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1. 发明授权

US4137313A 2,5-Dihydro-1,2-thiazino(5,6-b)indole-3-carboxamide-1,1-dioxides and salts thereof 失效
标题翻译： 2,5-二氢-1,2-噻嗪（5,6-b）吲哚-3-甲酰胺-1,1-二氧化物及其盐
公开(公告)号：US4137313A
公开(公告)日：1979-01-30
申请号：US872889
申请日：1978-01-27
申请人： Gunter Trummlitz , Wolfhard Engel , Ernst Seeger , Walter Haarmann , Gunther Engelhardt
发明人： Gunter Trummlitz , Wolfhard Engel , Ernst Seeger , Walter Haarmann , Gunther Engelhardt
IPC分类号： A61K31/54 , A61P7/02 , A61P29/00 , C07D209/42 , C07D513/04 , C07D513/14 , A61K31/38
CPC分类号： C07D513/04 , C07D209/42 , C07D513/14 , Y10S514/822
摘要： Compounds of the formula ##STR1## WHEREIN R.sub.1 is hydrogen, methyl or ethyl;R.sub.2 is methyl or ethyl;Y is hydrogen, fluorine, chlorine, bromine, methoxy, methyl, ethyl or trifluoromethyl; andAr is 2-thiazolyl which may have one or two methyl or ethyl substituents attached thereto; 5,6-dihydro-4H-cyclopentathiazol-2-yl; 4,5,6,7-tetrahydro-2-benzothiazolyl; 2-benzothiazolyl; 3-isothiazolyl which may have a methyl substituent attached thereto; 2-pyridyl which may have a methyl or hydroxyl substituent attached thereto; 3-pyridyl; 4-pyridyl; 4-pyrimidinyl; pyrazinyl; 2-benzimidazolyl; 2-oxazolyl which may have a methyl substituent attached thereto; 2-benzoxazolyl; or phenyl which may have a fluoro, chloro, bromo, methyl, ethyl, trifluoromethyl or methoxy substituent attached thereto; and non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases. The compounds as well as their salts are useful as antiphlogistics and blood platelet aggregation inhibitors.
摘要翻译：式中的化合物，其中R1是氢，甲基或乙基; R2是甲基或乙基; Y是氢，氟，氯，溴，甲氧基，甲基，乙基或三氟甲基; 并且Ar是可以具有一个或两个连接到其上的甲基或乙基取代基的2-噻唑基; 5,6-二氢-4H-环戊基噻唑-2-基; 4,5,6,7-四氢-2-苯并噻唑基; 2-苯并噻唑基可具有与其连接的甲基取代基的3-异噻唑基; 可以具有连接到其上的甲基或羟基取代基的2-吡啶基; 3-吡啶基; 4-吡啶基; 4-嘧啶基; 吡嗪基 2-苯并咪唑基; 可具有与其连接的甲基取代基的2-恶唑基; 2-苯并恶唑基; 或可具有与其连接的氟，氯，溴，甲基，乙基，三氟甲基或甲氧基取代基的苯基; 和与无机或有机碱形成的无毒的，药学上可接受的盐。化合物及其盐可用作消炎剂和血小板聚集抑制剂。

2. 发明授权

US4328235A Suppressing pain with benzothiazol-2(3H)-ones 失效
标题翻译：用苯并噻唑-2（3H）酮抑制疼痛
公开(公告)号：US4328235A
公开(公告)日：1982-05-04
申请号：US163965
申请日：1980-06-30
申请人： Gunter Trummlitz , Wolfhard Engel , Gunther Schmidt , Wolfgang Eberlein , Ernst Seeger , Gunther Engelhardt , Rainer Zimmermann
发明人： Gunter Trummlitz , Wolfhard Engel , Gunther Schmidt , Wolfgang Eberlein , Ernst Seeger , Gunther Engelhardt , Rainer Zimmermann
IPC分类号： A61K31/425 , A61K31/428 , A61P25/04 , A61P29/00 , C07D277/68
CPC分类号： C07D277/68 , A61K31/425
摘要： There are described pharmaceutical compositions containing as active substances benzothiazol-2(3H)-ones of the general formula ##STR1## wherein R represents a hydrogen atom or a methyl, methoxy, or ethoxy group. The pharmaceutical compositions serve as analgesics and antipyretics and possess little or no methemoglobin-forming activity.
摘要翻译：描述了含有作为活性物质的通式为“IMAGE”的苯并噻唑-2（3H） - 酮的药物组合物，其中R表示氢原子或甲基，甲氧基或乙氧基。药物组合物用作止痛剂和解热药，并且几乎没有或没有高铁血红蛋白形成活性。

