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1. 发明授权

US08280480B2 Stapedius muscle electrode 有权
标题翻译：脚趾肌电极
公开(公告)号：US08280480B2
公开(公告)日：2012-10-02
申请号：US12527263
申请日：2008-02-19
申请人： Hans Wilhelm Pau , Detlef Behrend , Wolfram Schmidt , Klaus-Peter Schmitz
发明人： Hans Wilhelm Pau , Detlef Behrend , Wolfram Schmidt , Klaus-Peter Schmitz
IPC分类号： A61B5/04
CPC分类号： A61B5/0492 , A61B5/6817 , A61N1/0541
摘要： The invention relates to a stapedius muscle electrode array for detecting the action elements generated when a human stapedius muscle is contracted. Said array comprises an electrode (2, 2′, 2″) that is adapted for bipolar discharge and is to be attached to a human stapedius muscle. The electrode has two flexible, elastic, electrically conducting elongate elements (2a, 2b), each of which has a distal (4a, 4b) and a proximal end (17a, 17b) and is helically preshaped along at least some of the length thereof to the distal end (4a, 4b) thereof in such a way that the distal end (4a, 4b) and a section of the respective elongate element (2a, 2b) which adjoins the distal end (4a, 4b) can be placed at least in part around the tendon (7) extending between the stapedius muscle and the stapes while the helical part can be guided along the tendon (7), can be moved in the direction of the stapedius muscle, and can be at least partly twisted into and/or slid onto the region of the muscle belly (6) adjoining the tendon (7). The two elongate elements (2a, 2b) are electrically insulated from one another, and the helical parts (3) thereof are intertwined in such a way as to run around a common centerline (11), allowing the helical parts (3) to be jointly placed around the tendon (7), be guided along the tendon (7), and be brought in contact with the stapedius muscle.
摘要翻译：本发明涉及一种用于检测当人类镫骨肌收缩时产生的动作元件的镫骨肌电极阵列。所述阵列包括适于双极放电并且连接到人类镫骨肌的电极（2,2'，2“）。电极具有两个柔性的，弹性的，导电的细长元件（2a，2b），每个元件具有远端（4a，4b）和近端（17a，17b），并且沿其长度的至少一部分螺旋状地预成形到远端（4a，4b），使远端（4a，4b）和与远端（4a，4b）相邻的相应的细长元件（2a，2b）的一部分可以放置在至少部分地围绕在镫骨和镫骨之间延伸的腱（7），而螺旋部分可以沿着腱（7）被引导，可以沿着镫骨肌的方向移动，并且可以至少部分地扭曲成和/或滑动到与肌腱（7）相邻的肌肉腹部（6）的区域上。两个细长元件（2a，2b）彼此电绝缘，并且其螺旋部分（3）以相互缠绕的方式相互缠绕，以便围绕共同的中心线（11）延伸，从而允许螺旋部分（3）为围绕腱（7）共同放置，沿腱（7）引导，并与镫骨肌接触。

