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1. 发明授权

US07208307B2 Preparation of acariogenic sugar substitutes 失效
标题翻译：准备食糖替代品
公开(公告)号：US07208307B2
公开(公告)日：2007-04-24
申请号：US10463509
申请日：2003-06-18
申请人： Ralf Mattes , Kathrin Klein , Hurbert Schiweck , Markwart Kunz , Mohammed Munir
发明人： Ralf Mattes , Kathrin Klein , Hurbert Schiweck , Markwart Kunz , Mohammed Munir
IPC分类号： C12N9/24 , C12N9/90
CPC分类号： C12N9/2451 , C12N9/90 , C12P19/16 , C12P19/24
摘要： The invention relates to sucrose isomerases, to DNA sequences that code for sucrose isomerases, and to novel processes for the production of non-cariogenic sugars.
摘要翻译：本发明涉及蔗糖异构酶，编码蔗糖异构酶的DNA序列，以及生产非致龋糖的新方法。

2. 发明授权

US06998258B1 L-pantolactone-hydrolase and a method for producing D-pantolactone 失效
标题翻译： L-泛酸内酯水解酶和D-泛酸内酯的制备方法
公开(公告)号：US06998258B1
公开(公告)日：2006-02-14
申请号：US10111451
申请日：2000-10-20
申请人： Maria Kesseler , Bernhard Hauer , Thomas Friedrich , Ralf Mattes
发明人： Maria Kesseler , Bernhard Hauer , Thomas Friedrich , Ralf Mattes
IPC分类号： C12N9/14 , C12N15/55 , C12P7/26
CPC分类号： C12P17/04 , C12N9/18 , C12P41/005
摘要： The present invention relates to proteins which have an enzymatic activity for hydrolyzing L-pantolactone. The invention further relates to nucleic acids which code for these proteins, to nucleic acid constructs, vectors, genetically modified microorganisms and to a process for preparing D-pantolactone.
摘要翻译：本发明涉及具有水解L-泛酸内酯的酶活性的蛋白质。本发明还涉及编码这些蛋白质的核酸，核酸构建体，载体，遗传修饰的微生物以及制备D-泛酸内酯的方法。

3. 发明授权

US5453363A Process for the activation of t-PA or Ing after genetic expression in prokaryotes 失效
标题翻译：在原核生物中遗传表达后激活t-PA或Ing的方法
公开(公告)号：US5453363A
公开(公告)日：1995-09-26
申请号：US206044
申请日：1994-03-02
申请人： Rainer Rudolph , Stephan Fischer , Ralf Mattes
发明人： Rainer Rudolph , Stephan Fischer , Ralf Mattes
IPC分类号： C07K1/113 , C07K14/565 , C12N9/72 , C07K14/745 , C07K16/00 , C12N15/00 , C12P21/02
CPC分类号： C12N9/6459 , C07K1/1133 , C07K14/565 , C12Y304/21069 , Y10S435/849 , Y10S435/877
摘要： A process for the activation of t-PA or IgG after expression in prokaryotes is described. The process includes cell digestion, solubilization under denaturing and reducing conditions and activation under oxidizing conditions in the presence of GSH/GSSG.
摘要翻译：描述了在原核生物中表达后激活t-PA或IgG的方法。该过程包括细胞消化，变性和还原条件下的溶解和在GSH / GSSG存在下在氧化条件下的活化。

4. 发明授权

US07393679B2 Whole cell catalyst 有权
标题翻译：全细胞催化剂
公开(公告)号：US07393679B2
公开(公告)日：2008-07-01
申请号：US10334990
申请日：2003-01-02
申请人： Joseph Altenbuchner , Ralf Mattes , Christoph Syldatk , Anja Wiese , Burkard Wilms , Andreas Bommarius , Wilhelm Tischer
发明人： Joseph Altenbuchner , Ralf Mattes , Christoph Syldatk , Anja Wiese , Burkard Wilms , Andreas Bommarius , Wilhelm Tischer
IPC分类号： C12N1/21 , C12N15/00 , C12N1/00 , C12N15/74 , C12P13/04 , C07H21/04 , C12N9/00 , C12N5/10 , C07K14/00
CPC分类号： C12P13/227 , C12N9/80 , C12N9/86 , C12N9/90 , C12P41/009 , C12Y305/02002
摘要： A whole cell catalyst is described comprising a hydantoinase, a racemase and a carbamoylase. Thus this catalyst is able to degrade hydantoins directly into the amino acids.Additionally, a process for the production of this catalysts and for the production of amino acids is claimed.
摘要翻译：描述了包含乙内酰脲酶，消旋酶和氨基甲酰化酶的全细胞催化剂。因此，该催化剂能够将乙内酰脲直接降解成氨基酸。另外，要求生产该催化剂和用于生产氨基酸的方法。

