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1. 发明授权

US5354657A Process for the highly specific detection of nucleic acids in solid 失效
标题翻译：在溶液中高度特异性检测核酸的方法
公开(公告)号：US5354657A
公开(公告)日：1994-10-11
申请号：US993820
申请日：1992-12-18
申请人： Hans J. Holtke , Rudolf Seibl , Christoph Kessler , Ralf Mattes , Hermann Graf
发明人： Hans J. Holtke , Rudolf Seibl , Christoph Kessler , Ralf Mattes , Hermann Graf
IPC分类号： C07H21/00 , C12Q1/68 , C07H21/04 , C12N15/00
CPC分类号： C07H21/00 , C12Q1/6804
摘要： The present invention provides a process for the detection of nucleic acids of definite sequence by hybridisation with two single-stranded nucleic acid probes present in the same solution phase complementary to different regions of the nucleic acid to be detected, one nucleic acid probe serving as detector probe and containing as labelling at least one hapten bound via a chemical linkage and the other nucleic acid probe serving as capturing probe and being bound to a solid matrix, wherein, as hapten, a steroid is used which on at least one position of the detector probe, which does not participate in the hydrogen bridge formation with the nucleic acid to be detected, is covalently bound via a bridge of at least four atoms, the nucleic acid to be detected, present in solution, is incubated with the detector probe and the capturing probe in any desired sequence, whereby the binding of the capturing probe on the matrix with the nucleic acid to be detected is brought about before, during or after the incubation, the remaining solution is separated off from the matrix-bound complex of the capturing probe, nucleic acid to be detected and detector probe and the complex detected via an anti-hapten antibody which is labelled.
摘要翻译：本发明提供了通过与存在于与要检测的核酸的不同区域互补的相同溶液相中的两个单链核酸探针杂交来检测确定序列的核酸的方法，一个用作检测器的核酸探针探针并包含作为标记至少一个通过化学连接结合的半抗原，并且另一个核酸探针用作捕获探针并结合到固体基质上，其中作为半抗原，使用类固醇，其在检测器的至少一个位置上不参与与要检测的核酸的氢桥形成的探针通过至少四个原子的桥共价结合，将存在于溶液中的要检测的核酸与检测器探针和以任何期望的顺序捕获探针，由此捕获探针在基质上与待检测的核酸的结合在 r后，将剩余的溶液与捕获探针的基质结合复合物，待检测的核酸和检测器探针分离，并通过经标记的抗半抗原抗体检测复合物。

2. 发明授权

US5702888A Process for the detection of nucleic acids 失效
标题翻译：检测核酸的方法
公开(公告)号：US5702888A
公开(公告)日：1997-12-30
申请号：US371320
申请日：1995-01-11
申请人： Hans-Joachim Holtke , Rudolf Seibl , Gudrun Schmitz , Hans Robert Scholer , Christoph Kessler , Ralf Mattes
发明人： Hans-Joachim Holtke , Rudolf Seibl , Gudrun Schmitz , Hans Robert Scholer , Christoph Kessler , Ralf Mattes
IPC分类号： G01N33/53 , C07H21/00 , C12Q1/68 , G01N33/567 , C07H21/04
CPC分类号： C12Q1/6816 , C07H21/00 , C12Q1/6804 , C12Q1/686
摘要： For the detection of nucleic acids of definite sequence by hybridisation with a complementary nucleic acid probe which contains bound via a chemical bonding at least one hapten as labelling one uses, as hapten, a steroid which is bound vie a bridge of at least 4 atoms length to at least one position of the nucleic acid probe which does not participate in hydrogen bridge formation and detects the hybridised probe via an in turn labelled anti-hapten antibody.
摘要翻译：为了通过与互补核酸探针杂交来检测确定序列的核酸，所述互补核酸探针含有通过化学键合键合至少一个半抗原作为标记，使用作为半抗原的类固醇，所述类固醇结合至少4个原子长度的桥至不参与氢桥形成的核酸探针的至少一个位置，并通过反过来标记的抗半抗原抗体检测杂交的探针。

