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1. 发明申请

US20120004317A1 Tapentadol for use in the treatment of irritable bowel syndrome 审中-公开
标题翻译：他喷他多用于治疗肠易激综合征
公开(公告)号：US20120004317A1
公开(公告)日：2012-01-05
申请号：US13172103
申请日：2011-06-29
申请人： Klaus SCHIENE , Petra Bloms-Funke , Thomas Christoph , Wolfgang Schroeder
发明人： Klaus SCHIENE , Petra Bloms-Funke , Thomas Christoph , Wolfgang Schroeder
IPC分类号： A61K31/137 , A61P1/06
CPC分类号： A61K31/137 , A61K9/0053 , A61K9/20 , A61K31/135
摘要： The invention relates to tapentadol for use in the treatment of Irritable Bowel Syndrome
摘要翻译：本发明涉及用于治疗肠易激综合征的他喷他多

2. 发明授权

US08084470B2 Substituted nicotinamide compounds and uses thereof 有权
标题翻译：取代的烟酰胺化合物及其用途
公开(公告)号：US08084470B2
公开(公告)日：2011-12-27
申请号：US12212369
申请日：2008-09-17
申请人： Beatrix Merla , Sven Kuehnert , Robert Frank , Dagmar Kaulartz , Wolfgang Schroeder , Gregor Bahrenberg , Klaus Schiene
发明人： Beatrix Merla , Sven Kuehnert , Robert Frank , Dagmar Kaulartz , Wolfgang Schroeder , Gregor Bahrenberg , Klaus Schiene
IPC分类号： C07D409/14 , A61K31/444
CPC分类号： C07D213/82 , C07D401/12 , C07D405/12 , C07D409/12
摘要： Substituted nicotinamide compounds corresponding to formula I a process for their preparation, pharmaceutical compositions containing these compounds, and the use thereof for the treatment or inhibition conditions such as pain, epilepsy, migraine, anxiety states, or urinary incontinence.
摘要翻译：对应于式I的取代烟酰胺化合物，其制备方法，含有这些化合物的药物组合物及其用于治疗或抑制病症如疼痛，癫痫，偏头痛，焦虑状态或尿失禁的用途。

3. 发明申请

US20090286831A1 VR1 Receptor Ligands and u-Opioid Receptor Ligands for the Treatment of Pain 审中-公开
标题翻译： VR1受体配体和u-阿片受体配体治疗疼痛
公开(公告)号：US20090286831A1
公开(公告)日：2009-11-19
申请号：US12425721
申请日：2009-04-17
申请人： Babette-Yvonne KOEGEL , Thomas CHRISTOPH , Gregor BAHRENBERG , Robert FRANK , Wolfgang SCHROEDER , Jean DE VRY , Eric-Paul PAQUES , Derek SAUNDERS , Klaus SCHIENE , Bernd SUNDERMANN , Jeewoo LEE , Hyung-Chul RYU
发明人： Babette-Yvonne KOEGEL , Thomas CHRISTOPH , Gregor BAHRENBERG , Robert FRANK , Wolfgang SCHROEDER , Jean DE VRY , Eric-Paul PAQUES , Derek SAUNDERS , Klaus SCHIENE , Bernd SUNDERMANN , Jeewoo LEE , Hyung-Chul RYU
IPC分类号： A61K31/445 , A61P25/00 , A61K31/4545 , A61K31/4535
CPC分类号： A61K45/06 , A61K31/357 , A61K31/4468 , A61K31/451 , A61K31/4545 , A61K31/485 , A61K2300/00
摘要： A pharmaceutical composition comprising i) at least one composition that has affinity to the μ-opioid receptor, and at least one compound that has affinity to the VR1 receptor, or ii) at least one compound, in particular at least one compound corresponding to formula (I), (II), (III), (IV) or (V), that has affinity to the μ-opioid receptor and to the VR1 receptor, and also to the use of the pharmaceutical compositions i) and ii) for the production of a drug for the treatment of pain.
摘要翻译：一种药物组合物，其包含i）至少一种对μ-阿片样物质受体具有亲和性的组合物和至少一种对VR1受体具有亲和性的化合物，或ii）至少一种化合物，特别是至少一种对应于式（I），（II），（III），（IV）或（V）），其对μ-阿片受体和VR1受体具有亲和性，并且还涉及药物组合物i）和ii）生产用于治疗疼痛的药物。