2. 发明申请

US20110282177A1 Electrode Arrangement and Measuring Device for Measuring the Electrical Activity in an Electrically Active Tissue 有权
标题翻译：用于测量电活性组织中的电活性的电极布置和测量装置
公开(公告)号：US20110282177A1
公开(公告)日：2011-11-17
申请号：US12601156
申请日：2008-06-04
申请人： Detlef Behrend , Klaus-Peter Schmitz , Hans Wilhelm Pau , Katrin Sternberg , Wolfram Schmidt
发明人： Detlef Behrend , Klaus-Peter Schmitz , Hans Wilhelm Pau , Katrin Sternberg , Wolfram Schmidt
IPC分类号： A61B5/0492
CPC分类号： A61B5/6817 , A61B5/0492 , A61B5/121 , A61B5/6815 , A61B5/6838 , A61B5/6848 , A61N1/0541 , A61N1/36036
摘要： The invention relates to an electrode arrangement and a measuring device for measuring the action flow and/or the action potential of an electrically active tissue. The aim of the invention is to provide a simple and economically producible electrode for measuring action flows and/or action potentials in electrically active tissues (preferably the stapedius muscle tissue), ensuring that the electrode is fixed securely, but reversibly, in the muscle tissue and that the muscle tissue is disturbed as little as possible. The electrode arrangement according to the invention comprises a first electrode (2) and a fixing element (3), the first electrode (2) being connected to a first, long electrical line (4) and consisting of a long base body (6) comprising a first end (7) and a second end (8). The first electrical line (4) is connected to the base body (6) in the region of the second end (8) thereof, and means are provided for reversibly fixing the fixing element (3) to the first electrode (2).
摘要翻译：本发明涉及一种用于测量电活性组织的作用流和/或动作电位的电极装置和测量装置。本发明的目的是提供一种用于测量电活动组织（优选吻合肌肉组织）中的作用流动和/或动作电位的简单且经济地生产的电极，确保电极在肌肉组织中可靠地可逆地固定并且尽可能少地扰乱肌肉组织。根据本发明的电极装置包括第一电极（2）和固定元件（3），所述第一电极（2）连接到第一长电线（4）并由长基体（6）组成，包括第一端（7）和第二端（8）。第一电线（4）在其第二端（8）的区域中连接到基体（6），并且设置用于将固定元件（3）可逆地固定到第一电极（2）的装置。

3. 发明授权

US4359582A Extraction of pantolactone from its aqueous solutions 失效
标题翻译：从其水溶液中提取泛酸内酯
公开(公告)号：US4359582A
公开(公告)日：1982-11-16
申请号：US10726
申请日：1979-02-08
申请人： Joachim Paust , Wolfram Schmidt
发明人： Joachim Paust , Wolfram Schmidt
IPC分类号： C07D307/33 , C07D307/20
CPC分类号： C07D307/33
摘要： Pantolactone is extracted from its aqueous solutions using methyl tert.-butyl ether as the extractant.
摘要翻译：使用甲基叔丁基醚作为萃取剂，从其水溶液中提取泛酸内酯。

4. 发明授权

US09418449B2 Device and method for measuring surfaces 有权
标题翻译：用于测量表面的装置和方法
公开(公告)号：US09418449B2
公开(公告)日：2016-08-16
申请号：US14110585
申请日：2012-03-14
申请人： Tilo Lilienblum , Wolfram Schmidt
发明人： Tilo Lilienblum , Wolfram Schmidt
IPC分类号： G06K9/00 , G06T7/60 , G01B21/20 , G01B21/30 , G01B11/24
CPC分类号： G06T7/604 , G01B11/24 , G01B21/20 , G01B21/30 , G06T7/64 , G06T2207/20024
摘要： According to the invention, a method for detecting and measuring local shape deviations in flat, curved, or domed surfaces of a test object, wherein three-dimensional measurement data (D) of the surfaces are evaluated by means of an evaluating apparatus, is designed and further developed, with regard to nondestructive testing of test objects with objective and easy-to-interpret assessment results, in such a way that the evaluating apparatus uses at least one virtual filter element as a concave filter for detecting concave sub-areas in flat or convex surfaces and/or as a convex filter for detecting convex sub-areas in flat or concave surfaces, that the filter element determines magnitudes of the shape deviations, and that said magnitudes are output by means of an outputting apparatus as measured values. The invention specifies a device for performing a corresponding method.
摘要翻译：根据本发明，一种用于检测和测量测试对象的平面，弯曲或圆顶表面中的局部形状偏差的方法，其中通过评估装置评估表面的三维测量数据（D），其被设计为并且进一步开发了关于具有客观和容易解释的评估结果的测试对象的非破坏性测试，使得评估装置使用至少一个虚拟滤波器元件作为凹面滤波器来检测平面中的凹形子区域或凸形表面和/或凸起的过滤器，用于检测平坦或凹面中的凸出的子区域，滤波器元件确定形状偏差的大小，并且所述量值通过输出装置作为测量值输出。本发明规定了用于执行相应方法的装置。

