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1. 发明授权

US4790318A Cardiac pacer for pacing a human heart 失效
标题翻译：心脏起搏器用于起搏人心脏
公开(公告)号：US4790318A
公开(公告)日：1988-12-13
申请号：US874597
申请日：1986-06-16
申请人： Hakan Elmqvist , Anders Lekholm , Sven-Erik Hedberg , David C. Amundson
发明人： Hakan Elmqvist , Anders Lekholm , Sven-Erik Hedberg , David C. Amundson
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36521
摘要： A cardiac pacer which generates pacing pulses at a predetermined pacing rate, includes a device for generating an alternating signal which is unable to pace the heart. The pacing pulses and the alternating signal are transmitted together to the heart. The alternating signal after transmittal to the heart is measured and processed such that a respiratory signal is obtained. The predetermined pacing rate is then varied dependent on the respiratory signal.

2. 发明授权

US4722341A Atrium-controlled heart pacemaker 失效
标题翻译：心房控制的心脏起搏器
公开(公告)号：US4722341A
公开(公告)日：1988-02-02
申请号：US910999
申请日：1986-09-24
申请人： Sven-Erik Hedberg , Anders Lekholm , Anders Lindgren
发明人： Sven-Erik Hedberg , Anders Lekholm , Anders Lindgren
IPC分类号： A61N1/37 , A61N1/362 , A61N1/365 , A61N1/36
CPC分类号： A61N1/3622
摘要： An atrium controlled heart pacemaker has a switching stage which is controlled in dependence upon the appearance of atrial signals. The switching stage switches the heart pacemaker to a VVI mode for a predetermined number of stimulation pulses or natural ventricular events, or a predetermined time, upon the appearance of at least one atrial signal before a selected time limit. The time limit is derived from the difference between a smallest synchronous interval and the AV delay.
摘要翻译：心房控制的心脏起搏器具有切换阶段，其根据心房信号的出现进行控制。在选择的时间限制之前出现至少一个心房信号时，切换台将心脏起搏器切换到预定数量的刺激脉冲或自然心室事件或预定时间的VVI模式。时间限制是从最小同步间隔和AV延迟之间的差值得出的。

3. 发明授权

US4714079A Atrium-controlled heart pacemaker 失效
标题翻译：心房控制的心脏起搏器
公开(公告)号：US4714079A
公开(公告)日：1987-12-22
申请号：US910998
申请日：1986-09-24
申请人： Sven-Erik Hedberg , Anders Lekholm , Anders Lindgren
发明人： Sven-Erik Hedberg , Anders Lekholm , Anders Lindgren
IPC分类号： A61N1/365 , A61N1/368 , A61N1/36
CPC分类号： A61N1/368 , A61N1/3682
摘要： An atrium-controlled heart pacemaker operates using set parameters including a smallest synchronous interval (SSI) between two stimulation pulses, a minimum atrial-ventricular delay time (AVmin) and a maximum atrial-ventricular delay time (AVmax). A control unit, dependent upon the appearance of an atrial signal, controls operation of the pacemaker such that the pacemaker operates with a variable pulse rate (DDD mode) when the atrial signal appears after a point in time SSI-AVmin, operates the pacemaker with a highest synchronous pulse rate when the atrial signal is between the points in time SSI-AVmin and SSI-AVmax, and causes no stimulation pulses to be emitted when the atrial signal appears before the point in time SSI-AVmax.
摘要翻译：心房控制的心脏起搏器使用设定参数进行操作，包括两个刺激脉冲之间的最小同步间隔（SSI），最小心房延迟时间（AVmin）和最大心房延迟时间（AVmax）。根据心房信号的出现，控制单元控制起搏器的操作，使得起搏器以可变脉冲速率（DDD模式）操作，当心房信号在时间点SSI-AVmin后出现时，起搏器与当心房信号在时间点SSI-AVmin和SSI-AVmax之间时最高的同步脉搏率，并且当心房信号在时间点SSI-AVmax之前出现时，不会发出刺激脉冲。