3. 发明授权

US5344757A Process for the detection of nucleic acids 失效
标题翻译：检测核酸的方法
公开(公告)号：US5344757A
公开(公告)日：1994-09-06
申请号：US415307
申请日：1990-01-09
申请人： Hans-Joachim Holtke , Rudolf Seibl , Gudrun Schmitz , Hans R. Scholer , Christoph Kessler , Ralf Mattes
发明人： Hans-Joachim Holtke , Rudolf Seibl , Gudrun Schmitz , Hans R. Scholer , Christoph Kessler , Ralf Mattes
IPC分类号： G01N33/53 , C07H21/00 , C12Q1/68 , G01N33/567
CPC分类号： C12Q1/6816 , C07H21/00 , C12Q1/6804 , C12Q1/686
摘要： For the detection of nucleic acids of definite sequence by hybridisation with a complementary nucleic acid probe which contains bound via a chemical bonding at least one hapten as labelling one uses, as hapten, a steroid which is bound via a bridge of at least 4 atoms length to at least one position of the nucleic acid probe which does not participate in hydrogen bridge formation and detects the hybridised probe via an in turn labelled anti-hapten antibody.
摘要翻译： PCT No.PCT / EP89 / 00026 Sec。 371 1990年1月9日第 102（e）1990年1月9日PCT PCT 1月12日PCT PCT。出版物WO89 / 06698 日期为1989年7月27日。为了通过与互补核酸探针杂交来检测确定序列的核酸，所述互补核酸探针含有通过化学键合结合至少一个半抗原作为标记，使用作为半抗原的类固醇，其通过至少4个原子长度的桥与至少一个不参与氢桥形成的核酸探针的位置，并通过反过来标记的抗半抗原抗体检测杂交的探针。

4. 发明授权

US5753433A Method for the sensitive detection of nucleic acids 失效
标题翻译：敏感检测核酸的方法
公开(公告)号：US5753433A
公开(公告)日：1998-05-19
申请号：US307414
申请日：1994-09-19
申请人： Christoph Kessler , Rudiger Ruger , Rudolf Seibl , Cornelia Kruse-Muller , Sibylle Berner
发明人： Christoph Kessler , Rudiger Ruger , Rudolf Seibl , Cornelia Kruse-Muller , Sibylle Berner
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34 , C12Q1/70
CPC分类号： C12Q1/6855
摘要： Method for the specific detection of nucleic acids in a sample by reaction of the sample with one or several labelled nucleotide triphosphates and one or several enzymes which catalyse the production of a labelled nucleic acid B which contains this nucleotide, non-thermally denaturation, reacting the sample with a nucleic acid probe C which is sufficiently complementary to nucleic acid B and which contains at least one immobilizable group, if desired, contacting the nucleic acid hybrid D formed with a solid phase which recognizes and binds the immobilizable group, removing the liquid from the solid phase and determining the label on the solid phase as a measure for the presence of the nucleic acid.
摘要翻译：用于通过样品与一种或几种标记的三磷酸标记的核苷酸和一种或多种催化产生含有该核苷酸的非热变性的标记核酸B的产生的酶来反应样品中的核酸的方法，用与核酸B充分互补的核酸探针C的样品，如果需要，其含有至少一个可固定基团，如果需要，将形成的核酸混合物D与识别并结合可固化基团的固相接触，从固相和确定固相上的标记作为核酸存在的量度。

