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1. 发明申请

US20130018767A1 APPARATUS AND METHOD FOR ACQUIRING CLIENT DATA TO PROCESS A FINANCIAL ACCOUNT 审中-公开
标题翻译：获取客户数据以处理财务账户的方法和方法
公开(公告)号：US20130018767A1
公开(公告)日：2013-01-17
申请号：US13180994
申请日：2011-07-12
申请人： Simon Williams , Zachary H. Lynde
发明人： Simon Williams , Zachary H. Lynde
IPC分类号： G06Q40/00
CPC分类号： G06Q10/00 , G06Q40/00
摘要： A method for acquiring data to process a financial account is provided which includes receiving a request to process the financial account. The request includes a print stream of data for a client received in a print protocol. The method further includes converting the print stream of data into wire format data, and transmitting the wire format data to a server to process the financial account. A method is provided for processing a financial account which includes receiving a request from a client to process the financial account. The request includes a print stream of data for a client received in a print protocol. The method further includes extracting data elements from the received wire format data, and processing the financial account using the extracted data elements. The receiving includes receiving encrypted wire format data which has been converted from the print stream of data for the client received in a print protocol.
摘要翻译：提供一种用于获取处理金融账户的数据的方法，其包括接收处理该金融账户的请求。该请求包括用于以打印协议接收的客户端的打印数据流。该方法还包括将打印数据流转换为有线格式数据，并将有线格式数据发送到服务器以处理该金融账户。提供一种用于处理金融账户的方法，其中包括从客户端接收处理该金融账户的请求。该请求包括用于以打印协议接收的客户端的打印数据流。该方法还包括从接收到的有线格式数据中提取数据元素，以及使用所提取的数据元素处理金融账户。接收包括接收已经从打印协议中接收的客户端的打印数据流转换的加密有线格式数据。

2. 发明申请

US20100111856A1 ZIRCONIUM-RADIOLABELED, CYSTEINE ENGINEERED ANTIBODY CONJUGATES 审中-公开
标题翻译：青霉素 - 放射性标记物，CYSTEINE工程抗体结合蛋白
公开(公告)号：US20100111856A1
公开(公告)日：2010-05-06
申请号：US12612912
申请日：2009-11-05
申请人： Herman Gill , Jagath R. Junutula , Henry B. Lowman , Jan Marik , Jeff Tinianow , Simon Williams
发明人： Herman Gill , Jagath R. Junutula , Henry B. Lowman , Jan Marik , Jeff Tinianow , Simon Williams
IPC分类号： A61K51/10 , C07K16/00 , C07D207/18 , C07C237/00 , C07K1/13
CPC分类号： A61K51/1093 , A01K2267/0331 , A61K51/1027 , A61K51/1051 , C07C259/06 , C07C323/60 , C07C2601/14 , C07K16/00 , C07K16/32 , C07K2317/21 , C07K2317/51 , C07K2317/52 , C07K2317/55 , C07K2317/624
摘要： Antibodies are engineered by replacing one or more amino acids of a parent antibody with non cross-linked, highly reactive cysteine amino acids. Antibody fragments may also be engineered with one or more cysteine amino acids to form cysteine engineered antibody fragments (ThioFab). Methods of design, preparation, screening, and selection of the cysteine engineered antibodies are provided. Cysteine engineered antibodies (Ab) are conjugated with one or more zirconium complex (Z) labels through a linker (L) to form cysteine engineered zirconium-labeled antibody conjugates having Formula I: Ab-(L-Z)p I where p is 1 to 4. Imaging methods and diagnostic uses for zirconium-radiolabeled, cysteine engineered antibody conjugate compositions are disclosed.
摘要翻译：通过用非交联的高反应性半胱氨酸氨基酸替代亲本抗体的一个或多个氨基酸来设计抗体。抗体片段也可以用一个或多个半胱氨酸氨基酸进行工程化以形成半胱氨酸改造的抗体片段（ThioFab）。提供了设计，制备，筛选和选择半胱氨酸改造的抗体的方法。半胱氨酸改造的抗体（Ab）通过接头（L）与一个或多个锆络合物（Z）标记物缀合以形成具有式I：Ab-（LZ）p I的半胱氨酸改造的锆标记的抗体缀合物，其中p为1至4 公开了用于放射性标记的半胱氨酸改造的抗体缀合物组合物的成像方法和诊断用途。