4. 发明授权

US09162066B2 Method and system for stimulating a heart 有权
标题翻译：刺激心脏的方法和系统
公开(公告)号：US09162066B2
公开(公告)日：2015-10-20
申请号：US13508968
申请日：2011-05-31
申请人： Sven-Erik Hedberg , Nils Holmstrom , Karin Jarverud
发明人： Sven-Erik Hedberg , Nils Holmstrom , Karin Jarverud
IPC分类号： A61N1/368 , A61N1/362
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3682 , A61N1/3684
摘要： A first ventricle is stimulated at a stimulation site, a point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation is estimated and a first activation time interval substantially corresponding to the time interval required for at least one depolarization wave to travel from the stimulation site in the first ventricle to the AV node is computed. A similar process is used to compute a second activation time interval for the other ventricle. Based on these activation time intervals and a difference between the intervals, a pacing therapy can be determined.
摘要翻译：在刺激部位刺激第一脑室，估计从刺激产生的至少一个去极化波到达AV节点的时间点，并且基本对应于至少一个去极化所需的时间间隔的第一激活时间间隔计算从第一脑室的刺激部位到AV节点的波。使用类似的过程来计算另一个心室的第二激活时间间隔。基于这些激活时间间隔和间隔之间的差异，可以确定起搏治疗。

5. 发明申请

US20120310296A1 DETERMINATION OF CARDIAC RESYNCHRONIZATION THERAPY SETTINGS 有权
标题翻译：心脏康复治疗方法的确定
公开(公告)号：US20120310296A1
公开(公告)日：2012-12-06
申请号：US13471167
申请日：2012-05-14
申请人： Kjell Noren , Anders Bjorling , Tomas Svensson , Sven-Erik Hedberg , Allen Keel , Stuart Rosenberg , Kyungmoo Ryu
发明人： Kjell Noren , Anders Bjorling , Tomas Svensson , Sven-Erik Hedberg , Allen Keel , Stuart Rosenberg , Kyungmoo Ryu
IPC分类号： A61N1/365
CPC分类号： A61N1/36507 , A61N1/3682 , A61N1/3684 , A61N1/37252
摘要： CRT settings for an implantable medical device are determined by applying pacing pulses to heart chambers of a scheme of different combinations of interchamber delays. A respective width parameter value representing an R or P wave width is determined for each such delay combination based on an ECG representing signal and the width parameter values are employed to estimate a parametric model defining the width parameter as a function of interchamber delays. Candidate interchamber delays that minimize the width parameter are determined from the parametric model and employed to determine optimal CRT settings. The technique provides an efficient way of finding optimal CRT settings when multiple pacing sites are available in a heart chamber.
摘要翻译：用于可植入医疗装置的CRT设置通过将不同组合的车间延迟的方案应用于心室来进行起搏脉冲来确定。基于ECG表示信号为每个这样的延迟组合确定表示R或P波宽的相应宽度参数值，并且使用宽度参数值来估计定义作为间歇延迟的函数的宽度参数的参数模型。从参数模型中确定最小化宽度参数的候选车间延迟，并用于确定最佳CRT设置。该技术提供了一种在心室中可用多个起搏部位时可以找到最佳CRT设置的有效方式。

6. 发明授权

US08321016B2 Implantable medical device and a method comprising means for detecting and classifying ventricular tachyarrhythmias 有权
标题翻译：植入式医疗装置和包括用于检测和分类室性快速性心律失常的装置的方法
公开(公告)号：US08321016B2
公开(公告)日：2012-11-27
申请号：US12602533
申请日：2007-06-13
申请人： Nils Holmström , Andreas Blomqvist , Sven-Erik Hedberg , Malin Öhlander
发明人： Nils Holmström , Andreas Blomqvist , Sven-Erik Hedberg , Malin Öhlander
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/3702 , A61B5/0464 , A61B5/053 , A61B5/7264
摘要： In a method and implantable medical device for ventricular tachyarrhythmia detection and classification, upon detection of a ventricular tachyarrhythmia based on an electrocardiogram signal, cardiogenic impedance data representative of ventricular volume dynamics are collected and used for classifying the detected tachyarrhythmia as stable or unstable. In the latter case but typically not in the former case, defibrillation shocks or other forms of therapy are applied to combat the unstable ventricular tachyarrhythmia.
摘要翻译：在用于室性快速性心律失常检测和分类的方法和可植入医疗装置中，在基于心电图信号检测到心室快速性心律失常时，收集表示心室容积动力学的心源阻抗数据，并用于将检测到的心律失常分类为稳定或不稳定。在后一种情况下，但通常不是在前一种情况下，应用除颤电击或其他形式的治疗来对抗不稳定性室性快速性心律失常。

