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1. 发明授权

US4712555A Physiologically responsive pacemaker and method of adjusting the pacing interval thereof 失效
标题翻译：生理反应起搏器和调整其起搏间隔的方法
公开(公告)号：US4712555A
公开(公告)日：1987-12-15
申请号：US716831
申请日：1985-03-27
申请人： Hans T. Thornander , John W. Poore , Jason A. Sholder , James R. Thacker , David C. Amundson
发明人： Hans T. Thornander , John W. Poore , Jason A. Sholder , James R. Thacker , David C. Amundson
IPC分类号： A61N1/08 , A61N1/365 , A61N1/368 , A61N1/37 , A61N1/36
CPC分类号： A61N1/365 , A61N1/368 , A61N1/3712 , A61N1/3714 , A61N1/3716
摘要： A pacemaker and physiological sensor for use therewith that allows the rate at which the pacemaker delivers electrical stimulation pulses to the heart, or the escape interval during which a natural heart event must occur before an electrical stimulation pulse is delivered, to be adjusted as needed in order to satisfy the body's physiological needs. The sensor measures the depolarization time interval between an atrial stimulation pulse, A, and the responsive atrial or ventricle depolarization, P or R respectively, as an indication of the physiological demands placed on the heart. The time interval between a ventricular stimulation pulse, V, and the responsive ventricular depolarization, R, may also be measured and used as an indication of physiological need, and hence as an alternative criteria for rate control. Atrial depolarization is sensed by detecting a P-wave, and ventricular depolarization is preferably sensed by detecting an R-wave. A method of measuring A-P, A-R, or V-R intervals is used to ascertain if these intervals are increasing or decreasing. If, over several heart cycles or beats, an increase or decrease in these measurements is detected, the pacing interval set by the pacemaker is adjusted in an appropriate direction in order to adjust the heart stimulation rate accordingly.
摘要翻译：用于其的起搏器和生理传感器允许起搏器向心脏传递电刺激脉冲的速率，或者在传送电刺激脉冲之前必须发生自然心脏事件的逃逸间隔，以根据需要进行调整为了满足身体的生理需要。传感器测量心房刺激脉冲A与反应性心房或心室去极化P或R之间的去极化时间间隔，作为对心脏的生理需求的指示。也可以测量心室刺激脉冲V与响应性心室去极化R之间的时间间隔，并将其用作生理需要的指示，并因此用作速率控制的替代标准。通过检测P波来感测心房去极化，并且优选通过检测R波来感测心室去极化。使用测量A-P，A-R或V-R间隔的方法来确定这些间隔是否增加或减少。如果在几个心脏周期或节拍中检测到这些测量值的增加或减少，起搏器设定的起搏间隔将在适当的方向进行调节，以便相应地调整心脏刺激速率。

2. 发明申请

US20080287942A1 RF Ablation Catheter with Side-Eye Infrared Imager 审中-公开
标题翻译：射频消融导管与侧眼红外成像仪
公开(公告)号：US20080287942A1
公开(公告)日：2008-11-20
申请号：US11750251
申请日：2007-05-17
申请人： David C. Amundson
发明人： David C. Amundson
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00375 , A61B2018/00839 , A61B2090/3614 , A61B2090/373
摘要： An ablation catheter has an imager useful in connection with an ablation operation such as used in the treatment of a cardiac arrhythmia. The catheter has an ablation electrode positioned on a catheter tip, and the imager is located on a side of the catheter. Because the catheter tip is generally articulated when the lesion is formed, this position of the imager provides an image that corresponds with the position of the catheter when it is used to form a lesion. Rings for recording tissue electrograms are also positioned on the catheter tip. This arrangement allows the user to accurately place and contact the electrode and to monitor the ablation process such as by viewing bubbles and thrombi that may undesirably be formed.
摘要翻译：消融导管具有与用于治疗心律失常的消融手术有关的成像器。导管具有定位在导管尖端上的消融电极，并且成像器位于导管的一侧。因为当形成病变时导管尖端通常是铰接的，所以成像器的该位置提供与用于形成病变时的导管位置对应的图像。用于记录组织电描记图的环也位于导管尖端上。这种布置允许使用者准确地放置和接触电极并监视消融过程，例如通过观察可能不期望地形成的气泡和血栓。

3. 发明申请

US20100034227A1 INFRARED IMAGING USING MULTIPLE WAVELENGTHS 审中-公开
标题翻译：使用多波长的红外成像
公开(公告)号：US20100034227A1
公开(公告)日：2010-02-11
申请号：US12377316
申请日：2007-08-14
申请人： David C. Amundson , Larry Blankenship
发明人： David C. Amundson , Larry Blankenship
IPC分类号： H01S5/00 , H01L27/15 , H01L33/00
CPC分类号： A61B5/0086 , A61B5/02007
摘要： For an infrared imaging catheter, means of achieving a spread of wavelengths or multiple wavelengths through a stacking arrangement of “monochromatic” laser diodes or LED's are disclosed. Since a stack of diodes or LED's have different temperatures, they produce a wavelength spread many times greater than a single laser diode or LED. The wavelength spread reduces speckle in the corresponding image. Adding wavelengths also improves the corresponding infrared image, since different wavelengths have different light penetration capabilities and can emphasize different biological entities.
摘要翻译：对于红外成像导管，公开了通过“单色”激光二极管或LED的堆叠布置实现波长或多个波长的扩展的手段。由于二极管或LED的堆叠具有不同的温度，因此它们产生比单个激光二极管或LED大许多倍的波长。波长扩展减少了相应图像中的斑点。添加波长也可以改善对应的红外图像，因为不同的波长具有不同的光穿透能力，并且可以强调不同的生物实体。

