshaped along at least some of the length thereof to the distal end (4a, 4b) thereof in such a way that the distal end (4a, 4b) and a section of the respective elongate element (2a, 2b) which adjoins the distal end (4a, 4b) can be placed at least in part around the tendon (7) extending between the stapedius muscle and the stapes while the helical part can be guided along the tendon (7), can be moved in the direction of the stapedius muscle, and can be at least partly twisted into and/or slid onto the region of the muscle belly (6) adjoining the tendon (7). The two elongate elements (2a, 2b) are electrically insulated from one another, and the helical parts (3) thereof are intertwined in such a way as to run around a common centerline (11), allowing the helical parts (3) to be jointly placed around the tendon (7), be guided along the tendon (7), and be brought in contact with the stapedius muscle.
摘要翻译：本发明涉及一种用于检测当人类镫骨肌收缩时产生的动作元件的镫骨肌电极阵列。所述阵列包括适于双极放电并且连接到人类镫骨肌的电极（2,2'，2“）。电极具有两个柔性的，弹性的，导电的细长元件（2a，2b），每个元件具有远端（4a，4b）和近端（17a，17b），并且沿其长度的至少一部分螺旋状地预成形到远端（4a，4b），使远端（4a，4b）和与远端（4a，4b）相邻的相应的细长元件（2a，2b）的一部分可以放置在至少部分地围绕在镫骨和镫骨之间延伸的腱（7），而螺旋部分可以沿着腱（7）被引导，可以沿着镫骨肌的方向移动，并且可以至少部分地扭曲成和/或滑动到与肌腱（7）相邻的肌肉腹部（6）的区域上。两个细长元件（2a，2b）彼此电绝缘，并且其螺旋部分（3）以相互缠绕的方式相互缠绕，以便围绕共同的中心线（11）延伸，从而允许螺旋部分（3）为围绕腱（7）共同放置，沿腱（7）引导，并与镫骨肌接触。

3. 发明申请

US20110282177A1 Electrode Arrangement and Measuring Device for Measuring the Electrical Activity in an Electrically Active Tissue 有权
标题翻译：用于测量电活性组织中的电活性的电极布置和测量装置
公开(公告)号：US20110282177A1
公开(公告)日：2011-11-17
申请号：US12601156
申请日：2008-06-04
申请人： Detlef Behrend , Klaus-Peter Schmitz , Hans Wilhelm Pau , Katrin Sternberg , Wolfram Schmidt
发明人： Detlef Behrend , Klaus-Peter Schmitz , Hans Wilhelm Pau , Katrin Sternberg , Wolfram Schmidt
IPC分类号： A61B5/0492
CPC分类号： A61B5/6817 , A61B5/0492 , A61B5/121 , A61B5/6815 , A61B5/6838 , A61B5/6848 , A61N1/0541 , A61N1/36036
摘要： The invention relates to an electrode arrangement and a measuring device for measuring the action flow and/or the action potential of an electrically active tissue. The aim of the invention is to provide a simple and economically producible electrode for measuring action flows and/or action potentials in electrically active tissues (preferably the stapedius muscle tissue), ensuring that the electrode is fixed securely, but reversibly, in the muscle tissue and that the muscle tissue is disturbed as little as possible. The electrode arrangement according to the invention comprises a first electrode (2) and a fixing element (3), the first electrode (2) being connected to a first, long electrical line (4) and consisting of a long base body (6) comprising a first end (7) and a second end (8). The first electrical line (4) is connected to the base body (6) in the region of the second end (8) thereof, and means are provided for reversibly fixing the fixing element (3) to the first electrode (2).
摘要翻译：本发明涉及一种用于测量电活性组织的作用流和/或动作电位的电极装置和测量装置。本发明的目的是提供一种用于测量电活动组织（优选吻合肌肉组织）中的作用流动和/或动作电位的简单且经济地生产的电极，确保电极在肌肉组织中可靠地可逆地固定并且尽可能少地扰乱肌肉组织。根据本发明的电极装置包括第一电极（2）和固定元件（3），所述第一电极（2）连接到第一长电线（4）并由长基体（6）组成，包括第一端（7）和第二端（8）。第一电线（4）在其第二端（8）的区域中连接到基体（6），并且设置用于将固定元件（3）可逆地固定到第一电极（2）的装置。