3. 发明授权

US4259336A 4-Hydroxy-2H-[1]-benzothieno [2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxides and salts thereof 失效
标题翻译： 4-羟基-2H- [1] - 苯并噻吩并[2,3-e] -1,2-噻嗪-3-甲酰胺-1,1-二氧化物及其盐
公开(公告)号：US4259336A
公开(公告)日：1981-03-31
申请号：US86743
申请日：1979-10-22
申请人： Wolfhard Engel , Gunter Trummlitz , Ernst Seeger , Walter Haarmann , Gunther Engelhardt , Rainer Zimmermann
发明人： Wolfhard Engel , Gunter Trummlitz , Ernst Seeger , Walter Haarmann , Gunther Engelhardt , Rainer Zimmermann
IPC分类号： A61K31/54 , A61P9/08 , A61P9/10 , A61P29/00 , C07D333/70 , C07D513/04 , A61K31/38
CPC分类号： C07D513/04 , C07D333/70 , Y10S514/822
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, halogen or alkyl of 1 to 3 carbon atoms; R.sub.2 is hydrogen or alkyl of 1 to 3 carbon atoms; andR.sub.3 is aromatic hydrocarbyl of 6 to 10 carbon atoms or an aromatic heterocycle of 2 to 9 carbon atoms and 1 to 2 nitrogen atoms and/or an oxygen or a sulfur atom, where each of said aromatic substituents may in turn be substituted with one or two alkyls of 1 to 6 carbon atoms, halogen, hydroxyl, trifluoromethyl, halophenyl or alkoxy of 1 to 3 carbon atoms;and non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases; the compounds as well as their salts are useful as analgesics, antipyretics, antithrombotic and antiphlogistics.
摘要翻译：其中R 1是氢，卤素或1至3个碳原子的烷基; R2是氢或1至3个碳原子的烷基; 并且R 3是6至10个碳原子的芳族烃基或2至9个碳原子和1至2个氮原子和/或氧或硫原子的芳族杂环，其中每个所述芳族取代基可以依次被一个或两个1至6个碳原子的烷基，卤素，羟基，三氟甲基，卤代苯基或具有1至3个碳原子的烷氧基; 和与无机或有机碱形成的无毒的，药理学上可接受的盐; 化合物及其盐可用作镇痛药，解热药，抗血栓和消炎药。

4. 发明授权

US4233299A 4-Hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxides and salts thereof 失效
标题翻译： 4-羟基-2H-1,2-苯并噻嗪-3-甲酰胺-1,1-二氧化物及其盐
公开(公告)号：US4233299A
公开(公告)日：1980-11-11
申请号：US966963
申请日：1978-12-06
申请人： Gunter Trummlitz , Wolfhard Engel , Ernst Seeger , Gunther Engelhardt
发明人： Gunter Trummlitz , Wolfhard Engel , Ernst Seeger , Gunther Engelhardt
IPC分类号： A61K31/427 , A61K31/54 , A61K31/5415 , A61P29/00 , C07D275/06 , C07D279/02 , C07D417/12 , C07D513/14 , A61K31/38
CPC分类号： C07D275/06 , C07D279/02 , C07D417/12 , C07D513/14
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, methyl or ethyl;R.sub.2 is methyl, ethyl or n-propyl; andY is hydrogen, methyl, methoxy, fluorine or chlorine;and non-toxic, pharmacologically acceptable salts thereof formed with an inorganic or organic base. The compounds as well as their salts are useful as antiphlogistics.
摘要翻译：其中R 1是氢，甲基或乙基; R2是甲基，乙基或正丙基; Y为氢，甲基，甲氧基，氟或氯; 和与无机或有机碱形成的无毒的，药学上可接受的盐。化合物及其盐可用作消炎剂。

