专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08798765B2 Determination of cardiac resynchronization therapy settings 有权
标题翻译：心脏再同步治疗设置的测定
公开(公告)号：US08798765B2
公开(公告)日：2014-08-05
申请号：US13471167
申请日：2012-05-14
申请人： Kjell Noren , Anders Bjorling , Tomas Svensson , Sven-Erik Hedberg , Allen Keel , Stuart Rosenberg , Kyungmoo Ryu
发明人： Kjell Noren , Anders Bjorling , Tomas Svensson , Sven-Erik Hedberg , Allen Keel , Stuart Rosenberg , Kyungmoo Ryu
IPC分类号： A61N1/365 , A61N1/372 , A61N1/368
CPC分类号： A61N1/36507 , A61N1/3682 , A61N1/3684 , A61N1/37252
摘要： CRT settings for an implantable medical device are determined by applying pacing pulses to heart chambers of a scheme of different combinations of interchamber delays. A respective width parameter value representing an R or P wave width is determined for each such delay combination based on an ECG representing signal and the width parameter values are employed to estimate a parametric model defining the width parameter as a function of interchamber delays. Candidate interchamber delays that minimize the width parameter are determined from the parametric model and employed to determine optimal CRT settings. The technique provides an efficient way of finding optimal CRT settings when multiple pacing sites are available in a heart chamber.
摘要翻译：用于可植入医疗装置的CRT设置通过将不同组合的车间延迟的方案应用于心室来进行起搏脉冲来确定。基于ECG表示信号为每个这样的延迟组合确定表示R或P波宽的相应宽度参数值，并且使用宽度参数值来估计定义作为间歇延迟的函数的宽度参数的参数模型。从参数模型中确定最小化宽度参数的候选车间延迟，并用于确定最佳CRT设置。该技术提供了一种在心室中可用多个起搏部位时可以找到最佳CRT设置的有效方式。

2. 发明申请

US20120310296A1 DETERMINATION OF CARDIAC RESYNCHRONIZATION THERAPY SETTINGS 有权
标题翻译：心脏康复治疗方法的确定
公开(公告)号：US20120310296A1
公开(公告)日：2012-12-06
申请号：US13471167
申请日：2012-05-14
申请人： Kjell Noren , Anders Bjorling , Tomas Svensson , Sven-Erik Hedberg , Allen Keel , Stuart Rosenberg , Kyungmoo Ryu
发明人： Kjell Noren , Anders Bjorling , Tomas Svensson , Sven-Erik Hedberg , Allen Keel , Stuart Rosenberg , Kyungmoo Ryu
IPC分类号： A61N1/365
CPC分类号： A61N1/36507 , A61N1/3682 , A61N1/3684 , A61N1/37252
摘要： CRT settings for an implantable medical device are determined by applying pacing pulses to heart chambers of a scheme of different combinations of interchamber delays. A respective width parameter value representing an R or P wave width is determined for each such delay combination based on an ECG representing signal and the width parameter values are employed to estimate a parametric model defining the width parameter as a function of interchamber delays. Candidate interchamber delays that minimize the width parameter are determined from the parametric model and employed to determine optimal CRT settings. The technique provides an efficient way of finding optimal CRT settings when multiple pacing sites are available in a heart chamber.
摘要翻译：用于可植入医疗装置的CRT设置通过将不同组合的车间延迟的方案应用于心室来进行起搏脉冲来确定。基于ECG表示信号为每个这样的延迟组合确定表示R或P波宽的相应宽度参数值，并且使用宽度参数值来估计定义作为间歇延迟的函数的宽度参数的参数模型。从参数模型中确定最小化宽度参数的候选车间延迟，并用于确定最佳CRT设置。该技术提供了一种在心室中可用多个起搏部位时可以找到最佳CRT设置的有效方式。