4. 发明授权

US4156429A Implantable electrode 失效
标题翻译：可植入电极
公开(公告)号：US4156429A
公开(公告)日：1979-05-29
申请号：US840577
申请日：1977-10-11
申请人： David C. Amundson
发明人： David C. Amundson
IPC分类号： A61N1/05 , A61N1/04
CPC分类号： A61N1/0565
摘要： An improved implantable electrode for delivery of electrical stimulation pulses or signals to an organ such as the heart from an electrical pulse generator. The electrode is normally exposed to the organ to be stimulated and is, in turn, electrically coupled to a conductive lead extending from the pulse generator, with the electrode being a body which substantially completely envelopes the lead. The electrode comprises a plurality of electrically conductive metallic filaments compressed together to form a generally fibrous body which may in certain instances be pliant or flexible in nature. The filaments preferably have a mean, effective diameter less than about 100 microns and form from about 3% to 30% of the total volume of the fibrous member, and preferably from 5% to 20%. In one embodiment, the filaments are retained as a bundle within a metallic grid enclosure.
摘要翻译：一种用于从电脉冲发生器传送电刺激脉冲或信号到诸如心脏的器官的改进的可植入电极。电极通常暴露于被刺激的器官，并且又电连接到从脉冲发生器延伸的导电引线，电极是基本上完全包围引线的主体。电极包括多个压缩在一起的导电金属细丝，以形成大体上纤维的主体，在某些情况下，其可以是柔软的或柔性的。长丝优选具有小于约100微米的平均有效直径，并且形成纤维构件总体积的约3％至30％，优选为5％至20％。在一个实施例中，细丝作为束保持在金属网格外壳内。

5. 发明授权

US06178346B1 Infrared endoscopic imaging in a liquid with suspended particles: method and apparatus 有权
标题翻译：红外内窥镜成像在具有悬浮颗粒的液体中：方法和装置
公开(公告)号：US06178346B1
公开(公告)日：2001-01-23
申请号：US09178566
申请日：1998-10-23
申请人： David C. Amundson , H. John Hanlin
发明人： David C. Amundson , H. John Hanlin
IPC分类号： A61B500
CPC分类号： A61B5/0086 , A61B1/00165 , A61B1/042 , A61B1/063 , A61B1/0669 , A61B1/07 , A61B5/0075
摘要： A device and method for imaging an object that is situated within a fluid environment having suspended particles uses infrared illumination. In a representative application, a catheter having fiber optics is inserted into the vasculature of a patient. The fiber optics transmits infrared light to an optical head at a distal end of the catheter, which transmits the light into a bloody environment to an object to be imaged. Light reflecting from the object is collected and transmitted throughout the fiber optic to an infrared camera, so that an image is formed. Proper selection of the wavelength of infrared illumination allows objects to be imaged through what would otherwise be an opaque liquid. The invention has particular utility in the field of medical imaging.
摘要翻译：用于成像位于具有悬浮颗粒的流体环境内的物体的装置和方法使用红外照明。在代表性的应用中，将具有光纤的导管插入患者的脉管系统中。光纤将红外光透射到导管的远端处的光学头，该光头将光传输到血液环境中，使其成像。从物体反射的光被收集并通过光纤传输到红外相机，从而形成图像。正确选择红外照明的波长可使物体通过不透明液体进行成像。本发明在医学成像领域具有特殊的用途。

6. 发明授权

US4790318A Cardiac pacer for pacing a human heart 失效
标题翻译：心脏起搏器用于起搏人心脏
公开(公告)号：US4790318A
公开(公告)日：1988-12-13
申请号：US874597
申请日：1986-06-16
申请人： Hakan Elmqvist , Anders Lekholm , Sven-Erik Hedberg , David C. Amundson
发明人： Hakan Elmqvist , Anders Lekholm , Sven-Erik Hedberg , David C. Amundson
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36521
摘要： A cardiac pacer which generates pacing pulses at a predetermined pacing rate, includes a device for generating an alternating signal which is unable to pace the heart. The pacing pulses and the alternating signal are transmitted together to the heart. The alternating signal after transmittal to the heart is measured and processed such that a respiratory signal is obtained. The predetermined pacing rate is then varied dependent on the respiratory signal.