5. 发明授权

US3992535A 4-Hydroxy-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxides and salts thereof 失效
标题翻译： 4-羟基-2H-萘并（{2,1-e {9-1,2-噻嗪-3-甲酰胺-1,1-二氧化物及其盐
公开(公告)号：US3992535A
公开(公告)日：1976-11-16
申请号：US626623
申请日：1975-10-29
申请人： Gunter Trummlitz , Helmut Teufel , Wolfhard Engel , Ernst Seeger , Walter Haarmann , Gunther Engelhardt
发明人： Gunter Trummlitz , Helmut Teufel , Wolfhard Engel , Ernst Seeger , Walter Haarmann , Gunther Engelhardt
IPC分类号： C07D275/06 , C07D279/02 , C07D417/12 , C07D513/04 , A61K31/54
CPC分类号： C07D275/06 , C07D279/02
摘要： Compounds of the formula ##SPC1##WhereinR.sub.1 is hydrogen, methyl or ethyl, andAr is phenyl, 3-chlorophenyl, 3-bromophenyl, 2-fluorophenyl, 3-fluorophenyl, 4-fluorophenyl, 3-tolyl, 2-methoxyphenyl, 3-methoxyphenyl, 2-pyridyl, 4-methyl-2-pyridyl, 6-methyl-2-pyridyl, 3-hydroxy-2-pyridyl, 3-pyridyl, 4-pyridyl, 6-chloro-3-pyridazinyl, 2-pyrazinyl, 6-chloro-2-pyrazinyl, 6-chloro-4-pyrimidinyl, 2-thiazolyl, 4-methyl-2-thiazolyl, 4-ethyl-2-thiazolyl, 5-methyl-2-thiazolyl, 5-ethyl-2-thiazolyl, 4,5-dimethyl-2-thiazolyl, 4-ethyl-5-methyl-2-thiazolyl, 5-ethyl-4-methyl-2-thiazolyl, 2-benzothiazolyl, 4,5,6,7-tetrahydro-2-benzothiazolyl, 5,6-dihydro-7H-thiopyrano[4,3-d]thiazol-2-yl, 3-methyl-5-isothiazolyl, 1,3,4-thiadiazolyl, 5-methyl-1,3,4-thiadiazol-2-yl or 5-methyl-3-isoxazolyl,And non-toxic, pharmacologically acceptable salts thereof formed with an inorganic or organic base; the compounds as well as their salts are useful as inhibitors of platelet adhesion and aggregation.
摘要翻译：式WHERE R1的化合物是氢，甲基或乙基，Ar是苯基，3-氯苯基，3-溴苯基，2-氟苯基，3-氟苯基，4-氟苯基，3-甲苯基，2-甲氧基苯基，3-甲氧基苯基， 2-吡啶基，4-甲基-2-吡啶基，6-甲基-2-吡啶基，3-羟基-2-吡啶基，3-吡啶基，4-吡啶基，6-氯-3-哒嗪基，2-吡嗪基，6-吡啶基， 4-氯-2-吡嗪基，6-氯-4-嘧啶基，2-噻唑基，4-甲基-2-噻唑基，4-乙基-2-噻唑基，5-甲基-2-噻唑基，5-乙基-2-噻唑基， 4,5-二甲基-2-噻唑基，4-乙基-5-甲基-2-噻唑基，5-乙基-4-甲基-2-噻唑基，2-苯并噻唑基，4,5,6,7-四氢-2- 苯并噻唑基，5,6-二氢-7H-噻喃并[4,3-d]噻唑-2-基，3-甲基-5-异噻唑基，1,3,4-噻二唑基，5-甲基-1,3,4-噻二唑基，噻二唑-2-基或5-甲基-3-异恶唑基，以及与无机或有机碱形成的非毒性，药理学上可接受的盐; 化合物作为它们的盐作为板材粘合和聚集的抑制剂有用。