5. 发明授权

US06884611B2 Preparation of acariogenic sugar substitutes 失效
标题翻译：准备食糖替代品
公开(公告)号：US06884611B2
公开(公告)日：2005-04-26
申请号：US10061269
申请日：2002-02-04
申请人： Ralf Mattes , Kathrin Klein , Hurbert Schiweck , Markwart Kunz , Mohammed Munir
发明人： Ralf Mattes , Kathrin Klein , Hurbert Schiweck , Markwart Kunz , Mohammed Munir
IPC分类号： C12N1/21 , C12N9/44 , C12N9/90 , C12P19/16 , C12P19/24 , C12P21/06 , C07H21/04 , C12N1/20 , C12N9/00
CPC分类号： C12N9/2451 , C12N9/90 , C12P19/16 , C12P19/24
摘要： The invention relates to sucrose isomerases, to DNA sequences that code for sucrose isomerases, and to novel processes for the production of non-cariogenic sugars.
摘要翻译：本发明涉及蔗糖异构酶，编码蔗糖异构酶的DNA序列，以及生产非致龋糖的新方法。

6. 发明授权

US06713288B1 Whole cell catalysts 有权
标题翻译：全细胞催化剂
公开(公告)号：US06713288B1
公开(公告)日：2004-03-30
申请号：US09407062
申请日：1999-09-28
申请人： Josef Altenbuchner , Andreas Bommarius , Ralf Mattes , Christoph Syldatk , Wilhelm Tischer , Anja Wiese , Burkard Wilms
发明人： Josef Altenbuchner , Andreas Bommarius , Ralf Mattes , Christoph Syldatk , Wilhelm Tischer , Anja Wiese , Burkard Wilms
IPC分类号： C12P1304
CPC分类号： C12P13/227 , C12N9/80 , C12N9/86 , C12N9/90 , C12P41/009 , C12Y305/02002
摘要： A microorganism is described which is transformed with DNAs which encode a hydantoinnase, a racemase, and a carbamoylase. As a result, the microorganism is able to degrade hydantoins directly to amino acids. A process for the production of the microorganism and a process for producing amino acids with the microorganism is also described.
摘要翻译：描述了用编码乙内酰脲酶，消旋酶和氨甲酰基酶的DNA转化的微生物。结果，微生物能够将乙内酰脲直接降解成氨基酸。还描述了生产微生物的方法和用微生物生产氨基酸的方法。

7. 发明授权

US5354657A Process for the highly specific detection of nucleic acids in solid 失效
标题翻译：在溶液中高度特异性检测核酸的方法
公开(公告)号：US5354657A
公开(公告)日：1994-10-11
申请号：US993820
申请日：1992-12-18
申请人： Hans J. Holtke , Rudolf Seibl , Christoph Kessler , Ralf Mattes , Hermann Graf
发明人： Hans J. Holtke , Rudolf Seibl , Christoph Kessler , Ralf Mattes , Hermann Graf
IPC分类号： C07H21/00 , C12Q1/68 , C07H21/04 , C12N15/00
CPC分类号： C07H21/00 , C12Q1/6804
摘要： The present invention provides a process for the detection of nucleic acids of definite sequence by hybridisation with two single-stranded nucleic acid probes present in the same solution phase complementary to different regions of the nucleic acid to be detected, one nucleic acid probe serving as detector probe and containing as labelling at least one hapten bound via a chemical linkage and the other nucleic acid probe serving as capturing probe and being bound to a solid matrix, wherein, as hapten, a steroid is used which on at least one position of the detector probe, which does not participate in the hydrogen bridge formation with the nucleic acid to be detected, is covalently bound via a bridge of at least four atoms, the nucleic acid to be detected, present in solution, is incubated with the detector probe and the capturing probe in any desired sequence, whereby the binding of the capturing probe on the matrix with the nucleic acid to be detected is brought about before, during or after the incubation, the remaining solution is separated off from the matrix-bound complex of the capturing probe, nucleic acid to be detected and detector probe and the complex detected via an anti-hapten antibody which is labelled.
摘要翻译：本发明提供了通过与存在于与要检测的核酸的不同区域互补的相同溶液相中的两个单链核酸探针杂交来检测确定序列的核酸的方法，一个用作检测器的核酸探针探针并包含作为标记至少一个通过化学连接结合的半抗原，并且另一个核酸探针用作捕获探针并结合到固体基质上，其中作为半抗原，使用类固醇，其在检测器的至少一个位置上不参与与要检测的核酸的氢桥形成的探针通过至少四个原子的桥共价结合，将存在于溶液中的要检测的核酸与检测器探针和以任何期望的顺序捕获探针，由此捕获探针在基质上与待检测的核酸的结合在 r后，将剩余的溶液与捕获探针的基质结合复合物，待检测的核酸和检测器探针分离，并通过经标记的抗半抗原抗体检测复合物。