3. 发明授权

US08527051B1 Detection and reduction of phrenic nerve stimulation 有权
标题翻译：检测和减少膈神经刺激
公开(公告)号：US08527051B1
公开(公告)日：2013-09-03
申请号：US13545776
申请日：2012-07-10
申请人： Sven-Erik Hedberg , Tomas Svensson , Kjell Noren , Stuart Rosenberg , Kyungmoo Ryu , Edward Karst
发明人： Sven-Erik Hedberg , Tomas Svensson , Kjell Noren , Stuart Rosenberg , Kyungmoo Ryu , Edward Karst
IPC分类号： A61N1/37
CPC分类号： A61N1/36521 , A61N1/3702
摘要： The present invention provides implantable medical devices for detecting phrenic nerve stimulation. A pacing module is configured to deliver pacing pulses having a predetermined pulse amplitude and/or width within the refractory period of the left ventricle. The pacing pulses are repeatedly delivered during a number of cardiac cycles, and the pacing pulses are delivered at different delays relative to an onset of the refractory period of the left ventricle in different cardiac cycles. An impedance measurement module is configured to measure impedance signals in time windows synchronized with the delivery of pacing pulses in the refractory period of the left ventricle. A phrenic nerve stimulation, PNS, detection module is configured to gather at least one impedance signal from each time window, create aggregated impedance signals using the impedance signals from the different time windows, and analyze the aggregated impedance signals to detect PNS.
摘要翻译：本发明提供了用于检测膈神经刺激的可植入医疗装置。起搏模块被配置为在左心室的不应期内输送具有预定脉冲幅度和/或宽度的起搏脉冲。起搏脉冲在多个心动周期期间重复递送，起搏脉冲相对于不同心脏周期中左心室的不应期的开始以不同的延迟递送。阻抗测量模块被配置为测量与在左心室的不应期中递送起搏脉冲同步的时间窗内的阻抗信号。膈神经刺激，PNS检测模块配置为从每个时间窗口收集至少一个阻抗信号，使用来自不同时间窗口的阻抗信号创建聚合阻抗信号，并分析聚合阻抗信号以检测PNS。

4. 发明授权

US08532774B1 Detection and reduction of phrenic nerve stimulation 有权
标题翻译：检测和减少膈神经刺激
公开(公告)号：US08532774B1
公开(公告)日：2013-09-10
申请号：US13545794
申请日：2012-07-10
申请人： Sven-Erik Hedberg , Tomas Svensson , Kjell Noren , Stuart Rosenberg , Kyungmoo Ryu , Edward Karst
发明人： Sven-Erik Hedberg , Tomas Svensson , Kjell Noren , Stuart Rosenberg , Kyungmoo Ryu , Edward Karst
IPC分类号： A61N1/37
CPC分类号： A61N1/36521 , A61B5/042 , A61B5/0538 , A61N1/3686 , A61N1/3702
摘要： The present invention provides methods for detecting phrenic nerve stimulation. A pacing module is instructed to deliver pacing pulses having a predetermined pulse amplitude and/or width within the refractory period of the left ventricle. The pacing pulses are repeatedly delivered during a number of cardiac cycles and wherein the pacing pulses are delivered at different delays relative to an onset of the refractory period of the left ventricle in different cardiac cycles. Impedance signals are measured in time windows synchronized with the delivery of pacing pulses in the refractory period of the left ventricle using at least one electrode configuration. At least one impedance signal is gathered from each time window, aggregated impedance signals are created using the impedance signals from the different time windows, and the aggregated impedance signals are analyzed to detect PNS.
摘要翻译：本发明提供了检测膈神经刺激的方法。指示起搏模块在左心室的不应期内输送具有预定脉搏幅度和/或宽度的起搏脉冲。起搏脉冲在多个心动周期期间重复递送，并且其中起搏脉冲相对于在不同心脏周期中的左心室的不应期的开始以不同的延迟递送。使用至少一个电极配置，在与左心室的不应期中的起搏脉冲的递送同步的时间窗口中测量阻抗信号。从每个时间窗口收集至少一个阻抗信号，使用来自不同时间窗口的阻抗信号创建聚合阻抗信号，并分析聚合阻抗信号以检测PNS。