6. 发明授权

US3950427A Araliphatic ketones and carbinols 失效
标题翻译：脂肪族酮和甲醇
公开(公告)号：US3950427A
公开(公告)日：1976-04-13
申请号：US532174
申请日：1974-12-12
申请人： Wolfhard Engel , Josef Nickl , Helmut Teufel , Gunther Engelhardt , Ernst Seeger , Gunter Trummlitz
发明人： Wolfhard Engel , Josef Nickl , Helmut Teufel , Gunther Engelhardt , Ernst Seeger , Gunter Trummlitz
IPC分类号： C07C49/20 , C07C27/00 , C07C29/136 , C07C29/143 , C07C29/145 , C07C29/17 , C07C29/40 , C07C33/18 , C07C33/24 , C07C33/28 , C07C33/30 , C07C33/34 , C07C33/38 , C07C33/40 , C07C33/46 , C07C33/48 , C07C33/50 , C07C45/00 , C07C45/29 , C07C45/30 , C07C45/62 , C07C45/67 , C07C49/233 , C07C49/235 , C07C49/237 , C07C67/00 , C25B3/04 , C07C49/76 , C07C49/80
CPC分类号： C25B3/04 , C07C29/143 , C07C29/145 , C07C29/17 , C07C29/175 , C07C29/40 , C07C33/24 , C07C33/28 , C07C33/30 , C07C33/34 , C07C33/38 , C07C33/46 , C07C33/483 , C07C33/486 , C07C33/50 , C07C45/004 , C07C45/29 , C07C45/513 , C07C45/62 , C07C45/74 , C07C49/215 , C07C49/217 , C07C49/225 , C07C49/233 , C07C49/235 , C07C49/237 , C07B2200/09 , C07C2101/14 , C07C2101/18
摘要： Compounds of the formula ##SPC1##WhereinR.sub.1 is isobutyl, phenyl, o-fluoro-phenyl, o-chloro-phenyl, cyclopentyl, cyclohexyl, methyl-cyclo-hexyl or cycloheptyl,R.sub.2 is hydrogen, fluorine, chlorine or bromine,R.sub.3 is methyl, ethyl or, when R.sub.1 is phenyl, fluoro-phenyl or chloro-phenyl, or R.sub.1 is cyclohexyl and R.sub.2 is halogen, also hydrogen,Z.sub.1 and Z.sub.2 are hydrogen or together form an additional carbon-to-carbon bond,A is ##EQU1## or ##EQU2## and M IS 2, 4, 6, 8 OR WHEN R.sub.1 is halo-phenyl, isobutyl, cyclohexyl, methyl-cyclohexyl, cyclopentyl or cycloheptyl and/or R.sub.2 is halogen and/or R.sub.3 is methyl or ethyl and/or A is --CH(OH)--, also O; the compounds are useful as antiphlogistics.
摘要翻译：式WHERE R1的化合物是异丁基，苯基，邻 - 氟 - 苯基，邻 - 氯 - 苯基，环戊基，环己基，甲基 - 环己基或环庚基，R2是氢，氟，氯或溴，R3是甲基，乙基或者当R 1为苯基，氟代苯基或氯代苯基或R 1为环己基且R 2为卤素时，氢，Z 1和Z 2为氢或一起形成另外的碳 - 碳键，A为O并原-C - 或HOH ANGLE -C-和M为2,4,6,8或当R 1为卤代苯基，异丁基，环己基，甲基 - 环己基，环戊基或环庚基和/或R 2为卤素和/或R 3为甲基或乙基和/或A是-CH（OH） - ，也是O; 该化合物可用作消炎药。