4. 发明授权

US08725227B2 Electrode arrangement and measuring device for measuring the electrical activity in an electrically active tissue 有权
标题翻译：用于测量电活性组织中的电活动的电极装置和测量装置
公开(公告)号：US08725227B2
公开(公告)日：2014-05-13
申请号：US12601156
申请日：2008-06-04
申请人： Detlef Behrend , Klaus-Peter Schmitz , Hans Wilhelm Pau , Katrin Sternberg , Wolfram Schmidt
发明人： Detlef Behrend , Klaus-Peter Schmitz , Hans Wilhelm Pau , Katrin Sternberg , Wolfram Schmidt
IPC分类号： A61B5/0492 , A61F11/00
CPC分类号： A61B5/6817 , A61B5/0492 , A61B5/121 , A61B5/6815 , A61B5/6838 , A61B5/6848 , A61N1/0541 , A61N1/36036
摘要： The invention relates to an electrode arrangement and a measuring device for measuring the action flow and/or the action potential of an electrically active tissue. The aim of the invention is to provide a simple and economically producible electrode for measuring action flows and/or action potentials in electrically active tissues (preferably the stapedius muscle tissue), ensuring that the electrode is fixed securely, but reversibly, in the muscle tissue and that the muscle tissue is disturbed as little as possible. The electrode arrangement according to the invention comprises a first electrode (2) and a fixing element (3), the first electrode (2) being connected to a first, long electrical line (4) and consisting of a long base body (6) comprising a first end (7) and a second end (8). The first electrical line (4) is connected to the base body (6) in the region of the second end (8) thereof, and means are provided for reversibly fixing the fixing element (3) to the first electrode (2).
摘要翻译：本发明涉及一种用于测量电活性组织的作用流和/或动作电位的电极装置和测量装置。本发明的目的是提供一种用于测量电活动组织（优选吻合肌肉组织）中的作用流动和/或动作电位的简单且经济地生产的电极，确保电极在肌肉组织中可靠地可逆地固定并且尽可能少地扰乱肌肉组织。根据本发明的电极装置包括第一电极（2）和固定元件（3），所述第一电极（2）连接到第一长电线（4）并由长基体（6）组成，包括第一端（7）和第二端（8）。第一电线（4）在其第二端（8）的区域中连接到基体（6），并且设置用于将固定元件（3）可逆地固定到第一电极（2）的装置。

5. 发明申请

US20100268054A1 Electrode Configuration and Measuring Device for Measuring the Electrical Activity in Electrically Active Tissue 有权
标题翻译：用于测量电活性组织中电活性的电极配置和测量装置
公开(公告)号：US20100268054A1
公开(公告)日：2010-10-21
申请号：US12763374
申请日：2010-04-20
申请人： Detlef Behrend , Klaus-Peter Schmitz , Hans Wilhelm Pau , Katrin Sternberg , Wolfram Schmidt
发明人： Detlef Behrend , Klaus-Peter Schmitz , Hans Wilhelm Pau , Katrin Sternberg , Wolfram Schmidt
IPC分类号： A61B5/0492
CPC分类号： A61B5/0492 , A61B5/121 , A61B5/6815 , A61B5/6817 , A61B5/6838 , A61B5/6848 , A61B5/6849 , A61B2562/125
摘要： An electrode arrangement for sensing electrical activity in target tissue is described. A support electrode has an elongate electrode body with a base end and a penetrating end for insertion into the target tissue. A fixation electrode has an elongate electrode body with a base end and a penetrating end at an angle to the electrode body. The electrodes are joined together with their electrode bodies in parallel so that the penetrating end of the fixation electrode penetrates a fixed distance into the target tissue so that at least one of the electrodes senses electrical activity in the target tissue.
摘要翻译：描述了用于感测靶组织中的电活动的电极装置。支撑电极具有细长电极体，其具有基端和用于插入目标组织的穿透端。固定电极具有细长电极体，其具有基端和与电极体成角度的贯通端。电极与其电极体平行连接在一起，使得固定电极的穿透端穿过目标组织的固定距离，使得至少一个电极感测目标组织中的电活动。