7. 发明申请

US20110319769A1 ISCHEMIC STATUS MONITORING 审中-公开
标题翻译： ISCHEMIC状态监测
公开(公告)号：US20110319769A1
公开(公告)日：2011-12-29
申请号：US13255460
申请日：2009-03-13
申请人： Sven-Erik Hedberg , Tomas Svensson , Michael Broomé , Karin Järverud , Stefan Hjelm
发明人： Sven-Erik Hedberg , Tomas Svensson , Michael Broomé , Karin Järverud , Stefan Hjelm
IPC分类号： A61N1/365 , A61B5/026
CPC分类号： A61B5/0452 , A61B5/026 , A61B5/053 , A61B5/1116 , A61B5/1118 , A61B5/4836 , A61B5/6846 , A61B5/7405 , A61B5/7455 , A61N1/3702
摘要： An ischemia monitoring system has detectors for detecting the onset of an ischemic event of a tissue in subject, the end of the ischemic event and the end of a following recovery from the ischemic event, respectively. A time processor determines the duration of the ischemic event and the recovery period based on the detected onset and end times. A status processor co-processes the two determined time durations for the purpose of monitoring the ischemic status of the subject and detecting any deterioration in ischemic status for the latest ischemic event as compared to previous ischemic events that have occurred in the subject's tissue.
摘要翻译：缺血监测系统具有检测器，用于分别检测受试者组织的缺血事件的发作，缺血事件的结束以及从缺血事件中恢复的结束。时间处理器基于检测到的开始和结束时间来确定缺血事件的持续时间和恢复期。状态处理器协调处理两个确定的持续时间以便监测受试者的缺血状态并且检测与在受试者组织中发生的先前缺血事件相比，最新缺血事件的缺血状态的任何恶化。

8. 发明申请

US20100298904A1 IMPLANTABLE HEART STIMULATOR FOR MEASURING DYSSYNCHRONY USING IMPEDANCE 有权
标题翻译：用于测量使用阻抗的DYSSYNCHRONY的可植入心脏刺激仪
公开(公告)号：US20100298904A1
公开(公告)日：2010-11-25
申请号：US12863381
申请日：2008-01-28
申请人： Andreas Blomqvist , Nils Holmström , Malin Öhlander , Sven-Erik Hedberg
发明人： Andreas Blomqvist , Nils Holmström , Malin Öhlander , Sven-Erik Hedberg
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61B5/053 , A61B5/0538 , A61N1/3684
摘要： Implantable heart stimulator connectable to an electrode arrangement has a pulse generator adapted to deliver stimulation pulses to a heart of a subject; an impedance measurement unit adapted monitor at least one heart chamber of the heart of the subject to measure the impedance in the at least one monitored heart chamber for generating an impedance signal corresponding to the measured impedance. The impedance signal is applied to a processor where the signal is processed, according to specified criteria, and a fractionation index value is determined represented by the curve length of the impedance signal during a predetermined measurement period. The fractionation index value is a measure of different degrees of mechanical dyssynchrony of the heart.
摘要翻译：可连接到电极装置的可植入心脏刺激器具有适于将刺激脉冲输送到受试者心脏的脉冲发生器; 阻抗测量单元适于监测所述受试者心脏的至少一个心室，以测量所述至少一个监测的心室中的阻抗，以产生对应于所测量的阻抗的阻抗信号。根据规定的标准，将阻抗信号施加到处理器，信号被处理，并且在预定测量期间由阻抗信号的曲线长度确定分数指数值。分离指数值是心脏不同程度的机械不同步的度量。

