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1. 发明授权

US09474645B2 Punctal plugs for the delivery of active agents 有权
标题翻译：用于递送活性剂的针刺塞
公开(公告)号：US09474645B2
公开(公告)日：2016-10-25
申请号：US11759269
申请日：2007-06-07
申请人： Han Cui , Zhigang Li , Edgar V. Menezes , Aruna Nathan , Michael J. Trezza, II
发明人： Han Cui , Zhigang Li , Edgar V. Menezes , Aruna Nathan , Michael J. Trezza, II
IPC分类号： A61F2/00 , A61F13/00 , A61F2/14 , A61F9/00 , A61F9/007 , A61K9/00
CPC分类号： A61F9/0017 , A61F9/00772 , A61K9/0051
摘要： The invention provides punctal plugs for the delivery of active agent to one or both of the tear fluid of the eye and to the nasolacrimal duct that comprise a body, at least one cap, and optionally a collarette.
摘要翻译：本发明提供了用于将活性剂递送到眼睛的泪液和包括身体，至少一个帽和任选的肩胛骨的鼻泪管的一个或两个的泪点。

2. 发明授权

US09173773B2 Punctal plugs for the delivery of active agents 有权
标题翻译：用于递送活性剂的针刺塞
公开(公告)号：US09173773B2
公开(公告)日：2015-11-03
申请号：US11759327
申请日：2007-06-07
申请人： Maureen J. Borgia , Hassan Chaouk , Han Cui , Walter Laredo , Zhigang Li , Aruna Nathan , Michael J. Trezza, II
发明人： Maureen J. Borgia , Hassan Chaouk , Han Cui , Walter Laredo , Zhigang Li , Aruna Nathan , Michael J. Trezza, II
IPC分类号： A61F2/00 , A61F13/00 , A61F9/007 , A61F9/00 , A61M31/00
CPC分类号： A61F9/00772 , A61F9/0017 , A61M31/002
摘要： The invention provides punctal plugs for the delivery of active agent to one or both of the tear fluid of the eye and to the nasolacrimal duct. The plugs of the invention have a body, a reservoir contained within the body, and optionally a collarette. The reservoir has at least one opening and contains a polymeric material and at least one active agent.
摘要翻译：本发明提供了用于将活性剂递送到眼睛的泪液和鼻泪管中的一种或两种的泪点塞。本发明的塞子具有主体，容纳在主体内的储存器，以及可选地是围兜。储存器具有至少一个开口并且包含聚合材料和至少一种活性剂。

3. 发明申请

US20110022007A1 OPHTHALMIC DEVICES FOR THE CONTROLLED RELEASE OF ACTIVE AGENTS 有权
标题翻译：用于控制释放活性剂的透明设备
公开(公告)号：US20110022007A1
公开(公告)日：2011-01-27
申请号：US12779238
申请日：2010-05-13
申请人： Zhigang Li , Michael J. Trezza, II , Maureen J. Borgia , Aruna Nathan , Bret A. Coldren
发明人： Zhigang Li , Michael J. Trezza, II , Maureen J. Borgia , Aruna Nathan , Bret A. Coldren
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61F9/00772 , A61F2250/0068 , A61K9/0043 , A61K9/0051
摘要： The invention provides devices useful for the delivery of active agents to the eye in a controlled manner. In the devices of the invention, the active agent is present within the device in a continuous or discontinuous concentration gradient.
摘要翻译：本发明提供了用于以受控方式将活性剂递送至眼睛的装置。在本发明的装置中，活性剂以连续或不连续的浓度梯度存在于装置内。

4. 发明申请

US20090306608A1 OPHTHALMIC DEVICES FOR THE CONTROLLED RELEASE OF ACTIVE AGENTS 审中-公开
标题翻译：用于控制释放活性剂的透明设备
公开(公告)号：US20090306608A1
公开(公告)日：2009-12-10
申请号：US12437163
申请日：2009-05-07
申请人： Zhigang Li , Michael J. Trezza, II , Maureen J. Borgia , Aruna Nathan , Bret A. Coldren
发明人： Zhigang Li , Michael J. Trezza, II , Maureen J. Borgia , Aruna Nathan , Bret A. Coldren
IPC分类号： A61F9/00 , A61M31/00
CPC分类号： A61F9/0017 , A61F9/00772 , A61F2250/0068 , A61K9/0043 , A61K9/0051
摘要： The invention provides devices useful for the delivery of active agents to the eye in a controlled manner. In the devices of the invention, the active agent is present within the device in a continuous or discontinuous concentration gradient.
摘要翻译：本发明提供了用于以受控方式将活性剂递送至眼睛的装置。在本发明的装置中，活性剂以连续或不连续的浓度梯度存在于装置内。