7. 发明授权

US4730618A Cardiac pacer for pacing a human heart and pacing method 失效
标题翻译：心脏起搏器用于起搏人心和起搏方法
公开(公告)号：US4730618A
公开(公告)日：1988-03-15
申请号：US874585
申请日：1986-06-16
申请人： Anders Lekholm , David C. Amundson
发明人： Anders Lekholm , David C. Amundson
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36521 , Y10S128/902
摘要： A cardiac pacer which generates pacing pulses at a predetermined pacing rate includes a device for making a body activity measurement. The measured body activity signal is non-linearly amplified such that signal portions having higher amplitudes are more amplified than signal portions having lower amplitudes. The non-linearly amplified body activity signal is integrated over a period of time. The predetermined pacing rate is varied dependent on the integrated signal.
摘要翻译：以预定的起搏速度产生起搏脉冲的心脏起搏器包括用于进行身体活动测量的装置。测量的身体活动信号被非线性放大，使得具有较高幅度的信号部分比具有较低振幅的信号部分被放大得多。非线性放大的身体活动信号在一段时间内被积分。预定起搏速率取决于积分信号而变化。

8. 发明授权

US07527625B2 Transparent electrode for the radiofrequency ablation of tissue 有权
标题翻译：用于组织射频消融的透明电极
公开(公告)号：US07527625B2
公开(公告)日：2009-05-05
申请号：US10912732
申请日：2004-08-04
申请人： Bradley P. Knight , Larry Blankenship , John H. Hanlin , David C. Amundson
发明人： Bradley P. Knight , Larry Blankenship , John H. Hanlin , David C. Amundson
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2017/00907 , A61B2018/00077 , A61B2018/00148
摘要： A novel transparent electrode that uses a conductive coating to allow delivery of current to the heart as well as outward imaging through the electrode is described. The embodiments disclose a catheter incorporating an endoscope, whose imaging tip is coated with a conductive coating that is transparent in the endoscopic image. However, a transparent electrode may be fashioned for any imaging modality, such as intracardiac echocardiography (ICE), that finds the electrode to be transparent to the energy used. This electrode coating may be a thin, optically transparent or translucent coating of platinum or gold or may be a pattern with enough open spaces to see the underlying tissue, such as looking through a screen. A wire is connected to the conductive coating and routed to a radiofrequency generator.
摘要翻译：描述了使用导电涂层以允许将电流传递到心脏以及通过电极进行外部成像的新型透明电极。实施例公开了一种结合内窥镜的导管，其内窥镜图像中透明的导电涂层的成像尖端被涂覆。然而，透明电极可以用于任何成像模态，例如心内超声心动图（ICE），其发现电极对所使用的能量是透明的。该电极涂层可以是铂或金的薄的光学透明或半透明涂层，或者可以是具有足够开放空间的图案，以查看下面的组织，例如通过屏幕观察。导线连接到导电涂层并被引导到射频发生器。

9. 发明授权

US4697591A Cardiac pacer for pacing a human heart and pacing method 失效
标题翻译：心脏起搏器用于起搏人心和起搏方法
公开(公告)号：US4697591A
公开(公告)日：1987-10-06
申请号：US874591
申请日：1986-06-16
申请人： Anders Lekholm , David C. Amundson
发明人： Anders Lekholm , David C. Amundson
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36521
摘要： A cardiac pacer which generates pacing pulses at a predetermined pacing rate includes a device for processing the pacing pulses according to an impedance measurement such that a respiratory signal is obtained. The predetermined pacing rate is then varied dependent on the respiratory signal.
摘要翻译：以预定的起搏速度产生起搏脉冲的心脏起搏器包括根据阻抗测量来处理起搏脉冲以使获得呼吸信号的装置。然后根据呼吸信号改变预定起搏速率。

10. 发明授权

US4313442A Atrial rate sensitive cardiac pacer apparatus 失效
标题翻译：心房率敏感心脏起搏器
公开(公告)号：US4313442A
公开(公告)日：1982-02-02
申请号：US170947
申请日：1980-07-21
申请人： Mark B. Knudson , David C. Amundson
发明人： Mark B. Knudson , David C. Amundson
IPC分类号： A61N1/368 , A61N1/36
CPC分类号： A61N1/368
摘要： An electrical pacer device which responds to cardiac demand so as to alter the cardiac output in a fashion to satisfy that demand. Changes in the fundamental period of the atrial electrical cycle are detected and averaged over a predetermined time interval and the resulting control signal is used to raise and lower the ventricular heart rate to increase and decrease the foresaid cardiac output. At the same time, means are provided for continuously driving the ventricular rate toward a predetermined lower rate (the at rest rate) on a time cycle which is significantly longer than the above-mentioned predetermined time interval.
摘要翻译：一种响应于心脏需求以便以满足该需求的方式改变心输出量的电子起搏装置。在预定时间间隔内检测和平均心房电循环的基本周期的变化，并且使用所得到的控制信号来提高和降低心室心率以增加和减少预期的心输出量。同时，提供了用于在明显长于上述预定时间间隔的时间周期上将心室率持续地驱动到预定的较低速率（静止时）的装置。

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