5. 发明申请

US20150078651A1 DEVICE AND METHOD FOR MEASURING SURFACES 有权
标题翻译：用于测量表面的装置和方法
公开(公告)号：US20150078651A1
公开(公告)日：2015-03-19
申请号：US14110585
申请日：2012-03-14
申请人： Tilo Lilienblum , Wolfram Schmidt
发明人： Tilo Lilienblum , Wolfram Schmidt
IPC分类号： G06T7/60 , G01B21/30 , G01B11/24 , G01B21/20
CPC分类号： G06T7/604 , G01B11/24 , G01B21/20 , G01B21/30 , G06T7/64 , G06T2207/20024
摘要： A method for detecting and measuring local deviations from the form in planar, curved, or arched surfaces of a test object is provided, whereby three-dimensional measurements (D) of the surfaces are processed with an evaluation unit, embodied and further developed with regards to a non-destructive examination of test objects with objective and easily interpreted assessment results such that the evaluation device uses at least one virtual filter element as a concave filter for detecting concave partial areas in planar or convex surfaces and/or as a convex filter for detecting convex partial areas in planar or concave surfaces, that the filter element determines values of the deviations from the form, and that they are displayed via a display device in the form of measurements.A device for executing a respective method is provided.
摘要翻译：提供了一种用于检测和测量与测试对象的平面，弯曲或拱形表面中的形式的局部偏差的方法，由此表面的三维测量（D）用评估单元进行处理，具体化并进一步开发对具有客观和容易解释的评估结果的测试对象进行非破坏性检查，使得评估装置使用至少一个虚拟滤波器元件作为凹面滤波器来检测平面或凸面中的凹部分区域和/或用作凸面滤波器检测平面或凹面中的凸部分区域，过滤元件确定与形式的偏差的值，并且以测量的形式通过显示装置显示它们。提供了一种执行各自方法的装置。

6. 发明申请

US20090326432A1 OCULAR IMPLANT 有权
公开(公告)号：US20090326432A1
公开(公告)日：2009-12-31
申请号：US12524719
申请日：2008-01-25
申请人： Wolfram Schmidt , Katrin Sternberg , Detlef Behrend , Rudolf Guthoff , Klaus-Peter Schmitz
发明人： Wolfram Schmidt , Katrin Sternberg , Detlef Behrend , Rudolf Guthoff , Klaus-Peter Schmitz
IPC分类号： A61M5/00
CPC分类号： A61F9/00781
摘要： The present invention relates to an ocular implant, particularly a glaucoma stent.It is the object of the present invention to devise an ocular implant which allows the ocular eye pressure to be regulated, i.e., to be maintained at a desired level, while preventing the flow resistance from increasing over time, for example due to fibrosis.In order to achieve this object, the ocular implant according to the invention comprises a small tube (5), the wall surface (3) of which encloses a hollow duct that is open on both sides in the longitudinal direction of the hollow duct, wherein a first opening (1) allowing ocular humor to flow in and a second opening (2) allowing the ocular humor to be discharged is provided, and wherein the wall surface (3) is formed by a liquid-tight material, and wherein at least one pressure-controlled valve (4) is disposed in the area of the wall surface (3).
摘要翻译：本发明涉及眼部植入物，特别是青光眼支架。本发明的目的是设计一种允许眼睛压力被调节，即保持在期望水平的眼部植入物，同时防止流动阻力随时间增加，例如由于纤维化。为了实现该目的，根据本发明的眼部植入物包括小管（5），其壁表面（3）围绕中空管道，中空管道在中空管道的纵向两侧敞开，其中提供允许眼睛流入的第一开口（1）和允许眼睛被排出的第二开口（2），并且其中壁表面（3）由液体密封材料形成，并且其中至少一个压力控制阀（4）设置在壁表面（3）的区域中。