5. 发明授权

US08377042B2 Ophthalmic devices for the controlled release of active agents 有权
标题翻译：用于控释活性剂的眼科装置
公开(公告)号：US08377042B2
公开(公告)日：2013-02-19
申请号：US12779238
申请日：2010-05-13
申请人： Zhigang Li , Michael J. Trezza, II , Maureen J. Borgia , Aruna Nathan , Bret A. Coldren
发明人： Zhigang Li , Michael J. Trezza, II , Maureen J. Borgia , Aruna Nathan , Bret A. Coldren
IPC分类号： A61K9/22
CPC分类号： A61F9/0017 , A61F9/00772 , A61F2250/0068 , A61K9/0043 , A61K9/0051
摘要： The invention provides devices useful for the delivery of active agents to the eye in a controlled manner. In the devices of the invention, the active agent is present within the device in a continuous or discontinuous concentration gradient.
摘要翻译：本发明提供了用于以受控方式将活性剂递送至眼睛的装置。在本发明的装置中，活性剂以连续或不连续的浓度梯度存在于装置内。

6. 发明申请

US20070298075A1 PUNCTAL PLUGS FOR THE DELIVERY OF ACTIVE AGENTS 有权
标题翻译：用于交付活性药剂的阴囊
公开(公告)号：US20070298075A1
公开(公告)日：2007-12-27
申请号：US11759327
申请日：2007-06-07
申请人： Maureen Borgia , Hassan Chaouk , Han Cui , Walter Laredo , Zhigang Li , Aruna Nathan , Michael Trezza
发明人： Maureen Borgia , Hassan Chaouk , Han Cui , Walter Laredo , Zhigang Li , Aruna Nathan , Michael Trezza
IPC分类号： A61F2/00 , A61F13/00
CPC分类号： A61F9/00772 , A61F9/0017 , A61M31/002
摘要： The invention provides punctal plugs for the delivery of active agent to one or both of the tear fluid of the eye and to the nasolacrimal duct. The plugs of the invention have a body, a reservoir contained within the body, and optionally a collarette. The reservoir has at least one opening and contains a polymeric material and at least one active agent.
摘要翻译：本发明提供了用于将活性剂递送到眼睛的泪液和鼻泪管中的一种或两种的泪点塞。本发明的塞子具有主体，容纳在主体内的储存器，以及可选地是围兜。储存器具有至少一个开口并且包含聚合材料和至少一种活性剂。

7. 发明申请

US20080045911A1 PUNCTAL PLUGS FOR THE DELIVERY OF ACTIVE AGENTS 审中-公开
标题翻译：用于交付活性药剂的阴囊
公开(公告)号：US20080045911A1
公开(公告)日：2008-02-21
申请号：US11759281
申请日：2007-06-07
申请人： Maureen Borgia , Hassan Chaouk , Han Cui , Walter Laredo , Zhigang Li , Aruna Nathan , Michael Trezza
发明人： Maureen Borgia , Hassan Chaouk , Han Cui , Walter Laredo , Zhigang Li , Aruna Nathan , Michael Trezza
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61F9/00772 , A61K9/0004 , A61K9/0051
摘要： The invention provides punctal plugs for the delivery of active agents. The plugs have a body throughout which at least one active agent is dispersed or that is coated with a polymeric material containing at least one active agent.
摘要翻译：本发明提供用于递送活性剂的泪点塞。塞子具有主体，至少一种活性剂分散在其中，或者涂覆有含有至少一种活性剂的聚合材料。

