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    • 1. 发明授权
    • Friction bearing system for a rapidly rotating shaft
    • 用于快速旋转轴的摩擦轴承系统
    • US4872769A
    • 1989-10-10
    • US267245
    • 1988-11-04
    • Hans KrauseRudi RossHelmut Koch
    • Hans KrauseRudi RossHelmut Koch
    • F16C17/08F16C32/00G02B26/04
    • F16C32/00F16C17/08G02B26/04
    • In a friction bearing system for a rapidly rotating shaft of an apparatus for measuring the optical absorption of a sample under analysis by way of an optical radiation source projecting a beam on the sample, the chopper system for the periodical interruption of the beam includes a rotatably mounted chopper disk provided with light-admitting openings and a controlled-speed drive system, as well as a radiation detector for the light affected by the sample. Both ends of the shaft fixedly joined to the chopper disk are provided with pivots corresponding to bushes, one of which is held by a spider which is affixed to the housing part that holds the other bush. The spider is provided with a bore running at an angle to the shaft, and the longitudinal axis of this bore intersects the axis of rotation of the shaft. A magnet is held for longitudinal displacement in the bore and its field acts upon a ring disposed on the shaft in order to assure the quiet and wear-free spinning of the chopper disk.
    • 在用于通过在样品上投射光束的光辐射源测量分析中的样品的光吸收的装置的快速旋转轴的摩擦轴承系统中,用于波束的周期性中断的斩波器系统包括可旋转 具有光入口的安装的斩波盘和受控速度驱动系统,以及用于受样品影响的光的辐射探测器。 固定连接到斩波盘的轴的两端设置有对应于衬套的枢轴,其中一个由固定到保持另一个衬套的壳体部分的一个蜘蛛保持。 该蜘蛛设置有与轴成一定角度的孔,并且该孔的纵向轴线与轴的旋转轴线相交。 保持磁体在孔中的纵向位移,并且其磁场作用在设置在轴上的环上,以确保斩波盘的安静和无磨损的旋转。
    • 3. 发明授权
    • Pharmaceutical formulations: liposomes incorporating aromatic polyene
antibiotics
    • 药物制剂:掺入芳香多烯抗生素的脂质体
    • US4999199A
    • 1991-03-12
    • US269638
    • 1988-11-10
    • Elias J. AnaissieGeorgios SamonisHans KrauseGerald P. Bodey
    • Elias J. AnaissieGeorgios SamonisHans KrauseGerald P. Bodey
    • A61K9/127
    • A61K31/70A61K9/127
    • The present invention involves a pharmaceutical formulation comprising a liposome having a therapeutically effective concentration of an aromatic polyene macrolide antibiotic. The aromatic polyene macrolide antibiotic usable in the practice of the present invention is selected from the group consisting of candicidin, hamycin, aurefungin, ascosin, ayfattin, azacolutin, DJ400-B, trichomycin, levorin, heptamycin, candimycin or perimycin. The most preferred aromatic polyene macrolide antibiotic is candicidin. An important aspect of the present invention is a method for treating disseminated fungal infection in an animal comprising administering to an animal such as a human a pharmaceutical formulation comprising a liposome having a therapeutically effective amount of aromatic polyene macrolide antibiotic as described above. The preferred method of such administering is parenteral and the therapeutically effective amount is between about 1 mg/kg body weight and about 20 mg/kg body weight, more preferably between about 2.5 mg/kg body weight and about 6 mg/kg body weight. The parenteral administration is intravenous, intraarterial, subcutaneous, intramuscular, intralymphatic, intraperitoneal or intrapleural. The microorganisms which may be treated by the methods of the present invention comprise C. albicans, C. tropicalis, C. neoformans, aspergillus, cryptococcus, phycomycetes, fusarium, or trichosporin.
    • 本发明涉及包含具有治疗有效浓度的芳族多烯大环内酯抗生素的脂质体的药物制剂。 可用于本发明实践中的芳香族多烯大环内酯类抗生素选自念珠菌素,马铃薯霉素,aurefungin,ascosin,ayfattin,azacolutin,DJ400-B,trichomycin,levorin,庚霉素,candimycin或perimycin。 最优选的芳香族多烯大环内酯类抗生素是水cand啶。 本发明的一个重要方面是用于治疗动物中播散性真菌感染的方法,包括向动物如人类施用包含具有治疗有效量的如上所述的芳族多烯大环内酯类抗生素的脂质体的药物制剂。 这种施用的优选方法是肠胃外,治疗有效量为约1mg / kg体重与约20mg / kg体重之间,更优选约2.5mg / kg体重至约6mg / kg体重。 肠胃外给药是静脉内,动脉内,皮下,肌内,淋巴内,腹膜内或胸膜内。 可以通过本发明的方法处理的微生物包括白色念珠菌,热带热带弧菌,新生隐球菌,曲霉菌,隐球菌属,菌纲菌,镰孢菌素或trichosporin。
    • 6. 发明授权
    • Method and apparatus for measuring the optical absorption of samples
    • 测量样品光吸收的方法和装置
    • US08035816B2
    • 2011-10-11
    • US12295845
    • 2007-04-10
    • Albert RandowHelmut DandlHans Krause
    • Albert RandowHelmut DandlHans Krause
    • G01N21/59
    • G01N21/274G01J3/02G01J3/0232G01J3/42G01J2001/4242G01N21/3518
    • In a method and apparatus for measuring the optical absorption of samples having a light source (1), a photoelectric converter (8), a measurement beam path extending between the light source (1) and the converter (8), in which path the sample to be examined is arranged, a reference beam path extending between the light source (1) and the converter (8), in which path a reference sample is arranged, and a motor-driven chopper disc (10), the chopper disc (10) is configured with a first number of first openings (15) unblocking only the measurement beam path and a second number of second openings (16) unblocking only the path for the reference beam. A lock-in amplifier (21) and a device (17) for synchronising the lock-in amplifier (21) with the chopper disc (10) is connected to the converter (8) and an evaluation circuit (26) establishes the quotient of the transmitted intensity of the reference beam path detected by the converter (8) and the transmitted intensity of the measurement beam path detected by the converter (8) as a measurement for the concentration of the sample in such a way that the decrease in the intensity of the beam by absorption leads to an increase in sensitivity.