7. 发明授权

US4294766A Preparation of pure potassium ribonate and ribonolactone 失效
标题翻译：制备纯的核糖核酸核糖和核糖内酯
公开(公告)号：US4294766A
公开(公告)日：1981-10-13
申请号：US100724
申请日：1979-12-06
申请人： Wolfram Schmidt , Joachim Paust
发明人： Wolfram Schmidt , Joachim Paust
IPC分类号： C07B31/00 , C07B57/00 , C07C51/00 , C07C51/41 , C07C59/105 , C07C67/00 , C07D307/33 , C07D307/32
CPC分类号： C07D307/33 , C07C51/41
摘要： An improved process for the preparation of potassium ribonate and of ribonolactone, which is an interesting intermediate for the preparation of riboflavin (vitamin B.sub.2), starting from potassium arabonate. An aqueous potassium arabonate solution is epimerized by adding a water-soluble non-ionic organic solvent, after which the greater part of the non-epimerized potassium arabonate can be separated off in a crystalline form. The mother liquor, which essentially contains potassium ribonate in addition to a small amount of unconverted potassium arabonate, is greatly concentrated and cooled, whereupon pure potassium ribonate crystallizes out; the latter can be lactonized in the conventional manner. Alternatively, the mixture of potassium arabonate and potassium ribonate, contained in the concentrated mother liquor, can be lactonized and the resulting lactone mixture, containing at least 70% by weight of ribonolactone, can be separated by fractional crystallization using dioxane or ethylene glycol monomethyl ether.
摘要翻译：用于制备核糖核酸和核糖内酯的改进方法，其是从阿拉伯酸钾开始制备核黄素（维生素B2）的有意义的中间体。通过加入水溶性非离子有机溶剂将阿拉伯糖酸钾水溶液差向异构化，之后大部分非差向异构化的阿拉伯糖酸钾可以以结晶形式分离出来。除了少量未转化的阿拉伯糖酸钾之外，基本上含有核糖核酸的母液被大大浓缩并冷却，因此纯的核糖核酸钾结晶出来; 后者可以以常规方式内酯化。或者，将浓缩母液中所含的阿拉伯糖酸钾和核糖酸钾的混合物进行内酯化，并且可以通过使用二恶烷或乙二醇单甲醚的分级结晶分离含有至少70重量％核糖内酯的所得内酯混合物。

8. 发明授权

US08725227B2 Electrode arrangement and measuring device for measuring the electrical activity in an electrically active tissue 有权
标题翻译：用于测量电活性组织中的电活动的电极装置和测量装置
公开(公告)号：US08725227B2
公开(公告)日：2014-05-13
申请号：US12601156
申请日：2008-06-04
申请人： Detlef Behrend , Klaus-Peter Schmitz , Hans Wilhelm Pau , Katrin Sternberg , Wolfram Schmidt
发明人： Detlef Behrend , Klaus-Peter Schmitz , Hans Wilhelm Pau , Katrin Sternberg , Wolfram Schmidt
IPC分类号： A61B5/0492 , A61F11/00
CPC分类号： A61B5/6817 , A61B5/0492 , A61B5/121 , A61B5/6815 , A61B5/6838 , A61B5/6848 , A61N1/0541 , A61N1/36036
摘要： The invention relates to an electrode arrangement and a measuring device for measuring the action flow and/or the action potential of an electrically active tissue. The aim of the invention is to provide a simple and economically producible electrode for measuring action flows and/or action potentials in electrically active tissues (preferably the stapedius muscle tissue), ensuring that the electrode is fixed securely, but reversibly, in the muscle tissue and that the muscle tissue is disturbed as little as possible. The electrode arrangement according to the invention comprises a first electrode (2) and a fixing element (3), the first electrode (2) being connected to a first, long electrical line (4) and consisting of a long base body (6) comprising a first end (7) and a second end (8). The first electrical line (4) is connected to the base body (6) in the region of the second end (8) thereof, and means are provided for reversibly fixing the fixing element (3) to the first electrode (2).
摘要翻译：本发明涉及一种用于测量电活性组织的作用流和/或动作电位的电极装置和测量装置。本发明的目的是提供一种用于测量电活动组织（优选吻合肌肉组织）中的作用流动和/或动作电位的简单且经济地生产的电极，确保电极在肌肉组织中可靠地可逆地固定并且尽可能少地扰乱肌肉组织。根据本发明的电极装置包括第一电极（2）和固定元件（3），所述第一电极（2）连接到第一长电线（4）并由长基体（6）组成，包括第一端（7）和第二端（8）。第一电线（4）在其第二端（8）的区域中连接到基体（6），并且设置用于将固定元件（3）可逆地固定到第一电极（2）的装置。