9. 发明申请

US20100010600A1 PIEZOELECTRIC SENSOR, A METHOD FOR MANUFACTURING A PIEZOELECTRIC SENSOR AND A MEDICAL IMPLANTABLE LEAD COMPRISING SUCH A PIEZOELECTRIC SENSOR 有权
标题翻译：压电传感器，制造压电传感器的方法和包含这种压电传感器的医用可植入引线
公开(公告)号：US20100010600A1
公开(公告)日：2010-01-14
申请号：US12298218
申请日：2006-04-25
申请人： Tom Eriksson , Kenth Nilsson , Sven-Erik Hedberg
发明人： Tom Eriksson , Kenth Nilsson , Sven-Erik Hedberg
IPC分类号： A61N1/05 , H01L41/22 , G01L9/08
CPC分类号： A61N1/056 , A61B5/0215 , A61N1/0565 , A61N1/36542 , A61N1/36564 , G01L9/0026 , G01L9/08 , H01L41/087 , H01L41/1132
摘要： In a piezoelectric sensor, a method for the manufacture thereof, and an implantable lead embodying such a piezoelectric sensor, a layer of piezoelectric material, having aligned, polarized dipoles, is applied to a tubular supporting substrate, the layer of piezoelectric material having at least one electrode at an outer surface thereof and at least one electrode at an inner surface thereof. The piezoelectric material is applied on the inner circumference of the tubular supporting substrate.
摘要翻译：在压电传感器中，其制造方法以及体现这种压电传感器的可植入引线，具有排列的极化偶极子的压电材料层被施加到管状支撑衬底，压电材料层至少具有一个电极在其外表面和至少一个电极在其内表面。压电材料被施加在管状支撑衬底的内圆周上。

10. 发明授权

US07353061B2 Biventricular stimulation device with shortened inter-ventricular delay 有权
标题翻译：双心室刺激装置具有缩短的心室间延迟
公开(公告)号：US07353061B2
公开(公告)日：2008-04-01
申请号：US10573281
申请日：2003-09-25
申请人： Sven-Erik Hedberg , Anders Björling , Per Lagercrantz
发明人： Sven-Erik Hedberg , Anders Björling , Per Lagercrantz
IPC分类号： A61N1/00
CPC分类号： A61N1/371 , A61N1/368 , A61N1/3684
摘要： A biventricular cardiac stimulation device has a pulse generator for delivering stimulation pulses at least to the ventricles of a patient's heart. An evoked response detector has independent first and second ventricular sensing channels for ventricular evoked response detection in the ventricles. The pulse generator is controlled to deliver stimulation pulses to the second ventricle with a VV time delay after delivery of a stimulation pulse to the first-stimulated ventricle, the VV time delay being shorter than an evoked response detection time window that follows delivery of the stimulation pulse to the first-stimulated ventricle. An evoked response detector closes the evoked response detection window, or discards detections therein, in response to the emission of a stimulation pulse to the second-stimulated ventricle during the evoked response detection time window of the first-stimulated ventricle.
摘要翻译：双心室心脏刺激装置具有脉冲发生器，用于至少向患者心脏的心室输送刺激脉冲。诱发反应检测器具有独立的第一和第二心室感应通道，用于心室中的心室诱发反应检测。脉冲发生器被控制以在将刺激脉冲递送到第一刺激心室之后以VV时间延迟将刺激脉冲递送到第二心室，VV时间延迟短于在刺激递送之后的诱发响应检测时间窗口脉冲到第一刺激的心室。响应于在第一刺激的心室的诱发响应检测时间窗口期间向第二刺激的心室发射刺激脉冲，诱发响应检测器关闭诱发响应检测窗口或丢弃其中的检测。

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