4. 发明授权

US5794668A Filling stream adjusting process 失效
标题翻译：灌装流调整过程
公开(公告)号：US5794668A
公开(公告)日：1998-08-18
申请号：US732415
申请日：1996-10-22
申请人： Wolfgang Schroeder
发明人： Wolfgang Schroeder
IPC分类号： B65B3/34 , B65B3/30 , B65B57/14 , G02B27/00 , G05D7/06 , G05D11/13 , B65B1/30 , B65B3/28 , B65B57/06
CPC分类号： G05D7/0682 , B65B3/30 , B65B57/145 , G05D11/132 , G02B2027/0132 , Y10T16/513
摘要： A procedure for adjusting a filling jet of flow-controlled automatic filler machines. The task is of providing an inventive solution, ensuring an even, clean supply of the medium volume flow via the filling pipe into the container. The task is solved by determining and storing the speed of a filling jet emerging from a filling pipe. The actual speed values of a volume flow emerging from a pump is measured with a speed sensor and the thus gained values are compared in order to adjust the speed of an emerging filler jet. At the same time the flow output of the pump is changed until the stored set value of the filler jet speed at the volume sensor corresponds to the speed of the medium volume flow measured at the speed sensor. Only then the filling process into the vessels is started.
摘要翻译： PCT No.PCT / DE96 / 00337 Sec。 371日期1996年10月22日第 102（e）日期1996年10月22日PCT 1996年2月20日PCT PCT。出版物WO96 / 26110 PCT 日期1996年8月29日流量控制自动填充机的灌装喷嘴调整程序。该任务是提供创造性的解决方案，确保通过填充管均匀，干净地供应中等体积的流入容器。通过确定和存储从填充管中出来的填充喷嘴的速度来解决该任务。使用速度传感器测量从泵出来的体积流量的实际速度值，并比较如此获得的值以便调整出现的填充射流的速度。同时，改变泵的流量输出，直到体积传感器上的喷射喷射速度的存储设置值对应于在速度传感器处测量的介质体积流量的速度。只有这样才能开始进入容器的填充过程。

5. 发明授权

US5787943A Process and device for dosing free-flowing media 失效
标题翻译：用于定量自由流动介质的过程和设备
公开(公告)号：US5787943A
公开(公告)日：1998-08-04
申请号：US732414
申请日：1996-10-22
申请人： Wolfgang Schroeder
发明人： Wolfgang Schroeder
IPC分类号： B65B3/34 , G05D7/06 , G05D11/13 , B65B1/30 , B65B3/28 , B65B57/06 , B65B57/14
CPC分类号： G05D7/0682 , B65B3/34 , G05D11/132
摘要： A procedure and a device for dosing free-flowing media irrespective of its viscosity into containers. It is based on the task of providing an inventive solution for filling machines of the procedure, allowing the dosing of free-flowing media into containers within an exact time regime. The task is solved by the filling media moving through the filling pump, flowing passed a flow sensor in a filling media flow, with the flow speed being measured and transmitted to a regulator in which the set value is stored which is then compared with the actual value measured in the flow sensor. To adapt the actual value to the set value, the output of the filling pump is changed until the actual and set values of the flow speed correspond. With the thus exactly determined flow speed, the filling flow of the filling media arrives at the starting sensor arranged at the outlet opening of the filling pipe and activates the sensor by flowing through a sensor section. The starting sensor is connected to a counter, counting time cycles via a time interval, thus enabling the time control of the filling volume.
摘要翻译： PCT No.PCT / DE96 / 00338 Sec。 371日期1996年10月22日第 102（e）日期1996年10月22日PCT 1996年2月20日PCT PCT。公开号WO96 / 26111 日期1996年8月29日一种用于自由流动介质计量的方法，不管其粘度在容器中。这是基于为程序的灌装机提供创造性解决方案的任务，允许在精确的时间范围内将自由流动的介质投放到容器中。该任务通过填充介质移动通过填充泵来解决，流经填充介质流中的流量传感器，流速被测量并传输到其中存储设定值的调节器，然后将其与实际值在流量传感器中测量的值。为了使实际值适应设定值，填充泵的输出发生变化，直到流量的实际值和设定值对应。利用如此精确确定的流速，填充介质的填充流量到达布置在填充管的出口处的启动传感器，并且通过流过传感器部分来启动传感器。启动传感器连接到计数器，通过时间间隔计数时间周期，从而实现填充量的时间控制。