    • 在用于测量具有光源(1)的样品的光吸收的方法和装置中,光电转换器(8),在光源(1)和转换器(8)之间延伸的测量光束路径,其中路径 布置要检查的样本,在光源(1)和转换器(8)之间延伸的参考光束路径,其中布置参考样本的路径,以及电动驱动的斩波盘(10),斩波盘 10)配置有仅解除测量光束路径的第一数量的第一开口(15)和仅解除参考光束的路径的第二数量的第二开口(16)。 锁定放大器(21)和用于使锁定放大器(21)与斩波盘(10)同步的装置(17)连接到转换器(8),并且评估电路(26)建立 由转换器(8)检测的参考光束路径的透射强度和由转换器(8)检测的测量光束路径的透射强度作为样品浓度的测量,使得强度的降低 通过吸收导致光束的增加。
    • 7. 发明申请
    • METHOD AND APPARATUS FOR MEASURING THE OPTICAL ABSORPTION OF SAMPLES
    • 用于测量样品的光学吸收的方法和装置
    • US20090168064A1
    • 2009-07-02
    • US12295845
    • 2007-04-10
    • Albert RandowHelmut DandlHans Krause
    • Albert RandowHelmut DandlHans Krause
    • G01N21/59
    • G01N21/274G01J3/02G01J3/0232G01J3/42G01J2001/4242G01N21/3518
    • In a method and apparatus for measuring the optical absorption of samples having a light source (1), a photoelectric converter (8), a measurement beam path extending between the light source (1) and the converter (8), in which path the sample to be examined is arranged, a reference beam path extending between the light source (1) and the converter (8), in which path a reference sample is arranged, and a motor-driven chopper disc (10), the chopper disc (10) is configured with a first number of first openings (15) unblocking only the measurement beam path and a second number of second openings (16) unblocking only the path for the reference beam. A lock-in amplifier (21) and a device (17) for synchronising the lock-in amplifier (21) with the chopper disc (10) is connected to the converter (8) and an evaluation circuit (26) establishes the quotient of the transmitted intensity of the reference beam path detected by the converter (8) and the transmitted intensity of the measurement beam path detected by the converter (8) as a measurement for the concentration of the sample in such a way that the decrease in the intensity of the beam by absorption leads to an increase in sensitivity.
    • 在用于测量具有光源(1)的样品的光吸收的方法和装置中,光电转换器(8),在光源(1)和转换器(8)之间延伸的测量光束路径,其中路径 布置要检查的样本,在光源(1)和转换器(8)之间延伸的参考光束路径,其中布置参考样本的路径,以及电动驱动的斩波盘(10),斩波盘 10)配置有仅解除测量光束路径的第一数量的第一开口(15)和仅解除参考光束的路径的第二数量的第二开口(16)。 锁定放大器(21)和用于使锁定放大器(21)与斩波盘(10)同步的装置(17)连接到转换器(8),并且评估电路(26)建立 由转换器(8)检测的参考光束路径的透射强度和由转换器(8)检测的测量光束路径的透射强度作为样品浓度的测量,使得强度的降低 通过吸收导致光束的增加。
    • 10. 发明授权
    • Furnace charging throat construction
    • 炉充充喉施工
    • US4878655A
    • 1989-11-07
    • US100526
    • 1987-09-24
    • Bernhard HennekenBruno KammerlingEckhard-K. ScholzWolfgang SchroderHans Krause
    • Bernhard HennekenBruno KammerlingEckhard-K. ScholzWolfgang SchroderHans Krause
    • C21B7/18F27B1/20
    • C21B7/18F27B1/20F27D3/0033F27D3/10F27D2003/105
    • In a throat stopper for shaft furnaces, in particular blast furnaces with two hoppers of which an upper hopper is rotatable through a drive device, the upper hopper is designed, by means of a stationary hood equipped with charging flap valves, as a sluice chamber to be closed pressureproof. For sealing the stationary hood relative to the rotatable upper hopper, there is disposed, at the hood, a peripheral flexible inflatable bellows. The bellows can be pressed against the wall of the upper hopper pneumatically or hydraulically. While material is being charged in the upper hopper, one of the charging valves is open and the bellows is pressureless. During, or shortly thereafter, the charging, the upper hopper is rotated. For during the lower hopper, the valves of the upper hopper are closed, bellows is inflated, and the upper hopper is hopper are closed, bellows is inflated, and the upper sluice chamber is pressurized.
    • 在用于竖炉的喉部止动器中,特别是具有两个料斗的高炉,其中上料斗可以通过驱动装置旋转,上料斗通过装有充气阀门的固定罩设计为闸门室 封闭防压。 为了相对于可旋转的上料斗密封固定罩,在罩处设置有外围柔性的可充气波纹管。 波纹管可以气动或液压地压在上料斗的壁上。 当材料在上料斗中充电时,其中一个充气阀打开,波纹管是无压力的。 在此期间,或之后不久,充电,上料斗旋转。 对于下料斗期间,上料斗的阀关闭,波纹管充气,上料斗料斗关闭,波纹管膨胀,上闸阀加压。