3. 发明申请

US20090126612A1 Waterwheel 审中-公开
标题翻译：水车
公开(公告)号：US20090126612A1
公开(公告)日：2009-05-21
申请号：US11986504
申请日：2007-11-21
申请人： Simon Williams , Anthony M. Stewart
发明人： Simon Williams , Anthony M. Stewart
IPC分类号： B63B1/00 , B63B21/24 , B66D1/00 , F03B7/00
CPC分类号： F03B17/062 , B63B35/44 , F05B2240/931 , F05B2250/70 , F05B2250/71 , Y02E10/28
摘要： An undershot waterwheel is described. The waterwheel has a rotational axis and paddles rotatable about the rotational axis. At least one paddle comprises a blade that is curved when viewed parallel to the rotational axis. Optionally, the waterwheel may be mounted on a watercraft.
摘要翻译：描述了一个低级水车。水轮具有旋转轴线，并且可围绕旋转轴线旋转。至少一个桨叶包括当平行于旋转轴线观察时弯曲的叶片。可选地，水轮可以安装在船只上。

4. 发明申请

US20070185561A1 Polymeric, Degradable Drug-Eluting Stents and Coatings 有权
标题翻译：聚合物，可降解药物洗脱支架和涂层
公开(公告)号：US20070185561A1
公开(公告)日：2007-08-09
申请号：US11671632
申请日：2007-02-06
申请人： Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Niels Grabow , David Martin , Simon Williams
发明人： Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Niels Grabow , David Martin , Simon Williams
IPC分类号： A61F2/06
CPC分类号： C08L67/04 , A61K47/34 , A61L15/26 , A61L17/105 , A61L17/12 , A61L27/18 , A61L27/26 , A61L29/049 , A61L29/06 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/148 , A61L31/18 , C08G63/06 , C08K3/014 , C08K5/0016 , C08K5/005 , C08K5/0083 , C08L2666/18
摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation.
摘要翻译：可吸收支架和可吸收支架涂层已经开发出具有改进的性能。这些装置优选包含4-羟基丁酸酯和任选的聚-L-乳酸和其它可吸收的聚合物和添加剂的生物相容性共聚物或均聚物。这些材料的组合物可用于制造提供有利的径向强度，抵抗反冲和蠕变的可吸收支架，可以在球囊导管上塑性膨胀，并且可以在体内迅速部署。衍生自这些材料的支架涂层提供生物相容性均匀的延展性涂层，并且可以在没有涂层开裂和/或分层的情况下扩展，并且可以用作药物掺入的涂层基质。

5. 发明申请

US20060177513A1 Embolization using poly-4-hydroxybutyrate particles 审中-公开
标题翻译：使用聚-4-羟基丁酸酯颗粒栓塞
公开(公告)号：US20060177513A1
公开(公告)日：2006-08-10
申请号：US11342172
申请日：2006-01-27
申请人： David Martin , Donald Crabtree , Simon Williams
发明人： David Martin , Donald Crabtree , Simon Williams
IPC分类号： A61K31/765 , A61K9/14
CPC分类号： A61L24/046 , A61K9/0019 , A61K31/765 , A61K47/34 , A61L2430/36 , C08L23/20
摘要： Absorbable particles which comprises poly-4-hydroxybutyrate and/or its copolymers are formulated in injectable suspension suitable for prophylactic or therapeutic embolization, which comprises administering to a human or animal the injectable suspension process for producing particles of the poly-4-hydroxybutyrate and/or its copolymer.
摘要翻译：将包含聚-4-羟基丁酸酯和/或其共聚物的可吸收颗粒配制成适用于预防性或治疗性栓塞的可注射悬浮液，其包括向人或动物施用可注射悬浮液以产生聚-4-羟基丁酸酯和/ 或其共聚物。

6. 发明授权

US06421446B1 Apparatus for creating 3D audio imaging over headphones using binaural synthesis including elevation 失效
标题翻译：用于使用包括海拔的双耳合成在耳机上创建3D音频成像的装置
公开(公告)号：US06421446B1
公开(公告)日：2002-07-16
申请号：US09210036
申请日：1998-12-11
申请人： Terry Cashion , Simon Williams
发明人： Terry Cashion , Simon Williams
IPC分类号： H04R500
CPC分类号： H04S1/005
摘要： The apparent location of sound signals as perceived by a person listening to the sound signals over headphones can be positioned or moved in azimuth, elevation and range by a range control block and a location control block. Several range control blocks and location control blocks can be provided depending on the number of input sound signals to be positioned or moved. All of the range and location control is provided by the range control blocks and location control blocks so that the resultant signals require only a fixed number of filters regardless of the number of input audio signals to provide the signal processing. Such signal processing resulting in accurate positioning and moving of the sound source is accomplished using front and back early reflection filters, left and right reverberation filters, front and back azimuth placement filters having a head related transfer function, and up and down elevation placement filters.
摘要翻译：通过耳机听到声音信号的人感觉到的声音信号的明显位置可以通过范围控制块和位置控制块在方位角，高程和范围内定位或移动。可以根据待定位或移动的输入声音信号的数量来提供多个范围控制块和位置控制块。所有的范围和位置控制由范围控制块和位置控制块提供，使得所得到的信号仅需要固定数量的滤波器，而不管输入音频信号的数量如何以提供信号处理。使用前后反射滤波器，左和右混响滤波器，具有头部相关传递函数的前后方位放置滤波器以及上下放大放大滤波器来实现导致声源的精确定位和移动的这种信号处理。