6. 发明授权

US5002922A Catalyst for the amination of alcohols under hydrogenating conditions 失效
标题翻译：用于在氢化条件下胺化胺的催化剂
公开(公告)号：US5002922A
公开(公告)日：1991-03-26
申请号：US457334
申请日：1989-12-27
申请人： Matthias Irgang , Juergen Schossig , Wolfgang Schroeder , Siegfried Winderl
发明人： Matthias Irgang , Juergen Schossig , Wolfgang Schroeder , Siegfried Winderl
IPC分类号： C07D295/02 , B01J21/06 , B01J23/74 , B01J23/75 , B01J23/755 , B01J37/03 , C07B61/00 , C07C209/16 , C07C211/03 , C07C211/09 , C07C213/02 , C07C217/08 , C07D295/023
CPC分类号： B01J37/18 , B01J21/066 , B01J23/74 , B01J23/755 , B01J37/03 , C07C209/16 , C07C213/02 , C07D295/023 , Y02P20/582
摘要： Catalysts whose active material contains, in addition to from 20 to 85% by weight, calculated as ZrO.sub.2, of oxygen-containing zirconium compounds, from 1 to 30% by weight, calculated as CuO, of oxygen-containing compounds of copper and from 1 to 40% by weight each, calculated as CoO or NiO, respectively, of oxygen-containing compounds of cobalt and of nickel are used for the amination of alcohols under hydrogenating conditions.
摘要翻译：催化剂的活性材料除了按ZrO 2计20至85重量％外还含有氧含量的锆化合物，以CuO计为1至30重量％的含氧化合物铜和1 至40重量％，分别以CoO或NiO计，钴和镍的含氧化合物用于在氢化条件下胺化胺。

7. 发明授权

US4845218A Preparation of n-methylpiperazine 失效
标题翻译：正甲基哌嗪的制备
公开(公告)号：US4845218A
公开(公告)日：1989-07-04
申请号：US15238
申请日：1987-02-17
申请人： Wolfgang Schroeder
发明人： Wolfgang Schroeder
IPC分类号： C07D295/02 , B01J23/00 , B01J23/70 , B01J23/72 , C07B61/00 , C07D295/023
CPC分类号： C07D295/023
摘要： A process for the preparation of N-methylpiperazine from diethanolamine and methylamine, wherein the reaction is carried out at elevated temperature and superatmospheric pressure in the presence of hydrogen over a metal-containing catalyst.
摘要翻译：从二乙醇胺和甲胺制备N-甲基哌嗪的方法，其中反应在高温和超大气压下在氢气存在下在含金属的催化剂上进行。

8. 发明授权

US4786727A Preparation of hexamethyleneimine 失效
标题翻译：六亚甲基亚胺的制备
公开(公告)号：US4786727A
公开(公告)日：1988-11-22
申请号：US608447
申请日：1984-05-09
申请人： Wolfgang Schroeder , Wolfgang Franzischka , Herbert Mueller
发明人： Wolfgang Schroeder , Wolfgang Franzischka , Herbert Mueller
IPC分类号： C07D295/023 , C07D295/02
CPC分类号： C07D295/023
摘要： Hexamethylenemine is obtained by hydrogenating .epsilon.-caprolactam, the latter being vaporized and hydrogenated under a working pressure of less than 10 bar, the gas phase being unsaturated in respect of caprolactam, and the residence time being short.
摘要翻译：六亚甲基胺是通过氢化ε-己内酰胺得到的，ε-己内酰胺在小于10巴的工作压力下蒸发和氢化，气相在己内酰胺方面是不饱和的，停留时间短。