8. 发明申请

US20060008574A1 Galactosyl isomalt, method for production and use thereof 审中-公开
标题翻译：半乳糖异麦芽酮糖醇，其制备方法和用途
公开(公告)号：US20060008574A1
公开(公告)日：2006-01-12
申请号：US10515488
申请日：2003-06-06
申请人： Alireza Begli , Michael Klingeberg , Markwart Kunz , Ralf Mattes , Sven Schroder , Joachim Thiem , Manfred Vogel
发明人： Alireza Begli , Michael Klingeberg , Markwart Kunz , Ralf Mattes , Sven Schroder , Joachim Thiem , Manfred Vogel
IPC分类号： A23G3/00
CPC分类号： A23G3/346 , A21D2/181 , A21D13/02 , A21D13/80 , A23C9/1307 , A23D7/0056 , A23D9/007 , A23G2200/06 , A23G2200/14 , A23K20/163 , A23K50/40 , A23L2/60 , A23L5/00 , A23L7/00 , A23L7/126 , A23L7/135 , A23L19/03 , A23L19/09 , A23L21/00 , A23L21/12 , A23L27/33 , A23L29/30 , A23L33/125 , A23V2002/00 , A61K31/702 , C07H3/06 , C07H15/04 , C12P19/14 , A23V2250/5024
摘要： This invention concerns a method for preparation of galactosyl isomalt and galactosyl isomalt, the products and intermediate products that are obtained, and their use.
摘要翻译：本发明涉及一种制备半乳糖异麦芽糖糖醇和半乳糖异麦芽糖的方法，所得产品和中间产物及其应用。

9. 发明授权

US06352848B1 Recombinant L-N-carbamoylase from Arthrobacter aurescens and method of producing L-amino acids therewith 有权
标题翻译：来自节杆菌杆菌的重组L-N-氨基甲酰基酶及其生产L-氨基酸的方法
公开(公告)号：US06352848B1
公开(公告)日：2002-03-05
申请号：US09285055
申请日：1999-04-02
申请人： Josef Altenbuchner , Ralf Mattes , Markus Pietzsch , Christoph Syldatk , Anja Wiese , Burkard Wilms
发明人： Josef Altenbuchner , Ralf Mattes , Markus Pietzsch , Christoph Syldatk , Anja Wiese , Burkard Wilms
IPC分类号： C12N914
CPC分类号： C12N9/80 , C12P13/04
摘要： A novel rec-L-N-carbamoylase from Arthrobacter aurescens and its method of use for producing L-amino acids. The recombinantly produced L-carbamoylase is unexpectedly stable, so that an industrial method of producing L-amino acids can be established with it, in contrast to previously known L-carbamoylases.
摘要翻译：来自节杆菌食管癌的新型rec-L-N-氨基甲酰化酶及其制备L-氨基酸的方法。重组产生的L-氨基甲酰化酶是意想不到的稳定的，因此与之前已知的L-氨基甲酰化酶相反，可以与其建立L-氨基酸的工业生产方法。

10. 发明授权

US06270988B1 Process for producing recombinant proteins using a gene for tRNA 失效
标题翻译：使用tRNA基因生产重组蛋白的方法
公开(公告)号：US06270988B1
公开(公告)日：2001-08-07
申请号：US08009423
申请日：1993-01-27
申请人： Ulrich Brinkmann , Ralf Mattes , Stephan Fischer
发明人： Ulrich Brinkmann , Ralf Mattes , Stephan Fischer
IPC分类号： C12P2102
CPC分类号： C12N9/6456 , C12N15/11 , C12N15/67 , C12N15/70
摘要： The present invention provides a process for the expression of a recombinant gene, which contains AGA and/or AGG codons for arginine, in Escherichia coli after transformation with an expression vector which contains the recombinant gene, wherein the amount of t-RNA present in the E. coli cells which incorporates arginine and recognises the codons AGG and AGA is increased to at least fivefold of the amount normally occurring in these cells.
摘要翻译：本发明提供了在含有重组基因的表达载体转化后，在大肠杆菌中表达含有精氨酸的AGA和/或AGG密码子的重组基因的方法，其中存在于将精氨酸并且识别密码子AGG和AGA的大肠杆菌细胞增加至通常在这些细胞中发生的量的至少5倍。

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