7. 发明授权

US4533664A Antithrombotic N-(6-chloro-pyrazin-2-yl)-4-Hydroxy-2H-1,2-benzothiazine-3-carboxamide-1 ,1-dioxide derivatives, composition, and method of use 失效
标题翻译：抗血栓形成的N-（6-氯 - 吡嗪-2-基）-4-羟基-2H-1,2-苯并噻嗪-3-甲酰胺-1,1-二氧化物衍生物，组合物和使用方法
公开(公告)号：US4533664A
公开(公告)日：1985-08-06
申请号：US537592
申请日：1983-09-30
申请人： Gunter Trummlitz , Wolfhard Engel , Ernst Seeger , Walter Haarmann
发明人： Gunter Trummlitz , Wolfhard Engel , Ernst Seeger , Walter Haarmann
IPC分类号： A61K31/497 , A61K31/54 , A61K31/5415 , A61P7/02 , C07D417/12 , A61K31/38 , C07D417/02
CPC分类号： C07D417/12
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, methyl, methoxy, fluorine or chlorine; andR.sub.2 is hydrogen, methyl, ethyl or n-propyl;and non-toxic, pharmacologically acceptable salts thereof formed with an inorganic or organic base. The compounds as well as the salts are useful as antithrombotics.
摘要翻译：其中R 1是氢，甲基，甲氧基，氟或氯的式IMA化合物; R2是氢，甲基，乙基或正丙基; 和与无机或有机碱形成的无毒的，药学上可接受的盐。化合物以及盐可用作抗血栓形成剂。

8. 发明授权

US4430355A Condensed isothiazolo-3 (2H)-one-1-1-dioxides 失效
标题翻译：缩合异噻唑-3（2H） - 酮-1,1-二氧化物
公开(公告)号：US4430355A
公开(公告)日：1984-02-07
申请号：US297004
申请日：1981-08-27
申请人： Gunter Trummlitz , Ernst Seeger , Wolfhard Engel
发明人： Gunter Trummlitz , Ernst Seeger , Wolfhard Engel
IPC分类号： A23L27/30 , C07D307/64 , C07D307/68 , C07D333/34 , C07D333/38 , C07D513/04 , C07D275/06 , A23L1/236
CPC分类号： C07D513/04 , A23L27/30 , A23L27/34 , C07D307/64 , C07D307/68 , C07D333/34 , C07D333/38
摘要： Compounds of the formula ##STR1## wherein X is oxygen or sulfur;R.sub.1 is hydrogen, methyl or ethyl; andR.sub.2 is methyl or ethyl;and non-toxic, physiologically acceptable salts thereof formed with an inorganic or organic base. The compounds as well as their salts are useful as sweetening agents.
摘要翻译：下式的化合物：其中X是氧或硫; R1是氢，甲基或乙基; R2为甲基或乙基; 和与无机或有机碱形成的无毒的生理上可接受的盐。化合物及其盐可用作甜味剂。

9. 发明授权

US4233333A 4,5-Dimethyl-thieno[3,2-d]isothiazolo-3(2H)-one-1,1-dioxides, compositions, and methods of use as a sweetener 失效
标题翻译： 4,5-二甲基 - 噻吩并[3,2-d]异噻唑-3（2H） - 酮-1,1-二氧化物，组合物和用作甜味剂的方法
公开(公告)号：US4233333A
公开(公告)日：1980-11-11
申请号：US952958
申请日：1978-10-20
申请人： Gunter Trummlitz , Ernst Seeger , Wolfhard Engel
发明人： Gunter Trummlitz , Ernst Seeger , Wolfhard Engel
IPC分类号： A23L27/30 , C07D307/64 , C07D307/68 , C07D333/34 , C07D333/38 , C07D513/04 , C07D275/00
CPC分类号： C07D513/04 , A23L27/30 , A23L27/34 , C07D307/64 , C07D307/68 , C07D333/34 , C07D333/38
摘要： Compounds of the formula ##STR1## wherein X is oxygen or sulfur;R.sub.1 is hydrogen, methyl or ethyl; andR.sub.2 is methyl or ethyl;and non-toxic, physiologically acceptable salts thereof formed with an inorganic or organic base. The compounds as well as their salts are useful as sweetening agents.
摘要翻译：下式的化合物：其中X是氧或硫; R1是氢，甲基或乙基; R2为甲基或乙基; 和与无机或有机碱形成的无毒的生理上可接受的盐。化合物及其盐可用作甜味剂。