5. 发明授权

US09572620B2 System and method for treating arrhythmias in the heart using information obtained from heart wall motion 有权
标题翻译：使用从心脏壁运动获得的信息来治疗心脏心律失常的系统和方法
公开(公告)号：US09572620B2
公开(公告)日：2017-02-21
申请号：US12980586
申请日：2010-12-29
申请人： Kyungmoo Ryu , Thao T. Ngo , Euljoon Park , Stuart Rosenberg , Allen Keel , Wenbo Hou , Steve Koh , Kjell Noren , Michael Yang
发明人： Kyungmoo Ryu , Thao T. Ngo , Euljoon Park , Stuart Rosenberg , Allen Keel , Wenbo Hou , Steve Koh , Kjell Noren , Michael Yang
IPC分类号： A61B18/12 , A61B5/11 , A61B18/08 , A61B18/14 , A61B18/20 , A61B18/00 , A61B18/02 , A61N7/02
CPC分类号： A61B18/1206 , A61B5/1107 , A61B8/488 , A61B18/082 , A61B18/1492 , A61B18/20 , A61B34/20 , A61B2018/00351 , A61B2018/00375 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00702 , A61B2018/00726 , A61B2018/00744 , A61B2018/00863 , A61B2018/0088 , A61B2018/00892 , A61B2018/0212 , A61B2034/2051 , A61B2034/2059 , A61B2218/002 , A61N7/022
摘要： A system and method for treating an arrhythmia in a heart are provided. The system includes an electronic control unit configured to monitor movement of one or more position sensor over a period of time. The position sensors may, for example, comprise electrodes or coils configured to generate induced voltages and currents in the presence of electromagnetic fields. The positions sensors are in contact with portions of heart tissue and changes in position are representative of motion of that tissue. The electronic control unit is further configured to generate an indicator, responsive to the movements of the sensors over the period of time, of a characteristic of the heart affected by delivery of ablation energy to heart tissue. In this manner, the effectiveness and safety of cardiac tissue ablation for treatment of the arrhythmia can be assessed and a post-ablation therapy regimen determined.
摘要翻译：提供了用于治疗心脏心律失常的系统和方法。该系统包括电子控制单元，其构造成在一段时间内监测一个或多个位置传感器的移动。位置传感器可以例如包括配置成在存在电磁场的情况下产生感应电压和电流的电极或线圈。位置传感器与心脏组织的部分接触并且位置变化代表该组织的运动。电子控制单元还被配置为响应于传感器在一段时间内的移动，产生受到将消融能量递送到心脏组织的心脏特征的指示器。以这种方式，可以评估心脏组织消融治疗心律失常的有效性和安全性，并确定消融后治疗方案。

6. 发明授权

US08903510B2 Electrode configurations for leads or catheters to enhance localization using a localization system 有权
标题翻译：导线或导管的电极配置，以增强使用定位系统的定位
公开(公告)号：US08903510B2
公开(公告)日：2014-12-02
申请号：US12695815
申请日：2010-01-28
申请人： Stuart Rosenberg , Thao Thu Nguyen , Kyungmoo Ryu , Kjell Noren , Allen Keel , Wenbo Hou , Steve Koh , Michael Yang
发明人： Stuart Rosenberg , Thao Thu Nguyen , Kyungmoo Ryu , Kjell Noren , Allen Keel , Wenbo Hou , Steve Koh , Michael Yang
IPC分类号： A61N1/00 , A61B5/053 , A61N1/05
CPC分类号： A61B5/0538 , A61B5/0536 , A61B2562/0209 , A61N1/05 , A61N1/056
摘要： An exemplary method includes positioning a lead in a patient where the lead has a longitudinal axis that extends from a proximal end to a distal end and where the lead includes an electrode with an electrical center offset from the longitudinal axis of the lead body; measuring electrical potential in a three-dimensional potential field using the electrode; and based on the measuring and the offset of the electrical center, determining lead roll about the longitudinal axis of the lead body where lead roll may be used for correction of field heterogeneity, placement or navigation of the lead or physiological monitoring (e.g., cardiac function, respiration, etc.). Various other methods, devices, systems, etc., are also disclosed.
摘要翻译：一种示例性方法包括将引线定位在患者体内，其中引线具有从近端延伸到远端的纵向轴线，并且其中引线包括具有偏离引线主体的纵向轴线的电中心的电极; 使用所述电极测量三维势场中的电位; 并且基于电气中心的测量和偏移，确定围绕引线主体的纵轴的引导辊，其中引导辊可用于校正磁场异质性，引线的放置或导航或生理监测（例如，心脏功能，呼吸等）。还公开了各种其它方法，装置，系统等。