5. 发明授权

US5635350A Reagents and kits for determining polymerase activity 失效
标题翻译：用于测定聚合酶活性的试剂和试剂盒
公开(公告)号：US5635350A
公开(公告)日：1997-06-03
申请号：US382891
申请日：1995-02-03
申请人： Josef Eberle , Rudolf Seibl , Christoph Kessler , Bernhard Konig
发明人： Josef Eberle , Rudolf Seibl , Christoph Kessler , Bernhard Konig
IPC分类号： C12Q1/48 , C12Q1/68 , C12Q1/70 , G01N33/573
CPC分类号： G01N33/573 , C12Q1/48 , C12Q1/703 , Y10S435/81
摘要： Method of determining polymerase activity by incubating the polymerase with a template nucleic acid, one detectable mononucleoside triphosphate and one immobilizable nucleoside triphosphate, binding the immobilizable nucleotides to a solid phase and detecting the bound delectable nucleotides and tests based thereon.
摘要翻译：通过用模板核酸，一种可检测的单核苷三磷酸和一种可固定核苷三磷酸孵育聚合酶来测定聚合酶活性的方法，将可固定的核苷酸与固相结合，并基于此检测结合的可选择的核苷酸和测试。

6. 发明授权

US5413906A Method of determining polymerase activity 失效
标题翻译：确定聚合酶活性的方法
公开(公告)号：US5413906A
公开(公告)日：1995-05-09
申请号：US974595
申请日：1993-03-19
申请人： Josef Eberle , Rudolf Seibl , Christoph Kessler , Bernhard Konig
发明人： Josef Eberle , Rudolf Seibl , Christoph Kessler , Bernhard Konig
IPC分类号： C12Q1/48 , C12Q1/68 , C12Q1/70 , G01N33/573 , C12P19/34
CPC分类号： G01N33/573 , C12Q1/48 , C12Q1/703 , Y10S435/81
摘要： Method of determining polymerase activity by incubating the polymerase with a template nucleic acid, one detectable mononucleoside triphosphate and one immobilizable nucleoside triphosphate, binding the immobilizable nucleotides to a solid phase and detecting the bound detectable nucleotides and tests based thereon.
摘要翻译： PCT No.PCT / EP91 / 01016 Sec。 371日期1993年3月19日 102（e）1993年3月19日PCT PCT 1991年5月31日PCT。出版物WO92 / 04467 1992年3月19日。通过用模板核酸，一个可检测的单核苷三磷酸和一个可固定的核苷三磷酸孵育聚合酶来测定聚合酶活性的方法，将可固定的核苷酸与固相结合并检测结合的可检测的核苷酸并基于其测试。

7. 发明授权

US5369003A Process for the specific production of ribonucleic acids 失效
标题翻译：具体生产核糖核酸的方法
公开(公告)号：US5369003A
公开(公告)日：1994-11-29
申请号：US951983
申请日：1992-09-28
申请人： Udo Reischl , Rudiger Rueger , Christoph Kessler , Rudolf Seibl
发明人： Udo Reischl , Rudiger Rueger , Christoph Kessler , Rudolf Seibl
IPC分类号： C12N15/09 , C12Q1/68
CPC分类号： C12Q1/6865
摘要： Process for the production of ribonucleic acids or for the detection of template nucleic acids based on a transcription technique using two oligonucleotides which can hybridize to adjacent regions on the template nucleic acid without ligation of these oligonucleotides.
摘要翻译：用于生产核糖核酸或用于基于转录技术检测模板核酸的方法，其使用两种寡核苷酸，其可以与模板核酸上的相邻区域杂交而不连接这些寡核苷酸。

8. 发明授权

US08622336B2 Stabilizer 有权
标题翻译：稳定剂
公开(公告)号：US08622336B2
公开(公告)日：2014-01-07
申请号：US13150790
申请日：2011-06-01
申请人： Hanno Brenner , Christoph Kessler , Wolfgang Kreitmair-Steck
发明人： Hanno Brenner , Christoph Kessler , Wolfgang Kreitmair-Steck
IPC分类号： B64C11/00
CPC分类号： B64D1/22 , B64C27/04
摘要： A rotary aircraft which carries a hanging sling load on at least one support cable, benefits from a stabilizer which generates control signals R to be applied or modulated onto the flight control of the aircraft. At least one sling load pendulum motion detecting unit provides the stabilizer with data on the pendulum motion of the sling load. Additionally, the stabilizer is set up with a working range determination unit S3 for determining the space where free movement is possible in which the rotary aircraft with sling load can move without collision. The stabilizer generates control signals R in dependency of the determined pendulum motion of the sling load and the determined working range.
摘要翻译：在至少一个支撑电缆上承载吊吊负载的旋转飞机受益于产生要应用或调制到飞行器的飞行控制上的控制信号R的稳定器。至少一个吊装载荷摆动运动检测单元为吊具提供有关吊索载荷的摆动运动的数据。此外，稳定器设置有工作范围确定单元S3，用于确定具有悬挂载荷的旋转飞行器可以在没有碰撞的情况下移动的空间。稳定器根据确定的吊架载荷的摆动和所确定的作业范围产生控制信号R.