10. 发明授权

US4288437A 2-[(Amino)-aryl-methylene]-benzo[b]thiophen-3(2H)-ones 失效
标题翻译： 2 - [（氨基） - 芳基 - 亚甲基] - 苯并[b]噻吩-3（2H） - 酮
公开(公告)号：US4288437A
公开(公告)日：1981-09-08
申请号：US173173
申请日：1980-07-28
申请人： Wolfhard Engel , Gunter Trummlitz , Ernst Seeger , Joachim Kahling
发明人： Wolfhard Engel , Gunter Trummlitz , Ernst Seeger , Joachim Kahling
IPC分类号： A61K31/38 , A61K31/381 , A61K31/44 , A61K31/4433 , A61K31/445 , A61K31/495 , A61K31/535 , A61P25/08 , C07D333/62 , C07D333/64 , C07D409/06
CPC分类号： C07D333/62 , C07D333/64
摘要： Compounds of the formula ##STR1## wherein Ar is phenyl; mono- or di-substituted phenyl, where the substituents are one to two halogens, one to two alkyls of 1 to 3 carbon atoms, or one amino, nitro, cyano or trifluoromethyl; or pyridinyl;R is hydrogen, chlorine, methyl or methoxy;R.sub.1 is hydrogen or methyl;R.sub.2 is hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, methyl-(cycloalkyl of 3 to 8 carbon atoms) or --A--R.sub.4,where A is alkylene of 2 to 3 carbon atoms, and R.sub.4 is hydroxyl, methylamino, dimethylamino, N-methyl-ethylamino, diethylamino, pyrrolidino, piperidino, hexamethyleneimino, morpholino or 4-methyl-1-piperazinyl; orR.sub.1 and R.sub.2, together with each other and the nitrogen atom to which they are attached, form a 4- to 7-membered, saturated or mono-unsaturated, unsubstituted or substituted heterocycle which may contain nitrogen, oxygen, sulfur, sulfinyl or sulfonyl as additional ring members, where the substituents are alkyls of 1 to 3 carbon atoms.The compounds are useful as anticonvulsants.
摘要翻译：其中Ar是苯基的式IMAMA的化合物; 单取代或二取代的苯基，其中取代基是一至两个卤素，一至二个碳原子数为1至2个的烷基，或一个氨基，硝基，氰基或三氟甲基; 或吡啶基; R是氢，氯，甲基或甲氧基; R1是氢或甲基; R2是氢，1至6个碳原子的烷基，2至6个碳原子的烯基，2至6个碳原子的炔基，3至8个碳原子的环烷基，甲基 - 3至8个碳原子的环烷基或-A -R4，其中A为2至3个碳原子的亚烷基，R4为羟基，甲基氨基，二甲基氨基，N-甲基 - 乙基氨基，二乙基氨基，吡咯烷子基，哌啶子基，六亚甲基亚氨基，吗啉代或4-甲基-1-哌嗪基; 或R 1和R 2彼此连接并与它们相连的氮原子形成可含有氮，氧，硫，亚磺酰基或磺酰基的4-至7-元饱和或单不饱和的未被取代或取代的杂环作为另外的环成员，其中取代基是1至3个碳原子的烷基。该化合物可用作抗惊厥药。

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