7. 发明授权

US08326419B2 Therapy optimization via multi-dimensional mapping 有权
标题翻译：通过多维映射进行治疗优化
公开(公告)号：US08326419B2
公开(公告)日：2012-12-04
申请号：US12755366
申请日：2010-04-06
申请人： Stuart Rosenberg , Kyungmoo Ryu , Allen Keel , Wenbo Hou , Thao Thu Nguyen , Steve Koh , Kjell Noren , Michael Yang
发明人： Stuart Rosenberg , Kyungmoo Ryu , Allen Keel , Wenbo Hou , Thao Thu Nguyen , Steve Koh , Kjell Noren , Michael Yang
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A61B5/042 , A61B5/7203 , A61N1/3627 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36578 , A61N1/3684 , A61N1/37258 , A61N1/37264
摘要： An exemplary method includes accessing cardiac information acquired via a catheter located at various positions in a venous network of a heart of a patient where the cardiac information comprises position information, electrical information and mechanical information; mapping local electrical activation times to anatomic positions to generate an electrical activation time map; mapping local mechanical activation times to anatomic positions to generate a mechanical activation time map; generating an electromechanical delay map by subtracting local electrical activation times from corresponding local mechanical activation times; and rendering at least the electromechanical delay map to a display. Various other methods, devices, systems, etc., are also disclosed.
摘要翻译：一种示例性方法包括访问位于患者心脏的静脉网络中的各个位置处的导管获取的心脏信息，其中所述心脏信息包括位置信息，电信息和机械信息; 将局部电激活时间映射到解剖位置以产生电激活时间图; 将局部机械激活时间映射到解剖位置以产生机械激活时间图; 通过从相应的局部机械激活时间减去局部电激活时间来产生机电延迟图; 并将至少机电延迟图呈现给显示器。还公开了各种其它方法，装置，系统等。

8. 发明授权

US08175693B2 Cardiac resynchronization therapy optimization using electromechanical delay from realtime electrode motion tracking 有权
标题翻译：使用实时电极运动跟踪的机电延迟的心脏再同步治疗优化
公开(公告)号：US08175693B2
公开(公告)日：2012-05-08
申请号：US13206395
申请日：2011-08-09
申请人： Stuart Rosenberg , Allen Keel , Kyungmoo Ryu , Wenbo Hou , Kjell Noren , Thao Ngo , Michael Yang
发明人： Stuart Rosenberg , Allen Keel , Kyungmoo Ryu , Wenbo Hou , Kjell Noren , Thao Ngo , Michael Yang
IPC分类号： A61B5/04
CPC分类号： A61N1/3627 , A61B5/0422 , A61B5/0452 , A61B5/1107 , A61B5/6876 , A61B2562/043 , A61N1/36514 , A61N1/36578 , A61N1/3684 , A61N1/37252
摘要： An exemplary method includes providing a mechanical activation time (MA time) for a myocardial location, the location defined at least in part by an electrode and the mechanical activation time determined at least in part by movement of the electrode; providing an electrical activation time (EA time) for the myocardial location; and determining an electromechanical delay (EMD) for the myocardial location based on the difference between the mechanical activation time (MA time) and the electrical activation time (EA time).
摘要翻译：示例性方法包括提供用于心肌位置的机械活化时间（MA时间），至少部分地由电极限定的位置和至少部分地通过电极的移动确定的机械活化时间; 为心肌位置提供电激活时间（EA时间）; 并且基于机械激活时间（MA时间）和电激活时间（EA时间）之间的差异来确定心肌位置的机电延迟（EMD）。