6. 发明申请

US20100145177A1 Stapedius Muscle Electrode 有权
标题翻译： Stapedius肌肉电极
公开(公告)号：US20100145177A1
公开(公告)日：2010-06-10
申请号：US12527263
申请日：2008-02-19
申请人： Hans Wilhelm Pau , Detlef Behrend , Wolfram Schmidt , Klaus-Peter Schmitz
发明人： Hans Wilhelm Pau , Detlef Behrend , Wolfram Schmidt , Klaus-Peter Schmitz
IPC分类号： A61B5/0492
CPC分类号： A61B5/0492 , A61B5/6817 , A61N1/0541
摘要： The invention relates to a stapedius muscle electrode array for detecting the action elements generated when a human stapedius muscle is contracted. Said array comprises an electrode (2, 2′, 2″) that is adapted for bipolar discharge and is to be attached to a human stapedius muscle. The electrode has two flexible, elastic, electrically conducting elongate elements (2a, 2b), each of which has a distal (4a, 4b) and a proximal end (17a, 17b) and is helically preshaped along at least some of the length thereof to the distal end (4a, 4b) thereof in such a way that the distal end (4a, 4b) and a section of the respective elongate element (2a, 2b) which adjoins the distal end (4a, 4b) can be placed at least in part around the tendon (7) extending between the stapedius muscle and the stapes while the helical part can be guided along the tendon (7), can be moved in the direction of the stapedius muscle, and can be at least partly twisted into and/or slid onto the region of the muscle belly (6) adjoining the tendon (7). The two elongate elements (2a, 2b) are electrically insulated from one another, and the helical parts (3) thereof are intertwined in such a way as to run around a common centerline (11), allowing the helical parts (3) to be jointly placed around the tendon (7), be guided along the tendon (7), and be brought in contact with the stapedius muscle.
摘要翻译：本发明涉及一种用于检测当人类镫骨肌收缩时产生的动作元件的镫骨肌电极阵列。所述阵列包括适于双极放电并且连接到人类镫骨肌的电极（2,2'，2“）。电极具有两个柔性的，弹性的，导电的细长元件（2a，2b），每个元件具有远端（4a，4b）和近端（17a，17b），并且沿其长度的至少一部分螺旋状地预成形到远端（4a，4b），使远端（4a，4b）和与远端（4a，4b）相邻的相应的细长元件（2a，2b）的一部分可以放置在至少部分地围绕在镫骨和镫骨之间延伸的腱（7），而螺旋部分可以沿着腱（7）被引导，可以沿着镫骨肌的方向移动，并且可以至少部分地扭曲成和/或滑动到与肌腱（7）相邻的肌肉腹部（6）的区域上。两个细长元件（2a，2b）彼此电绝缘，并且其螺旋部分（3）以相互缠绕的方式相互缠绕，以便围绕共同的中心线（11）延伸，从而允许螺旋部分（3）为围绕腱（7）共同放置，沿腱（7）引导，并与镫骨肌接触。

7. 发明申请

US20090326432A1 OCULAR IMPLANT 有权
公开(公告)号：US20090326432A1
公开(公告)日：2009-12-31
申请号：US12524719
申请日：2008-01-25
申请人： Wolfram Schmidt , Katrin Sternberg , Detlef Behrend , Rudolf Guthoff , Klaus-Peter Schmitz
发明人： Wolfram Schmidt , Katrin Sternberg , Detlef Behrend , Rudolf Guthoff , Klaus-Peter Schmitz
IPC分类号： A61M5/00
CPC分类号： A61F9/00781
摘要： The present invention relates to an ocular implant, particularly a glaucoma stent.It is the object of the present invention to devise an ocular implant which allows the ocular eye pressure to be regulated, i.e., to be maintained at a desired level, while preventing the flow resistance from increasing over time, for example due to fibrosis.In order to achieve this object, the ocular implant according to the invention comprises a small tube (5), the wall surface (3) of which encloses a hollow duct that is open on both sides in the longitudinal direction of the hollow duct, wherein a first opening (1) allowing ocular humor to flow in and a second opening (2) allowing the ocular humor to be discharged is provided, and wherein the wall surface (3) is formed by a liquid-tight material, and wherein at least one pressure-controlled valve (4) is disposed in the area of the wall surface (3).
摘要翻译：本发明涉及眼部植入物，特别是青光眼支架。本发明的目的是设计一种允许眼睛压力被调节，即保持在期望水平的眼部植入物，同时防止流动阻力随时间增加，例如由于纤维化。为了实现该目的，根据本发明的眼部植入物包括小管（5），其壁表面（3）围绕中空管道，中空管道在中空管道的纵向两侧敞开，其中提供允许眼睛流入的第一开口（1）和允许眼睛被排出的第二开口（2），并且其中壁表面（3）由液体密封材料形成，并且其中至少一个压力控制阀（4）设置在壁表面（3）的区域中。