7. 发明授权

US5974153A Method and system for sound expansion 失效
标题翻译：声音扩展方法和系统
公开(公告)号：US5974153A
公开(公告)日：1999-10-26
申请号：US858594
申请日：1997-05-19
申请人： Terry K. Cashion , Simon Williams , John Arthur , Mark Williams
发明人： Terry K. Cashion , Simon Williams , John Arthur , Mark Williams
IPC分类号： H04S1/00 , H04H5/00 , H04R5/00
CPC分类号： H04S1/002
摘要： Monaural inputs are accepted for presentation to a pair of speakers. The output sound image from that pair of speakers is such that a listener will perceive that the sound is stereo and that certain sounds come from a non-existent center speaker and that other sounds come from locations beyond the physical boundaries of the two speakers. The system operates to preserve full tone range at both speakers and does not split the sound from a particular instrument between both speakers. The system can be used to provide sound signals to the rear speakers of a multiple speaker system when the sound input to the rear speakers is either monaural or stereo.
摘要翻译：单声道输入被接受以呈现给一对扬声器。来自该对扬声器的输出声音图像使得听众将感知到声音是立体声的，并且某些声音来自不存在的中心扬声器，并且其他声音来自超出两个扬声器的物理边界的位置。该系统操作以保持两个扬声器的全音色范围，并且不会在两个扬声器之间分离特定乐器的声音。当输入到后置扬声器的声音是单声道或立体声时，该系统可用于向多扬声器系统的后置扬声器提供声音信号。

8. 发明授权

US5371799A Stereo headphone sound source localization system 失效
标题翻译：立体声耳机声源定位系统
公开(公告)号：US5371799A
公开(公告)日：1994-12-06
申请号：US69870
申请日：1993-06-01
申请人： Danny D. Lowe , Terry Cashion , Simon Williams
发明人： Danny D. Lowe , Terry Cashion , Simon Williams
IPC分类号： H04S1/00 , H04S7/00 , H04R25/00
CPC分类号： H04S1/005 , H04S2420/01 , H04S7/305
摘要： A system for processing an audio signal for playback over headphones in which the apparent sound source is located outside of the head of the listener processes the input signal as if it were made up of a direct wave portion, an early reflections portion, and a reverberations portion. The direct wave portion of the signal is processed in filters whose filter coefficients are chosen based upon the desired azimuth of the virtual sound source location. The early reflection portion is passed through a bank of filters connected in parallel whose coefficients are chosen based on each reflection azimuth. The outputs of these filters are passed through scalars to adjust the amplitude to simulate a desired range of the virtual sound source. The reverberation portion is processed without any sound source location information, using a random number generator, for example, and the output is attenuated in an exponential attenuator to be faded out. The outputs of the scalars and attenuators are then all summed to produce left and right headphone signals for playback over the respective headphone transducers.
摘要翻译：用于处理用于通过耳机播放的音频信号的系统，其中表观声源位于收听者的头部外部处理输入信号，如同它由直接波段，早期反射部分和混响组成一部分。基于虚拟声源位置的期望方位来选择滤波器系数的滤波器对信号的直接波部分进行处理。早期反射部分通过并联连接的一组滤波器，其系数基于每个反射方位来选择。这些滤波器的输出通过标量来调节振幅以模拟虚拟声源的期望范围。例如，使用随机数发生器来处理混响部分而没有任何声源位置信息，并且输出在指数衰减器中被衰减以被淡出。然后将标量和衰减器的输出相加以产生用于在相应的耳机换能器上重放的左和右耳机信号。