9. 发明授权

US08155739B2 Cardiac resynchronization therapy optimization using mechanical dyssynchrony and shortening parameters from realtime electrode motion tracking 有权
标题翻译：心脏再同步治疗优化使用机械不同步和缩短参数从实时电极运动跟踪
公开(公告)号：US08155739B2
公开(公告)日：2012-04-10
申请号：US12476043
申请日：2009-06-01
申请人： Allen Keel , Stuart Rosenberg , Kyungmoo Ryu , Wenbo Hou , Thao Thu Nguyen , Kjell Noren , Michael Yang
发明人： Allen Keel , Stuart Rosenberg , Kyungmoo Ryu , Wenbo Hou , Thao Thu Nguyen , Kjell Noren , Michael Yang
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61B5/11 , A61B5/686 , A61B5/6869 , A61B5/7207 , A61N1/36514 , A61N1/36578 , A61N1/3684
摘要： Therapy optimization includes tracking electrode motion using an electroanatomic mapping system and generating, based on tracked electrode motion, one or more mechanical dyssynchrony metrics to thereby guide a clinician in therapy optimization (e.g., via optimal electrode sites, optimal therapy parameters, etc.). Such a method may include a vector analysis of electrode motion with respect to factors such as times in cardiac cycle, phases of a cardiac cycle, and therapy conditions, e.g., pacing sites, pacing parameters and pacing or no pacing. Differences in position-with-respect-to-time data for electrodes may also be used to provide measurements of mechanical dyssynchrony.
摘要翻译：治疗优化包括使用电解剖映射系统跟踪电极运动，并且基于跟踪的电极运动产生一个或多个机械不同步度量，从而指导临床医生进行治疗优化（例如通过最佳电极位置，最佳治疗参数等）。这样的方法可以包括关于诸如心脏周期中的时间，心动周期的相位以及治疗条件（例如，起搏部位，起搏参数和起搏或无起搏）的因素的电极运动的矢量分析。电极位置相对时间数据的差异也可用于提供机械不同步的测量。

10. 发明申请

US20110066203A1 ELECTRODE AND LEAD STABILITY INDEXES AND STABILITY MAPS BASED ON LOCALIZATION SYSTEM DATA 审中-公开
标题翻译：基于本地化系统数据的电极和引线稳定性指标和稳定性
公开(公告)号：US20110066203A1
公开(公告)日：2011-03-17
申请号：US12562018
申请日：2009-09-17
申请人： Stuart Rosenberg , Thao Thu Nguyen , Kyungmoo Ryu , Kjell Noren , Allen Keel , Wenbo Hou , Michael Yang
发明人： Stuart Rosenberg , Thao Thu Nguyen , Kyungmoo Ryu , Kjell Noren , Allen Keel , Wenbo Hou , Michael Yang
IPC分类号： A61B5/05 , A61N1/08 , A61N1/365
CPC分类号： A61B5/042 , A61B5/6885 , A61N1/36114 , A61N1/36185 , A61N1/3622 , A61N1/3686 , A61N1/37 , A61N1/37247
摘要： A method includes selecting an electrode located in a patient; acquiring position information with respect to time for the electrode, during both acute and chronic states of the electrode, where the acquiring uses the electrode for repeatedly measuring electrical potentials in an electrical localization field established in the patient; calculating an acute state stability metric and a chronic state stability metric for the electrode based on the acquired position information with respect to time; and comparing the acute state stability metric to the chronic state stability metric to decide whether the electrode, as located in the patient in the chronic state, comprises a stable location for delivery of a therapy. The chronic state stability metric of an electrode may be monitored over time to decide whether stability of the electrode has changed.
摘要翻译：一种方法包括选择位于患者体内的电极; 在电极的急性和慢性状态期间获取关于电极的时间的位置信息，其中采集电极用于在建立在患者中的电定位场中重复测量电位; 基于相对于时间获取的位置信息计算电极的急性状态稳定性度量和慢性状态稳定性度量; 以及将急性状态稳定性度量与慢性状态稳定性度量进行比较，以确定位于慢性状态的患者中的电极是否包括用于递送治疗的稳定位置。可以随时间监测电极的慢性状态稳定性度量，以确定电极的稳定性是否改变。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式