9. 发明授权

US08201771B2 Helicopter rotor control system with individual blade control 有权
标题翻译：直升机转子控制系统，具有独立的叶片控制
公开(公告)号：US08201771B2
公开(公告)日：2012-06-19
申请号：US12986664
申请日：2011-01-07
申请人： Christoph Kessler , Daniel Furst
发明人： Christoph Kessler , Daniel Furst
IPC分类号： B64C27/54
CPC分类号： B64C27/001 , B64C2027/7216 , Y02T50/34
摘要： A method of controlling rotor pitch in a helicopter comprising the steps of: generating at least one blade dynamics signal representing at least one dynamic force acting on at least one of a rotor blade rotating assembly and a helicopter non-rotating assembly, the rotor blade rotating assembly including a plurality of rotor blades and a pitch actuator for each rotor blade; extracting information representing the at least one dynamic force; generating a dynamic force compensation output representing a compensation for at least a portion of the at least one dynamic force; receiving flight control signals directing flight of the helicopter from flight controls of the helicopter; generating from the flight control signals and the dynamic force compensation output a compensated pitch control signal for each blade of the rotor blade rotating assembly, and providing a compensated pitch control signal to compensate for a portion of the at least one dynamic force.
摘要翻译：一种在直升机中控制转子节距的方法，包括以下步骤：产生至少一个叶片动力学信号，其表示作用于至少一个转子叶片旋转组件和直升机非旋转组件中的至少一个的动力，转子叶片旋转组件包括多个转子叶片和每个转子叶片的俯仰致动器; 提取表示所述至少一个动态力的信息; 产生表示对所述至少一个动态力的至少一部分的补偿的动态力补偿输出; 接收飞行控制信号，指挥直升机飞行从直升机的飞行控制; 从飞行控制信号产生并且动态力补偿输出用于转子叶片旋转组件的每个叶片的补偿俯仰控制信号，以及提供经补偿的桨距控制信号以补偿至少一个动态力的一部分。

10. 发明授权

US5134069A Type II restriction endonuclease SgrAI 失效
标题翻译： Ⅱ型限制性内切酶SGRAI
公开(公告)号：US5134069A
公开(公告)日：1992-07-28
申请号：US615439
申请日：1990-11-16
申请人： Klaus Kaluza , Bruno Frey , Gudrun Schmitz-Agheguian , Michael Jarsch , Christoph Kessler
发明人： Klaus Kaluza , Bruno Frey , Gudrun Schmitz-Agheguian , Michael Jarsch , Christoph Kessler
IPC分类号： C12N9/16 , C12N9/22 , C12R1/545
CPC分类号： C12N9/22 , Y10S435/897
摘要： The type III restriction endonuclease SgrAI has the following recognition sequence: ##STR1## cleaves DNA at the cleavage site indicated by the arrows, and is preferably obtainable from microorganisms of the genus Streptomyces. It can be used to recognize and cleave the double-stranded DNA sequence ##STR2## and its complementary sequence.
摘要翻译： III型限制性内切核酸酶SgrAI具有以下识别序列：在箭头所示的切割位点切割DNA，优选从链霉菌属的微生物获得。它可用于识别和切割双链DNA序列“IMAGE”及其互补序列。

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