9. 发明授权

US09162010B2 Drug eluting cochlear implants 有权
标题翻译：药物洗脱耳蜗植入物
公开(公告)号：US09162010B2
公开(公告)日：2015-10-20
申请号：US13284287
申请日：2011-10-28
申请人： Thomas Lenarz , Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Simon Williams , David Martin
发明人： Thomas Lenarz , Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Simon Williams , David Martin
IPC分类号： A61K9/00 , A61L31/10 , A61L27/34 , A61L27/54 , A61N1/36 , A61M31/00 , A61L31/08
CPC分类号： A61L27/34 , A61K9/0024 , A61L27/54 , A61L31/08 , A61L31/10 , A61L2300/258 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61M31/002 , A61N1/36036 , C08L67/04
摘要： Drug delivery systems and biocompatible coatings for use with implantable stimulation devices such as cochlear implants have been developed. These drug delivery systems and coatings comprise polyhydroxyalkanoate (PHA) polymers and copolymers. The drug delivery systems may be used to deliver pharmacologically active substances, for example, directly from a cochlear implant to the inner ear. The coatings can impart lubricity to cochlear devices for ease of insertion of the electrodes. In the preferred embodiment, the drug delivery system comprises a polyhydroxyalkanoate polymer, and in the most preferred embodiment, the PHA polymer comprises poly(4-hydroxybutyrate) (P(4HB)) or copolymer thereof. A particularly preferred embodiment is where the silicone sheath of the cochlear implant electrodes has been surface modified, and coated with P(4HB), and the P(4HB) either contains a pharmacologically active substance or has been coated with such a substance.
摘要翻译：已经开发了用于植入式刺激装置如耳蜗植入物的药物递送系统和生物相容性涂层。这些药物递送系统和涂层包含聚羟基链烷酸酯（PHA）聚合物和共聚物。药物递送系统可以用于将药理活性物质例如直接从耳蜗植入物递送到内耳。涂层可以赋予耳蜗装置润滑性，便于插入电极。在优选的实施方案中，药物递送系统包含聚羟基链烷酸酯聚合物，并且在最优选的实施方案中，PHA聚合物包含聚（4-羟基丁酸酯）（P（4HB））或其共聚物。一个特别优选的实施方案是其中耳蜗植入电极的硅氧烷鞘被表面改性并且涂覆有P（4HB），并且P（4HB）含有药理学活性物质或已被这种物质包被。

10. 发明申请

US20120283666A1 DRUG ELUTING COCHLEAR IMPLANTS 有权
标题翻译：药物涂抹胶印
公开(公告)号：US20120283666A1
公开(公告)日：2012-11-08
申请号：US13284287
申请日：2011-10-28
申请人： Thomas Lenarz , Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Simon Williams , David Martin
发明人： Thomas Lenarz , Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Simon Williams , David Martin
IPC分类号： A61M31/00 , A61N1/05
CPC分类号： A61L27/34 , A61K9/0024 , A61L27/54 , A61L31/08 , A61L31/10 , A61L2300/258 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61M31/002 , A61N1/36036 , C08L67/04
摘要： Drug delivery systems and biocompatible coatings for use with implantable stimulation devices such as cochlear implants have been developed. These drug delivery systems and coatings comprise polyhydroxyalkanoate (PHA) polymers and copolymers. The drug delivery systems may be used to deliver pharmacologically active substances, for example, directly from a cochlear implant to the inner ear. The coatings can impart lubricity to cochlear devices for ease of insertion of the electrodes. In the preferred embodiment, the drug delivery system comprises a polyhydroxyalkanoate polymer, and in the most preferred embodiment, the PHA polymer comprises poly(4-hydroxybutyrate) (P(4HB)) or copolymer thereof. A particularly preferred embodiment is where the silicone sheath of the cochlear implant electrodes has been surface modified, and coated with P(4HB), and the P(4HB) either contains a pharmacologically active substance or has been coated with such a substance.
摘要翻译：已经开发了用于植入式刺激装置如耳蜗植入物的药物递送系统和生物相容性涂层。这些药物递送系统和涂层包含聚羟基链烷酸酯（PHA）聚合物和共聚物。药物递送系统可以用于将药理活性物质例如直接从耳蜗植入物递送到内耳。涂层可以赋予耳蜗装置润滑性，便于插入电极。在优选的实施方案中，药物递送系统包含聚羟基链烷酸酯聚合物，并且在最优选的实施方案中，PHA聚合物包含聚（4-羟基丁酸酯）（P（4HB））或其共聚物。一个特别优选的实施方案是其中耳蜗植入电极的硅氧烷鞘被表面改性并且涂覆有P（4HB），并且P（4HB）含有药理学活性物质或已被这种物质包被。

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