8. 发明申请

US20070299516A1 PUNCTAL PLUGS FOR THE DELIVERY OF ACTIVE AGENTS 有权
标题翻译：用于交付活性药剂的阴囊
公开(公告)号：US20070299516A1
公开(公告)日：2007-12-27
申请号：US11759269
申请日：2007-06-07
申请人： Han Cui , Zhigang Li , Edgar Menezes , Aruna Nathan , Michael Trezza
发明人： Han Cui , Zhigang Li , Edgar Menezes , Aruna Nathan , Michael Trezza
IPC分类号： A61F2/14
CPC分类号： A61F9/0017 , A61F9/00772 , A61K9/0051
摘要： The invention provides punctal plugs for the delivery of active agent to one or both of the tear fluid of the eye and to the nasolacrimal duct that comprise a body, at least one cap, and optionally a collarette.
摘要翻译：本发明提供了用于将活性剂递送到眼睛的泪液和包括身体，至少一个帽和任选的肩胛骨的鼻泪管的一个或两个的泪点。

9. 发明授权

US09040072B2 Use of coupling agents to improve the interface in absorbable polymer composites 有权
标题翻译：使用偶联剂改善可吸收聚合物复合材料的界面
公开(公告)号：US09040072B2
公开(公告)日：2015-05-26
申请号：US11952218
申请日：2007-12-07
申请人： Yue Zhou , Kevin Cooper , Yufu Li , Zhigang Li
发明人： Yue Zhou , Kevin Cooper , Yufu Li , Zhigang Li
IPC分类号： A61F2/00 , A01N43/00 , A61K31/33 , C08K9/08 , C08L67/02 , C08L67/04 , C08L69/00 , C08L23/08
CPC分类号： C08K9/08 , C08L23/08 , C08L67/02 , C08L67/04 , C08L69/00 , C08L2666/04
摘要： A composite having a poly(ethylene-co-acrylic acid) coupling agent, a filler, and a biocompatible, biodegradable polymer matrix is disclosed. The composites are useful for biomedical applications such as, tissue engineering, drug delivery, and implantable medical devices.
摘要翻译：公开了具有聚（乙烯 - 共 - 丙烯酸）偶联剂，填料和生物相容的可生物降解的聚合物基质的复合材料。复合材料可用于生物医学应用，如组织工程，药物输送和可植入医疗器械。

10. 发明授权

US08779209B2 Method for salting-out extraction of acetone and butanol from a fermentation broth 有权
标题翻译：从发酵液中萃取丙酮和丁醇的方法
公开(公告)号：US08779209B2
公开(公告)日：2014-07-15
申请号：US13812133
申请日：2010-12-27
申请人： Yaqin Sun , Zhigang Li , Zhilong Xiu
发明人： Yaqin Sun , Zhigang Li , Zhilong Xiu
IPC分类号： C07C45/86 , C07C27/34
CPC分类号： C07C45/86 , C07C29/86 , C07C45/80 , C07C49/08 , C07C31/12
摘要： The present invention provided a method for salting-out extraction of acetone and butanol from a fermentation broth, characterized in that one type, or two or more types of salts and one type, or two or more types of extractants are added to an acetone-butanol-ethanol (ABE) fermentation broth, in which the salt saturation achieves 10%˜100%; and the volume ratio of the fermentation broth containing salts to the extractants is 1:0.1˜1:5. The mixture is allowed to stand until phase separation is formed. The top phase is a solvent phase or extraction phase enriched with acetone and butanol whereas the bottom phase is a salt-enriched phase or raffinate phase. This method involves many advantages, such as the simplified operation procedure, accelerated separation process and low separation cost, and therefore becomes a promising method of separating acetone and butanol in industrial application.
摘要翻译：本发明提供了一种从发酵液中提取丙酮和丁醇的方法，其特征在于将一种或两种或更多种类型的盐和一种或两种或更多种提取剂加入到丙酮 - 丁醇 - 乙醇（ABE）发酵液，盐饱和度达到10％〜100％; 含有盐的发酵液与萃取剂的体积比为1:0.1〜1:5。使混合物静置直至形成相分离。顶相是富含丙酮和丁醇的溶剂相或萃取相，而底相是富含富油相或萃余相。该方法具有操作简便，加速分离，分离成本低等优点，成为工业应用中分离丙酮和丁醇的有前景的方法。

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