9. 发明申请

US20120157815A1 Evoked Stapedius Reflex Threshold (ESRT) Tile Electrode 有权
标题翻译：诱发Stapedius反射阈值（ESRT）瓷砖电极
公开(公告)号：US20120157815A1
公开(公告)日：2012-06-21
申请号：US13326581
申请日：2011-12-15
申请人： Hans Wilhelm Pau , Detlef Behrend , Mareike Warkentin , Wolfram Schmidt , Olaf Specht , Daniel Schaudel , Guido Reetz
发明人： Hans Wilhelm Pau , Detlef Behrend , Mareike Warkentin , Wolfram Schmidt , Olaf Specht , Daniel Schaudel , Guido Reetz
IPC分类号： A61B5/0492 , A61B5/0488 , A61B5/04
CPC分类号： A61B5/0492 , A61B5/6815 , A61B5/6848 , A61B5/6878 , A61B5/6882 , A61B2562/04 , A61B2562/222 , A61N1/0502 , A61N1/0541
摘要： An electrode arrangement is described for sensing electrical activity in target tissue. An inner electrode has an elongate electrode body formed as a cylindrical section with an inner penetrating end for insertion into the stapedius muscle target tissue. An outer electrode fits over the inner electrode and an outer penetrating end for insertion into the target tissue. The two electrodes are joined together with their electrode bodies in parallel so that the penetrating ends of the electrodes penetrate in the same direction into the target tissue to sense electrical activity in the target tissue.
摘要翻译：描述了用于感测目标组织中的电活动的电极装置。内电极具有形成为圆柱形部分的细长电极体，其具有用于插入钉胸肌组织中的内穿透端。外部电极配合在内部电极和外部穿透端，用于插入目标组织。两个电极与它们的电极体平行连接在一起，使得电极的穿透端部朝向目标组织的相同方向穿透以感测靶组织中的电活动。

10. 发明申请

US20100268054A1 Electrode Configuration and Measuring Device for Measuring the Electrical Activity in Electrically Active Tissue 有权
标题翻译：用于测量电活性组织中电活性的电极配置和测量装置
公开(公告)号：US20100268054A1
公开(公告)日：2010-10-21
申请号：US12763374
申请日：2010-04-20
申请人： Detlef Behrend , Klaus-Peter Schmitz , Hans Wilhelm Pau , Katrin Sternberg , Wolfram Schmidt
发明人： Detlef Behrend , Klaus-Peter Schmitz , Hans Wilhelm Pau , Katrin Sternberg , Wolfram Schmidt
IPC分类号： A61B5/0492
CPC分类号： A61B5/0492 , A61B5/121 , A61B5/6815 , A61B5/6817 , A61B5/6838 , A61B5/6848 , A61B5/6849 , A61B2562/125
摘要： An electrode arrangement for sensing electrical activity in target tissue is described. A support electrode has an elongate electrode body with a base end and a penetrating end for insertion into the target tissue. A fixation electrode has an elongate electrode body with a base end and a penetrating end at an angle to the electrode body. The electrodes are joined together with their electrode bodies in parallel so that the penetrating end of the fixation electrode penetrates a fixed distance into the target tissue so that at least one of the electrodes senses electrical activity in the target tissue.
摘要翻译：描述了用于感测靶组织中的电活动的电极装置。支撑电极具有细长电极体，其具有基端和用于插入目标组织的穿透端。固定电极具有细长电极体，其具有基端和与电极体成角度的贯通端。电极与其电极体平行连接在一起，使得固定电极的穿透端穿过目标组织的固定距离，使得至少一个电极感测目标组织中的电活动。

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