9. 发明授权

US4778276A Device and process for continuous supply of hydraulically setting compound 失效
标题翻译：连续供应水硬化剂的装置和工艺
公开(公告)号：US4778276A
公开(公告)日：1988-10-18
申请号：US896815
申请日：1986-08-15
申请人： Adolf Meyer , Helmut Steinegger , Wolfgang Schroeder
发明人： Adolf Meyer , Helmut Steinegger , Wolfgang Schroeder
IPC分类号： B01F7/00 , B01F15/00 , B28C5/12 , B28C5/40 , B01F7/08 , B28C5/14 , B28C7/06
CPC分类号： B01F7/00641 , B01F15/0251 , B01F7/00708 , B01F7/022 , B01F7/04 , B01F7/048 , B28C5/1292 , B28C5/406
摘要： A device for continuously preparing a hydraulically setting mass comprises a tubular housing having a downstream outlet opening and an upstream supply station for a dry component material of the mass, the supply station including a storage bin for the dry material. A driven rotating shaft extends from the storage bin through the tubular housing towards the outlet opening, rotation of the shaft causing a feed flow in the direction of the outlet opening, and the rotating shaft is equipped with a dosing screw feeding the dry material out of the storage bin, a plurality of radially projecting mixing blades for mixing the material fed by the dosing screw, and an implement for finely granulating the mixed material downstream of the mixing blades, the granulating implement being comprised of at least two interdigitating comb-like elements, one of the comb-like elements being carried by the shaft for rotation therewith and another comb-like element being affixed to the tubular housing.
摘要翻译：用于连续制备液压固化物质的装置包括具有下游出口开口的管状壳体和用于所述物料的干组分材料的上游供应站，所述供应站包括用于所述干材料的储存箱。驱动旋转轴从存储箱通过管状壳体朝向出口开口延伸，轴的旋转导致沿着出口开口的方向的进给流，并且旋转轴配备有将干燥材料从存储箱，用于混合由配量螺杆供给的材料的多个径向突出的混合叶片和用于在混合叶片下游对混合材料进行细粒化的工具，该造粒工具由至少两个交叉的梳状元件其中一个梳状元件由轴承用以与其一起旋转，另一个梳状元件固定在管状壳体上。

10. 发明授权

US4067914A Manufacture of butynediol 失效
标题翻译：丁炔二醇的制造
公开(公告)号：US4067914A
公开(公告)日：1978-01-10
申请号：US671384
申请日：1976-03-29
申请人： Wolfgang Reiss , Siegfried Winderl , Wolfgang Schroeder , Herwig Hoffmann
发明人： Wolfgang Reiss , Siegfried Winderl , Wolfgang Schroeder , Herwig Hoffmann
IPC分类号： C07C29/42 , B01J31/00 , C07B61/00 , C07C27/00 , C07C33/046 , C07C67/00 , C07C29/00
CPC分类号： C07C33/046
摘要： In a process for the manufacture of butynediol by the reaction of formaldehyde and acetylene in aqueous solution, in which a catalyst is used which is produced by the action of acetylene and formaldehyde on copper (II) compounds, the catalyst becomes inactive when it is treated for a relatively long period with formaldehyde at elevated temperature in the absence of acetylene so that it must constantly remain in contact with acetylene-containing solution if its temperature is above 70.degree. C.
摘要翻译：在通过甲醛和乙炔在水溶液中反应制造丁炔二醇的方法中，其中使用通过乙炔和甲醛作用于铜（II）化合物而产生的催化剂，当处理时催化剂变得不活动在不存在乙炔的情况下，甲醛在高温下持续相当长的时间，如果其温度高于70℃，则必须与乙炔溶液一直保持接触。

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