8. 发明授权

US08206333B2 Ocular implant 有权
标题翻译：眼部植入
公开(公告)号：US08206333B2
公开(公告)日：2012-06-26
申请号：US12524719
申请日：2008-01-25
申请人： Wolfram Schmidt , Katrin Sternberg , Detlef Behrend , Rudolf Guthoff , Klaus-Peter Schmitz
发明人： Wolfram Schmidt , Katrin Sternberg , Detlef Behrend , Rudolf Guthoff , Klaus-Peter Schmitz
IPC分类号： A61M5/00
CPC分类号： A61F9/00781
摘要： The present invention relates to an ocular implant, particularly a glaucoma stent.It is the object of the present invention to devise an ocular implant which allows the ocular eye pressure to be regulated, i.e., to be maintained at a desired level, while preventing the flow resistance from increasing over time, for example due to fibrosis.In order to achieve this object, the ocular implant according to the invention comprises a small tube (5), the wall surface (3) of which encloses a hollow duct that is open on both sides in the longitudinal direction of the hollow duct, wherein a first opening (1) allowing ocular humor to flow in and a second opening (2) allowing the ocular humor to be discharged is provided, and wherein the wall surface (3) is formed by a liquid-tight material, and wherein at least one pressure-controlled valve (4) is disposed in the area of the wall surface (3).
摘要翻译：本发明涉及眼部植入物，特别是青光眼支架。本发明的目的是设计一种允许眼睛压力被调节，即保持在期望水平的眼部植入物，同时防止流动阻力随时间增加，例如由于纤维化。为了实现该目的，根据本发明的眼部植入物包括小管（5），其壁表面（3）围绕中空管道，中空管道在中空管道的纵向两侧敞开，其中提供允许眼睛流入的第一开口（1）和允许眼睛被排出的第二开口（2），并且其中壁表面（3）由液体密封材料形成，并且其中至少一个压力控制阀（4）设置在壁表面（3）的区域中。

9. 发明申请

US20110190866A1 POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS 有权
标题翻译：聚合，可降解药水和涂层
公开(公告)号：US20110190866A1
公开(公告)日：2011-08-04
申请号：US13057974
申请日：2009-07-17
申请人： Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Niels Grabow , David P. Martin , Simon F. Williams
发明人： Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Niels Grabow , David P. Martin , Simon F. Williams
IPC分类号： A61F2/84 , A61F2/82 , B05D7/00
CPC分类号： A61L31/18 , A61F2/82 , A61F2210/0004 , A61F2250/0067 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/606 , C08L67/04
摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delarmnating and can be used as a coating matrix for drug incorporation.
摘要翻译：可吸收支架和可吸收支架涂层已经开发出具有改进的性能。这些装置优选包含4-羟基丁酸酯和任选的聚-L-乳酸和其它可吸收的聚合物和添加剂的生物相容性共聚物或均聚物。这些材料的组合物可用于制造提供有利的径向强度，抵抗反冲和蠕变的可吸收支架，可以在球囊导管上塑性膨胀，并且可以在体内迅速部署。衍生自这些材料的支架涂层提供生物相容性均匀的延展性涂层，并且可以在没有涂层开裂和/或脱胶的情况下扩展，并且可以用作药物掺入的涂层基质。

10. 发明授权

US09592325B2 Polymeric, degradable drug-eluting stents and coatings 有权
标题翻译：聚合，可降解的药物洗脱支架和涂层
公开(公告)号：US09592325B2
公开(公告)日：2017-03-14
申请号：US12188113
申请日：2008-08-07
申请人： Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Niels Grabow , David Martin , Simon Williams
发明人： Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Niels Grabow , David Martin , Simon Williams
IPC分类号： A61F2/82 , A61L31/18 , A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A61L31/18 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/606 , A61L2420/08 , C08L67/04
摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation.
摘要翻译：可吸收支架和可吸收支架涂层已经开发出具有改进的性能。这些装置优选包含4-羟基丁酸酯和任选的聚-L-乳酸和其它可吸收的聚合物和添加剂的生物相容性共聚物或均聚物。这些材料的组合物可用于制造提供有利的径向强度，抵抗反冲和蠕变的可吸收支架，可以在球囊导管上塑性膨胀，并且可以在体内迅速部署。衍生自这些材料的支架涂层提供生物相容性均匀的延展性涂层，并且可以在没有涂层开裂和/或分层的情况下扩展，并且可以用作药物掺入的涂层基质。

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